51
Views
18
CrossRef citations to date
0
Altmetric
Review

Novel approaches in the management of refractory celiac disease

, , , , &
Pages 205-219 | Published online: 10 Jan 2014

References

  • Dube C, Rostom A, Sy R et al. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology128(4 Suppl. 1), S57–S67 (2005).
  • Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology120(3), 636–651 (2001).
  • Green PH. The many faces of celiac disease: clinical presentation of celiac disease in the adult population. Gastroenterology128(4 Suppl. 1), S74–S78 (2005).
  • Wahab PJ, Meijer JW, Mulder CJ. Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery. Am. J. Clin. Pathol.118(3), 459–463 (2002).
  • Daum S, Cellier C, Mulder CJ. Refractory coeliac disease. Best Pract. Res. Clin. Gastroenterol.19(3), 413–424 (2005).
  • Cellier C, Delabesse E, Helmer C et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet356(9225), 203–208 (2000).
  • Wahab PJ, Meijer JW, Goerres MS et al. Coeliac disease: changing views on gluten-sensitive enteropathy. Scand. J. Gastroenterol. (236 Suppl.), 60–65 (2002).
  • Biagi F, Corazza GR. Defining gluten refractory enteropathy. Eur. J. Gastroenterol. Hepatol.13(5), 561–565 (2001).
  • Al-Toma A, Verbeek WH, Hadithi M et al. Survival in refractory coeliac disease and enteropathy associated T cell lymphoma: retrospective evaluation of single centre experience. Gut57, 1373–1378 (2007).
  • Al-Toma A, Visser OJ, van Roessel HM et al. Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells. Blood109(5), 2243–2249 (2007).
  • When is a coeliac a coeliac? Report of a working group of the United European Gastroenterology Week in Amsterdam. Eur. J. Gastroenterol. Hepatol. (3), 1123–1128 (2001).
  • Patey-Mariaud De SN, Cellier C, Jabri B et al. Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method. Histopathology37(1), 70–77 (2000).
  • Cellier C, Patey N, Mauvieux L et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology114(3), 471–481 (1998).
  • Carbonnel F, Grollet-Bioul L, Brouet JC et al. Are complicated forms of celiac disease cryptic T-cell lymphomas? Blood92(10), 3879–3886 (1998).
  • Daum S, Hummel M, Weiss D et al. Refractory sprue syndrome with clonal intraepithelial lymphocytes evolving into overt enteropathy-type intestinal T-cell lymphoma. Digestion62(1), 60–65 (2000).
  • Koning F, Schuppan D, Cerf-Bensussan N et al. Pathomechanisms in celiac disease. Best Pract. Res. Clin. Gastroenterol.19(3), 373–387 (2005).
  • Maiuri L, Ciacci C, Ricciardelli I et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet362(9377), 30–37 (2003).
  • Hue S, Mention JJ, Monteiro RC et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity21(3), 367–377 (2004).
  • Meresse B, Chen Z, Ciszewski C et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity21(3), 357–366 (2004).
  • Mention JJ, Ben AM, Begue B et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology125(3), 730–745 (2003).
  • Di Sabatino SA, Ciccocioppo R, Cupelli F et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut55(4), 469–477 (2006).
  • Verbeek WH, Goerres MS, von Blomberg BM et al. Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in refractory celiac disease. Clin. Immunol.126(1), 48–56 (2008).
  • Bhagat G, Naiyer AJ, Shah JG et al. Small intestinal D8TCRγ/δNKG2A intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J. Clin. Invest.118(1), 281–293 (2008).
  • Sollid LM, Markussen G, Ek J et al. Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer. J. Exp. Med.169(1), 345–350 (1989).
  • Polvi A, Arranz E, Fernandez-Arquero M et al. HLA-DQ2-negative celiac disease in Finland and Spain. Hum. Immunol.59(3), 169–175 (1998).
  • Sollid LM. Molecular basis of celiac disease. Annu. Rev. Immunol.18, 53–81 (2000).
  • Vader W, Stepniak D, Kooy Y et al. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc. Natl Acad. Sci. USA100(21), 12390–12395 (2003).
