382
Views
10
CrossRef citations to date
0
Altmetric
Special Reports

Proteomics and the blood–brain barrier: how recent findings help drug development

&
Pages 251-258 | Received 18 Nov 2015, Accepted 15 Jan 2016, Published online: 06 Feb 2016

References

  • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev. 2005;57:173–185.
  • Abbott NJ. Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat. 2002;200:629–638.
  • Abbott NJ. Blood-brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis. 2013;36:437–449.
  • Neuwelt EA. Mechanisms of disease: the blood-brain barrier. Neurosurgery. 2004;54:131–142.
  • Muoio V, Persson PB, Sendeski MM. The neurovascular unit - concept review. Acta Physiol. 2014;210:790–798.
  • Cecchelli R, Berezowski V, Lundquist S, et al. Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov. 2007;6:650–661.
  • ElAli A, Thériault P, Rivest S. The role of pericytes in neurovascular unit remodeling in brain disorders. Int J Mol Sci. 2014;15:6453–6474.
  • Simard M, Arcuino G, Takano T, et al. Signaling at the gliovascular interface. J Neurosci. 2003;23:9254–9262.
  • Torbett BE, Baird A, Eliceiri BP. Understanding the rules of the road: proteomic approaches to interrogate the blood brain barrier. Front Neurosci. 2015;9:70.
  • Chun HB, Scott M, Niessen S, et al. The proteome of mouse brain microvessel membranes and basal lamina. J Cereb Blood Flow Metab. 2011;31:2267–2281.
  • Zhang JH, Badaut J, Tang J, et al. The vascular neural network–a new paradigm in stroke pathophysiology. Nat Rev Neurol. 2012;8:711–716.
  • Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol Dis. 2010;37:48–57.
  • Batrakova EV, Kabanov AV. Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers. J Control Release. 2008;130:98–106.
  • Pardridge WM. Targeted delivery of protein and gene medicines through the blood-brain barrier. Clin Pharmacol Ther. 2015;97:347–361.
  • Zuchero YJY, Chen X, Bien-Ly N, et al. Discovery of novel blood-brain barrier targets to enhance brain uptake of therapeutic antibodies. Neuron. 2015. doi:10.1016/j.neuron.2015.11.024.
  • Mertsch K, Maas J. Blood-brain barrier penetration and drug development from an industrial point of view. Curr Med Chem Nerv Syst Agents. 2002;2:187–201.
  • Hawkins BT, Egleton RD. Pathophysiology of the blood-brain barrier: animal models and methods. Curr Top Dev Biol. 2007;80:277–309.
  • Zavitz K. Crossing the blood-brain barrier: profiling cognitive safety in clinical development [Internet]. Cambridge Cogn. 2015 [cited 2015 Nov 14]. Available from: www.cambridgecognition.com/blog/entry/crossing-the-blood-brain-barrier-profilingcognitive-safety-in-clinical-dev
  • He Q-Y, Chiu J-F. Proteomics in biomarker discovery and drug development. J Cell Biochem. 2003;89:868–886.
  • Pottiez G, Flahaut C, Cecchelli R, et al. Understanding the blood-brain barrier using gene and protein expression profiling technologies. Brain Res Rev. 2009;62:83–98.
  • Karamanos Y, Gosselet F, Dehouck M-P, et al. Blood-brain barrier proteomics: towards the understanding of neurodegenerative diseases. Arch Med Res. 2014;45:730–737.
  • Deracinois B, Flahaut C, Duban-Deweer S, et al. Comparative and quantitative global proteomics approaches: an overview. Proteomes. 2013;1:180–218.
  • Shusta EV. Blood-brain barrier genomics, proteomics, and new transporter discovery. NeuroRx. 2005;2:151–161.
  • Vandenhaute E, Sevin E, Hallier-Vanuxeem D, et al. Case study: adapting in vitro blood-brain barrier models for use in early-stage drug discovery. Drug Discov Today. 2012;17:285–290.
  • Ohtsuki S, Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res. 2007;24:1745–1758.
  • Ohtsuki S, Hirayama M, Ito S, et al. Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics. Expert Rev Proteomics. 2014;11:303–313.
  • Ohtsuki S, Ikeda C, Uchida Y, et al. Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol Pharm. 2013;10:289–296.
  • Cecchelli R, Aday S, Sevin E, et al. A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells. PLoS One. 2014;9:e99733.
  • Heikkinen AT, Lignet F, Cutler P, et al. The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development. Proteomics Clin Appl. 2015;9:732–744.
  • Pottiez G, Sevin E, Cecchelli R, et al. Actin, gelsolin and filamin-A are dynamic actors in the cytoskeleton remodelling contributing to the blood brain barrier phenotype. Proteomics. 2009;9:1207–1219.
  • Pottiez G, Deracinois B, Duban-Deweer S, et al. A large-scale electrophoresis- and chromatography-based determination of gene expression profiles in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. Proteome Sci. 2010;8:57.
  • Pottiez G, Duban-Deweer S, Deracinois B, et al. A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells. J Proteomics. 2011;75:628–641.
