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Review

Insulin-like growth factor-I receptor signaling and resistance in breast cancer

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Pages 33-46 | Published online: 10 Jan 2014

References

  • Adams TE, Epa VC, Garrett TPJ, Ward CW. Structure and function of the Type 1 insulin-like growth factor receptor. Cell. Mol. Life Sci. 57, 1050–1093 (2000).
  • Sachdev D, Yee D. The IGF system and breast cancer. Endocr. Relat. Cancer 8, 197–209 (2001).
  • Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis: 2001. Endocr. Rev. 22, 53–74 (2001).
  • Duan C, Xu Q. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Gen. Comp. Endocrinol. 142(1–2), 44–52 (2005).
  • Ricort JM. Insulin-like growth factor binding protein (IGFBP) signalling. Growth Horm. IGF Res. 4, 277–86 (2004).
  • Oates AJ, Schumaker LM, Jenkins SB et al. The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene. Breast Cancer Res. Treat. 47, 269–281 (1998).
  • White MF. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog. Horm. Res. 53, 119–138 (1998).
  • Le Roith. Regulation of proliferation and apoptosis by the insulin-like growth Factor I receptor. Growth Horm. IGF Res. 10(Suppl. A), S12–S13 (2000).
  • Tamemoto H, Kadowaki T, Tobe K et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372(6502), 182–186 (1994).
  • Qu BH, Karas M, Koval A, Le Roith D. Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation. J. Biol. Chem. 274(44), 31179–31184 (1999).
  • Dufourny B, Alblas J, van Teeffelen HA et al. Mitogenic signaling of insulin-like growth Factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J. Biol. Chem. 272(49), 31163–31171 (1997).
  • Jackson JG, White MF, Yee D. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J. Biol. Chem. 273(16), 9994–10003 (1998).
  • Surmacz E, Bartucci M. Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer. J. Exp. Clin. Cancer Res. 23(3), 385–394 (2004).
  • Bahr C, Groner B. The IGF-I receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function. Growth Factors 23(1), 1–14 (2005).
  • Doerr ME, Jones JI. The roles of integrins and extracellular matrix proteins in the insulin-like growth Factor I-stimulated chemotaxis of human breast cancer cells. J. Biol. Chem. 271(5), 2443–2447 (1996).
  • Sachdev D, Hartnell JS, Lee AV, Zhang X, Yee D. A dominant negative Type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. J. Biol. Chem. 279(6), 5017–5024 (2003).
  • Long L, Navab R, Brodt P. Regulation of the Mr 72,000 Type IV collagenase by the Type I insulin-like growth factor receptor. Cancer Res. 58(15), 3243–3247 (1998).
  • Lee OH, Bae SK, Bae MH et al. Identification of angiogenic properties of insulin-like growth Factor II in in vitro angiogenesis models. Br. J. Cancer 82(2), 385–391 (2000).
  • Mercurio AM, Bachelder RE, Chung J et al. Integrin laminin receptors and breast carcinoma progression. J. Mammary Gland Biol. Neoplasia 6(3), 299–309 (2001).
  • Koda M, Sulkowska M, Kanczuga-Koda L, Sulkowski S. Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases. J. Clin. Pathol. 58(6), 645–649 (2005).
  • Giles ED, Singh G. Role of insulin-like growth factor binding proteins (IGFBPs) in breast cancer proliferation and metastasis. Clin. Exp. Metastasis 20(6), 481–487 (2003).
  • Alessi DR. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem. Soc. Trans. 29(Pt 2), 1–14 (2001).
  • Peruzzi F, Prisco M, Dews M et al. Multiple signalling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol. Cell. Biol. 19(10), 7203–7215 (1999).
  • Heck S, Lezoualch F, Engert S, Behl C. Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor κB. J. Biol. Chem. 274(14), 9828–9835 (1999).
  • Kops GJ, Burgering BM. Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT). J. Anat. 197(Pt 4), 571–574 (2000).
  • O’Connor R, Fennelly C, Krause D. Regulation of survival signals from the insulin-like growth factor-I receptor. Biochem. Soc. Trans. 28(2), 47–51 (2000).
  • Le Roith D, Helman L. The new kid on the block(ade) of the IGF-I receptor. Cancer Cell 5(3), 201–202 (2004).
