Physiological conditions can be reflected in human urine proteome and metabolome

References

• Gao Y. Urine-an untapped goldmine for biomarker discovery? Science China. Life Sci 2013;56(12):1145-6
   Web of Science ®Google Scholar
• Decramer S, Gonzalez de Peredo A, Breuil B, et al. Urine in clinical proteomics. Mol Cell Proteomics 2008;7(10):1850-62
   PubMed Web of Science ®Google Scholar
• Lee RS, Monigatti F, Briscoe AC, et al. Optimizing sample handling for urinary proteomics. J Proteome Res 2008;7(9):4022-30
   PubMed Web of Science ®Google Scholar
• Li M. Urine reflection of changes in blood. Adv Exp Med Biol 2015;845:13-19
   PubMed Web of Science ®Google Scholar
• Coon JJ, Zurbig P, Dakna M, et al. CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics. Clinical applications 2008;2(7-8):964
   PubMed Web of Science ®Google Scholar
• Aregger F, Uehlinger DE, Witowski J, et al. Identification of IGFBP-7 by urinary proteomics as a novel prognostic marker in early acute kidney injury. Kidney Int 2014;85(4):909-19
   PubMed Web of Science ®Google Scholar
• Nkuipou-Kenfack E, Duranton F, Gayrard N, et al. Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease. PLoS ONE 2014;9(5):e96955
   PubMed Web of Science ®Google Scholar
• Mischak H, Delles C, Vlahou A, Vanholder R. Proteomic biomarkers in kidney disease: issues in development and implementation. Nat Rev Nephrol 2015;11(4):221-32
   PubMed Web of Science ®Google Scholar
• Gao Y. Roadmap to the urine biomarker era. MOJ Proteomics Bioinform 2014;1:00005
   PubMedGoogle Scholar
• Sun W, Chen Y, Li FX, et al. Dynamic urinary proteomic analysis reveals stable proteins to be potential biomarkers. Proteomics Clinical Applications 2009;3(3):370-82
   PubMed Web of Science ®Google Scholar
• Gao Y. Surfing the Wave of Urine. MOJ Proteomics Bioinform 2015;2(3):48
   Google Scholar
• Lenz EM, Bright J, Wilson ID, et al. Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects. J Pharm Biomed Anal 2004;36(4):841-9
   PubMed Web of Science ®Google Scholar
• Dumas ME, Maibaum EC, Teague C, et al. Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study. Anal Chem 2006;78(7):2199-208
   PubMed Web of Science ®Google Scholar
• Xiao Q, Moore SC, Boca SM, et al. Sources of variability in metabolite measurements from urinary samples. PLoS One 2014;9(5):e95749
   PubMed Web of Science ®Google Scholar
• Kochhar S, Jacobs DM, Ramadan Z, et al. Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics. Anal Biochem 2006;352(2):274-81
   PubMed Web of Science ®Google Scholar
• Thongboonkerd V, Chutipongtanate S, Kanlaya R. Systematic evaluation of sample preparation methods for gel-based human urinary proteomics: quantity, quality, and variability. J Proteome Res 2006;5(1):183-91
   PubMed Web of Science ®Google Scholar
• Liu X, Shao C, Wei L, et al. An individual urinary proteome analysis in normal human beings to define the minimal sample number to represent the normal urinary proteome. Proteome Sci 2012;10(1):70
   PubMed Web of Science ®Google Scholar
• Oh J, Pyo JH, Jo EH, et al. Establishment of a near-standard two-dimensional human urine proteomic map. Proteomics 2004;4(11):3485-97
   PubMed Web of Science ®Google Scholar
• Guo Z, Zhang Y, Zou L, et al. A proteomic analysis of individual and gender variations in normal human urine and cerebrospinal fluid using iTRAQ quantification. PLoS One 2015;10(7):e0133270
   PubMed Web of Science ®Google Scholar
• Becker L, Kheirandish-Gozal L, Peris E, et al. Contextualised urinary biomarker analysis facilitates diagnosis of paediatric obstructive sleep apnoea. Sleep Med 2014;15(5):541-9
   PubMed Web of Science ®Google Scholar
• Slupsky CM, Rankin KN, Wagner J, et al. Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. Anal Chem 2007;79(18):6995-7004
   PubMed Web of Science ®Google Scholar
• Psihogios NG, Gazi IF, Elisaf MS, et al. Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics. NMR Biomed 2008;21(3):195-207
   PubMed Web of Science ®Google Scholar
• Mamtimin B, Mian Q, Chen C, et al. Gender related metabonomic analysis of serum and urine samples from Xinjiang healthy Han subjects with magnetic resonance. Med Sci 2012;37(11):1135-40
