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Review

Impact of comorbidities on asthma

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Pages 731-742 | Published online: 10 Jan 2014

References

  • Bateman ED, Hurd SS, Barnes PJ et al. Global strategy for asthma management and prevention: GINA executive summary. Eur. Respir. J.31, 143–178 (2008).
  • Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy59(5), 469–478 (2004).
  • Barnes PJ, Jonsson B, Klim JB. The costs of asthma. Eur. Respir. J.9(4), 636–642 (1996).
  • Ober C. Perspectives on the past decade of asthma genetics. J. Allergy Clin. Immunol.116(2), 274–278 (2005).
  • Asher MI, Montefort S, Björkstén B et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases one and three repeat multicountry cross-sectional surveys. Lancet368(9537), 733–743 (2006).
  • Anderson HR, Gupta R, Kapetanakis V et al. International correlations between indicators of prevalence, hospital admissions and mortality for asthma in children. Int. J. Epidemiol.37(3), 573–582 (2008).
  • Rabe KF, Adachi M, Lai CK et al. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J. Allergy Clin. Immunol.114(1), 40–47 (2004).
  • Bateman ED, Boushey H, Busse WW, Clark TJH, Pauwels RA, Pedersen S. Can guideline-defined asthma control be achieved? Am. J. Respir. Crit. Care Med.170, 836–844 (2004).
  • Horne R, Price D, Cleland J et al. Can asthma control be improved by understanding the patient’s perspective? BMC Pulm. Med.7, 8 (2007).
  • Bousquet J, Van Cauwenberge P, Khaltaev N et al. Allergic rhinitis and its impact on asthma. J. Allergy Clin. Immunol.5(Suppl.), S147–S334 (2001).
  • Bousquet J, Khaltaev N, Cruz AA et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy63(Suppl. 86), S8–S160 (2008).
  • Jeffery PK, Haahtela T. Allergic rhinitis and asthma: inflammation in a one airway condition. BMC Pulm. Med.6(Suppl. 1), S5 (2006).
  • Leynaert B, Neukirch C, Kony S et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J. Allergy Clin. Immunol.113, 86–93 (2004).
  • Fokkens W, Lund V, Mullol J, Bachert C. European position paper on rhinosinusitis and nasal polyps. Rhinology20(Suppl.), S1–S136 (2007).
  • Gaugris S, Sazonov-Kocevar V, Thomas M. Burden of concomitant allergic rhinitis in adults with asthma. J. Asthma43, 1–7 (2006).
  • Nolte H, Nepper-Christensen S, Backer V. Unawareness and undertreatment of asthma and allergic rhinitis in a general population. Respir. Med.100, 354–336 (2006).
  • Price D, Kocevar VS, Zhang Q, Yin DD, Thomas M. Effect of a concomitant diagnosis of allergic rhinitis on asthma-related health care use by adults. Clin. Exp. Allergy35, 282–287 (2005).
  • Thomas M, Kocevar VS, Zhang Q, Yin DD, Price D. Asthma-related health care resource use among asthmatic children with and without concomitant allergic rhinitis. Pediatrics115, 129–131 (2005).
  • Celedon JC, Palmer LJ, Weiss ST, Wang B, Fang Z, Xu X. Asthma, rhinitis and skin test reactivity to aeroallergens in families of asthmatic subjects in Anqing, China. Am. J. Respir. Crit. Care Med.163, 1108–1112 (2001).
  • The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet351, 1225–1232 (1998).
  • Linneberg A, Simonsen JB, Petersen J, Stensballe LG, Benn CS. Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology. J. Allergy Clin. Immunol.117(1), 184–189 (2006).
  • Madonini E, Briatico-Vangosa G, Pappacoda A, Maccagni G, Cardani A, Saporiti F. Seasonal increase of bronchial reactivity in allergic rhinitis. J. Allergy Clin. Immunol.79, 358–363 (1987).
  • Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J. Allergy Clin. Immunol.109, 419–425 (2002).
  • Greisner WA 3rd, Settipane RJ, Settipane GA. Co-existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc.19(4), 185–188 (1998).