  • Dunn SE, Ehrlich M, Sharp NJH et al. A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res. 58(15), 3353–3361 (1998).
  • Gooch JL, Van Den Berg CL, Yee D. Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death-proliferative and anti-apoptotic effects. Breast Cancer Res. Treat. 56(1), 1–10 (1999).
  • Ciftci K, Su J, Trovitch PB. Growth factors and chemotherapeutic modulation of breast cancer cells. J. Pharm. Pharmacol. 55(8), 1135–1141 (2003).
  • Beech DJ, Parekh N, Pang Y. Insulin-like growth factor-I receptor antagonism results in increased cytotoxicity of breast cancer cells to doxorubicin and taxol. Oncol. Rep. 8(2), 325–329 (2001).
  • Min Y, Adachi Y, Yamamoto H et al. Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer. Cancer Res. 63(19), 6432–6441 (2003).
  • Mitsiades CS, Mitsiades NS, McMullan CJ et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 5(3), 221–230 (2004).
  • Warshamana-Greene GS, Litz, J, Buchdunger E, Garcia-Echeverria C, Hofman F, Krystal GW. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin. Cancer Res. 11(4), 1563–1571 (2005).
  • Turner BC, Haffty BG, Narayanan L et al. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res. 57(15), 3079–3083 (1997).
  • Macaulay VM, Salisbury, Bohula EA, Platford MP, Smorodinsky NI, Shiloh Y. Downregulation of the Type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene (30), 4029–4040 (2001).
  • Cosaceanu D, Carapancea M, Castro J et al. Modulation of response to radiation of human lung cancer cells following insulin-like growth factor 1 receptor inactivation. Cancer Lett. 222(2), 173–181 (2005).
  • Rochester MA, Riedemann J, Hellawell GO, Brewster SF, Macaulay VM. Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild type and mutant human prostate cancer. Cancer Gene Ther. 12(1), 90–100 (2005).
  • Nicholson RI, Hutcheson IR, Knowlden JM et al. Nonendocrine pathways and endocrine resistance: observations with anti-estrogens and signal transduction inhibitors in combination. Clin. Cancer Res. 10(1 Pt 2), 346S–352S (2004).
  • Yee D, Lee AV. Crosstalk between the insulin-like growth factors and estrogens in breast cancer. J. Mammary Gland Biol. Neoplasia 5, 107–115 (2000).
  • Hamelers IHL, Steenbergh PH Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells. Endocr. Relat. Cancer 10, 331–345 (2003).
  • Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R, Santen RJ. The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane. Proc. Natl Acad. Sci. USA 101(7), 2076–2081 (2004).
  • Daly RJ, Harris WH, Wang DY, Darbre PD. Autocrine production of insulin-like growth Factor II using an inducible expression system results in reduced estrogen sensitivity of MCF-7 human breast cancer cells. Cell Growth Differ. 2, 457–464 (1991).
  • Surmacz E, Burgaud J L. Overexpression of insulin receptor substrate 1 (IRS-1) in the human breast cancer cell line MCF-7 induces loss of estrogen requirements for growth and transformation. Clin. Cancer Res. 1, 1429–1436 (1995).
  • Abdul-Wahab K, Corcoran D, Perachiotti A, Darbre PD. Overexpression of insulin-like growth Factor II (IGFII) in ZR-75–1 human breast cancer cells: higher threshold levels of receptor (IGFIR) are required for a proliferative response than for effects on specific gene expression. Cell Prolif. 32, 271–287 (1999).
  • van den Berg HW, Claffie D, Boylan M, McKillen J, Lynch M, McKibben B. Expression of receptors for epidermal growth factor and insulin-like growth Factor I by ZR-75–1 human breast cancer cell variants is inversely related: the effect of steroid hormones on insulin-like growth Factor I receptor expression. Br. J. Cancer 73, 477–481 (1996).
  • Stephen RL, Shaw LE, Larsen C, Corcoran D, Darbre PD. Insulin-like growth factor receptor levels are regulated by cell density and by long-term estrogen deprivation in MCF7 human breast cancer cells. J. Biol. Chem. 276, 40080–40086 (2001).