   Google Scholar
• Zheng H, Yde CC, Arnberg K, et al. NMR-based metabolomic profiling of overweight adolescents: an elucidation of the effects of inter-/intraindividual differences, gender, and pubertal development. BioMed research international 2014;2014:537157
   PubMedGoogle Scholar
• Castagna A, Olivieri O, Milli A, et al. Female urinary proteomics: new insight into exogenous and physiological hormone-dependent changes. Proteomics Clinical Applications 2011;5(5-6):343-53
   PubMed Web of Science ®Google Scholar
• Zheng JH, Liu LG, Wang J, Jin Q. Urinary proteomic and non-prefractionation quantitative phosphoproteomic analysis during pregnancy and non-pregnancy. Bmc Genomics 2013;14
   Web of Science ®Google Scholar
• Walsh J, Wallace M, Brennan L, et al. Early pregnancy maternal urinary metabolomic profile to predict fetal adiposity and macrosomia. Am J Obstet Gynecol 2012;206(1):S293-4
   Web of Science ®Google Scholar
• Pinto J, Barros AS, Domingues MR, et al. Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine. J Proteome Res 2015;14(2):1263-74
   PubMed Web of Science ®Google Scholar
• Diaz SO, Barros AS, Goodfellow BJ, et al. Following healthy pregnancy by nuclear magnetic resonance (NMR) metabolic profiling of human urine. J Proteome Res 2013;12(2):969-79
   PubMed Web of Science ®Google Scholar
• Trivedi DK, Iles RK. HILIC-MS-based shotgun metabolomic profiling of maternal urine at 9-23 weeks of gestation – establishing the baseline changes in the maternal metabolome. Biomed Chromatogr 2015;29(2):240-5
   PubMed Web of Science ®Google Scholar
• Wallace M, Hashim YZ, Wingfield M, et al. Effects of menstrual cycle phase on metabolomic profiles in premenopausal women. Hum Reprod 2010;25(4):949-56
   PubMed Web of Science ®Google Scholar
• Baum M, Quigley R, Satlin L. Maturational changes in renal tubular transport. Curr Opin Nephrol Hypertens 2003;12(5):521-6
   PubMed Web of Science ®Google Scholar
• Froehlich JW, Vaezzadeh AR, Kirchner M, et al. An in-depth comparison of the male pediatric and adult urinary proteomes. Biochim Biophys Acta 2014;1844(5):1044-50
   PubMed Web of Science ®Google Scholar
• Zurbig P, Decramer S, Dakna M, et al. The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease. Proteomics 2009;9(8):2108-17
   PubMed Web of Science ®Google Scholar
• Bakun M, Senatorski G, Rubel T, et al. Urine proteomes of healthy aging humans reveal extracellular matrix (ECM) alterations and immune system dysfunction. Age (Omaha) 2014;36(1):299-311
   PubMed Web of Science ®Google Scholar
• Moltu SJ, Sachse D, Blakstad EW, et al. Urinary metabolite profiles in premature infants show early postnatal metabolic adaptation and maturation. Nutrients 2014;6(5):1913-30
   PubMed Web of Science ®Google Scholar
• Gu H, Pan Z, Xi B, et al. 1H NMR metabolomics study of age profiling in children. NMR Biomed 2009;22(8):826-33
   PubMed Web of Science ®Google Scholar
• Collino S, Montoliu I, Martin FP, et al. Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS One 2013;8(3):e56564
   PubMed Web of Science ®Google Scholar
• Bottini PV, Ribeiro Alves MA, Garlipp CR. Electrophoretic pattern of concentrated urine: comparison between 24-hour collection and random samples. Am J Kidney Dis 2002;39(1):E2
   PubMed Web of Science ®Google Scholar
• Russo LM, Bakris GL, Comper WD. Renal handling of albumin: a critical review of basic concepts and perspective. Am J Kidney Dis 2002;39(5):899-919
   PubMed Web of Science ®Google Scholar
• Zou L, Sun W. Human urine proteome: a powerful source for clinical research. Adv Exp Med Biol 2015;845:31-42
   PubMed Web of Science ®Google Scholar
• Available from: www.hkupp.org and www.eurokup.org
   Google Scholar
• Dallmann R, Viola AU, Tarokh L, et al. The human circadian metabolome. Proc Natl Acad Sci USA 2012;109(7):2625-9
   PubMed Web of Science ®Google Scholar
• Lenz EM, Bright J, Wilson ID, et al. A H-1 NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects. J Pharm Biomed Anal 2003;33(5):1103-15
   PubMed Web of Science ®Google Scholar
• Kim K, Mall C, Taylor SL, et al. Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment. PLoS One 2014;9(1):e86223
