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Review

Management of respiratory infections in the elderly

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Pages 505-516 | Published online: 10 Jan 2014

References

  • El-Solh AA, Sikka P, Ramadan F, Davies J. Etiology of severe pneumonia in the very elderly. Am. j Respir. Cat. Care Med. 163(3 Pt 1), 645–651 (2001).
  • Fernandez-Sabe N, Carratala J, Roson B, et al Community-acquired pneumonia in very elderly patients: causative organisms, clinical characteristics and outcomes. Medicine (Baltimore) 82,159–169 (2003).
  • Lieberman D, Lieberman D, Schlaeffer F, Porath A. Community-acquired pneumonia in old age: a prospective study of 91 patients admitted from home. Age Abreing26, 69–75 (1997).
  • •Prospective study of 91 community-acquired pneumonia (CAP) patients hospitali7ed from their homes with a clinical analysis and a very comprehensive serologic etiologic work-up.
  • Marston BJ, Plouffe JF, File TM Jr, et al Incidence of community-acquired pneumonia requiring hospitalization Results of a population-based active surveillance study in Ohio. The Community-Based Pneumonia Incidence Study Group. Arch. Intern. Med. 157, 1709–1718 (1997).
  • Ebright JR, Rytel MW. Bacterial pneumonia in the elderly. j Am Geriatric Soc. 28, 220 (1980).
  • Kaplan V, Clermont G, Griffin ME, et al Pneumonia: still the old man's friend? Arch. Intern. Med. 163, 317–323 (2003).
  • Zalacain R, Torres A, Celis R, et al Community-acquired pneumonia in the elderly: Spanish multicentre study. Eur Respir. J 21,294–302 (2003).
  • •A detailed analysis of various aspects of CAP based on a prospective, multicenter Spanish study of 503 elderly hospitalized patients.
  • Finkelstein MS, Petkun WM, Freedman ML, Antopol SC. Pneumococcal bacteremia in adults: Age-dependent differences in presentation and in outcome. A117. Geriatric Soc. 31,19–37 (1983).
  • Marrie TJ, Fine MJ, Kapoor WN, Coley CM, Singer DE, Obrosky DS. Community-acquired pneumonia and do not resuscitate orders. j Am. Geriatr Soc.50,290–299 (2002).
  • Lim WS, Macfarlane JT, Boswell TC, et al Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax 56, 296–301 (2001).
  • •A prospective British study of CAP in a population of 159 elderly patients that includes a comprehensive clinical analysis and serologic etiologic workup.
  • Riquelme R, Torres A, El-Ebiary M, et al Community-acquired pneumonia in the elderly: A multivariate analysis of risk and prognostic factors. Am. j Respir. Cat. Care Med. 154,1450–1455 (1996).
  • Venkatesan P, Glanoman J, Macfarlane JT, et al A hospital study of community acquired pneumonia in the elderly. Thorax 45,254-258 (1990).
  • Niederman MS, Fein AM. Pneumonia in the elderly. Geriatric Gun. N Am. 2, 241–268 (1986).
  • Verghese A, Berk SL. Bacterial pneumonia in the elderly. Medicine 62,271–285 (1983).
  • White RJ, Blainey AD, Harrison KJ, Clarke S. Causes of pneumonia presenting to a district general hospital. Thorax 36, 566–570 (1981).
  • Fein AM, Niederman MS. Severe pneumonia in the elderly. Clin. Geriatric Med. 10,121–143 (1994).
  • Arancibia F, Bauer TT, Ewig S, et al Community-acquired pneumonia due to Gram-negative bacteria and pseudomonas aeruginosa: incidence, risk and prognosis. Arch. Intern. Med. 162, 1849–1858 (2002).
  • •Risk factors for CAP caused by Gram-negative bacteria are presented.
  • Janssens JP, Gauthey L, Herrmann F, Thatch L, Michel JP. Community-acquired pneumonia in older patients. j Arn. Geriatric Soc. 44,539–544 (1996).
  • Marrie TJ, Haldane EV, Faulkner RS, Durant H, Kwan C. Community-acquired pneumonia requiring hospitalization: is it different in the elderly?' Am. Geriatric Soc. 33,671–680 (1985).
  • Cunha BA, Gingrich D, Rosenbaum GS. Pneumonia syndromes: a clinical approach in the elderly. Geriatric 45,49–55 (1990).