  • Martin LA, Farmer I, Johnston SR, Ali S, Marshall C, Dowsett M. Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long-term estrogen deprivation. J. Biol. Chem. 278, 30458–30468 (2003).
  • Guvakova MA, Surmacz E. Tamoxifen interferes with the insulin-like growth Factor I receptor (IGF-IR) signaling pathway in breast cancer cells. Cancer Res. 57, 2606–2610 (1997).
  • Wiseman LR, Johnson MD, Wakeling AE, Lykkesfeldt AE, May FE, Westley BR. Type I IGF receptor and acquired tamoxifen resistance in oestrogen-responsive human breast cancer cells. Eur. J. Cancer 29A, 2256–2264 (1993).
  • Parisot JP, Hu XF, DeLuise M, Zalcberg. Altered expression of the IGF-I receptor in a tamoxifen-resistant human breast cancer cell line. Br. J. Cancer 79, 693–700 (1999).
  • Brockdorff BL, Heiberg I, Lykkesfeldt AE. Resistance to different anti-estrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor Iα. Endocr. Relat. Cancer 10, 579–590 (2003).
  • Knowlden JM, Hutcheson IR, Barrow D, Gee JM, Nicholson RI. IGF-IR signalling in tamoxifen-resistant breast cancer: A supporting role to the role to the epidermal growth factor receptor. Endocrinology 146(11), 4609–4618 (2005).
  • Maxwell P, van den Berg HW. Changes in the secretion of insulin-like growth factor binding proteins -2 and -4 associated with the development of tamoxifen resistance and estrogen independence in human breast cancer cell lines. Cancer Lett. 139, 121–127 (1999).
  • Knowlden J, Hutcheson IR, Jones HE et al. Elevated levels of EGFR/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in Tamoxifen resistant MCF-7 cells. Endocrinology 144(3), 1032–1044 (2003).
  • Coppola D, Ferber A, Miura M et al. A functional insulin-like growth Factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol. Cell. Biol. 14, 4588–4595 (1994).
  • Gilmore AP, Valentijn AJ, Wang P et al. Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J. Biol. Chem. 277, 27643–27650 (2002).
  • Roudabush FL, Pierce KL, Maudsley S, Khan KD, Luttrell LM. Transactivation of the EGF receptor mediates IGF-I-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. J. Biol. Chem. 275, 22583–22589 (2000).
  • Wang D, Pati S, Li W, Humphrey LE, Brattain MG, Howell GM. Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. Oncogene 21, 2785–2796 (2002).
  • Gee JMW, Knowlden JM. Viewpoint: ADAM metalloproteases and EGFR signalling. Breast Cancer Res. 5, 223–224 (2003).
  • Balana ME, Labriola L, Salatino M et al. Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and Type I insulin-like growth factor receptor in mammary tumour cells. Oncogene 20(1), 34–47 (2001).
  • Biscardi JS, Maa M-C, Tice DA, Cox ME, Leu T-H, Parsons SJ. C-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr 1101 is associated with modulation of receptor function. J. Biol. Chem. 274(12), 8335–8343 (1999).
  • Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-1 receptor signaling and resistance to trastuzumab (Herceptin). J. Natl Cancer Inst. 93(24), 1852–1857 (2001).
  • Bartucci M, Morelli C, Mauro L, Ando' S, Surmacz E. Differential insulin-like growth Factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Cancer Res. 61(18), 6747–6754 (2001).
  • Brunner N, Moser C, Clarke R, Cullen K. IGF-I and IGF-II expression in human breast cancer xenografts: relationship to hormone independence. Breast Cancer Res. Treat. 22(1), 39–45 (1992).
  • Chernicky CL, Yi L, Tan H, Gan SU, Ilan J. Treatment of human breast cancer cells with antisense RNA to the Type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo. Cancer Gene Ther. 7(3), 84–95 (2000).
  • Arteaga CL. Interference of the IGF system as a strategy to inhibit breast cancer growth. Breast Cancer Res. Treat. 22(1), 101–106 (1992).
  • Surmacz E. Function of the IGF-I receptor in breast cancer. Mammary Gland Biol. Neoplasia 5(1), 95–105 (2000).
  • Happerfield LC, Miles DW, Barnes DM, Thomsen LL, Smith P, Hanby A. The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue. J. Pathol. 183(4), 412–417 (1997).
