The trials and tribulations of vitamin D: time for the ‘sunshine’ vitamin to come in out of the cold – or just more broken promises?

References

• Norman AW. The history of the discovery of vitamin D and its daughter. steroid hormone. Ann Nutr Metab 2012;61(3):199-206
   PubMed Web of Science ®Google Scholar
• Chesney RW. Theobald Palm and his remarkable observation: how the sunshine vitamin came to be recognized. Nutrients 2012;4(1):42-51
   PubMedGoogle Scholar
• Rajakumar K, Greenspan SL, Thomas SB, Holick MF. Solar ultraviolet radiation and vitamin D: a historical perspective. Am J Public Health 2007;97(10):1746-54
   PubMedGoogle Scholar
• Wolf G. The discovery of vitamin D: the contribution of Adolf Windaus. J Nutr 2004;134(6):1299-302
   PubMedGoogle Scholar
• Rajakumar K. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics 2003;112(2):e132-5
   PubMed Web of Science ®Google Scholar
• Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911-30
   PubMed Web of Science ®Google Scholar
• Institute of Medicine. Dietary reference intakes for calcium and vitamin D. The National Academies Press; Washington, DC: 2011
   Google Scholar
• Heinonen OP, Albanes D. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330(15):1029-35
   PubMed Web of Science ®Google Scholar
• Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996;334(18):1150-5
   PubMed Web of Science ®Google Scholar
• Manson JE, Bassuk SS, Lee I, et al. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 2012;33(1):159-71
   PubMed Web of Science ®Google Scholar
• Christakos S, Ajibade DV, Dhawan P, et al. Vitamin D. Metabolism. Endocrinol Metab Clin North Am 2010;39(2):243-53
   PubMed Web of Science ®Google Scholar
• Holick MF. Medical progress: vitamin D deficiency. N Engl J Med 2007;357(3):266-81
   PubMed Web of Science ®Google Scholar
• Christakos S, Seth T, Hirsch J, et al. Vitamin D biology revealed through the study of knockout and transgenic mouse models. Annu Rev Nutr 2013;33:71-85
   PubMedGoogle Scholar
• Holick MF. Vitamin D: a D-Lightful health perspective. Nutr Rev 2008;66(SUPPL.2):S182-94
   Google Scholar
• DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004;80(6 Suppl):1689S-96S
   PubMed Web of Science ®Google Scholar
• Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1a,25(OH) 2vitamin D 3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 2011;25(4):543-59
   PubMed Web of Science ®Google Scholar
• Schoindre Y, Benveniste O, Costedoat-Chalumeau N. Vitamin D and autoimmunity. Presse Med 2013;42(10):1358-63
   PubMedGoogle Scholar
• Volchenkov R, Karlsen M, Jonsson R, Appel S. Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scand J Immunol 2013;77(4):246-54
   PubMedGoogle Scholar
• Ralph AR, Lucas RM, Norval M. Vitamin D and solar ultraviolet radiation in the risk and treatment of tuberculosis. Lancet Infect Dis 2013;13(1):77-88
   PubMedGoogle Scholar
• Döring A, Paul F, Dörr J. Vitamin D and multiple sclerosis: the role for risk of disease and treatment. Nervenarzt 2013;84(2):173-89
   PubMedGoogle Scholar
• Takiishi T, Van Belle T, Gysemans C, Mathieu C. Effects of vitamin D on antigen-specific and non-antigen-specific immune modulation: relevance for type 1 diabetes. Pediatr Diabetes 2013;14(2):81-9
   PubMedGoogle Scholar
• Badenhoop K, Kahles H, Penna-Martinez M. Vitamin d, immune tolerance, and prevention of type 1 diabetes. Curr Diab Rep 2012;12(6):635-42
   PubMedGoogle Scholar
• Mutgi K, Koo J. Update on the role of systemic vitamin D in atopic dermatitis. Pediatr Dermatol 2013;30(3):303-7
   PubMedGoogle Scholar
• Tian Y, Wang C, Ye Z, et al. Effect of 1,25-Dihydroxyvitamin D3 on Th17 and Th1 response in patients with Behçet’s disease. Invest Ophthalmol Vis Sci 2012;53(10):6434-41
   PubMed Web of Science ®Google Scholar
• Nigwekar SU, Bhan I, Thadhani R. Ergocalciferol and cholecalciferol in CKD. Am J Kidney Dis 2012;60(1):139-56
   PubMed Web of Science ®Google Scholar
• Haines ST, Park SK. Vitamin D supplementation: what’s known, what to do, and what’s needed. Pharmacotherapy 2012;32(4):354-82