  • Deracinois B, Duban-Deweer S, Pottiez G, et al. TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. PLoS One. 2012;7:e48428.
  • Deracinois B, Pottiez G, Chafey P, et al. Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study. Proteomics. 2013;13:1185–1199.
  • Haqqani AS, Kelly J, Baumann E, et al. Protein markers of ischemic insult in brain endothelial cells identified using 2D gel electrophoresis and ICAT-based quantitative proteomics. J Proteome Res. 2007;6:226–239.
  • Lu Q, Murugesan N, Macdonald JA, et al. Analysis of mouse brain microvascular endothelium using immuno-laser capture microdissection coupled to a hybrid linear ion trap with Fourier transform-mass spectrometry proteomics platform. Electrophoresis. 2008;29:2689–2695.
  • Bergerat A, Decano J, Wu C-J, et al. Prestroke proteomic changes in cerebral microvessels in stroke-prone, transgenic[hCETP]-Hyperlipidemic, Dahl salt-sensitive hypertensive rats. Mol Med. 2011;17:588–598.
  • Minagar A, Alexander JS, Kelley RE, et al. Proteomic analysis of human cerebral endothelial cells activated by glutamate/MK-801: significance in ischemic stroke injury. J Mol Neurosci. 2009;38:182–192.
  • Ning M, Sarracino DA, Kho AT, et al. Proteomic temporal profile of human brain endothelium after oxidative stress. Stroke. 2011;42:37–43.
  • Onodera H, Arito M, Sato T, et al. Novel effects of edaravone on human brain microvascular endothelial cells revealed by a proteomic approach. Brain Res. 2013;1534:87–94.
  • Haqqani AS, Delaney CE, Tremblay T-L, et al. Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells. Fluids Barriers CNS. 2013;10:4.
  • Kumar A, Baycin-Hizal D, Shiloach J, et al. Coupling enrichment methods with proteomics for understanding and treating disease. Proteomics Clin Appl. 2015;9:33–47.
  • Mitsos A, Melas IN, Siminelakis P, et al. Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data. PLoS Comput Biol. 2009;5:e1000591.
  • Blackstock WP, Weir MP. Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol. 1999;17:121–127.
  • Khan A, Khan AU. Biomarker discovery and drug development: a proteomics approach. J Proteomics Bioinform. 2012;05:v–vi.
  • Ebhardt HA, Root A, Sander C, et al. Applications of targeted proteomics in systems biology and translational medicine. Proteomics. 2015;15:3193–3208.
  • Schultz L, Zurich M-G, Culot M, et al. Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models. Toxicol In Vitro. 2015;30:138–165.
  • Chen H-J, Shen Y-C, Shiao Y-J, et al. Multiplex brain proteomic analysis revealed the molecular therapeutic effects of Buyang Huanwu Decoction on cerebral ischemic stroke mice. PLoS One. 2015;10:e0140823.
  • Lionetto L, Gentile G, Bellei E, et al. The omics in migraine. J Headache Pain. 2013;14:55.
  • McCaffrey G, Staatz WD, Sanchez-Covarrubias L, et al. P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia. J Neurochem. 2012;122:962–975.
  • Tome ME, Schaefer CP, Jacobs LM, et al. Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels. J Neurochem. 2015;134:200–210.
  • Kamiie J, Ohtsuki S, Iwase R, et al. Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm Res. 2008;25:1469–1483.
  • Uchida Y, Ohtsuki S, Katsukura Y, et al. Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem. 2011;117:333–345.
  • Jacob A, Declèves X, Scherrmann J-M. Recent advances in quantitative proteomics as a sensitive tool to quantify drug transporters and drug metabolizing enzymes at the human blood-brain barrier. Biol Aujourdhui. 2012;206:177–183.
  • Kubo Y, Ohtsuki S, Uchida Y, et al. Quantitative determination of luminal and abluminal membrane distributions of transporters in porcine brain capillaries by plasma membrane fractionation and quantitative targeted proteomics. J Pharm Sci. 2015;104:3060–3068.
  • Uchida Y, Ito K, Ohtsuki S, et al. Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. J Neurochem. 2015;134:97–112.
  • Kaneko Y, Tachikawa M, Akaogi R, et al. Contribution of pannexin 1 and connexin 43 hemichannels to extracellular calcium-dependent transport dynamics in human blood-brain barrier endothelial cells. J Pharmacol Exp Ther. 2015;353:192–200.
  • Abbott NJ. Future perspectives. In: Di L, Kerns HE, editors. Blood-brain barrier in drug discovery. Optimizingbrain exposure of CNS drugs and minimizing brain side effects for peripheral drugs. Hoboken (NJ): Wiley; 2015. p. 569–579.
  • Xing C, Hayakawa K, Lok J, et al. Injury and repair in the neurovascular unit. Neurol Res. 2012;34:325–330.
  • Peluffo H, Unzueta U, Negro-Demontel ML, et al. BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS. Biotechnol Adv. 2015;33:277–287.
  • Batrakova EV, Kim MS. Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release. 2015;219:396–405.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.