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Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management

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Pages 921-936 | Published online: 10 Jan 2014

References

  • Bousquet J, Clark TJ, Hurd S et al. GINA guidelines on asthma and beyond. Allergy 62(2), 102–112 (2007).
  • Van Wonderen KE, Van Der Mark LB, Mohrs J, Bindels PJ, Van Aalderen WM, Ter Riet G. Different definitions in childhood asthma: how dependable is the dependent variable? Eur. Respir. J. 36(1), 48–56 (2010).
  • Murray CS, Simpson A, Custovic A. Allergens, viruses, and asthma exacerbations. Proc. Am. Thorac. Soc. 1(2), 99–104 (2004).
  • Papadopoulos NG, Arakawa H, Carlsen KH et al. International consensus on (ICON) pediatric asthma. Allergy 67(8), 976–997 (2012).
  • Bosse Y, Hudson TJ. Toward a comprehensive set of asthma susceptibility genes. Annu. Rev. Med. 58, 171–184 (2007).
  • Murk W, Walsh K, Hsu LI, Zhao L, Bracken MB, Dewan AT. Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. Hum. Hered. 71(2), 97–105 (2011).
  • Hagerhed-Engman L, Bornehag CG, Sundell J, Aberg N. Day-care attendance and increased risk for respiratory and allergic symptoms in preschool age. Allergy 61(4), 447–453 (2006).
  • Nicolaou NC, Simpson A, Lowe LA, Murray CS, Woodcock A, Custovic A. Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study. J. Allergy Clin. Immunol. 122(3), 500–506 (2008).
  • Nafstad P, Brunekreef B, Skrondal A, Nystad W. Early respiratory infections, asthma, and allergy: 10-year follow-up of the Oslo Birth Cohort. Pediatrics 116(2), e255–e262 (2005).
  • Ober C, Vercelli D. Gene-environment interactions in human disease: nuisance or opportunity? Trends Genet. 27(3), 107–115 (2011).
  • Simpson A, John SL, Jury F et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am. J. Respir. Crit. Care Med. 174(4), 386–392 (2006).
  • Martinez FD. Gene-environment interactions in asthma: with apologies to William of Ockham. Proc. Am. Thorac. Soc. 4(1), 26–31 (2007).
  • Lotvall J, Akdis CA, Bacharier LB et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J. Allergy Clin. Immunol. 127(2), 355–360 (2011).
  • Wilson NM. Wheezy bronchitis revisited. Arch. Dis. Child 64(8), 1194–1199 (1989).
  • Wright AL, Taussig LM. Lessons from long-term cohort studies. Childhood asthma. Eur. Respir. J. Suppl. 27, 17s–22s (1998).
  • Martinez FD. Development of wheezing disorders and asthma in preschool children. Pediatrics 109(2 Suppl.), 362–367 (2002).
  • Hancox RJ, Subbarao P, Sears MR. Relevance of birth cohorts to assessment of asthma persistence. Curr. Allergy Asthma Rep. 12(3), 175–184 (2012).
  • Silverman M, Wilson N. Wheezing phenotypes in childhood. Thorax 52(11), 936–967 (1997).
  • Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur. Respir. J. 29(1), 179–184 (2007).
  • Patino CM, Martinez FD. Interactions between genes and environment in the development of asthma. Allergy 56(4), 279–286 (2001).
  • Herzog R, Cunningham-Rundles S. Pediatric asthma: natural history, assessment, and treatment. Mt. Sinai. J. Med 78(5), 645–660 (2011).
  • Stochl J, Croudace T, Perez J et al. Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis. Qual. Life Res. 17, 17 (2012).
  • Colman I, Ploubidis GB, Wadsworth ME, Jones PB, Croudace TJ. A longitudinal typology of symptoms of depression and anxiety over the life course. Biol. Psychiatry 62(11), 1265–1271 (2007).
  • Abbott RA, Ploubidis GB, Huppert FA, Kuh D, Wadsworth ME, Croudace TJ. Psychometric evaluation and predictive validity of Ryff’s psychological well-being items in a UK birth cohort sample of women. Health Qual. Life Outcomes 4, 76 (2006).