   PubMed Web of Science ®Google Scholar
• Bischoff-Ferrari HA. The 25-hydroxyvitamin D threshold for better health. J Steroid Biochem Mol Biol 2007;103(3-5):614-19
   PubMedGoogle Scholar
• Bischoff-Ferrari HA. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol 2008;624:55-71
   PubMed Web of Science ®Google Scholar
• Vimaleswaran KS, Berry DJ, Lu C, et al. Causal Relationship between Obesity and Vitamin D. Status: bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Med 2013;10(2):e1001383
   PubMed Web of Science ®Google Scholar
• Norman AW, From vitamin D to hormone D. Fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008;88(2):491S-9S
   PubMed Web of Science ®Google Scholar
• Carlberg C, Campbell MJ. Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor. Steroids 2013;78(2):127-36
   PubMed Web of Science ®Google Scholar
• Binkley N, Krueger D, Cowgill CS, et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab 2004;89(7):3152-7
   PubMed Web of Science ®Google Scholar
• Snellman G, Melhus H, Gedeborg R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One 2010;5:7
   PubMedGoogle Scholar
• Chun RF, Peercy BE, Orwoll ES, et al. Vitamin D and DBP: the free hormone hypothesis revisited. J Steroid Biochem Mol Biol 2013. [Epub ahead of print]
   Google Scholar
• Powe CE, Evans MK, Wenger J, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med 2013;369(21):1991-2000
   PubMed Web of Science ®Google Scholar
• Safadi FF, Thornton P, Magiera H, et al. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest 1999;103(2):239-51
   PubMed Web of Science ®Google Scholar
• Nykjaer A, Dragun D, Walther D, et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999;96(4):507-15
   PubMed Web of Science ®Google Scholar
• Malloy PJ, Feldman D. Genetic disorders and defects in vitamin D action. Endocrinol Metab Clin North Am 2010;39(2):333-46
   PubMedGoogle Scholar
• Zoccali C, Yilmaz MI, Mallamaci F. FGF23: a mature renal and cardiovascular risk factor? Blood Purif 2013;36(1):52-7
   PubMedGoogle Scholar
• Quarles LD. Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease. Exp Cell Res 2012;318(9):1040-8
   PubMed Web of Science ®Google Scholar
• Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophys 2012;523(1):95-102
   PubMedGoogle Scholar
• Prentice A, Goldberg GR, Schoenmakers I. Vitamin D across the lifecycle: physiology and biomarkers. Am J Clin Nutr 2008;88(2):500S-6S
   PubMedGoogle Scholar
• Lamberg-Allardt CJE, Outila TA, Kärkkäinen MUM, et al. Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? J Bone Miner Res 2001;16(11):2066-73
   PubMedGoogle Scholar
• Arya V, Bhambri R, Godbole MM, Mithal A. Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int 2004;15(1):56-61
   PubMedGoogle Scholar
• Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y. Am J Clin Nutr 2004;80(3):752-8
   PubMed Web of Science ®Google Scholar
• De Sévaux RGL, Hoitsma AJ, Corstens FHM, Wetzels JFM. Treatment with vitamin D and calcium reduces bone loss after renal transplantation: a randomized study. J Am Soc Nephrol 2002;13(6):1608-14
   PubMed Web of Science ®Google Scholar
• Chapuy MC, Arlot ME, Duboeuf F, et al.Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992;327(23):1637-42
   PubMed Web of Science ®Google Scholar
• Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293(18):2257-64
   PubMed Web of Science ®Google Scholar
• Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009;169(6):551-61
   PubMedGoogle Scholar
• Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 2013;383(9912):146-55
   PubMedGoogle Scholar
• Jacques RM, Boonen S, Cosman F, et al. Relationship of changes in total hip bone mineral density to vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis treated with once-yearly zoledronic acid 5 mg: the HORIZON-Pivotal Fracture Trial (PFT). J Bone Miner Res 2012;27(8):1627-34
   PubMed Web of Science ®Google Scholar
• Avenell A, Gillespie WJ, Gillespie LD, O’Connell DL. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 2005(3):CD000227
   Google Scholar
• DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 2010;340:b5463
   PubMed Web of Science ®Google Scholar
• Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012;367(1):40-9
   PubMed Web of Science ®Google Scholar
• Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006;296(23):2832-8
   PubMed Web of Science ®Google Scholar
• Munger KL, Zhang SM, O’Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004;62(1):60-5
   PubMed Web of Science ®Google Scholar
• Salzer J, Hallmans G, Nyström M, et al. Vitamin D as a protective factor in multiple sclerosis. Neurology 2012;79(21):2140-5
   PubMed Web of Science ®Google Scholar
• Soilu-Hänninen M, Åivo J, Lindström B-, et al. A randomised, double blind, placebo controlled trial with vitamin D 3 as an add on treatment to interferon ß-1b in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2012;83(5):565-71
   PubMed Web of Science ®Google Scholar
• Anderson JL, May HT, Horne BD, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol 2010;106(7):963-8
   PubMed Web of Science ®Google Scholar
• Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas 2010;65(3):225-36
   PubMed Web of Science ®Google Scholar
• Vacek JL, Vanga SR, Good M, et al. Vitamin D deficiency and supplementation and relation to cardiovascular health. Am J Cardiol 2012;109(3):359-63
   PubMed Web of Science ®Google Scholar
• Afzal S, Bojesen SE, Nordestgaard BG. Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis. Clin Chem 2013;59(2):381-91
   PubMed Web of Science ®Google Scholar
• Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 2011;65(9):1005-15
   PubMed Web of Science ®Google Scholar
• Bergman P, Lindh ÅU, Björkhem-Bergman L, Lindh JD. Vitamin D and Respiratory Tract Infections: a systematic review and nmeta-analysis of randomized controlled trials. PLoS One 2013;8(6):e65835
   PubMed Web of Science ®Google Scholar
• Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010;91(5):1255-60
   PubMed Web of Science ®Google Scholar
• Li YC, Kong J, Wei M, et al. 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002;110(2):229-38
   PubMed Web of Science ®Google Scholar
• Gardner DG, Chen S, Glenn DJ. Vitamin D and the heart. Am J Physiol Regul Integr Comp Physiol 2013;305(9):R969-77
   PubMed Web of Science ®Google Scholar
• Beveridge LA, Witham MD. Vitamin D and the cardiovascular system. Osteoporos Int 2013;24(8):2167-80
   PubMed Web of Science ®Google Scholar
• Pittas AG, Chung M, Trikalinos T, et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med 2010;152(5):307-14
   PubMed Web of Science ®Google Scholar
• Pilz S, Kienreich K, Rutters F, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep 2013;13(2):261-70
   PubMed Web of Science ®Google Scholar
• Girgis CM, Clifton-Bligh RJ, Turner N, et al. Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clin Endocrinol (Oxf) 2013. [Epub ahead of print]
   Google Scholar
• Fabri M, Stenger S, Shin D-, et al. Vitamin D is required for IFN-γ-mediated antimicrobial activity of human macrophages. Sci Transl Med 2011;3(104):p. 104ra102
   Google Scholar
• Bolland MJ, Grey A, Gamble GD, Reid IR. Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set. Am J Clin Nutr 2011;94(4):1144-9
   PubMedGoogle Scholar
• Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health 2006;96(2):252-61
   PubMed Web of Science ®Google Scholar
• Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: global perspective. Ann Epidemiol 2009;19(7):468-83
   PubMed Web of Science ®Google Scholar
• Grant WB. Ecological studies of the UVB-vitamin D-cancer hypothesis. Anticancer Res 2012;32(1 PART 2):223-36
   PubMedGoogle Scholar
• Grant WB. Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin D level: implications for meta-analyses and setting vitamin D guidelines. Dermatoendocrinol 2011;3(3):199-204
   PubMedGoogle Scholar
• Grant WB. Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers. J Photochem Photobiol B 2010;101(2):130-6
   PubMedGoogle Scholar
• Lappe JM, Travers-Gustafson D, Davies KM, et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007;85(6):1586-91