  • Tan MJ, Tan JS, File TM Jr. Legionnaires disease with bacteremic coinfection. Clin. Infect. Dis. 35,533–539 (2002).
  • Marik P, Careau P The role of anaerobes in patients with ventilator-associated pneumonia and aspiration pneumonia: a prospective study. Chest 115,178–183 (1999).
  • Marik PE. Aspiration pneumonitis and aspiration pneumonia. N Engl. I Med. 344,665–671 (2001).
  • Mier L, Dreyfuss D, Darchy B, et al Is Penicillin G an adequate initial treatment for aspiration pneumonia? A prospective evaluation using a protected specimen brush and quantitative cultures. Intensive Carr Med. 19,279–284 (1993).
  • Marrie TJ, Blanchard W A comparison of nursing home-acquired pneumonia patients with patients with community-acquired pneumonia and nursing home patients without pneumonia. jAm. Geriatric Soc. 45,50–55 (1997).
  • Garb JL, Brown RB, Garb JR, Tuthill RVV. Differences in etiology of pneumonias in nursing home and community patients. JA/V/A 240,2169–2175 (1978).
  • Lim WS, Macfarlane JT. A prospective comparison of nursing home acquired pneumonia with community acquired pneumonia. Eur. Respir.j 18,362–368 (2001).
  • Riquelme R, Torres A, El-Ebiary M, et al Community-acquired pneumonia in the elderly: clinical and nutritional aspects. Am. Respir Grit. Care Med 156,1908–1914 (1997).
  • Musgrave T, Verghese A. Clinical features of pneumonia in the elderly. Sernin. Respir. Infect. 5,269–275 (1990).
  • Ahkee S, Srinath L, Ramirez J. Community-acquired pneumonia in the elderly: association of mortality with lack of fever and leukocytosis. South Med. 190, 296–298 (1997).
  • Metlay JP, Schulz R, Li YH, et al Influence of age on symptoms at presentation in patients with community-acquired pneumonia. Arch. Intern. Med. 157, 1453–1459 (1997).
  • Syrjala H, Broad M, Suramo I, Ojala A, Lahde S. High-resolution computed tomography for the diagnosis of community-acquired pneumonia. Clin. Infect. Dis. 27,358–363 (1998).
  • •An original study of the importance of high-resolution computed tomography in the diagnosis of CAP
  • Kauppinen MT, Lahde S, Syrjala H. Roentgenographic findings of pneumonia caused by Chlamyclia pneumoniae. A comparison with streptococcal pneumonia. Arch. Intern. Med. 156,1851–1856 (1996).
  • Farr BM, Kaiser DL, Harrison BD, Connolly CK. Prediction of microbial aetiology at admission to hospital for pneumonia from the presenting clinical features. Thorax 44, 1031–1035 (1989).
  • Niederman MS, Mandell LA, Anzueto A, et al Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy and prevention. Am. Respir Grit. Carr Med 163,1730–1754 (2001).
  • •• Detailed report by the American ThoracicSociety from 2001 on the various aspects of CAP including detailed guidelines for hospitalization and antibiotic therapy.
  • Bartlett JG, Breiman RF, Mandell LA, File TM Jr. Community-acquired pneumonia in adults: guidelines for management. Clin. Infect. Dis. 26,811–838 (1998).
  • ••Detailed report of the Infectious DiseaseSociety of America from 1998 on various aspects of CAP including detailed guidelines for hospitalization and antibiotic therapy.
  • BTS Guidelines for the Management of Community Acquired Pneumonia in Adults. Thorax 56 (Suppl. 4), IV1-64 (2001). A detailed report by the British Thoracic Society from 2001 on the various aspectsof CAP including detailed guidelines for hospitalization and antibiotic therapy.
  • Fine MJ, Auble TE, Yealy DM, et al A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J. Med. 336,243–250 (1997).
  • ••Based on analysis of a huge database ascore is proposed for determining the risk of death in CAP patients. This score was found to be effective in deciding whether to hospitalize these patients.
  • Atlas SJ, Benzer TI, Borowsky LH, et al Safely increasing the proportion of patients with community-acquired pneumonia treated as out-patients: an interventional trial. Arch. Intern. Med. 158,1350–1356 (1998).
