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Review

β-cell regeneration to treat Type 1 diabetes mellitus

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Pages 51-60 | Published online: 10 Jan 2014

References

  • American Diabetes Association. Diagnosis and classification of diabetes. Diabetes Care27(Suppl. I), S5–S10 (2004).
  • Wild S, Roglic G, Green A et al. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care27(5), 1047–1053 (2004).
  • Rubin RR, Peyrot M. Quality of life and diabetes. Diabetes Metab. Res. Rev.15(3), 205–218 (1999).
  • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med.329(14), 977–986 (1993).
  • Marshall AL, Chetwynd A, Morris JA et al. Type 1 diabetes mellitus in childhood: a matched case control study in Lancashire and Cumbria, UK. Diabet. Med.21(9), 1035–1040 (2004).
  • Notkins AL, Lernmark A. Autoimmune Type 1 diabetes: resolved and unresolved issues. J. Clin. Invest.108(9), 1247–1252 (2001).
  • Pozzilli P, Di Mario U. Autoimune diabetes not requiring insulin at diagnosis (latent autoimune diabetes of the adult). Diabetes Care24(8), 1460–1467 (2001).
  • Palmer JP, Fleming GA, Greenbaum CJ et al. C-peptide is the appropriate outcome measure for Type 1 diabetes clinical trials to preserve β-cell function. Diabetes53(1), 250–264 (2004).
  • Redondo MJ, Rewers M, Yu L et al. Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with Type 1A diabetes: prospective twin study. BMJ318(7319), 698–702 (1999).
  • Bennett ST, Todd JA. Human Type 1A diabetes and the insulin gene: principles of mapping polygenes. Annu. Rev. Genet.30, 343–370 (1996).
  • Fairweather D L, Rose NR. Type 1 diabetes: virus infection or autoimmune disease? Nat. Immunol.3(4), 383–340 (2002).
  • Devendra D, Liu E, Eisenbarth GS. Type 1 diabetes: recent developments. BMJ328(7442), 750–754 (2004).
  • Eizirik DL, Mandrup-Poulsen T. A choice of death: the signal transduction of immune-mediated β-cell apoptosis. Diabetologia44, 2115–2133 (2001).
  • Eizirik DL, Kutlu B, Rasschaert J, Darville M, Cardozo AK. Use of microarray analysis to unveil transcription factor and gene networks contributing to β-cell dysfunction and apoptosis. Ann. NY Acad. Sci.1005, 55–74 (2003).
  • Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic β-cell death in Type 1 and Type 2 diabetes: many differences, few similarities. Diabetes54(Suppl. 2), S97–S107 (2005).
  • The Epidemiology of Diabetes Interventions and Complications Research Group. The effect of intensive insulin therapy on the microvascular complications of Type 1 diabetes mellitus. JAMA287(19), 2563–2569 (2002).
  • The Diabetes Control and Complications Trial Research Group. Effect of intensive therapy on residual β-cell function in patients with Type 1 diabetes in the Diabetes Control and Complications Trial. Ann. Intern. Med.128(7), 517–523 (1998).
  • Couri CE, Foss MC, Voltarelli JC. Secondary prevention of Type 1 diabetes mellitus: stopping immune destruction and promoting β-cell regeneration. Braz. J. Med. Biol. Res.39(10), 1271–1280 (2006).
  • Elliott RB, Berryman CC, Crossley JR, James AG. Partial preservation of pancreatic β-cell function in children with diabetes. Lancet19(2), 631–632 (1981).
  • Harrison LC, Colman PG, Dean B, Baxter R, Martin FI. Increased in remission rate in newly diagnosed Type l diabetic subjects treated with azathioprine. Diabetes34(12), 1306–1308 (1985).
  • Cook JJ, Hudson I, Harrison LC et al. Double-blind controlled trial of azathioprine in children with newly diagnosed Type I diabetes. Diabetes38(6), 779–783 (1989).
  • Silverstein J, Maclaren N, Riley W, Spillar R, Radjenovic D, Jonhson S. Immunosupression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. N. Engl. J. Med.319(10), 599–604 (1988).
  • Assan R, Feutren G, Sirmai J et al. Plasma C-peptide levels and clinical remissions in recent-onset Type 1 diabetic patients treated with cyclosporin A and insulin. Diabetes39(7), 768–774 (1990).
  • Bougnères F, Landais P, Boisson C et al. Limited duration of remission of insulin dependency in children with recent overt Type I diabetes treated with low-dose cyclosporin. Diabetes39(10), 1264–1272 (1990).
  • Herold KC, Hagopian W, Auger JA et al. Anti-CD3 monoclonal antibodiy in new-onset Type 1 diabetes mellitus. N. Engl. J. Med.346(22), 1692–1698 (2002).
  • Keymeulen B, Vandemeulebroucke E, Ziegler AG et al. Insulin needs after CD3-antibody therapy in new-onset Type 1 diabetes. N. Engl. J. Med.352(25), 2598–2608 (2005).