  • Cruz AA, Popov T, Pawankar R et al. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA2LEN. Allergy62(Suppl. 84), 1–41 (2007).
  • Thomas M. Allergic rhinitis: evidence for impact on asthma. BMC Pulm. Med.6(Suppl. 1), S4 (2006).
  • British Thoracic Society Scottish Intercollegiate Guidelines Network. British guidelines on the management of asthma. Thorax63(Suppl. 4), S1–S121 (2008).
  • Price DB, Swern A, Tozzi CA, Philip G, Polos P. Effect of montelukast on lung function in asthma patients with allergic rhinitis: analysis from the COMPACT trial. Allergy61, 737–742 (2006).
  • Schramm B, Ehlken B, Smala A, Quednau K, Berger K, Nowak D. Cost of illness of atopic asthma and seasonal allergic rhinitis in Germany: 1-yr retrospective study. Eur. Respir. J.21, 116–122 (2003).
  • Bousquet J, Gaugris S, Kocevar VS et al. Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the improving asthma control trial. Clin. Exp. Allergy35, 723–727 (2005).
  • Schramm B, Ehlken B, Smala A, Quednau K, Berger K, Nowak D: Cost of illness of atopic asthma and seasonal allergic rhinitis in Germany: 1-yr retrospective study. Eur. Respir. J.21, 116–122 (2003).
  • Dahl R, Nielsen LP, Kips J et al. Intranasal and inhaled fluticasone propionate for pollen-induced rhinitis and asthma. Allergy60, 875–881 (2005).
  • Stelmach R, do Patrocinio TNM, Ribeiro M, Cukier A. Effect of treating allergic rhinitis with corticosteroids in patients with mild-to-moderate persistent asthma. Chest128, 3140–3147 (2005).
  • Nathan RA, Yancey SW, Waitkus-Edwards K et al. Fluticasone propionate nasal spray is superior to montelukast for allergic rhinitis while neither affects overall asthma control. Chest128, 1910–1920 (2005).
  • Crystal-Peters J, Neslusan C, Crown WH, Torres A. Treating allergic rhinitis in patients with comorbid asthma: the risk of asthma-related hospitalizations and emergency department visits. J. Allergy Clin. Immunol.109(1), 57–62 (2002).
  • Grant JA, Nicodemus CF, Findlay SR et al. Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial. J. Allergy Clin. Immunol.95, 923–932 (1995).
  • Grembiale RD, Camporota L, Naty S, Tranfa CM, Djukanovic R, Marsico SA. Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness. Am. J. Respir. Crit. Care Med.162, 2048–2052 (2000).
  • Polosa R, Li Gotti F, Mangano G et al. Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis. Allergy59, 1224–1228 (2004).
  • Möller C, Dreborg S, Ferdousi HA et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J. Allergy Clin. Immunol.109, 251–256 (2002).
  • Polosa R, Al-Delaimy WK, Russo C, Piccillo G, Sarva M. Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort study. Respir. Res.6, 153 (2005).
  • Holgate ST, Djukanovic R, Casale T, Bousquet J. Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin. Exp. Allergy35, 408–416 (2005).
  • Philip G, Nayak AS, Berger WE et al. The effect of montelukast on rhinitis symptoms in patients with asthma and seasonal allergic rhinitis. Curr. Med. Res. Opin.20, 1549–1558 (2004).
  • Baena-Cagnani CE, Berger WE, DuBuske LM et al. Comparative effects of desloratadine versus montelukast on asthma symptoms and use of β2-agonists in patients with seasonal allergic rhinitis and asthma. Int. Arch. Allergy Immunol.130, 307–313 (2003).
  • Zang Q, Thomas M, Wisniewsk T, Saznoov Kocevar V. Treatment and outcomes in patients with asthma and allergic rhinitis in the UK. Int. Arch. Allergy Immunol.142, 318–328 (2007).
  • Osler W. The Principles And Practice Of Medicine. Young J (Ed.). Pentland, Edinburgh, UK (1892).
  • Deshmukh VM, Toelle BG, Usherwood T, O’Grady B, Jenkins CR. Anxiety, panic and adult asthma: a cognitive behavioural perspective. Resp. Med.101, 194–202 (2007).