  • Marrie TJ, Lau CY, Wheeler SL, Wong CJ, Vandervoort MK, Feagan BG. A controlled trial of a critical pathway for treatment of community-acquired pneumonia. CAPITAL Study Investigators. Community-Acquired Pneumonia Intervention Trial Assessing Levofloxacin. JA/V/A 283,749–755 (2000).
  • Mody L, Sun R, Bradley S. Community-acquired pneumonia in older veterans: does the pneumonia prognosis index help? Arn. Geriatric Soc. 50,434–438 (2002).
  • Halm EA, Teirstein AS. Clinical practice. Management of community-acquired pneumonia. N Engl. I Med. 347, 2039–2045 (2002).
  • •Discussion of a specific case is used to present an update of practical aspects of the treatment of CAP in the elderly.
  • Menendez R, Ferrando D, Valles JM, Vallterra J. Influence of deviation from guidelines on the outcome of community-acquired pneumonia. Chest 122,612–617 (2002).
  • Dean NC, Silver MP, Bateman KA, James B, Hadlock CJ, Hale D. Decreased mortality after implementation of a treatment guideline for community-acquired pneumonia. Am. j Med. 110, 451–457 (2001).
  • Bartlett JG, Dowell SF, Mandell LA, File TM Jr, Musher DM, Fine MJ. Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Diseases Society of America. Clin. Infect. Dis. 31,347–382 (2000).
  • Gleason PP, Meehan TP, Fine JM, Galusha DH, Fine MJ. Associations between initial antimicrobial therapy and medical outcomes for hospitalized elderly patients with pneumonia. Arch. Intern. Med. 159, 2562–2572 (1999).
  • Houck PM, MacLehose RF, Niederman MS, Lowery JK. Empiric antibiotic therapy and mortality among medicare pneumonia in-patients in 10 western states: 1993,1995 and 1997. Chest 119,1420–1426 (2001).
  • Brown RB, Iannini P, Gross P, Kunkel M. Impact of initial antibiotic choice on clinical outco mes in community-acquired pneumonia: analysis of a hospital claims-made database. Chest 123,1503–1511 (2003).
  • Pallares R, Linares J, Vadillo M, et al Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain. N Engl. Med. 333,474–480 (1995).
  • Einarsson S, Kristjansson M, Kristinsson KG, Kjartansson G, Jonsson S. Pneumonia caused by penicillin-non-susceptible and penicillin-susceptible pneumococci in adults: a case-control study. Land. j Infect. Dis. 30,253–256 (1998).
  • Pallares R, Viladrich PF, Linares J, Cabellos C, Gudiol E Impact of antibiotic resistance on chemotherapy for pneumococcal infections. Mcrob. Drug-Resist. 4,339–347 (1998).
  • Yu VL, Chiou CC, Feldman C, et al An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered and clinical outcome. Gun. Infect. Dis. 37, 230–237 (2003).
  • File TM Jr, Tan JS. International guidelines for the treatment of community-acquired pneumonia in adults: the role of macrolides. Drugs 63,181–205 (2003).
  • Torres A, Muir JF, Corns P, et al Effectiveness of oral moxifloxacin in standard first-line therapy in community-acquired pneumonia. Eur Respir. 121, 135–143 (2003).
  • Zhanel GG, Ennis K, Vercaigne L, et al A critical review of the fluoroquinolones: focus on respiratory infections. Drugs62, 13–59 (2002).
  • •A comprehensive review of the various fluoroquinolones and their role in respiratory tract infections.
  • Nicholson SC, Wilson WR, Naughton BJ, Gothelf S, Webb CD. Efficacy and safety of gatifloxacin in elderly out-patients with community-acquired pneumonia. Diagn. Microbial. Infect. Dis. 44,117–125 (2002).
  • Ramirez JA, Vargas S, Ritter GW, et al Early switch from intravenous to oral antibiotics and early hospital discharge: a prospective observational study of 200 consecutive patient with community-acquired pneumonia. Arch. Intern. Med. 159,2449–2454 (1999).
  • Ramirez JA, Bordon J. Early switch from intravenous to oral antibiotics in hospitalized patients with bacteremic community-acquired Streptococcus pneumoniae pneumonia. Arch. Intern Med. 161,848–850 (2001).
  • Rhew DC, Tu GS, Ofman J, Henning JM, Richards MS, Weingarten SR. Early switch and early discharge strategies in patients with community-acquired pneumonia: a meta-analysis. Arch. Intern. Med. 161, 722–727 (2001).