  • Raz I, Elias D, Avron A, Metzger M, Cohen IR. β-cell function in newly-onset Type 1 diabetes and immunomodulation with a heat shock protein peptide (DiaPep277): a randomised, double-blind, Phase II trial. Lancet358(9295), 1749–1753 (2001).
  • Saudek F, Havrdova T, Boucek P, Novota P, Skibova J. Polyclonal anti-T-cell therapy for Type 1 diabetes mellitus of recent onset. Rev. Diabet. Stud.1(2), 80–88 (2004).
  • Burt RK, Slavin S, Burns WH, Marmont AM. Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Blood99(3), 768–784 (2002).
  • Burt RK, Traynor A, Statkute L et al. Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus. JAMA295(5), 527–535 (2006).
  • Voltarelli JC, Couri CEB, Stracieri ABPL et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed Type 1 diabetes mellitus. JAMA297(14), 1568–1576 (2007).
  • Voltarelli JC, Burt RK, Kenyon N, Kaufman DB, Squiers E. Hematopoietic stem cell transplantation as treatment for Type 1 diabetes. In: Stem Cell Therapy for Autoimmmune Diseases. Burt R, Marmont A (Eds). Landes Bioscience TX, USA, 442–447 (2004).
  • European Nicotinamide Diabetes Intervention Trial Group: European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of Type 1 diabetes. Lancet363(9413), 925–931 (2004).
  • Diabetes Prevention Trial – Type 1 Diabetes Study Group. Effects of insulin in relatives of patients with Type 1 diabetes mellitus. N. Engl. J. Med.346(22), 1685–1691 (2002).
  • Diabetes Prevention Trial – Type 1 Study Group. Effects of oral insulin in relatives of patients with Type 1 diabetes. Diabetes Care28(5), 1068–1076 (2005).
  • Nakayama M, Abiru N, Moriyama H et al. Prime role for an insulin epitope in the development of Type 1 diabetes in NOD mice. Nature435, 220–223 (2005).
  • Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of Type 1 diabetes: a birth-cohort study. Lancet358(9292), 1500–1503 (2004).
  • Staeva-Vieira T, Peakman M, von Herrath M. Translational mini-review series on Type 1 diabetes: immune-based therapeutic approaches for Type 1 diabetes. Clin. Exp. Immunol.148, 17–31 (2007).
  • Bonner-Weir S, Sharma A. Pancreatic stem cell. J. Pathol.197(4), 519–526 (2002).
  • Swenne I. Pancreatic β-cell growth and diabetes mellitus. Diabetologia35(3), 193–201 (1992).
  • Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology138(4), 1750–1762 (1997).
  • Finegood DT, Scaglia R, Bonner-Weir S. Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes44(3), 249–256 (1995).
  • Kuroda A, Yamasaki Y, Imagawa A. β-cell regeneration in a patient with Type 1 diabetes mellitus who was receiving immunosuppressive therapy. Ann. Intern. Med.139(10), 81 (2003).
  • Fischbach GD, Fischbach RL. Stem cells: science, policy and ethics. J. Clin. Invest.114(10), 1364–1370 (2004).
  • Wagers AJ, Weissman IL. Plasticity of adults stem cells. Cell116(5), 639–648 (2004).
  • Seaberg R, Smukler SR, Kieffer TJ et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat. Biotechnol.22(9), 1115–1124 (2004).
  • Georgia S, Blushan A. β cell replication is the primary mechanism of maintaining postnatal β cell mass. J. Clin. Invest.114(7), 963–968 (2004).
  • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature429(6987), 41–46 (2004).
  • Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by β cell regeneration. J. Clin. Invest.117(9), 2553–2561 (2007).
  • Suzuki A, Nakauchi H, Tanigichi H. Prospective isolation of pancreatic multipotent progenitors using flow-cytometric cell sorting. Diabetes53(8), 2143–2152 (2004).
  • Noguchi Y, Nakajima-Yamada T, Yamada K et al. R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models. Eur. J. Pharmacol.506(3), 285–295 (2005).
  • Bonner-Weir S, Taneja M, Weir GC et al.In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl Acad. Sci. USA97(14), 7999–8004 (2000).
  • Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am. J. Physiol. Endocrinol. Metab.284(2), E259–E266 (2003).
  • Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest.111(6), 843–850 (2003).
  • Choi JB, Uchino H, Azuma K et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic β cells. Diabetologia46(10), 1366–1374 (2003).
  • Hess D, Li L, Martin M et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat. Biotechnol.21, 763–770 (2003).
  • Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA. Recruitment of bone marrow-derived endothelial cells to sites of pancreatic β-cell injury. Diabetes53, 91–98 (2004).
  • Hasegawa Y, Ogihara T, Yamada T et al. Bone marrow (BM) transplantation promotes β-cell regeneration after acute injury through BM cell mobilization. Endocrinology148, 2006–2015 (2007).