  • Carr RE. Panic disorder and asthma. J. Asthma36, 143–152 (1999).
  • Busse WW, Kiecolt-Glaser JK, Coe C et al. Stress and asthma: NHLBI workshop summary. Am. J. Respir. Crit. Care Med.151, 249–252 (1995).
  • Cooper CL, Parry GD, Saul C et al. Anxiety and panic fear in adults with asthma: prevalence in primary care. BMC Fam. Pract.26(8), 62 (2007).
  • Blackman JA, Gurka MJ. Developmental and behavioural comorbidities of asthma in children. J. Dev. Behav. Paediatr.28, 92–99 (2007).
  • Goodwin RD, Fergusson DM, Horwood LJ. Asthma and depressive and anxiety disorders among young persons in the community. Psychol. Med.34(8), 1465–1474 (2004).
  • Abramson MJ, Bailey MJ, Forbes AB, Walters EH; Victorian Asthma Mortality Study Group. How well do doctors know their patients with severe asthma? Intern. Med. J.33(12), 557–565 (2003).
  • Heaney LG, Conway E, Kelly C, Gamble J. Prevalence of psychiatric morbidity in a difficult asthma population: relationship to asthma outcome. Resp. Med.99, 1152–1159 (2005).
  • Robinson DS, Campbell DA, Durham SR, Pfeffer J, Barnes PJ, Chung KF. Asthma and Allergy Research Group of the National Heart and Lung Institute. Systematic assessment of difficult to treat asthma. Eur. Respir. J.22, 478–448 (2003).
  • Goodwin R. Mental disorders and asthma in the community. Arch. Gen. Psych.60(11), 1125–1130 (2003).
  • Spinhoven P, Peski-Oosterbaan AS, Van der Does AJ, Willems LN, Sterk PJ. Association of anxiety with perception of histamine induced bronchoconstriction in patients with asthma. Thorax52, 149–152 (1997).
  • Hibbert G, Pilsbury D. Demonstration and treatment of hyperventilation causing asthma. Br. J. Psychiatry153, 687–689 (1988).
  • Hasler G, Gergen PJ, Kleinbaum DG et al. Asthma and panic in young adults: a 20-year prospective community study. Am. J. Respir. Crit. Care Med.171(11), 1224–1230 (2005).
  • Rimington LD, Davies DH, Lowe D, Pearson MG. Relationship between anxiety, depression, and morbidity in adult asthma patients. Thorax56, 266–271 (2001).
  • Lavoie KL, Cartier A, Labrecque M et al. Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients? Respir. Med.99, 1249–1257 (2005).
  • Martínez-Moragón E, Perpiñá M, Belloch A, de Diego A, Martínez-Francés M. Determinants of dyspnea in patients with different grades of stable asthma. J. Asthma40(8), 945–953 (2003).
  • Chetta A, Gerra G, Foresi A et al. Personality profiles and breathlessness perception in outpatients with different grading of asthma. Am. J. Respir. Crit. Care Med.157, 116–122 (1998).
  • ten Brinke A, Ouwerkerk ME, Zwinderman AH et al. Psychopathology in patients with severe asthma is associated with increased health care utilization. Am. J. Respir. Crit. Care Med.163, 1093–1096 (2001).
  • Wainwright NW, Surtees PG, Wareham NJ, Harrison BD. Psychosocial factors and incident asthma hospital admissions in the EPIC-Norfolk cohort study. Allergy63(3), 382 (2007).
  • Kullowatz A, Kanniess F, Dahme B, Magnussen H, Ritz T. Association of depression and anxiety with health care use and quality of life in asthma patients. Respir. Med.101(3), 638–644 (2007).
  • Barton CA, McKenzie DP, Walters EH, Abramson MJ; Victorian Asthma Mortality Study Group. Interactions between psychosocial problems and management of asthma: who is at risk of dying? J. Asthma42(4), 249–256 (2000).
  • Thomas M, Griffiths C. Asthma and panic. Scope for intervention? Am. J. Resp. Crit. Care Med.171, 1224–1230 (2005).
  • Ader R, Cohen N, Felten D. Psychoneuroimmunology: interactions between the nervous system and the immune system. Lancet345, 99–103 (1995).
