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Review

Management of neonatal sepsis by Gram-negative pathogens

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Pages 929-938 | Published online: 10 Jan 2014

References

  • Lawn JE, Wilczynska-Ketende K, Cousens SN. Estimating the causes of 4 million neonatal deaths in the year 2000. Int. J. Epidemiol.35(3), 706–718 (2006).
  • Kaufman D, Fairchild KD. Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin. Microbiol. Rev.17(3), 638–680 (2004).
  • Stoll BJ, Hansen N, Fanaroff AA et al. Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N. Engl. J. Med.347(4), 240–247 (2002).
  • Stoll BJ, Hansen NI, Higgins RD et al. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of Gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002–2003. Pediatr. Infect. Dis. J.24(7), 635–639 (2005).
  • Stoll BJ, Hansen N, Fanaroff AA et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics110(2 Pt 1), 285–291 (2002).
  • Adams-Chapman I, Stoll BJ. Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Curr. Opin. Infect. Dis.19(3), 290–297 (2006).
  • Stoll BJ, Hansen NI, Adams-Chapman I et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA292(19), 2357–2365 (2004).
  • Schrag SJ, Stoll BJ. Early-onset neonatal sepsis in the era of widespread intrapartum chemoprophylaxis. Pediatr. Infect. Dis. J.25(10), 939–940 (2006).
  • Shah SS, Ehrenkranz RA, Gallagher PG. Increasing incidence of Gram-negative rod bacteremia in a newborn intensive care unit. Pediatr. Infect. Dis. J.18(7), 591–595 (1999).
  • Ronnestad A, Abrahamsen TG, Medbo S et al. Septicemia in the first week of life in a Norwegian national cohort of extremely premature infants. Pediatrics115(3), E262–E268 (2005).
  • Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B. Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics109(1), 34–39 (2002).
  • Joshi SG, Ghole VS, Niphadkar KB. Neonatal Gram-negative bacteremia. Indian J. Pediatr.67(1), 27–32 (2000).
  • Musoke RN, Revathi G. Emergence of multidrug-resistant Gram-negative organisms in a neonatal unit and the therapeutic implications. J. Trop. Pediatr.46(2), 86–91 (2000).
  • Stoll BJ, Hansen N. Infections in VLBW infants: studies from the NICHD Neonatal Research Network. Semin. Perinatol.27(4), 293–301 (2003).
  • Graham PL 3rd, Della-Latta P, Wu F, Zhou J, Saiman L. The gastrointestinal tract serves as the reservoir for Gram-negative pathogens in very low birth weight infants. Pediatr. Infect. Dis. J.26(12), 1153–1156 (2007).
  • Singh N, Patel KM, Leger MM et al. Risk of resistant infections with Enterobacteriaceae in hospitalized neonates. Pediatr. Infect. Dis. J.21(11), 1029–1033 (2002).
  • Pessoa-Silva CL, Meurer Moreira B, Camara Almeida V et al. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit: risk factors for infection and colonization. J. Hosp. Infect.53(3), 198–206 (2003).
  • Schrag SJ, Hadler JL, Arnold KE, Martell-Cleary P, Reingold A, Schuchat A. Risk factors for invasive, early-onset Escherichia coli infections in the era of widespread intrapartum antibiotic use. Pediatrics118(2), 570–576 (2006).
  • Graham PL 3rd, Begg MD, Larson E, Della-Latta P, Allen A, Saiman L. Risk factors for late onset Gram-negative sepsis in low birth weight infants hospitalized in the neonatal intensive care unit. Pediatr. Infect. Dis. J.25(2), 113–117 (2006).
  • Leigh L, Stoll BJ, Rahman M, McGowan J Jr. Pseudomonas aeruginosa infection in very low birth weight infants: a case–control study. Pediatr. Infect. Dis. J.14(5), 367–371 (1995).
  • Moolenaar RL, Crutcher JM, San Joaquin VH et al. A prolonged outbreak of Pseudomonas aeruginosa in a neonatal intensive care unit: did staff fingernails play a role in disease transmission? Infect. Control Hosp. Epidemiol.21(2), 80–85 (2000).
  • Rapkin RH. Pseudomonas cepacia in an intensive care nursery. Pediatrics57(2), 239–243 (1976).