  • Louka AS, Nilsson S, Olsson M et al. HLA in coeliac disease families: a novel test of risk modification by the ‘other’ haplotype when at least one DQA1*05-DQB1*02 haplotype is carried. Tissue Antigens60(2), 147–154 (2002).
  • Zubillaga P, Vidales MC, Zubillaga I et al. HLA-DQA1 and HLA-DQB1 genetic markers and clinical presentation in celiac disease. J. Pediatr. Gastroenterol. Nutr.34(5), 548–554 (2002).
  • Congia M, Cucca F, Frau F et al. A gene dosage effect of the DQA1*0501/DQB1*0201 allelic combination influences the clinical heterogeneity of celiac disease. Hum. Immunol.40(2), 138–142 (1994).
  • Al-Toma A, Goerres MS, Meijer JW et al. Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma. Clin. Gastroenterol. Hepatol.4(3), 315–319 (2006).
  • Holmes GK, Prior P, Lane MR et al. Malignancy in coeliac disease – effect of a gluten free diet. Gut30(3), 333–338 (1989).
  • Hadithi M, von Blomberg BM, Crusius JB et al. Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease. Ann. Intern. Med.147(5), 294–302 (2007).
  • Greco L, Romino R, Coto I et al. The first large population based twin study of coeliac disease. Gut50(5), 624–628 (2002).
  • Bevan S, Popat S, Braegger CP et al. Contribution of the MHC region to the familial risk of coeliac disease. J. Med. Genet.36(9), 687–690 (1999).
  • Monsuur AJ, de Bakker PI, Alizadeh BZ et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat. Genet.37(12), 1341–1344 (2005).
  • Hunt KA, Monsuur AJ, McArdle WL et al. Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut55(7), 969–972 (2006).
  • Amundsen SS, Monsuur AJ, Wapenaar MC et al. Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. Hum. Immunol.67(4–5), 341–345 (2006).
  • Giordano M, Marano C, Mellai M et al. A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population. Genes Immun.7(7), 606–608 (2006).
  • Nunez C, Marquez A, Varade J et al. No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population. Tissue Antigens68(6), 489–492 (2006).
  • Sanchez E, Alizadeh BZ, Valdigem G et al.MYO9B gene polymorphisms are associated with autoimmune diseases in Spanish population. Hum. Immunol.68(7), 610–615 (2007).
  • Koskinen LL, Korponay-Szabo IR, Viiri K et al. Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association. J. Med. Genet. (2007) (Epub ahead of print).
  • Wolters VM, Verbeek WH, Zhernakova A et al. The MYO9B gene is a strong risk factor for developing refractory celiac disease. Clin. Gastroenterol. Hepatol.5(12), 1399–1405, 1405 (2007).
  • van Heel DA, Franke L, Hunt KA et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat. Genet.39(7), 827–829 (2007).
  • Halstensen TS, Scott H, Brandtzaeg P. Intraepithelial T cells of the TcR γ/δ+ CD8- and V δ 1/J δ 1+ phenotypes are increased in coeliac disease. Scand. J. Immunol.30(6), 665–672 (1989).
  • Savilahti E, Arato A, Verkasalo M. Intestinal γ/δ receptor-bearing T lymphocytes in celiac disease and inflammatory bowel diseases in children. Constant increase in celiac disease. Pediatr. Res.28(6), 579–581 (1990).
  • Kutlu T, Brousse N, Rambaud C et al. Numbers of T cell receptor (TCR) α/β+ but not of TcR γ/δ+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet. Gut34(2), 208–214 (1993).
  • Jarvinen TT, Kaukinen K, Laurila K et al. Intraepithelial lymphocytes in celiac disease. Am. J. Gastroenterol.98(6), 1332–1337 (2003).
  • Maki M, Holm K, Collin P et al. Increase in γ/δ T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut32(11), 1412–1414 (1991).
  • Sturgess R, Kontakou M, Nelufer J et al. γ/δ T-cell receptor expression in the jejunal epithelium of patients with dermatitis herpetiformis and coeliac disease. Clin. Exp. Dermatol.18(4), 318–321 (1993).
  • Trejdosiewicz LK, Calabrese A, Smart CJ et al. γ/δ T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease. Clin. Exp. Immunol.84(3), 440–444 (1991).
  • Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology102(1), 330–354 (1992).
  • Rostami K, Kerckhaert J, Tiemessen R et al. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. Am. J. Gastroenterol.94(4), 888–894 (1999).
  • Rostom A, Dube C, Cranney A et al. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology128(4 Suppl. 1), S38–S46 (2005).
  • Collin P, Maki M, Keyrilainen O et al. Selective IgA deficiency and coeliac disease. Scand. J. Gastroenterol.27(5), 367–371 (1992).
  • Abrams JA, Diamond B, Rotterdam H et al. Seronegative celiac disease: increased prevalence with lesser degrees of villous atrophy. Dig. Dis. Sci.49(4), 546–550 (2004).
  • Vahedi K, Mascart F, Mary JY et al. Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease. Am. J. Gastroenterol.98(5), 1079–1087 (2003).
  • Peters JH, Wierdsma NJ, Teerlink T et al. Poor diagnostic accuracy of a single fasting plasma citrulline concentration to assess intestinal energy absorption capacity. Am. J. Gastroenterol.102(12), 2814–2819 (2007).
  • Isaacson PG, Wright DH, Ralfkiaer E. Enteropathy-type T-cell lymphoma. In: Classification of tumours: pathology and Genetics of tumours of hematopoietic and lymphoid tissues. Jaffe ES, Harris NL, Stein H et al (Eds). IARC Press, Lyon, France 208–209 (2001).
  • Bagdi E, Diss TC, Munson P et al. Mucosal intra-epithelial lymphocytes in enteropathy-associated T-cell lymphoma, ulcerative jejunitis, and refractory celiac disease constitute a neoplastic population. Blood94(1), 260–264 (1999).
  • Goerres MS, Meijer JW, Wahab PJ et al. Azathioprine and prednisone combination therapy in refractory coeliac disease. Aliment. Pharmacol. Ther.18(5), 487–494 (2003).
  • Al-Toma A, Goerres MS, Meijer JW et al. Cladribine therapy in refractory celiac disease with aberrant T cells. Clin. Gastroenterol. Hepatol.4(11), 1322–1327 (2006).
  • Al-Toma A, Verbeek WH, Visser OJ et al. Disappointing outcome of autologous stem cell transplantation for enteropathy-associated T-cell lymphoma. Dig. Liver Dis.39(7), 634–641 (2007).
  • Daum S, Weiss D, Hummel M et al. Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue. Gut49(6), 804–812 (2001).
  • Yamamoto H, Sekine Y, Sato Y et al. Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest. Endosc.53(2), 216–220 (2001).
  • Hadithi M, Al-Toma A, Oudejans J et al. The value of double-balloon enteroscopy in patients with refractory celiac disease. Am. J. Gastroenterol.102(5), 987–996 (2007).
  • Ashton-Key M, Diss TC, Pan L et al. Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy-associated T-cell lymphoma. Am. J. Pathol.151(2), 493–498 (1997).
  • Mallant M, Hadithi M, Al-Toma AB et al. Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma. World J. Gastroenterol.13(11), 1696–1700 (2007).
  • Tomei E, Diacinti D, Marini M et al. Abdominal CT findings may suggest coeliac disease. Dig. Liver Dis.37(6), 402–406 (2005).
  • van Weyenberg SJB, Mallant M, Al-Toma A, Jacobs MA, Mulder CJ, Waesberghe JH. Magnetic Resonance Enteroclysis in adult coeliac disease: findings and comparisons between subtypes with different prognosis. OP-G-239 Gut56(Suppl.3), A56 (2007).
  • Hadithi M, Mallant M, Oudejans J et al. 18F-FDG PET versus CT for the detection of enteropathy-associated T-cell lymphoma in refractory celiac disease. J. Nucl. Med.47(10), 1622–1627 (2006).
  • Longstreth GF. Successful treatment of refractory sprue with cyclosporine. Ann. Intern. Med.119(10), 1014–1016 (1993).
  • Wahab PJ, Crusius JB, Meijer JW et al. Cyclosporin in the treatment of adults with refractory coeliac disease – an open pilot study. Aliment. Pharmacol. Ther.14(6), 767–774 (2000).