   PubMed Web of Science ®Google Scholar
• Saccenti E, Tenori L, Verbruggen P, et al. Of monkeys and men: a metabolomic analysis of static and dynamic urinary metabolic phenotypes in two species. PLoS One 2014;9:9
   PubMed Web of Science ®Google Scholar
• Walsh MC, Brennan L, Malthouse JP, et al. Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. Am J Clin Nutr 2006;84(3):531-9
   PubMed Web of Science ®Google Scholar
• Li M, Zhao M, Gao Y. Effect of transient blood glucose increases after oral glucose intake on the human urinary proteome. Proteomics. Clin Appl 2015
   Google Scholar
• Binder H, Wirth H, Arakelyan A, et al. Time-course human urine proteomics in space-flight simulation experiments. BMC Genomics 2014;15(Suppl 12):S2
   PubMed Web of Science ®Google Scholar
• Mullen W, Gonzalez J, Siwy J, et al. A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. J Agric Food Chem 2011;59(24):12850-7
   PubMed Web of Science ®Google Scholar
• Silva S, Bronze MR, Figueira ME, et al. Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study. Am J Clin Nutr 2015;101(1):44-54
   PubMed Web of Science ®Google Scholar
• Beckmann M, Lloyd AJ, Haldar S, et al. Dietary exposure biomarker-lead discovery based on metabolomics analysis of urine samples. Proc Nutr Soc 2013;72(3):352-61
   PubMed Web of Science ®Google Scholar
• May DH, Navarro SL, Ruczinski I, et al. Metabolomic profiling of urine: response to a randomised, controlled feeding study of select fruits and vegetables, and application to an observational study. Br J Nutr 2013;110(10):1760-70
   PubMed Web of Science ®Google Scholar
• Pujos-Guillot E, Hubert J, Martin JF, et al. Mass spectrometry-based metabolomics for the discovery of biomarkers of fruit and vegetable intake: citrus fruit as a case study. J Proteome Res 2013;12(4):1645-59
   PubMed Web of Science ®Google Scholar
• Andersen MB, Kristensen M, Manach C, et al. Discovery and validation of urinary exposure markers for different plant foods by untargeted metabolomics. Anal Bioanal Chem 2014;406(7):1829-44
   PubMed Web of Science ®Google Scholar
• Medina S, Ferreres F, Garcia-Viguera C, et al. Non-targeted metabolomic approach reveals urinary metabolites linked to steroid biosynthesis pathway after ingestion of citrus juice. Food Chem 2013;136(2):938-46
   PubMed Web of Science ®Google Scholar
• Llorach R, Medina S, Garcia-Viguera C, et al. Discovery of human urinary biomarkers of aronia-citrus juice intake by HPLC-q-TOF-based metabolomic approach. Electrophoresis 2014;35(11):1599-606
   PubMed Web of Science ®Google Scholar
• Gibbons H, McNulty BA, Nugent AP, et al. A metabolomics approach to the identification of biomarkers of sugar-sweetened beverage intake. Am J Clin Nutr 2015;101(3):471-7
   PubMed Web of Science ®Google Scholar
• Rothwell JA, Fillatre Y, Martin JF, et al. New biomarkers of coffee consumption identified by the non-targeted metabolomic profiling of cohort study subjects. PLoS ONE 2014;9(4):e93474
   PubMed Web of Science ®Google Scholar
• Garcia-Aloy M, Llorach R, Urpi-Sarda M, et al. Novel multimetabolite prediction of walnut consumption by a urinary biomarker model in a free-living population: the PREDIMED study. J Proteome Res 2014;13(7):3476-83
   PubMed Web of Science ®Google Scholar
• Zheng H, Yde CC, Clausen MR, et al. Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle. J Agric Food Chem 2015;63(10):2830-9
   PubMed Web of Science ®Google Scholar
• Sampson DL, Broadbent JA, Parker AW, et al. Urinary biomarkers of physical activity: candidates and clinical utility. Expert Rev Proteomics 2014;11(1):91-106
   PubMed Web of Science ®Google Scholar
• Zimmerli LU, Schiffer E, Zurbig P, et al. Urinary proteomic biomarkers in coronary artery disease. Mol Cell Proteomics 2008;7(2):290-8
   PubMed Web of Science ®Google Scholar
• Kohler M, Franz S, Regeniter A, et al. Comparison of the urinary protein patterns of athletes by 2D-gel electrophoresis and mass spectrometry-a pilot study. Drug Test Anal 2009;1(8):382-6
   PubMed Web of Science ®Google Scholar
• Kohler M, Walpurgis K, Thomas A, et al. Effects of endurance exercise on the urinary proteome analyzed by 2-D PAGE and Orbitrap MS. Proteomics. Clinical applications 2010;4(5):568-76