  • Harpin VA, Rutter N. Humidification of incubators. Arch. Dis. Child.60(3), 219–224 (1985).
  • Parry MF, Hutchinson JH, Brown NA, Wu CH, Estreller L. Gram-negative sepsis in neonates: a nursery outbreak due to hand carriage of Citrobacter diversus. Pediatrics65(6), 1105–1109 (1980).
  • Lin FC, Devoe WF, Morrison C et al. Outbreak of neonatal Citrobacter diversus meningitis in a suburban hospital. Pediatr. Infect. Dis. J.6(1), 50–55 (1987).
  • Weir E. Powdered infant formula and fatal infection with Enterobacter sakazakii.CMAJ166(12), 1570 (2002).
  • Stoll BJ, Hansen N, Fanaroff AA, Lemons JA. Enterobacter sakazakii is a rare cause of neonatal septicemia or meningitis in VLBW infants. J. Pediatr.144(6), 821–823 (2004).
  • Clark NC, Hill BC, O’Hara CM, Steingrimsson O, Cooksey RC. Epidemiologic typing of Enterobacter sakazakii in two neonatal nosocomial outbreaks. Diagn. Microbiol. Infect. Dis.13(6), 467–472 (1990).
  • van Acker J, de Smet F, Muyldermans G, Bougatef A, Naessens A, Lauwers S. Outbreak of necrotizing enterocolitis associated with Enterobacter sakazakii in powdered milk formula. J. Clin. Microbiol.39(1), 293–297 (2001).
  • Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA. Phylogenetic perspectives in innate immunity. Science284(5418), 1313–1318 (1999).
  • Opal SM. The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis. Int. J. Med. Microbiol.297(5), 365–377 (2007).
  • Calvano SE, Xiao W, Richards DR et al. A network-based analysis of systemic inflammation in humans. Nature437(7061), 1032–1037 (2005).
  • Reitsma PH, Branger J, Van Den Blink B, Weijer S, Van Der Poll T, Meijers JC. Procoagulant protein levels are differentially increased during human endotoxemia. J. Thromb. Haemost.1(5), 1019–1023 (2003).
  • Karlowicz MG, Buescher ES, Surka AE. Fulminant late-onset sepsis in a neonatal intensive care unit, 1988–1997, and the impact of avoiding empiric vancomycin therapy. Pediatrics106(6), 1387–1390 (2000).
  • Uauy RD, Fanaroff AA, Korones SB, Phillips EA, Phillips JB, Wright LL. Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. National Institute of Child Health and Human Development Neonatal Research Network. J. Pediatr.119(4), 630–638 (1991).
  • Gordon A, Isaacs D. Late onset neonatal Gram-negative bacillary infection in Australia and New Zealand: 1992–2002. Pediatr. Infect. Dis. J.25(1), 25–29 (2006).
  • Doran TI. The role of Citrobacter in clinical disease of children: review. Clin. Infect. Dis.28(2), 384–394 (1999).
  • Graham DR, Band JD. Citrobacter diversus brain abscess and meningitis in neonates. JAMA245(19), 1923–1925 (1981).
  • Friesen CA, Cho CT. Characteristic features of neonatal sepsis due to Haemophilus influenzae.Rev. Infect. Dis.8(5), 777–780 (1986).
  • Kellogg JA, Ferrentino FL, Goodstein MH, Liss J, Shapiro SL, Bankert DA. Frequency of low level bacteremia in infants from birth to two months of age. Pediatr. Infect. Dis. J.16(4), 381–385 (1997).
  • Schelonka RL, Chai MK, Yoder BA, Hensley D, Brockett RM, Ascher DP. Volume of blood required to detect common neonatal pathogens. J. Pediatr.129(2), 275–278 (1996).
  • Ng PC. Diagnostic markers of infection in neonates. Arch. Dis. Child. Fetal Neonatal Ed.89(3), F229–F235 (2004).
  • Da Silva O, Ohlsson A, Kenyon C. Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review. Pediatr. Infect. Dis. J.14(5), 362–366 (1995).
  • Wasunna A, Whitelaw A, Gallimore R, Hawkins PN, Pepys MB. C-reactive protein and bacterial infection in preterm infants. Eur. J. Pediatr.149(6), 424–427 (1990).