  • Mulder CJ, Wahab PJ, Meijer JW et al. A pilot study of recombinant human interleukin-10 in adults with refractory coeliac disease. Eur. J. Gastroenterol. Hepatol.13(10), 1183–1188 (2001).
  • Maurino E, Niveloni S, Chernavsky A et al. Azathioprine in refractory sprue: results from a prospective, open-label study. Am. J. Gastroenterol.97(10), 2595–2602 (2002).
  • Daum S, Ipczynski R, Heine B et al. Therapy with budesonide in patients with refractory sprue. Digestion73(1), 60–68 (2006).
  • Gillett HR, Arnott ID, McIntyre M et al. Successful infliximab treatment for steroid-refractory celiac disease: a case report. Gastroenterology122(3), 800–805 (2002).
  • Turner SM, Moorghen M, Probert CS. Refractory coeliac disease: remission with infliximab and immunomodulators. Eur. J. Gastroenterol. Hepatol.17(6), 667–669 (2005).
  • Goodman GR, Burian C, Koziol JA et al. Extended follow-up of patients with hairy cell leukemia after treatment with cladribine. J. Clin. Oncol.21(5), 891–896 (2003).
  • Dray X, Joly F, Lavergne-Slove A et al. A severe but reversible refractory sprue. Gut55(8), 1210–1211 (2006).
  • Vivas S, Ruiz de Morales JM, Ramos F et al. Alemtuzumab for refractory celiac disease in a patient at risk for enteropathy-associated T-cell lymphoma. N. Engl. J. Med.354(23), 2514–2515 (2006).
  • Verbeek WH, Mulder CJ, Zweegman S. Alemtuzumab for refractory celiac disease. N. Engl. J. Med.355(13), 1396–1397 (2006).
  • Dearden CE, Matutes E, Cazin B et al. High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H. Blood98(6), 1721–1726 (2001).
  • Dearden CE, Matutes E. Alemtuzumab in T-cell lymphoproliferative disorders. Best Pract. Res. Clin. Haematol.19(4), 795–810 (2006).
  • Catassi C, Fabiani E, Corrao G et al. Risk of non-Hodgkin lymphoma in celiac disease. JAMA287(11), 1413–1419 (2002).
  • Catassi C, Bearzi I, Holmes GK. Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology128(4 Suppl. 1), S79–S86 (2005).
  • Egan LJ, Walsh SV, Stevens FM et al. Celiac-associated lymphoma. A single institution experience of 30 cases in the combination chemotherapy era. J. Clin. Gastroenterol.21(2), 123–129 (1995).
  • Daum S, Ullrich R, Heise W et al. Intestinal non-Hodgkin’s lymphoma: a multicenter prospective clinical study from the German Study Group on Intestinal non-Hodgkin’s Lymphoma. J. Clin. Oncol.21(14), 2740–2746 (2003).
  • Bishton MJ, Haynes AP. Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma. Br. J. Haematol.136(1), 111–113 (2007).
  • van Besien KW, Mehra RC, Giralt SA et al. Allogeneic bone marrow transplantation for poor-prognosis lymphoma: response, toxicity and survival depend on disease histology. Am. J. Med.100(3), 299–307 (1996).
  • Vitolo U, Cortellazzo S, Liberati AM et al. Intensified and high-dose chemotherapy with granulocyte colony-stimulating factor and autologous stem-cell transplantation support as first-line therapy in high-risk diffuse large-cell lymphoma. J. Clin. Oncol.15(2), 491–498 (1997).
  • Hosing C, Saliba RM, McLaughlin P et al. Long-term results favor allogeneic over autologous hematopoietic stem cell transplantation in patients with refractory or recurrent indolent non-Hodgkin’s lymphoma. Ann. Oncol.14(5), 737–744 (2003).
  • Doocey RT, Toze CL, Connors JM et al. Allogeneic haematopoietic stem-cell transplantation for relapsed and refractory aggressive histology non-Hodgkin lymphoma. Br. J. Haematol.131(2), 223–230 (2005).
  • Gallamini A, Zaja F, Patti C et al. Alemtuzumab (Campath-1H) and CHOP chemotherapy as first-line treatment of peripheral T-cell lymphoma: results of a GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) prospective multicenter trial. Blood110(7), 2316–2323 (2007).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.