  • Campbell TS, Lavoie KL, Bacon SL, Schard D, Aboussafy D, Ditto D. Asthma self-efficacy, high frequency heart rate variability, and airflow obstruction during negative affect in daily life. Int. J. Psychophysiol.62, 109–114 (2006).
  • Cluley S, Cochrane GM. Psychological disorder in asthma is associated with poor control and poor adherence to inhaled steroids. Respir. Med.95, 37–39 (2001).
  • Dahlem NW, Kinsman RA, Horton DJ. Panic-fear in asthma: requests for as-needed medications in relation to pulmonary function measurements. J. Allergy Clin. Immunol.60, 295–300 (1977).
  • Peiffer C, Poline J, Thivard L, Aubier M, Samson Y. Neural substrates for the perception of acutely induced dyspnea. Am. J. Respir. Crit. Care Med.163, 951–957 (2001).
  • Yorke J, Fleming SL, Shuldham CM. Psychological interventions for adults with asthma. Cochrane Database Syst. Rev.1, CD002982 (2006).
  • Lehrer PM, Karavidas MK, Lu SE et al. Psychological treatment of comorbid asthma and panic disorder: a pilot study. J. Anxiety Disord.22(4), 671–683 (2008).
  • Brown ES, Vigil L, Khan DA, Liggin JD, Carmody TJ, Rush AJ. A randomized trial of citalopram vs. placebo in outpatients with asthma and major depressive disorder: a proof of concept study. Biol. Psychiatry58, 865–870 (2005).
  • Godding V, Kruth M, Jamart J. Joint consultation for high-risk asthmatic children and their families, with paediatrician and child psychiatrist as cotherapists: model and evaluation. Fam. Process36, 265–280 (1997).
  • Smith JR, Mildenhall S, Noble MJ et al. The Coping with Asthma Study: a randomised controlled trial of a home based, nurse led psychoeducational intervention for adults at risk of adverse asthma outcomes. Thorax60, 1003–1011 (2005).
  • Smith JR. A systematic review to examine the impact of psycho-educational interventions on health outcomes and costs in adults and children with difficult asthma. Health Technol. Assess.9(23), iii–iv, 1–167 (2005).
  • Ford ES. The epidemiology of obesity and asthma. J. Allergy Clin. Immunol.115, 897–909 (2005).
  • von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax56, 835–838 (2001).
  • Xu B, Pekkanen J, Laitinen J, Jarvelin MR. Body build from birth to adulthood and risk of asthma. Eur. J. Public Health12, 166–170 (2002).
  • Gold DR, Damokosh AI, Dockery DW, Berkey CS. Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr. Pulmonol.36, 514–521 (2003).
  • Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch. Intern. Med.159, 2582–2588 (1999).
  • Dolan CM, Fraher KE, Bleecker ER et al. Design and baseline characteristics of the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. Ann. Allergy Asthma Immunol.92, 32–39 (2004).
  • Saint-Pierre P, Bourdin A, Chanez P, Daures JP, Godard P. Are overweight asthmatics more difficult to control? Allergy61, 79–84 (2006).
  • Lavoie KL, Bacon SL, Labrecque M, Cartier A, Ditto B. Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir. Med.100, 648–657 (2006).
  • Corbo GM, Forastiere F, De Sario M et al.; the Sidria-2 Collaborative Group. Wheeze and asthma in children: associations with body mass index, sports, television viewing, and diet. Epidemiology19(5), 747–755 (2008).
  • Taveras EM, Camargo CA Jr, Rifas-Shiman SL et al. Association of birth weight with asthma-related outcomes at age 2 years. Pediatr. Pulmonol.41(7), 643–648 (2006).
  • Taveras EM, Rifas-Shiman SL, Camargo CA Jr et al. Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children. J. Allergy Clin. Immunol.121(5), 1161–1166 (2008).
  • Castro-Rodriguez JA, Garcia-Marcos L, Alfonseda Rojas JD, Valverde-Molina J, Sanchez-Solis M. Mediterranean diet as a protective factor for wheezing in preschool children. J. Pediatr.152(6), 823–828, E2 (2008).