   PubMed Web of Science ®Google Scholar
• Moukayed M, Grant WB. Molecular link between vitamin D and cancer prevention. Nutrients 2013;5(10):3993-4021
   PubMed Web of Science ®Google Scholar
• Gorham ED, Garland CF, Garland FC, et al.Optimal Vitamin D. Status for Colorectal Cancer Prevention. A quantitative meta analysis. Am J Prev Med 2007;32(3):210-16
   PubMed Web of Science ®Google Scholar
• Gandini S, Boniol M, Haukka J, et al. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer 2011;128(6):1414-24
   PubMed Web of Science ®Google Scholar
• Giovannucci E. Strengths and limitations of current epidemiologic Ssudies: vitamin D as a modifier of colon and prostate cancer risk. Nutr Rev 2007;65(Suppl 2):S77-9
   Google Scholar
• Toner CD, Davis CD, Milner JA. The Vitamin D and cancer conundrum: aiming at a moving target. J Am Diet Assoc 2010;110(10):1492-500
   PubMedGoogle Scholar
• Grant WB. An estimate of the global reduction in mortality rates through doubling vitamin D levels. Eur J Clin Nutr 2011;65(9):1016-26
   PubMedGoogle Scholar
• Mavroeidi A, O’Neill F, Lee PA, et al. Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57°N and 51°N: a longitudinal study. J Steroid Biochem Mol Biol 2010;121(1-2):459-61
   PubMed Web of Science ®Google Scholar
• Heaney RP, Holick MF. Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res 2011;26(3):455-7
   PubMed Web of Science ®Google Scholar
• Heaney RP. Guidelines for optimizing design and analysis of clinical studies of nutrient effects. Nutr Rev 2014;72(1):48-54
   PubMed Web of Science ®Google Scholar
• Heaney RP. Health is better at serum 25(OH)D above 30ng/mL. J Steroid Biochem Mol Biol 2013;136:224-8
   PubMed Web of Science ®Google Scholar
• Holick MF. The D-batable Institute of Medicine report: a D-lightful perspective. Endocr Pract 2011;17(1):143-9
   PubMedGoogle Scholar
• Holick MF. The IOM D-lemma. Public Health Nutr 2011;14(5):939-41
   PubMedGoogle Scholar
• Pramyothin P, Holick MF. Vitamin D supplementation: guidelines and evidence for subclinical deficiency. Curr Opin Gastroenterol 2012;28(2):139-50
   PubMed Web of Science ®Google Scholar
• Jonatan Salzer. Environmental risk factors for multiple sclerosis. Umeå University, Clinical Neuroscience; Umeå, Sweden: 2013
   Google Scholar
• Boucher BJ. The problems of vitamin d insufficiency in older people. Aging Dis 2012;3(4):313-29
   PubMed Web of Science ®Google Scholar
• Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988;67(2):373-8
   PubMed Web of Science ®Google Scholar
• Penny H, Frame S, Dickinson F, et al. Determinants of vitamin D status in long-term renal transplant patients. Clin Transplant 2012;26(6):E617-23
   Google Scholar
• Springbett P, Buglass S, Young AR. Photoprotection and vitamin D status. J Photochem Photobiol B 2010;101(2):160-8
   PubMedGoogle Scholar
• Davies PSW, Bates CJ, Cole TJ, et al. Vitamin D: seasonal and regional differences in preschool children in Great Britain. Eur J Clin Nutr 1999;53(3):195-8
   PubMedGoogle Scholar
• Ovesen L, Andersen R, Jakobsen J. Geographical differences in vitamin D status, with particular reference to European countries. Proc Nutr Soc 2003;62(4):813-21
   PubMedGoogle Scholar
• Hart PH, Gorman S. Exposure to UV wavelengths in sunlight suppresses immunity. To what extent is UV-induced vitamin D3 the mediator responsible? Clin Biochem Rev 2013;34(1):3-13
   PubMedGoogle Scholar
• Sayre RM, Dowdy JC. Darkness at noon: sunscreens and vitamin D3. Photochem Photobiol 2007;83(2):459-63
   PubMedGoogle Scholar
• Sollitto RB, Kraemer KH, DiGiovanna JJ. Normal vitamin D levels can be maintained despite rigorous photoprotection: six years’ experience with xeroderma pigmentosum. J Am Acad Dermatol 1997;37(6):942-7
   PubMed Web of Science ®Google Scholar
• Holvik K, Meyer HE, Haug E, Brunvand L. Prevalence and predictors of vitamin D deficiency in five immigrant groups living in Oslo, Norway: the Oslo immigrant health study. Eur J Clin Nutr 2005;59(1):57-63
   PubMed Web of Science ®Google Scholar