   PubMed Web of Science ®Google Scholar
• Pechlivanis A, Kostidis S, Saraslanidis P, et al. (1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine. J Proteome Res 2010;9(12):6405-16
   PubMed Web of Science ®Google Scholar
• Enea C, Seguin F, Petitpas-Mulliez J, et al. (1)H NMR-based metabolomics approach for exploring urinary metabolome modifications after acute and chronic physical exercise. Anal Bioanal Chem 2010;396(3):1167-76
   PubMed Web of Science ®Google Scholar
• Neal CM, Hunter AM, Brennan L, et al. Six weeks of a polarized training-intensity distribution leads to greater physiological and performance adaptations than a threshold model in trained cyclists. J Appl Physiol 2013;114(4):461-71
   PubMed Web of Science ®Google Scholar
• Krug S, Kastenmuller G, Stuckler F, et al. The dynamic range of the human metabolome revealed by challenges. FASEB J 2012;26(6):2607-19
   PubMed Web of Science ®Google Scholar
• Mukherjee K, Edgett BA, Burrows HW, et al. Whole blood transcriptomics and urinary metabolomics to define adaptive biochemical pathways of high-intensity exercise in 50-60 year old masters athletes. PLoS One 2014;9(3):e92031
   PubMed Web of Science ®Google Scholar
• Sheedy JR, Gooley PR, Nahid A, et al. (1)H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium-vitamin-D3 supplementation in older men. Appl Physiol Nutr Metab 2014;39(11):1294-304
   PubMed Web of Science ®Google Scholar
• Daskalaki E, Blackburn G, Kalna G, et al. A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output. Metabolites 2015;5(1):119-39
   PubMed Web of Science ®Google Scholar
• Daskalaki E, Easton C, G Watson D. The application of metabolomic profiling to the effects of physical activity. Current Metabolomics 2014;2(4):233-63
   Google Scholar
• Wallner-Liebmann S, Gralka E, Tenori L, et al. The impact of free or standardized lifestyle and urine sampling protocol on metabolome recognition accuracy. Genes Nutr 2015;10(1):441
   PubMed Web of Science ®Google Scholar
• Pinto-Sietsma SJ, Mulder J, Janssen WMT, et al. Smoking is related to albuminuria and abnormal renal function in nondiabetic persons. Ann Intern Med 2000;133(8):585-91
   PubMed Web of Science ®Google Scholar
• Airoldi L, Magagnotti C, Iannuzzi AR, et al. Effects of cigarette smoking on the human urinary proteome. Biochem Biophys Res Commun 2009;381(3):397-402
   PubMed Web of Science ®Google Scholar
• Aj NH, Gam LH. Identification of Urinary Protein Biomarkers for Tobacco Smoking. Biotechnol Appl Biochem 2015
   Google Scholar
• Vazquez-Fresno R, Llorach R, Alcaro F, et al. (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors. Electrophoresis 2012;33(15):2345-54
   PubMed Web of Science ®Google Scholar
• Xie GX, Ye M, Wang YG, et al. Characterization of Pu-erh Tea Using Chemical and Metabolic Profiling Approaches. J Agricult Food Chem 2009;57(8):3046-54
   PubMed Web of Science ®Google Scholar
• Alfadda AA, Turjoman AA, Moustafa AS, et al. A proteomic analysis of excreted and circulating proteins from obese patients following two different weight-loss strategies. Exp Biol Med 2014;239(5):568-80
   Web of Science ®Google Scholar
• Bouwman FG, de Roos B, Rubio-Aliaga I, et al. 2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting. BMC Med Genomics 2011;4:24
   PubMed Web of Science ®Google Scholar
• Rubio-Aliaga I, de Roos B, Duthie SJ, et al. Metabolomics of prolonged fasting in humans reveals new catabolic markers. Metabolomics 2011;7(3):375-87
   Web of Science ®Google Scholar
• Mainini V, Gianazza E, Chinello C, et al. Modulation of urinary peptidome in humans exposed to high altitude hypoxia. Mol Biosyst 2012;8(4):959-66
   PubMed Web of Science ®Google Scholar
• Pastushkova L, Kireev KS, Kononikhin AS, et al. Detection of renal tissue and urinary tract proteins in the human urine after space flight. PLoS One 2013;8(8):e71652
   PubMed Web of Science ®Google Scholar
• Lou BS, Wu PS, Liu YT, Wang JS. Effects of acute systematic hypoxia on human urinary metabolites using LC-MS-based metabolomics. High Altitude Med Biol 2014;15(2):192-202
   PubMed Web of Science ®Google Scholar