  • Barnett JH, Croudace TJ, Jaycock S et al. Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling. BMC Psychiatry 7, 16 (2007).
  • Pickles A, Bolton P, Macdonald H et al. Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism. Am. J. Hum. Genet. 57(3), 717–726 (1995).
  • Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N. Engl J. Med. 332(3), 133–138 (1995).
  • Lowe LA, Simpson A, Woodcock A, Morris J, Murray CS, Custovic A. Wheeze phenotypes and lung function in preschool children. Am. J. Respir. Crit. Care Med. 171(3), 231–237 (2005).
  • Kurukulaaratchy RJ, Fenn MH, Waterhouse LM, Matthews SM, Holgate ST, Arshad SH. Characterization of wheezing phenotypes in the first 10 years of life. Clin. Exp. Allergy 33(5), 573–578 (2003).
  • Lau S, Illi S, Sommerfeld C et al. Transient early wheeze is not associated with impaired lung function in 7-yr-old children. Eur. Respir. J. 21(5), 834–841 (2003).
  • Midodzi WK, Rowe BH, Majaesic CM, Saunders LD, Senthilselvan A. Predictors for wheezing phenotypes in the first decade of life. Respirology 13(4), 537–545 (2008).
  • Sherriff A, Peters TJ, Henderson J, Strachan D. Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int. J. Epidemiol. 30(6), 1473–1484 (2001).
  • Turner SW, Palmer LJ, Rye PJ et al. The relationship between infant airway function, childhood airway responsiveness, and asthma. Am. J. Respir. Crit. Care Med. 169(8), 921–927 (2004).
  • Henderson J, Granell R, Heron J et al. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax 63(11), 974–980 (2008).
  • Savenije OE, Granell R, Caudri D et al. Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. J. Allergy Clin. Immunol. 127(6), 1505–1512 (2011).
  • Granell R, Sterne JA, Henderson J. Associations of different phenotypes of wheezing illness in early childhood with environmental variables implicated in the aetiology of asthma. PLoS ONE 7(10), 31 (2012).
  • Chen Q, Just AC, Miller RL et al. Using latent class growth analysis to identify childhood wheeze phenotypes in an urban birth cohort. Ann. Allergy Asthma Immunol. 108(5), 311–315 (2012).
  • Lowe L, Murray CS, Martin L et al. Reported versus confirmed wheeze and lung function in early life. Arch. Dis. Child 89(6), 540–543 (2004).
  • Pickles A, Croudace T. Latent mixture models for multivariate and longitudinal outcomes. Stat. Methods Med. Res. 19(3), 271–289 (2009).
  • Belgrave DCM, Simpson A, Semic-Jusufagic A et al. Joint modeling of parentally-reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing. J. Allergy Clin. Immunol. doi:10.1016/j.jaci.2013.05.041 (2013) (Epub ahead of print).
  • Collins SA, Pike KC, Inskip HM et al. Validation of novel wheeze phenotypes using longitudinal airway function and atopic sensitization data in the first 6 years of life: Evidence from the Southampton Women’s survey. Pediatr. Pulmonol. 8(10), 22766 (2013).
  • Von Mutius E. Trajectories of childhood wheeze. J. Allergy Clin. Immunol. 127(6), 1513–1514(2011).
  • Castro-Rodriguez JA, Garcia-Marcos L. Wheezing and Asthma in childhood: an epidemiology approach. Allergol. Immunopathol. 36(5), 280–290 (2008).
  • Bosco A, Holt PG. Genome-wide expression profiling of T-cells in childhood wheeze. Eur. Respir. J. 32(5), 1138–1140 (2008).
  • Scott M, Kurukulaaratchy RJ, Raza A, Arshad SH. Understanding the nature and outcome of childhood wheezing. Eur. Respir. J. 33(3):700–1 (2009).
  • Kurukulaaratchy RJ, Waterhouse L, Matthews SM, Arshad SH. Are influences during pregnancy associated with wheezing phenotypes during the first decade of life? Acta. Paediatr. 94(5), 553–558 (2005).