  • Dunn AS, Peterson KL, Schechter CB, Rabito P, Gotlin AD, Smith LG. The utility of an in-hospital observation period after discontinuing intravenous antibiotics. Am. Med. 106,6–10 (1999).
  • Rhew DC, Hackner D, Henderson L, Ellrodt AG, Weingarten SR. The clinical benefit of in-hospital observation in 'low-risk' pneumonia patients after conversion from parenteral to oral antimicrobial therapy. Chest 113,142–146 (1998).
  • Sisk JE, Moskowitz AJ, Whang W, et al Cost-effectiveness of vaccination against pneumococcal bacteremia among elderly people. JAIVIA 278,1333–1339 (1997).
  • Wagner C, Popp W, Posch M, Vlasich C, Rosenberger-Spitzy A. Impact of pneumococcal vaccination on morbidity and mortality of geriatric patients: a case-controlled study. Cerontal 49,246–250 (2003).
  • Rubins JB, Janoff EN. Pneumococcal disease in the elderly: what is preventing vaccine efficacy? DITIF Aging18,305-311 (2001).
  • •A comprehensive review that summarizes the effectiveness of pneumococcal vaccination in the elderly.
  • Jackson LA, Neuzil KM, Yu O, et al Effectiveness of pneumococcal polysaccharide vaccine in older adults. N Engl J. Med. 348,1747–1755 (2003).
  • Gross PA, Hermogenes AW, Sacks HS, Lau J, Levandowski RA. The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature. Ann. Intern. Med. 123,518–527 (1995).
  • Vu T, Farish S, Jenkins M, Kelly H. A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community. Vaccine 20, 1831–1836 (2002).
  • Nichol KL, Nordin J, Mullooly J, Lask R, Fillbrandt K, Iwane M. Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly. N Engl J. Med. 348,1322–1332 (2003).
  • Voordouw BC, van der Linden PD,Simonian S, Van der Lei J, Sturkenboom MC, Stricker BH. Influenza vaccination in community-dwelling elderly: impact on mortality and influenza-associated morbidity. Arch. Intern Med. 163, 1089–1094 (2003).
  • Niederman MS, McCombs JS, Unger AN, Kumar A, Popovian R. The cost of treating community-acquired pneumonia. Clin. Ther. 20,820–837 (1998).
  • Fine MJ, Medsger AR, Stone RA, et al The hospital discharge decision for patients with community-acquired pneumonia. Results from the Pneumonia Patient Outcomes Research Team cohort study. Arch. Intern Med. 157,47–56 (1997).
  • Fine MJ, Hough LJ, Medsger AR, et al The hospital admission decision for patients with community-acquired pneumonia. Results from the Pneumonia Patient Outcomes Research Team cohort study. Arch. Intern. Med. 157,36–44 (1997).
  • Whittle J, Lin CJ, Lave JR, et al Relationship of provider characteristics to outcomes, process and costs of care for community-acquired pneumonia. Med Care 36,977–987 (1998).
  • Paladin° JA, Gudgel LD, Forrest A, Niederman MS. Cost-effectiveness of IV-to-oral switch therapy: azithromycin vs. cefuroxime with or without erythromycin for the treatment of community-acquired pneumonia. Chest 122,1271–1279 (2002).
  • Horowitz CR, Chassin MR. Improving the quality of pneumonia care that patients experience. Am.j Med 113,379–383 (2002).
  • Lidman C, Burman LG, Lagergren A, Ortqvist A. Limited value of routine microbiological diagnostics in patients hospitalized for community-acquired pneumonia. Scand. j Infect. Dis. 34, 873–879 (2002).
  • Rello J, Bodi M, Mariscal D, et al Microbiological testing and outcome of patients with severe community-acquired pneumonia. Chest 123,174–180 (2003).
  • Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Thoracic Society. Am. Respir. Ctit. Care Med 152, S77—S121 (1995).
  • Murphy TF, Sethi S. Chronic obstructive pulmonary disease: role of bacteria and guide to antibacterial selection in the older patient. Drugs Aging19,761-75 (2002).
  • ••A comprehensive and up-to-date review ofthe role and significance of various bacterial infections in AECOPD.
  • Ball P. Epidemiology and treatment ofchronic bronchitis and its exacerbations. Chest 108\(Suppl. 2), 43S-52S (1995).