  • Resnik JL, Reichart DB, Huey K, Webster NJ, Seely BL. Elevated insulin-like growth Factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Res. 58(6), 159–164 (1998).
  • Pandini G, Vigneri R, Costantino A et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signalling. Clin. Cancer Res. 5(7), 1935–1944 (1999).
  • Giani C, Campani D, Rasmussen A et al. Insulin-like growth Factor II (IGF-II) immunohistochemistry in breast cancer: relationship with the most important morphological and biochemical prognostic parameters. Int. J. Biol. Markers 17(2), 90–95 (2002).
  • Rocha RL, Hilsenbeck SG, Jackson JG et al. Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival. Clin. Cancer Res. 3(1), 103–109 (1997).
  • Gee JM, Robertson JF, Gutteridge E et al. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocr. Relat. Cancer 12(Suppl. 1), S99–S111 (2005).
  • Schnarr B, Strunz K, Ohsam J, Benner A, Wacker J, Mayer D. Downregulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer. Int. J. Cancer 89(6), 506–513 (2000).
  • Toropainen EM, Lipponen PK, Syrjanen KJ. Expression of insulin-like growth Factor II in female breast cancer as related to established prognostic factors and long-term prognosis. Anticancer Res. 15(6B), 2669–2674 (1995).
  • Bonneterre J, Peyrat JP, Beuscart R, De-maille A. Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer. Cancer Res. 50(21), 6931–6935 (1990).
  • Railo MJ, von Smitten K, Pekonen F. The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients. Eur. J. Cancer 30A(3), 307–311 (1994).
  • Mathieu MC, Clark GM, Allred DC, Goldfine ID, Vigneri R. Insulin receptor expression and clinical outcome in nodenegative breast cancer. Proc. Assoc. Am. Physicians 109, 565–571 (1997).
  • Perez-Tenorio G, Stal O; Southeast Sweden Breast Cancer Group. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br. J. Cancer 86(4), 540–545 (2002).
  • Baselga J. Clinical trials of Herceptin (traztuzumab). Eur. J. Cancer 37(Suppl. 1), 18–23 (2001).
  • Nicholson RI, Gee JMW, Harper ME. EGFR and cancer prognosis. Eur. J. Cancer 37(Suppl. 4), S9–S15 (2001).
  • Nicholson RI, Hutcheson IR, Hiscox SE et al. Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of antigrowth factor therapies to treat or delay endocrine resistance in breast cancer. Endocr. Relat. Cancer 12(Suppl. 1), S29–S36 (2005).
  • Ross JS, Schenkein DP, Pietrusko R et al. Targeted therapies for cancer. Am. J. Clin. Pathol. 122, 598–609 (2004).
  • Agrawal A, Gutteridge E, Gee JM, Nicholson RI, Robertson JF. Overview of tyrosine kinase inhibitors in clinical breast cancer. Endocr. Relat. Cancer 12(Suppl. 1), S135–S144 (2005).
  • Vidal L, Attard G, Kaye S, De Bono J. Reversing resistance to targeted therapy. J. Chemother. 16(Suppl. 4), 7–12 (2004).
  • Jones HE, Goddard L, Gee JMW et al. Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells. Endocr. Relat. Cancer 11, 1–22 (2004).
  • McClelland RA, Barrow D, Madden T et al. Enhanced epidermal growth factor receptor signalling in MCF7 breast cancer cells following long-term culture in the presence of the pure anti-oestrogen FASLODEXTM. Endocrinology 142(7), 2776–2788 (2001).
  • Jones HE, Gee JMW, Taylor KM et al. Development of strategies for the use of antigrowth factor treatments. Endocr. Relat. Cancer 12(Suppl. 1), S173–S182 (2005).
  • Chakravati A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastome cells through continued activation of phosphoinositide 3-kinase signalling. Cancer Res. 62, 200–207 (2002).
  • Liu B, Fang M, Lu Y, Mendelsohn J, Fan Z. Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. Oncogene 20, 1913–1922 (2001).
  • Gullick WJ. The Type I growth factor receptors and their ligands considered as a complex system. Endocr. Relat. Cancer 8, 75–82 (2001).