  • Stein RT, Martinez FD. Asthma phenotypes in childhood: lessons from an epidemiological approach. Paediatr. Respir. Rev. 5(2), 155–161 (2004).
  • Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, Thomas HM. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr. Allergy Immunol. 16(5), 386–392 (2005).
  • Stein RT, Sherrill D, Morgan WJ et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354(9178), 541–545 (1999).
  • Jackson DJ, Gangnon RE, Evans MD et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am. J. Respir. Crit. Care Med. 178(7), 667–672 (2008).
  • Stein RT, Martinez FD. Respiratory syncytial virus and asthma: still no final answer. Thorax 65(12), 1033–1034
  • Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A. Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet 368(9537), 754–762 (2006).
  • Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N. Engl J. Med. 354(19), 1998–2005 (2006).
  • Ducharme FM, Lemire C, Noya FJ et al. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N. Engl. J. Med. 360(4), 339–353 (2009).
  • Simpson A, Tan VY, Winn J et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am. J. Respir. Crit. Care Med. 181(11), 1200–1206 (2010).
  • Lazic N, Roberts G, Custovic A et al. Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts. Allergy 68(6), 764–770 (2013).
  • Wright AL. Analysis of epidemiological studies: facts and artifacts. Paediatr. Respir. Rev. 3(3), 198–204 (2002).
  • Smith JA, Drake R, Simpson A, Woodcock A, Pickles A, Custovic A. Dimensions of respiratory symptoms in preschool children: population-based birth cohort study. Am. J. Respir. Crit. Care Med. 177(12), 1358–1363 (2008).
  • Spycher BD, Silverman M, Brooke AM, Minder CE, Kuehni CE. Distinguishing phenotypes of childhood wheeze and cough using latent class analysis. Eur. Respir. J. 31(5), 974–981 (2008).
  • Spycher BD, Silverman M, Barben J et al. A disease model for wheezing disorders in preschool children based on clinicians’ perceptions. PLoS One 4(12), 0008533 (2009).
  • Brand PL, Baraldi E, Bisgaard H et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur. Respir. J. 32(4), 1096–1110 (2008).
  • Fitzpatrick AM, Teague WG, Meyers DA et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J. Allergy Clin. Immunol. 127(2), 382–389 (2011).
  • Just J, Gouvis-Echraghi R, Rouve S, Wanin S, Moreau D, Annesi-Maesano I. Two novel, severe asthma phenotypes identified during childhood using a clustering approach. Eur. Respir. J. 40(1), 55–60 (2012).
  • Herr M, Just J, Nikasinovic L et al. Risk factors and characteristics of respiratory and allergic phenotypes in early childhood. J. Allergy Clin. Immunol. 130(2), 389–396 (2012).
  • Castro-Rodriguez JA. The Asthma Predictive Index: a very useful tool for predicting asthma in young children. J. Allergy Clin. Immunol. 126(2), 212–216 (2010).
  • Matricardi PM, Illi S, Keil T, Wagner P, Wahn U, Lau S. Predicting persistence of wheezing: one algorithm does not fit all. Eur. Respir J. 35(3), 701–703 (2010).
  • Caudri D, Wijga A, Cm AS et al. Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age. J. Allergy Clin. Immunol. 124(5), 903–910 (2009).
  • Walker C, Kagi MK, Ingold P et al. Atopic dermatitis: correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity. Clin. Exp. Allergy 23(2), 145–153 (1993).
  • Hughes JM, Rimmer SJ, Salome CM et al. Eosinophilia, interleukin-5, and tumour necrosis factor-alpha in asthmatic children. Allergy 56(5), 412–418 (2001).
  • Klion AD, Law MA, Riemenschneider W et al. Familial eosinophilia: a benign disorder? Blood 103(11), 4050–4055 (2004).
  • Just J, Nicoloyanis N, Chauvin M, Pribil C, Grimfeld A, Duru G. Lack of eosinophilia can predict remission in wheezy infants? Clin. Exp. Allergy 38(5), 767–773 (2008).
