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Expert Review of Medical Devices Volume 13, 2016 - Issue 1
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Review

Moving toward the ideal insulin for insulin pumps

Eda CengizDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USACorrespondence[email protected]
,
Bruce BodeAtlanta Diabetes Associates, Atlanta, GA, USA
,
Michelle Van NameDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
&
William V TamborlaneYale Center for Clinical Investigation, Yale University School of Medicine, New Haven, CT, USA
Pages 57-69 | Published online: 11 Nov 2015

References

  • Papers of special note have been highlighted as:
  • • of interest
  • •• of significant interest
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  • Naik S, Kerr D, Begley J, et al. Influence of local skin temperature and choice of insulin analog on catheter occlusion rates during continuous insulin infusion: an exploratory study. Diabet Technol Ther. 2012;14:1018–1022.
  • Bode B, Weinstein R, Bell D, et al. Comparison of insulin aspart with buffered regular insulin and insulin lispro in continuous subcutaneous insulin infusion: a randomized study in type 1 diabetes. Diabet Care. 2002;25:439–444.
  • Bartolo PD, Pellicano F, Scaramuzza A, et al. Better postprandial glucose stability during continuous subcutaneous infusion with insulin aspart compared with insulin lispro in patients with type 1 diabetes. Diabet Technol Ther. 2008;10:495–498.
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  • Cengiz E, Weinzimer SA, Sherr JL, et al. Acceleration of insulin pharmacodynamic profile by a novel insulin infusion site warming device. Pediatr Diabet. 2013;14:168–173.

•• Study in adolescents with T1D that showed skin warming (38.5ºC) with InsuPatch was an effective means to accelerate the time–action profile of a standard bolus dose of insulin aspart

  • Cengiz E, Weinzimer SA, Sherr JL, et al. Faster in and faster out: accelerating insulin absorption and action by insulin infusion site warming. Diabet Technol Ther. 2014;16:20–25.

• Confirmatory study in adolescents with T1D showing that skin warming with (40ºC) InsuPatch40™ accelerated the time–action profile of insulin aspart

  • Pfutzner A, Hermanns N, Funke K, et al. The Barmer study: impact of standardized warming of the injection site to enhance insulin absorption and reduce prandial insulin requirements and hypoglycemia in obese patients with diabetes mellitus. Curr Med Res Opin. 2014;30:753–760.
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•• Study showed that SC co-injection of recombinant human hyaluronidase with a RAIA accelerated insulin exposure

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•• Study in adults with T1D showed that faster-acting insulin aspart, a new formulation of insulin aspart, resulted in faster onset of appearance and greater glucose-lowering effect than insulin aspart

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• Additional study in adults with T1D showing that skin warming (38.5ºC) with InsuPatch enhanced absorption of two different insulin analogs (aspart and lispro)

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•• This was a study in adults with T1D treated with VIAject®, a pH-neutral U-100 formulation of recombinant human insulin with EDTA and citric acid. VIAject® was absorbed faster than insulin lispro.

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