  • Kawamura M, Nishida H. The usefulness of serial C-reactive protein measurement in managing neonatal infection. Acta Paediatr.84(1), 10–13 (1995).
  • Franz AR, Steinbach G, Kron M, Pohlandt F. Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections. Pediatrics104(3 Pt 1), 447–453 (1999).
  • Dollner H, Vatten L, Austgulen R. Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules. J. Clin. Epidemiol.54(12), 1251–1257 (2001).
  • Pourcyrous M, Bada HS, Korones SB, Baselski V, Wong SP. Significance of serial C-reactive protein responses in neonatal infection and other disorders. Pediatrics92(3), 431–435 (1993).
  • Ronnestad A, Abrahamsen TG, Gaustad P, Finne PH. C-reactive protein (CRP) response patterns in neonatal septicaemia. APMIS107(6), 593–600 (1999).
  • Koksal N, Harmanci R, Cetinkaya M, Hacimustafaoglu M. Role of procalcitonin and CRP in diagnosis and follow-up of neonatal sepsis. Turk. J. Pediatr.49(1), 21–29 (2007).
  • Arkader R, Troster EJ, Lopes MR et al. Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome. Arch. Dis. Child.91(2), 117–120 (2006).
  • Vazzalwar R, Pina-Rodrigues E, Puppala BL, Angst DB, Schweig L. Procalcitonin as a screening test for late-onset sepsis in preterm very low birth weight infants. J. Perinatol.25(6), 397–402 (2005).
  • Gerdes JS. Clinicopathologic approach to the diagnosis of neonatal sepsis. Clin. Perinatol.18(2), 361–381 (1991).
  • Bhandari V, Wang C, Rinder C, Rinder H. Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics121(1), 129–134 (2008).
  • Jordan JA, Durso MB. Comparison of 16S rRNA gene PCR and BACTEC 9240 for detection of neonatal bacteremia. J. Clin. Microbiol.38(7), 2574–2578 (2000).
  • Jordan JA, Durso MB. Real-time polymerase chain reaction for detecting bacterial DNA directly from blood of neonates being evaluated for sepsis. J. Mol. Diagn.7(5), 575–581 (2005).
  • Shang S, Chen G, Wu Y, Du L, Zhao Z. Rapid diagnosis of bacterial sepsis with PCR amplification and microarray hybridization in 16S rRNA gene. Pediatr. Res.58(1), 143–148 (2005).
  • Heath PT, Nik Yusoff NK, Baker CJ. Neonatal meningitis. Arch. Dis. Child. Fetal Neonatal Ed.88(3), F173–F178 (2003).
  • American Academy of Pediatrics. E. coli and other Gram-negative bacilli. In: Report of the Committee on Infectious Diseases. Pickering L (Ed.). American Academy of Pediatrics, IL, USA 273–275 (2003).
  • Gordon A, Jeffery HE. Antibiotic regimens for suspected late onset sepsis in newborn infants. Cochrane Database Syst. Rev.3, CD004501 (2005).
  • Bizzarro MJ, Gallagher PG. Antibiotic-resistant organisms in the neonatal intensive care unit. Semin. Perinatol.31(1), 26–32 (2007).
  • Gupta A. Hospital-acquired infections in the neonatal intensive care unit – Klebsiella pneumoniae.Semin. Perinatol.26(5), 340–345 (2002).
  • Gupta A, Ampofo K, Rubenstein D, Saiman L. Extended spectrum β lactamase-producing Klebsiella pneumoniae infections: a review of the literature. J. Perinatol.23(6), 439–443 (2003).
  • Calil R, Marba ST, von Nowakonski A, Tresoldi AT. Reduction in colonization and nosocomial infection by multiresistant bacteria in a neonatal unit after institution of educational measures and restriction in the use of cephalosporins. Am. J. Infect. Control29(3), 133–138 (2001).
  • Capparelli E, Hochwald C, Rasmussen M, Parham A, Bradley J, Moya F. Population pharmacokinetics of cefepime in the neonate. Antimicrob. Agents Chemother.49(7), 2760–2766 (2005).