  • Cook D, Carey I, Whincup P et al. Effect of fresh fruit consumption on lung function and wheeze in children. Thorax52, 628–633 (1997).
  • Devereux G, Seaton A. Diet as a risk factor for atopy and asthma. J. Allergy Clin. Immunol.115(6), 1109–1117 (2005).
  • Shore S. Obesity and asthma: possible mechanisms J. Allergy Clin. Immunol.121, 1087–1093 (2008).
  • Zerah F, Harf A, Perlemuter L, Lorino H, Lorino AM, Atlan G. Effects of obesity on respiratory resistance. Chest103, 1470–1476 (1993).
  • Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest.112, 1785–1788 (2003).
  • Hallstrand TS, Fischer ME, Wurfel MM, Afari N, Buchwald D, Goldberg J. Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J. Allergy Clin. Immunol.116, 1235–1241 (2005).
  • Gunnbjornsdottir MI, Omenaas E, Gislason T et al. Obesity and nocturnal gastro–oesophageal reflux are related to onset of asthma and respiratory symptoms. Eur. Respir. J.24, 116–121 (2004).
  • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol.115, 911–919 (2005).
  • Hakala K, Stenius-Aarniala B, Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest118, 1315–1321 (2000).
  • Stenius-Aarniala B, Poussa T, Kvarnstrom J, Gronlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ320, 827–832 (2000).
  • Jaspersen D, Kulig M, Labenz J et al. Prevalence of extra-oesophageal manifestations in gastro–oesophageal reflux disease: an analysis based on the ProGERD Study. Aliment. Pharmacol. Ther.17, 1515–1520 (2003).
  • Overholt RH, Voorhees RJ. Esophageal reflux as a trigger in asthma. Dis. Chest.49(5), 464–466 (1966).
  • Field SK, Underwood M, Brant R et al. Prevalence of gastroesophageal reflux symptoms in asthma. Chest109(2), 316–322 (1996).
  • Havemann BD, Henderson CA, El-Serag HB. The association between gastro–oesophageal reflux disease and asthma: a systematic review. Gut56(12), 1654–1664 (2007).
  • Tucci F, Resti M, Fontana R, Novembre E, Lami CA, Vierucci A. Gastroesophageal reflux and bronchial asthma: prevalence and effect of cisapride therapy. J. Pediatr. Gastroenterol. Nutr.17(3), 265–270 (1993).
  • Sontag SJ, O’Connell S, Khandelwal S et al. Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology99, 613–620 (1990).
  • Mays EE. Intrinsic asthma in adults: association with gastro–esophageal reflux. JAMA236, 2626–2628 (1976).
  • Sontag SJ, O’Connell S, Khandelwal S et al. Effect of positions, eating, and bronchodilators on gastroesophageal reflux in asthmatics. Dig. Dis. Sci.35, 849–856 (1990).
  • Ruigomez A, Rodriguez LAG, Wallander M, Johansson S, Thomas M, Price D. Gastroesophageal reflux disease and asthma: a longitudinal study in UK general practice. Chest128, 85–93 (2005).
  • Ruhl CE, Sonnenberg A, Everhart JE. Hospitalization with respiratory disease following hiatal hernia and reflux esophagitis in a prospective, population-based study. Ann. Epidemiol.11, 477–483 (2001).
  • Field SK, Gelfand GAJ, McFadden SD. The effects of antireflux surgery on asthmatics with gastroesophageal reflux. Chest116, 766–774 (1999).
  • Gibson PG, Henry RL, Coughlan JL. Gastro–oesophageal reflux treatment for asthma in adults and children. Cochrane Database Syst. Rev.2, CD001496 (2003).
  • McFadden ER, Lyons HA. Arterial blood gas tension in asthma. N. Engl. J. Med.278, 1027–1032 (1968).
  • Osborne CA, O’Connor BJ, Lewis A et al. Hyperventilation and asymptomatic chronic asthma. Thorax55, 1016–1022 (2000).
  • Laffey JG, Kavanagh BP. Hypocapnia. N. Engl. J. Med.347(1), 43–53 (2002).
  • Gardner WN. The pathophysiology of hyperventilation disorders. Chest109(2), 516–534 (1996).
