2,091
Views
10
CrossRef citations to date
0
Altmetric
Drug Profile

OMS302 (phenylephrine and ketorolac injection) 1%/0.3% to maintain intraoperative pupil size and to prevent postoperative ocular pain in cataract surgery with intraocular lens replacement

, &

References

  • Congdon N, O’Colmain B, Klaver CC, et al. Causes and prevalence of visual impairment among adults in the United States. Arch Opthalmol 2004;122(4):477-85
  • American academy of opthalmology cataract and anterior segment panel. preferred practice pattern® Guidelines. Cataract in the Adult Eye. San Francisco, CA: american Academy of Ophthalmology; 2011. Available from: www.aao.org/ppp
  • Cullen KA, Hall MJ, Golosinskiy A. Ambulatory Surgery in the United States, 2006. National health statistics reports; no 11. Revised Hyattsville, MD: National Center for Health Statistics 2009
  • Dubois V, Wittles N, Lamont M, et al. Randomized controlled single-blind study of conventional versus depot drug delivery prior to cataract surgery. BMC Ophthalmol 2006;6:36
  • Zanetti FR, Fulco EA, Chaves FR, et al. Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: a randomized trial. Indian J Ophthalmol 2012;60:277-81
  • Joseph J, Wang HS. Phacoemulsification with poorly dilated pupils. J Cataract Refract Surg 1993;19:551-6
  • Dada T, Sharma N, Vajpayee RB, Dada VK. Conversion from phacoemulsification to extracapsular cataract extraction: incidence, risk factors, and visual outcome. J Cataract Refract Surg 1998;24:1521-4
  • Waitzman MB. Prostaglandins and the eye: rapid transition from basic to applied and implications for expanded clinical consideration. Metab Pediatr Syst Ophthalmol 1982;6:17-26
  • Srinivasan R, Madhavaranga Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. J Cataract Refract Surg 2002;28:517-20
  • Lundberg B, Behndig A. Intracameral mydriatics in phacoemulsification cataract surgery. J Cataract Refract Surg 2003;29:2366-71
  • Hejny C, Edelhauser HF. Surgical pharmacology: intraocular solutions and drugs used for cataract surgery. In: Buratto L, Werner L, Zanini M, Apple D, editors. Phacoemulsification: Principle and Techniques. Slack; Thorofare, NJ: 2003. p. 230-6
  • Keulen-de Vos HC, van Rij G, Renardel de Lavalette JC, Jansen JT. Effect of indomethacin in preventing surgically induced miosis. Br J Ophthalmol 1983;67:94-6
  • Fine HF, Iranmanesh R, Del Priore LV, et al. Surgical outcomes after massive subretinal hemorrhage secondary to age-related macular degeneration. Retina 2010;30:1588-94
  • Goldman JM, Karp CL. Adjunct devices for managing challenging cases in cataract surgery: pupil expansion and stabilization of the capsular bag. Curr Opin Ophthalmol 2007;18:44-51; Review
  • Cionni RJ, Barros MG, et al. Cataract surgery without preoperative eyedrops. J Cataract Refract Surg 2003;29:2281-3
  • Lundberg B, Behndig A. Intramydriatics in phacoemulsification surgery obviate the need for epinephrine irrigation. Acta Ophthalmol Scand 2007;85:546-50
  • Cutler Peck CM, Brubaker J, Clouser S, et al. Toxic anterior segment syndrome: common causes. J Cataract Refract Surg 2010;36:1073-80
  • FDA alerts health care professionals of infection risk from repackaged Avastin intravitreal injections. U.S. Food and Drug Administration web site. 2011. Available from: www.fda.gov/Drugs/DrugSafety/ucm270296.htm updated 30 August 2011 [Accessed 7 August, 2014]
  • Porela-Tiihonen S, Kaarniranta K, Kokki M, et al. A prospective study on postoperative pain after cataract surgery. Clinical Ophthalmol 2013;7:1429-35
  • Solomon KD, Vroman DT, Barker D, Gehlken J. Comparison of ketorolac tromethamine 0.5% and rimexolone 1% to control inflammation after cataract extraction. Prospective randomized double-masked study. J Cataract Refract Surg 2001;27:1232-7
  • O’Brien TP. Emerging guidelines for use of NSAID therapy to optimize cataract surgery patient care. Curr Med Res Opin 2005;21:1131-7. Review Erratum in Curr Med Res Opin 2005;21:1431-2
  • Heath P, Geiter CW. Use of phenylephrine hydrochloride, neo-synephrine hydrochloride, in ophthalmology. Arch Ophthal 1949;41:172-7