  • Jones RN, Sader HS, Fritsche TR, Pottumarthy S. Comparisons of parenteral broad-spectrum cephalosporins tested against bacterial isolates from pediatric patients: report from the SENTRY Antimicrobial Surveillance Program (1998–2004). Diagn. Microbiol. Infect. Dis.57(1), 109–116 (2007).
  • Edwards JR. Meropenem: a microbiological overview. J. Antimicrob. Chemother.36(Suppl. A), 1–17 (1995).
  • Hoban DJ, Jones RN, Yamane N, Frei R, Trilla A, Pignatari AC. In vitro activity of three carbapenem antibiotics. Comparative studies with biapenem (L-627), imipenem, and meropenem against aerobic pathogens isolated worldwide. Diagn. Microbiol. Infect. Dis.17(4), 299–305 (1993).
  • American Academy of Pediatrics. Table-4.1. Tables of antibacterial drug dosages. In: Report of the Committee on Infectious Diseases. Pickering L (Ed.). American Academy of Pediatrics, IL, USA 700–701 (2003).
  • Linden P. Safety profile of meropenem: an updated review of over 6,000 patients treated with meropenem. Drug Saf.30(8), 657–668 (2007).
  • De Cunto A, Tana M, Vendettuoli V et al. Use of meropenem in preterm newborns. Survey of the literature and case series. Minerva Pediatr.59(6), 755–760 (2007).
  • Muscato JJ, Wilbur DW, Stout JJ, Fahrlender RA. An evaluation of the susceptibility patterns of Gram-negative organisms isolated in cancer centres with aminoglycoside usage. J. Antimicrob. Chemother.27(Suppl. C), 1–7 (1991).
  • Buesing MA, Jorgensen JH. In vitro activity of aztreonam in combination with newer β-lactams and amikacin against multiply resistant Gram-negative bacilli. Antimicrob. Agents Chemother.25(2), 283–285 (1984).
  • Constantopoulos A, Thomaidou L, Loupa H, Papoulias G. Successful response of severe neonatal Gram-negative infection to treatment with aztreonam. Chemotherapy35(Suppl. 1), 101–105 (1989).
  • Cuzzolin L, Fanos V, Zambreri D, Padovani EM, Benoni G. Pharmacokinetics and renal tolerance of aztreonam in premature infants. Antimicrob. Agents Chemother.35(9), 1726–1728 (1991).
  • Kilpatrick M, Girgis N, Farid Z, Bishay E. Aztreonam for treating meningitis caused by Gram-negative rods. Scand. J. Infect. Dis.23(1), 125–126 (1991).
  • Lentnek AL, Williams RR. Aztreonam in the treatment of Gram-negative bacterial meningitis. Rev. Infect. Dis.13(Suppl. 7), S586–S590 (1991).
  • Millar MR, Gorham P, Baxter H, Flannigan K, Congdon P. Pharmacokinetics of aztreonam in very low birthweight neonates. Eur. J. Clin. Microbiol.6(6), 691–692 (1987).
  • Sklavunu-Tsurutsoglu S, Gatzola-Karaveli M, Hatziioannidis K, Tsurutsoglu G. Efficacy of aztreonam in the treatment of neonatal sepsis. Rev. Infect. Dis.13(Suppl. 7), S591–S593 (1991).
  • Baker CJ. New uses of intravenous immune globulin in newborn infants. J. Clin. Immunol.10(6 Suppl.), S47–S52 (1990).
  • Ohlsson A, Lacy JB. Intravenous immunoglobulin for suspected or subsequently proven infection in neonates. Cochrane Database Syst. Rev.1, CD001239 (2004).
  • Norrby-Teglund A, Haque KN, Hammarstrom L. Intravenous polyclonal IgM-enriched immunoglobulin therapy in sepsis: a review of clinical efficacy in relation to microbiological aetiology and severity of sepsis. J. Intern. Med.260(6), 509–516 (2006).
  • Mohan P, Brocklehurst P. Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia. Cochrane Database Syst. Rev.4, CD003956 (2003).
  • Carr R, Modi N, Dore C. G-CSF and GM-CSF for treating or preventing neonatal infections. Cochrane Database Syst. Rev.3, CD003066 (2003).
  • Haque K, Mohan P. Pentoxifylline for neonatal sepsis. Cochrane Database Syst. Rev.4, CD004205 (2003).