• Shaw NJ, Pal BR. Vitamin D deficiency in UK Asian families: activating a new concern. Arch Dis Child 2002;86(3):147-9
   PubMedGoogle Scholar
• Awumey EM, Mitra DA, Hollis BW, et al. Vitamin D metabolism is altered in Asian Indians in the southern United States: a clinical research center study. J Clin Endocrinol Metab 1998;83(1):169-73
   PubMed Web of Science ®Google Scholar
• Ørnsrud R, Lock EJ, Glover CN, Flik G. Retinoic acid cross-talk with calcitriol activity in Atlantic salmon (Salmo salar). J Endocrinol 2009;202(3):473-82
   PubMedGoogle Scholar
• Reichrath J, Lehmann B, Carlberg C, et al. Vitamins as hormones. Horm Metab Res 2007;39(2):71-84
   PubMedGoogle Scholar
• Cross SF, Dalla Pozza L, Munns CF. Hypercalcemia and osteoblastic lesions induced by 13-cis-retinoic acid mimicking relapsed neuroblastoma. Pediatr Blood Cancer 2009;53(4):666-8
   PubMedGoogle Scholar
• Mugishima H, Chin M, Suga M, et al. Hypercalcemia induced by 13 cis-retinoic acid in patients with neuroblastoma. Pediatr Int 2008;50(2):235-7
   PubMedGoogle Scholar
• Conaway HH, Henning P, Lerner UH. Vitamin a metabolism, action, and role in skeletal homeostasis. Endocr Rev 2013;34(6):766-97
   PubMedGoogle Scholar
• Whiting SJ, Calvo MS. Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults? Mol Nutr Food Res 2010;54(8):1077-84
   PubMedGoogle Scholar
• Jacobus CH, Holick MF, Shao Q, et al. Hypervitaminosis D associated with drinking milk. N Engl J Med 1992;326(18):1173-7
   PubMedGoogle Scholar
• Masterjohn C. Vitamin D toxicity redefined: vitamin K and the molecular mechanism. Med Hypotheses 2007;68(5):1026-34
   PubMedGoogle Scholar
• Vieth R. Vitamin D toxicity, policy, and science. J Bone Miner Res 2007;22(Suppl 2):V64-8
   PubMedGoogle Scholar
• Kallas M, Green F, Hewison M, et al. Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review. J Clin Endocrinol Metab 2010;95(7):3111-17
   PubMedGoogle Scholar
• Favus MJ. editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 2nd edition. Raven Press; NY: USA: 1993
   Google Scholar
• Barbour GL, Coburn JW, Slatopolsky E, et al. Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin d. N Engl J Med 1981;305(8):440-3
   PubMed Web of Science ®Google Scholar
• Feldman D, Pike JW, Glorieux FH. editors. In: Vitamin D. 2nd edition). Elsevier; San Diego, CA, USA: 2005
   Google Scholar
• Engelsen O. The relationship between ultraviolet radiation exposure and vitamin D status. Nutrients 2010;2(5):482-95
   PubMed Web of Science ®Google Scholar
• Dobson R, Giovannoni G, Ramagopalan S. The month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude. J Neurol Neurosurg Psychiatry 2013;84(4):427-32
   PubMed Web of Science ®Google Scholar
• Farrar MD, Kift R, Felton SJ, et al. Recommended summer sunlight exposure amounts fail to produce sufficient vitamin D status in UK adults of South Asian origin. Am J Clin Nutr 2011;94(5):1219-24
   PubMed Web of Science ®Google Scholar
• Alvarez JA, Wasse H, Tangpricha V. Vitamin D supplementation in pre-dialysis chronic kidney disease: a systematic review. Dermatoendocrinol 2012;4(2):118-27
   PubMedGoogle Scholar
• Schmid A, Walther B. Natural vitamin D content in animal products. Adv Nutr 2013;4(4):453-62
   PubMed Web of Science ®Google Scholar
• Björn LO, Wang T. Vitamin D in an ecological context. Int J Circumpolar Health 2000;59(1):26-32
   PubMedGoogle Scholar
• Madsen KH, Rasmussen LB, Andersen R, et al. Randomized controlled trial of the effects of vitamin D-fortified milk and bread on serum 25-hydroxyvitamin D concentrations in families in Denmark during winter: the VitmaD study. Am J Clin Nutr 2013;98(2):374-82
   PubMed Web of Science ®Google Scholar
• Burgaz A, Åkesson A, Öster A, et al. Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter. Am J Clin Nutr 2007;86(5):1399-404
   PubMed Web of Science ®Google Scholar
• Brustad M, Alsaker E, Engelsen O, et al. Vitamin D status of middle-aged women at 65-71°N in relation to dietary intake and exposure to ultraviolet radiation. Public Health Nutr 2004;7(2):327-35