  • Eller J, Ede A, Schaberg T, Niederman MS, Mauch H, Lode H. Infective exacerbations of chronic bronchitis: relation between bacteriologic etiology and lung function. Chest 113,1542–1548 (1998).
  • Soler N, Torres A, Ewig S, et al Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am.. 1. Respir. Grit. Care Med. 157, 1498–1505 (1998).
  • Blasi F, Legnani D, Lombardo VM, et al Chlamydia pneumoniae infection in acute exacerbations of COPD. Eur Respir. j 6, 19–22 (1993).
  • Beaty CD, Grayston JT, Wang S-P, Kuo C-C, Reto CS, Martin TR. Chlamydia pneumoniae, strain TWAR, infection in patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 144,1408–1410 (1991).
  • Lieberman D, Ben-Yaakov M, Lazarovich Z, Ohana B, Boldur I. Chlamydia pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease: analysis of 250 hospitalizations. Eur. j Clin. Microbial. Infect. Dis. 20,698–704 (2001).
  • Lieberman D, Shmarkov O, Gelfer Y, Ben-Yaakov M, Lazarovich Z, Boldur I. Serological evidence of Legionella species infection in acute exacerbation of COPD. Eur. Respir. 19,392–397 (2002).
  • Lieberman D, Ben-Yaakov M, Shmarkov O, et al Serological evidence of Mycoplasma pneumoniae infection in acute exacerbation of COPD. Diagn. Microbial. Infect. Dis. 44, 1–6 (2002).
  • Roig J, Soler X, Domingo C, de Celis G. Serological evidence of Legionella species infection in acute exacerbation of COPD. Eur Respir. 1. 20,504-505; author reply 505–506 (2002).
  • Lieberman D, Lieberman D, Ben-Yaakov M, et al Infectious etiologies in acute exacerbation of COPD. Diagn. Microbial. Infect. Dis. 40,95–102 (2001).
  • •A prospective serological-based study of the etiologies of AECOPD in a large population.
  • Destache CJ, Dewan N, O'Donohue WJ, Campbell JC, Angelillo VA. Clinical and economic considerations in the treatment of acute exacerbations of chronic bronchitis.. 1. Antimiavb. Chemother 43(Suppl. A), 107–113 (1999).
  • Sherk PA, Grossman RE The chronic obstructive pulmonary disease exacerbation. Clin. Chest Med. 21,705–721 (2000).
  • Yohannes AM, Hardy CC. Treatment of chronic obstructive pulmonary disease in older patients: a practical guide. Drugs Aging20, 209–228 (2003).
  • Wouters EE Economic analysis of the Confronting COPD survey: an overview of results. Respir Med. 97(Suppl. C), S3-14 (2003).
  • Lieberman D, Lieberman D, Korsonsky I, et al al. A comparative study of the etiology of adult upper and lower respiratory tract infections in the community. Diagn. Mcrobiol Infect. Dir. 42,21–28 (2002).
  • Macfarlane JT, Colville A, Guion A, Macfarlane RM, Rose DH. Prospective study of aetiology and outcome of adult lower-respiratory-tract infections in the community. Lancet 341,511–514 (1993).
  • Lieberman D, Ben-Yaakov M, Lazarovich Z, et al Infectious aetiologies in elderly patients hospitalised with non-pneumonic lower respiratory tract infection. Age Ageing 32,95–101 (2003).
  • •A prospective study of 133 elderly patients hospitalized with NP-RTI with a comprehensive serological work-up.
  • Gleckman RA. Bronchial infections: acute bronchitis and acute exacerbations of chronic bronchitis. Comprom. Ther. 13, 44–48 (1987).
  • Billas A. Lower respiratory tract infections. Prim. Carr 17,811–824 (1990).
  • Welti M, Jaton K, Altwegg M, Sahli R, Wenger A, Bille J. Development of a multiplex real-time quantitative PCR assay to detect Chlamydia pneumoniae, Legionella pneumophila and Mycoplasma pneumoniae in respiratory tract secretions. Diagn. Microbial. Infect. Dis. 45,85–95 (2003).
  • Marcos MA, Jimenez de Anta MT, De la Bellacasa JP, et al Rapid urinary antigen test for diagnosis of pneumococcal community-acquired pneumonia in adults. Eur. Respic 1. 21,209-214 (2003).

Websites

  • Community acquired pneumonia CAP Prognostic Calculator. http://ursa.kcom.edu/CAPcalcklefault.htm (Viewed August 2003)

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