  • Adams TE, McKern NM, Ward CW. Signalling by the Type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor. Growth Factors 22(2), 89–95 (2004).
  • Lichtner RB. Estrogen/EGF receptor interactions in breast cancer: rationale for new therapeutic combination strategies. Biomed. Pharmacother. 57, 447–451 (2003).
  • Gutteridge E, Gee JM, Nicholson RI, Robertson JFR. Biological markers associated with response to gefitinib (ZD1839) in patients with breast cancer. Proc. Am. Soc. Clin. Oncol. 23, 38 (2004) (Abstract 648).
  • Lu Y, Zi X, Zhao Y, Pollak M. Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signlling pathway in breast cancer cells. Biochem. Biophys. Res. Comm. 313, 709–715 (2004).
  • Ibrahim YH, Yee D. Insulin-like growth factor-I and breast cancer therapy. Clin. Cancer Res. 11(2 Pt 2), S944–S950 (2005).
  • Hofmann F, Garcia-Echeverria C. Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov. Today 10(15), 1041–1047 (2005).
  • Maloney EK, McLaughlin JL, Dagdigian NE et al. An anti-insulin like growth Factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res. 63, 5073–5083 (2003).
  • Burtrum D, Zhu Z, Lu D et al. A fully human monoclonal antibody to the insulin-like growth Factor I receptor blocks ligand-dependent signalling and inhibits human tumor growth in vivo. Cancer Res. 63(24), 8912–8921 (2003).
  • Goetsch A, Gonzalez A, Leger O et al. recombinant humanized anti-insulin-like growth factor receptor Type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int. J. Cancer 113(2), 316–328 (2005).
  • Ye JJ, Liang SJ, Guo N et al. Combined effects of tamoxifen and a chimeric humanized single chain antibody against the Type I IGF receptor on breast tumor growth in vivo. Horm. Metab. Res. 35(11–12), 836–842 (2003).
  • Cohen BD, Baker DA, Soderstrom C et al. Combination therapy enhances the inhibition of tumor growth with the fully human antitype 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin. Cancer Res. 11(5), 2063–2073 (2005).
  • Garcia-Echeverria C, Pearson MA, Marti A et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5(3), 231–239 (2004).
  • Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 64(1), 236–242 (2004).
  • Scotlandi K, Avnet S, Benini S et al. Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells. Int. J. Cancer 101(1), 11–16 (2002).
  • Ingle JN, Suman VJ, Kardinal CG et al. A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma. Cancer 85(6), 1284–1292 (1999).
  • Camirand A, Zakikhani M, Young F, Pollak M. Inhibition of insulin-like growth factor-1 receptor signalling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa™) in human breast cancer cells. Breast Cancer Res. 7(4), R570–R579 (2005).
  • Steinbach JP, Eisenmann C, Klumpp A, Weller M. Co-inhibition of epidermal growth factor receptor and Type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. Biochem. Biophys. Res. Comm. 321(3), 524–530 (2004).
  • Lu D, Zhang H, Koo H et al. A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity. J. Biol. Chem. 280(20), 19665–19672 (2005).
  • Camirand A, Pollak M. Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells. Med. Sci. Monit. 8(12), BR521–BR526 (2002).
  • Camirand A, Pollak M. Co-targeting IGF-IR and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells. Br. J. Cancer 90(9), 1825–1829 (2004).
  • Frasca F, Pandini G, Vigneri R, Goldfine ID. Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells. Breast Dis. 17, 73–89 (2003).
  • Denley A, Wallace JC, Cosgrove LJ, Forbes BE. The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review. Horm. Metab. Res. 35, 778–785 (2003).
  • Jones HE, Gee JMW, Barrow D, Wakeling AE, Guy S, Nicholson RI. De novo resistance to epidermal growth factor receptor blockade by gefitinib in colorectal cancer cells involves increased insulin receptor isoform A signalling. Eur. J. Cancer 2(8), 102 (2004) (Abstract 336).
  • Frasca F, Pandini G, Scalia P et al. Insulin receptor isoform A, a newly recognized, high affinity insulin-like growth Factor II receptor in fetal and cancer cells. Mol. Cell. Biol. 19, 3278–3288 (1999).
  • Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A. Insulin/insulin-like growth Factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277(42), 39684–39695 (2002).

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