  • Bruton A, Holgate, S. Hypocapnia and asthma: a mechanism for breathing retraining? Chest127, 1808–1811 (2005).
  • Ringsberg KC, Akerlind I. Presence of hyperventilation in patients with asthma-like symptoms but negative asthma test responses: provocation with voluntary hyperventilation and mental stress. J. Allergy Clin. Immunol.103, 601–608 (1998).
  • Han JN, Stegen K, Simkens K et al. Unsteadiness of breathing in patients with hyperventilation syndrome and anxiety disorders. Eur. Respir. J.10, 167–176 (1997).
  • Heaney LG, Robinson DS. Severe asthma treatment: need for characterising patients. Lancet365(9463), 974–976 (2005).
  • Mikita J, Parker J. How is difficult asthma managed? Eur. Respir. J.28(5), 968–973 (2006).
  • Weinberger M, Abu-Hasan M. Pseudo-asthma: when cough, wheezing, and dyspnea are not asthma. Pediatrics120(4), 855–864 (2007).
  • Thomas M, McKinley RK, Freeman E, Foy C, Price D. The prevalence of dysfunctional breathing in adults in the community with and without asthma. Prim. Care Respir. J.14(2), 78–82 (2005).
  • Thomas M, McKinley RK, Freeman E et al. Prevalence of dysfunctional breathing in patients treated for asthma in primary care: cross sectional survey. BMJ322, 1098–1100 (2001).
  • Roberts NJ, Robinson DS, Partridge MR. High levels of medical utilization by ambulatory patients with vocal cord dysfunction as compared to age- and gender-matched asthmatics. Chest129, 905–908 (2006).
  • Christopher KL, Wood RP, Eckert RC et al. Vocal-cord dysfunction presenting as asthma. N. Engl. J. Med.308, 1566–1570 (1983).
  • Thomas M. Breathing exercises and asthma. Thorax58(8), 649–645 (2003).
  • Bruton A, Thomas M. Breathing therapies and bronchodilator use in asthma. Thorax61, 643–645 (2006).
  • Holloway E, West R. Integrated breathing and relaxation training (the Papworth Method) for adults with asthma in primary care: a randomised controlled trial. Thorax62, 1033–1034 (2007).
  • Thomas M, McKinley RK, Freeman E, Foy C, Prodger P, Price D. Breathing retraining for dysfunctional breathing in asthma: a randomised controlled trial. Thorax58(2), 110–115 (2003).
  • Slader CA, Reddel HK, Spencer LM et al. Double blind randomised controlled trial of two different breathing techniques in the management of asthma. Thorax61(8), 643–645 (2006).
  • Cooper S, Oborne J, Nelson S et al. The effect of two breathing exercises (Butekyo and Pranayama) in asthma: a randomised controlled trial. Thorax58, 674–679 (2003).
  • Manocha R, Marks G, Kenchington P, Peters D, Salome CM. Sahaja yoga in the management of moderate to severe asthma: a randomised controlled trial. Thorax57, 110–115 (2002).
  • Opat AJ, Cohen MM, Bailey MJ, Abramson MJ. A clinical trial of the Buteyko breathing technique in asthma as taught by a video. J. Asthma37, 557–564 (2000).
  • Holloway E, Ram FSF. Breathing exercises for asthma. Cochrane Database Syst. Rev.1, CD001277 (2004).
  • Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur. Respir. J.24, 822–833 (2004).
  • Hylkema MN, Sterk PJ, de Boer WI, Postma DS. Tobacco use in relation to COPD and asthma. Eur. Respir. J.29(3), 438–445 (2007).
  • Jensen E, Dahl R, Steffensen F. Bronchial reactivity to cigarette smoke relation to lung function, respiratory symptoms, serum-immunoglobulin E and blood eosinophil and leukocyte counts. Respir. Med.94, 119–127 (2000).
  • Gallefoss F, Bakke P. Does smoking affect the outcome of patient education and self management in asthmatics? Patient Educ. Couns.49, 91–97 (2003).