  • Lagasse E, Connors H, Al-Dhalimy M et al. Purified hematopoietic stem cell can differentiate into hepatocytes in vivo. Nat. Med.6(11), 1229–1234 (2000).
  • Theise ND, Badve S, Saxena R et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology,31(1), 235–240 (2000).
  • Kang EM, Zickler MM, Burns S et al. Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established. Exp. Hematol.33(6), 699–705 (2005).
  • Butler AE, Huang A, Rao PN et al. Hematopoietic stem cells derived from adult donors are not a source of pancreatic β-cells in adult nondiabetic humans. Diabetes56(7), 1810–1816 (2007).
  • Nelson JL, Torres I, Louie FM et al. Pre-existing autoimmune diseasein patients with long term survival after allogeneic bone marrow transplantation. J. Rheumatol.24(48), 23–29 (1997).
  • Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult bone marrow. Nature418(6893), 41–49 (2002).
  • Chen LB, Jiang XB, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet β-cells. World J. Gastroenterol.10(20), 3016–3020 (2004).
  • Tang DQ, Cao LZ, Burkhardt BR et al.In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes53(7), 1721–1732 (2004).
  • Lee HR, Seo MJ, Reger RL et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc. Natl Acad. Sci. USA103(46), 17438–17443 (2006).
  • Sun Y, Chen L, Hou XG et al. Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin. Med. J. (Engl.)120(9), 771–776 (2007).
  • Timper K, Seboek D, Eberhardt M et al. Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagons expressing cells. Biochem. Biophys. Res. Commun.341(4), 1155–1160 (2006).
  • Ruhnke M, Ungefroren H, Nussler et al. Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology128(7), 1774–1786 (2005).
  • Tuma-Mubarak J, Fernandez-Viña R, Yalan AC et al. Autologous bone marrow mononuclear cell (ABMMC) transplantation in Type 1 and Type 2 insulin-dependent diabetes mellitus patients. International Society of Cell Therapy Meeting. Sydney, Australia 24–27 June (2007).
  • Novoa JE, Medina MA, Gordillo F et al. The Conzi’s effect in human diabetes mellitus: from bone marrow progenitor cells (BMPCs) to β cells. Archivos de Medicina Interna1(Suppl. 1), 34 (2007).
  • Ende N, Chen R, Reddi AS. Effect of human umbilical cord blood cells on glycemia and insulitis in Type 1 diabetic mice. Biochem. Biophys. Res. Commun.325(3), 665–669 (2004).
  • Ende N, Chen R, Reddi AS. Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in Type 2 diabetic mice. Biochem. Biophys. Res. Commun.321(1), 168–71 (2004).
  • Naruse K, Hamada Y, Nakashima E et al. Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Diabetes54(6), 1823–1828 (2005).
  • Haller MJ, Viener HL, Brusko T et al. Insulin requirements, HbA1c, and stimulated C-peptide following autologous umbilical cord blood transfusion in children with T1D. Abstracts ADA 67th Scientific Sessions. A82 (2007).
  • Petersen BE, Goff JP, Greenberger JS, Michalopoulos GK. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Hepatology27(2), 433–445 (1998).
  • Yang L, Li S, Hatch H et al.in vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc. Natl Acad. Sci. USA99(12), 8078–8083 (2002).
  • Kim S, Shin JS, Kim HJ, Fisher RC, Lee MJ, Kim CW. Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration. Lab. Invest.87(7), 702–712 (2007).
  • Assady S, Maor G, Amit M, Itskovitzs-Eldor J, Skorecki KL, Tzukerman M. Insulin production by human embryonic stem cells. Diabetes50(8), 1691–1697 (2001).
  • Soria B, Roche E, Berna G, Leon-Quito T, Reig JA, Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes49(2), 157–162 (2000).
  • Hansson M, Tonning A, Frandsen U et al. Artifactual insulin release from differentiated embryonic stem cells. Diabetes53(10), 2603–2609 (2004).
  • Jaenisch R. Human cloning – the science and ethics of nuclear transplantation. N. Engl. J. Med.351(27), 2787–2791 (2004).
  • Chong S, Normile D. Stem cells. How young Korean researchers helped unearth a scandal. Science311(5757), 22–25 (2006).
  • Smykodub OI, Noritskaya AV. Embryonic stem cells in new onset Type 2 diabetes mellitus. Cytotherapy6(4), 402 (2004).
  • Smykodub OI, Noritskaya AV. Embryonic stem cells in pernicious decompensated Type 2 diabetes mellitus. Cytotherapy6(4), 402 (2004).
  • Sinden JD. ReNeuron Group plc. Regenerative Med.1(1), 143–147 (2006).
  • Colman A, Alliston D. ES Cell International and regenerative medicine. Regenerative Med.1(2), 287–292 (2006).
  • Bresson D, von Herrath M. Moving towards efficient therapies in Type 1 diabetes: to combine or not to combine? Autoimmune Rev.6(5), 315–322 (2007).

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