  • Bernard GR, Vincent JL, Laterre PF et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med.344(10), 699–709 (2001).
  • Abraham E, Laterre PF, Garg R et al. Drotrecogin α (activated) for adults with severe sepsis and a low risk of death. N. Engl. J. Med.353(13), 1332–1341 (2005).
  • Kylat RI, Ohlsson A. Recombinant human activated protein C for severe sepsis in neonates. Cochrane Database Syst. Rev.2, CD005385 (2006).
  • Benjamin DK, Jr., Miller W, Garges H et al. Bacteremia, central catheters, and neonates: when to pull the line. Pediatrics107(6), 1272–1276 (2001).
  • Nazemi KJ, Buescher ES, Kelly RE Jr, Karlowicz MG. Central venous catheter removal versus in situ treatment in neonates with enterobacteriaceae bacteremia. Pediatrics111(3), E269–E274 (2003).
  • Stewart DL, Dela Cruz TV, Ziegler C, Goldsmith LJ. The use of extracorporeal membrane oxygenation in patients with gram-negative or viral sepsis. Perfusion12(1), 3–8 (1997).
  • Horwitz JR, Elerian LF, Sparks JW, Lally KP. Use of extracorporeal membrane oxygenation in the septic neonate. J. Pediatr. Surg.30(6), 813–815 (1995).
  • Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B. Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. Clin. Infect. Dis.40(2), 218–224 (2005).
  • Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J. Perinatol.24(3), 175–180 (2004).
  • Unhanand M, Mustafa MM, McCracken GH Jr, Nelson JD. Gram-negative enteric bacillary meningitis: a twenty-one-year experience. J. Pediatr.122(1), 15–21 (1993).
  • McCracken GH Jr, Mustafa MM, Ramilo O, Olsen KD, Risser RC. Cerebrospinal fluid interleukin 1-β and tumor necrosis factor concentrations and outcome from neonatal Gram-negative enteric bacillary meningitis. Pediatr. Infect. Dis. J.8(3), 155–159 (1989).
  • Stone PW, Gupta A, Loughrey M et al. Attributable costs and length of stay of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae outbreak in a neonatal intensive care unit. Infect. Control. Hosp. Epidemiol.24(8), 601–606 (2003).
  • O’Grady N P, Alexander M, Dellinger EP et al. Guidelines for the prevention of intravascular catheter-related infections. Am. J. Infect. Control30(8), 476–489 (2002).
  • Adams-Chapman I, Stoll BJ. Prevention of nosocomial infections in the neonatal intensive care unit. Curr. Opin. Pediatr.14(2), 157–164 (2002).
  • Aly H, Herson V, Duncan A et al. Is bloodstream infection preventable among premature infants? A tale of two cities. Pediatrics115(6), 1513–1518 (2005).
  • Schelonka RL, Scruggs S, Nichols K, Dimmitt RA, Carlo WA. Sustained reductions in neonatal nosocomial infection rates following a comprehensive infection control intervention. J. Perinatol.26(3), 176–179 (2006).
  • Horbar JD, Rogowski J, Plsek PE et al. Collaborative quality improvement for neonatal intensive care. NIC/Q Project Investigators of the Vermont Oxford Network. Pediatrics107(1), 14–22 (2001).
  • Rogowski JA, Horbar JD, Plsek PE et al. Economic implications of neonatal intensive care unit collaborative quality improvement. Pediatrics107(1), 23–29 (2001).
  • Ohlsson A, Lacy JB. Intravenous immunoglobulin for preventing infection in preterm and/or low-birth-weight infants. Cochrane Database Syst. Rev.1, CD000361 (2004).
  • Barclay AR, Stenson B, Simpson JH, Weaver LT, Wilson DC. Probiotics for necrotizing enterocolitis: a systematic review. J. Pediatr. Gastroenterol. Nutr.45(5), 569–576 (2007).
  • Deshpande G, Rao S, Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials. Lancet369(9573), 1614–1620 (2007).
  • Puopolo K.M. Bacterial and fungal infections. In: Manual of Neonatal Care. Cloherty JP, Eichenwald EC, Stark AR (Eds). Lippincott Williams & Wilkins, PA, USA 274–300 (2008).

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