  • Sacco O, Sale R, Silvestri M et al. Total and allergen-specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites. Pediatr. Allergy Immunol. 14(6), 475–481 (2003).
  • Heaton T, Rowe J, Turner S et al. An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet 365(9454), 142–149 (2005).
  • Van De Kant KD, Klaassen EM, Jobsis Q, Nijhuis AJ, Van Schayck OC, Dompeling E. Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control study. BMC Public Health 9(210), 1471–2458 (2009).
  • Hauk PJ, Krawiec M, Murphy J et al. Neutrophilic airway inflammation and association with bacterial lipopolysaccharide in children with asthma and wheezing. Pediatr. Pulmonol. 43(9), 916–923 (2008).
  • Van Der Valk RJ, Caudri D, Savenije O et al. Childhood wheezing phenotypes and FeNO in atopic children at age 8. Clin. Exp. Allergy 42(9), 1329–1336 (2012).
  • Chawes BL, Buchvald F, Bischoff AL et al. Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze. Am. J. Respi.r Crit. Care Med. 182(2), 138–142 (2010).
  • Olin AC, Rosengren A, Thelle DS, Lissner L, Toren K. Increased fraction of exhaled nitric oxide predicts new-onset wheeze in a general population. Am. J. Respir. Crit. Care Med. 181(4), 324–327 (2010).
  • Bastain TM, Islam T, Berhane KT et al. Exhaled nitric oxide, susceptibility and new-onset asthma in the Children’s Health Study. Eur. Respir. J. 37(3), 523–531 (2011).
  • Bates CA, Silkoff PE. Exhaled nitric oxide in asthma: from bench to bedside. J. Allergy Clin. Immunol. 111(2), 256–262 (2003).
  • Paredi P, Kharitonov SA, Barnes PJ. Analysis of expired air for oxidation products. Am. J. Respir. Crit. Care Med. 166(12 Pt 2), S31–S37 (2002).
  • Von Mutius E, Illi S, Hirsch T, Leupold W, Keil U, Weiland SK. Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children. Eur. Respir. J. 14(1), 4–11 (1999).
  • Baraldi E, De Jongste JC. Measurement of exhaled nitric oxide in children, 2001. Eur. Respir. J. 20(1), 223–237 (2002).
  • Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am. J. Respir. Crit. Care. Med. 163(7), 1693–1722 (2001).
  • Linn WS, Rappaport EB, Berhane KT, Bastain TM, Avol EL, Gilliland FD. Exhaled nitric oxide in a population-based study of southern California schoolchildren. Respir. Res. 10(28), 1465–9921 (2009).
  • Gratziou C, Lignos M, Dassiou M, Roussos C. Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis. Eur. Respir. J. 14(4), 897–901 (1999).
  • Franklin PJ, Turner SW, Le Souef PN, Stick SM. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children. Thorax 58(12), 1048–1052 (2003).
  • Prasad A, Langford B, Stradling JR, Ho LP. Exhaled nitric oxide as a screening tool for asthma in school children. Respir. Med. 100(1), 167–173 (2006).
  • Hopkin JM. The diagnosis of asthma, a clinical syndrome. Thorax 67(7), 660–662 (2012).
  • Sittka A, Vera J, Lai X, Schmeck BT. Asthma phenotyping, therapy, and prevention: what can we learn from systems biology? Pediatr. Res. 73(4 Pt 2), 543–552 (2013).
  • Calvo FQ, Fillet M, De Seny D et al. Biomarker discovery in asthma-related inflammation and remodeling. Proteomics 9(8), 2163–2170 (2009).
  • O’neil SE, Sitkauskiene B, Babusyte A et al. Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment. Respir. Res. 12(124), 1465–9921 (2011).
  • Schultz A, Brand PL. Phenotype-directed treatment of pre-school-aged children with recurrent wheeze. J. Paediatr. Child Health 48(2), 1440–1754 (2012).
  • Van Aalderen WM, Sprikkelman AB. Inhaled corticosteroids in childhood asthma: the story continues. Eur. J. Pediatr. 170(6), 709–718 (2011).

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