  • Sippel JM, Pedula KL, Vollmer WM, Buist AS, Osborne ML. Associations of smoking with hospital-based care and quality of life in patients with obstructive airway disease. Chest115, 691–696 (1999).
  • Turner M, Noertjojo K, Vedal S, Bai T, Crump S, Fitzgerald JM. Risk factors for near fatal asthma. A case–control study in hospitalized patients with asthma. Am. J. Respir. Crit. Care Med.157, 1804–1809 (1998).
  • Pedersen B, Dahl R, Karlstrom R, Peterson CG, Venge P. Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking. Am. J. Respir. Crit. Care Med.153(5), 1519–1529 (1996).
  • Boulet LP, Lemiere C, Archambault F, Carrier G, Descary MC, Deschesnes F. Smoking and asthma: clinical and radiologic features, lung function, and airway inflammation. Chest129(3), 661–668 (2006).
  • Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur. Respir. J.25(3), 552–563 (2005).
  • Fauler J, Frolich JC. Cigarette smoking stimulates cysteinyl leukotriene production in man. Eur. J. Clin. Invest.27(1), 43–47 (1997).
  • Chalmers GW, Macleod KJ, Little SA, Thomson LJ, McSharry CP, Thomson NC. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax57, 226–230 (2002).
  • Tomlinson JE, McMahon AD, Chaudhuri R, Thompson JM, Wood SF, Thomson NC. Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax60(4), 282–287 (2005).
  • Lazarus SC, Chinchilli V, Rollings NJ et al. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am. J. Respir. Crit. Care Med.175, 783–790 (2007).
  • Barnes PJ. Theophylline: new perspectives for an old drug. Am. J. Respir. Crit. Care Med.167, 813–818 (2003).
  • Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15 year follow-up study of ventilatory function in adults with asthma. N. Engl. J. Med.339, 1194–1200 (1998).
  • Chaudhuri R, Livingston E, McMahon AD et al. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am. J. Respir. Crit. Care Med.174(2), 127–133 (2006).
  • Kapoor R, Menon C, Hoffstad O, Bilker W, Leclerc P, Margolis DJ. The prevalence of atopic triad in children with physician-confirmed atopic dermatitis. J. Am. Acad. Dermatol.58(1), 68–73 (2008).
  • Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis – a prospective follow-up to 7 years of age. Allergy55, 240–245 (2000).
  • Holgate ST. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol.28(6), 248–251 (2007).
  • Raj AA, Birring SS, Green R, Grant A, de Caestecker J, Pavord ID. Prevalence of inflammatory bowel disease in patients with airways disease. Respir. Med.102(5), 780–785 (2008).
  • Rudwaleit M, Andermann B, Alten R et al. Atopic disorders in ankylosing spondylitis and rheumatoid arthritis. Ann. Rheum. Dis.61(11), 951–954 (2002).
  • Caffarelli C, Cavagni G, Pierdomenico R, Chiari G, Spattini A, Vanelli M. Coexistence of IgE-mediated allergy and Type 1 diabetes in childhood. Int. Arch. Allergy Immunol.134(4), 288–294 (2004).
  • Cakir M, Akcay S, Karakas T, Gedik Y, Okten A, Orhan F. Prevalence of atopy in children with Type 1 diabetes mellitus, hepatitis B virus carriers, and healthy children: role of T helper 1 (Th1)-type immune response. Allergy Asthma Proc.29(2), 166–170 (2008).
  • Taylor R, Bateman E, Boulet LP et al. A new perspective in concepts of asthma severity and control. Eur. Respir. J.32(3), 545–554 (2008).
  • Haldar P, Pavord I, Shaw D et al. Cluster analysis and clinical asthma phenotypes. Am. J. Respir. Crit. Care Med.178(3), 218–224 (2008).
  • Herland K, Akselsen JP, Skjønsberg OH, Bjermer L. How representative are clinical study patients with asthma or COPD for a larger ‘real life’ population of patients with obstructive lung disease? Respir. Med.99(1), 11–19 (2005).
  • Haughney J, Price D, Kaplan A et al. Achieving asthma control in practice: understanding the reasons for poor control. Respir. Med. DOI:10.1016/j.rmed.2008.08.003 (2008) (Epub ahead of print).

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