   PubMedGoogle Scholar
• Vieth R, Chan P-R, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 2001;73(2):288-94
   PubMed Web of Science ®Google Scholar
• Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr 2007;85(1):6-18
   PubMed Web of Science ®Google Scholar
• Gravesen E, Hofman-Bang J, Lewin E, Olgaard K. Ergocalciferol treatment and aspects of mineral homeostasis in patients with chronic kidney disease stage 4-5. Scand J Clin Lab Invest 2013;73(2):107-16
   PubMed Web of Science ®Google Scholar
• Reichrath J, Reichrath S. The relevance of the vitamin D endocrine system (VDES) for tumorigenesis, prevention, and treatment of non-melanoma skin cancer (NMSC): present concepts and future perspectives. Dermatoendocrinol 2013;5(1):38-50
   PubMedGoogle Scholar
• Ala-Houhala MJ, Karppinen T, Vähävihu K, et al. Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation. Acta Derm Venereol 2014;94(2):146-51
   PubMedGoogle Scholar
• Ala-Houhala MJ, Vähävihu K, Hasan T, et al. Narrow-band ultraviolet B exposure increases serum vitamin D levels in haemodialysis patients. Nephrol Dial Transplant 2012;27(6):2435-40
   PubMedGoogle Scholar
• Ala-Houhala MJ, Vähävihu K, Hasan T, et al. Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration. Br J Dermatol 2012;167(1):160-4
   PubMedGoogle Scholar
• Ala-Houhala MJ, Vähävihu K, Snellman E, et al. A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D. Nephron Clin Pract 2013;124(1-2):17-22
   PubMedGoogle Scholar
• Terra VA, Souza-Neto FP, Pereira RC, et al. Nitric oxide is responsible for oxidative skin injury and modulation of cell proliferation after 24 hours of UVB exposures. Free Radic Res 2012;46(7):872-82
   PubMed Web of Science ®Google Scholar
• Clemens TL, Adams JS, Henderson SL, Holick MF. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet 1982;1(8263):74-6
   PubMed Web of Science ®Google Scholar
• Bacon CJ, Gamble GD, Horne AM, et al. High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int 2009;20(8):1407-15
   PubMed Web of Science ®Google Scholar
• Heaney RP. Vitamin D--baseline status and effective dose. N Engl J Med 2012;367(1):77-8
   PubMed Web of Science ®Google Scholar
• Hollis BW. Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment. Endocrinol Metab Clin North Am 2010;39(2):271-86
   PubMed Web of Science ®Google Scholar
• Khosla S. What do we tell our patients about calcium and vitamin D supplementation? J Clin Endocrinol Metab 2011;96(1):69-71
   PubMedGoogle Scholar
• VITAL. Available from: www.vitalstudy.org
   Google Scholar
• clinicaltrials.gov (NCT01169259). Available from: clinicaltrials.gov/show/NCT01169259
   Google Scholar
• Palinski W, Napoli C. The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. FASEB J 2002;16(11):1348-60
   PubMed Web of Science ®Google Scholar
• Grant WB. Critique of the U-shaped serum 25-hydroxyvitamin D level-disease response relation. Dermatoendocrinol 2009;1(6):289-93
   PubMedGoogle Scholar
• Lappe JM, Heaney RP. Why randomized controlled trials of calcium and vitamin D sometimes fail. Dermatoendocrinol 2012;4(2):95-100
   PubMedGoogle Scholar
• Maxmen A. The vitamin D-lemma. Nature 2011;475(7354):23-5
   PubMed Web of Science ®Google Scholar
• Battault S, Whiting SJ, Peltier SL, et al. Vitamin D metabolism, functions and needs: from science to health claims. Eur J Nutr 2013;52(2):429-41
   PubMedGoogle Scholar
• Bailey BA, Manning T, Peiris AN. Vitamin D testing patterns among six Veterans Medical Centers in the Southeastern United States: links with medical costs. Mil Med 2012;177(1):70-6
   PubMedGoogle Scholar
• Vitamin D assessment (ViDA) study. Available from: www.fmhs.auckland.ac.nz/soph/depts/epi/vida/
   Google Scholar
• Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev 2013;12(10):976-89
   PubMed Web of Science ®Google Scholar
• Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diab Endo 2014;2(1):76-89
   PubMed Web of Science ®Google Scholar
• Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diab Endo 2014. [Epub ahead of print]
   Google Scholar