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Expert Review of Clinical Immunology Volume 12, 2016 - Issue 1
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Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy

Spencer P LarsonCenter for Clinical & Translational Science, Creighton University School of Medicine, Omaha, NE, USA;Department of Obstetrics and Gynecology, Creighton University School of Medicine, Omaha, NE, USA
,
Oormila KovilamDepartment of Obstetrics and Gynecology, Creighton University School of Medicine, Omaha, NE, USA
&
Devendra K AgrawalCenter for Clinical & Translational Science, Creighton University School of Medicine, Omaha, NE, USACorrespondence[email protected]
Pages 39-48 | Published online: 15 Oct 2015

References

  • Reference annotations
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• This study investigated alterations in the gene profiles of placentas from patients with ICP. Among many changes, it found specific chemokines to be upregulated.

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• In this article, the roles of estradiol, progesterone metabolites and BSEP are discussed with regard to the etiology of ICP.

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• This research is the first to investigate changes in IL-17 levels of ICP. They found IL-17 to be significantly increased in patients with severe ICP, or who had total bile acid levels ≥ 40μmol/L.

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• This study explored a future treatment for ICP by using a FXR agonist in a mouse model. They found that the FXR agonist attenuated cell apoptosis and edema accumulation in the placenta.

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