  • Boyer KC, McDonald P, Zoetis T. A novel formulation of ketorolac tromethamine for intranasal administration: preclinical safety evaluation. Int J Toxicol 2010;29:467-78
  • ACULAR (ketorolac tromethamine ophthalmic solution) 0.5% [package insert]. Allergan Inc; Palo Alto, CA: Revised June 2012
  • Phenylephrine hydrochloride ophthalmic solution, USP 2.5% and 10% [package insert]. Paragon BioTeck, Inc; Portland, OR: Revised June 2014
  • Nakamura S, Taniguchi T, Suzuki F, et al. Evaluation of alpha1-adrenoceptors in the rabbit iris: pharmacological characterization and expression of mRNA. Br J Pharmacol 1999;127:1367-74
  • Ishikawa H, Miller DD, Patil PN. Comparison of post-junctional alpha-adrenoceptors in iris dilator muscle of humans, and albino and pigmented rabbits. Naunyn Schmiedebergs Arch Pharmacol 1996;354:765-72
  • Batenburg WW, van Esch JH, Garrelds IM, et al. Carvedilol-induced antagonism of angiotensin II: a matter of alpha1-adrenoceptor blockade. J Hypertens 2006;24:1355-63
  • Kozlowska H, Schlicker E, Kozlowski M, et al. Ligands at beta2-, beta3-, and the low-affinity state of beta1-adrenoceptors block the alpha1-adrenoceptor-mediated constriction in human pulmonary and rat mesenteric arteries. J Cardiovasc Pharmacol 2005;46:76-82
  • Veeser M, Hofmann T, Roth R, et al. Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis. Acta Anaesthesiol Scand 2012;56:810-16
  • Hoffman BB, Taylor P. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems. In: Hardman JG, Limbird LE, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. McGraw-Hill; Nashville: 2001. p. 115-53
  • Rome LH, Lands WE. Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc Natl Acad Sci USA 1975;72:4863-5
  • Rowlinson SW, Kiefer JR, Prusakiewicz JJ, et al. A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem 2003;278:45763-9
  • Jett MF, Ramesha CS, Brown CD, et al. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther 1999;288:1288-97
  • Gillis JC, Brogden RN. Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. Drugs 1997;53:139-88
  • Keates RH, McGowan KA. Clinical trial of flurbiprofen to maintain pupillary dilation during cataract surgery. Ann Ophthalmol 1984;16:919-21
  • Flach AJ, Lavelle CJ, Olander KW, et al. The effect of ketorolac tromethamine solution 0.5% in reducing postoperative inflammation after cataract extraction and intraocular lens implantation. Ophthalmology 1988;95:1279-84
  • Heier J, Cheetham JK, Degryse R, et al. Ketorolac tromethamine 0.5% ophthalmic solution in the treatment of moderate to severe ocular inflammation after cataract surgery: a randomized, vehicle-controlled clinical trial. Am J Ophthalmol 1999;127:253-9
  • Flach AJ, Dolan BJ, Irvine AR. Effectiveness of ketorolac tromethamine 0.5% ophthalmic solution for chronic aphakic and pseudophakic cystoid macular edema. Am J Ophthalmol 1987;103:479-86
  • Flach AJ, Jampol LM, Weinberg D, et al. Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine. Am J Ophthalmol 1991;112:514-19
  • Kim SJ, Adams NA, Toma HS, et al. Safety of intravitreal ketorolac and diclofenac: an electroretinographic and histopathologic study. Retina 2008;28:595-605
  • ACULAR LS (ketorolac tromethamine ophthalmic solution) 0.4% [package insert]. Allergan Inc; Irvine, CA: Revised November 2012
  • ACUVAIL (ketorolac tromethamine ophthalmic solution) 0.45% [package insert]. Allergan, Inc; Irvine, CA: Revised November 2012
  • Crandall A, Dunn S, Whitaker JD, et al. OMS302 maintains mydriasis and decreases postoperative pain in cataract surgery. Poster presented at: american Academy of Ophthalmology Annual Meeting; October 22-25 2011. Orlando, FL
  • Lindstrom RL, Loden JC, Walters TR, et al. Intracameral phenylephrine and ketorolac injection (OMS302) for maintenance of intraoperative pupil diameter and reduction of postoperative pain in intraocular lens replacement with phacoemulsification. Clin Ophthalmol 2014;8:1735-44
  • Rosenblatt M, Whitaker S, Ng E, et al. A phase 3 clinical trial of the drug product OMS302 delivered intracamerally in BSS during intraocular lens replacement (ILR) surgery. Poster presented at: American Academy of Ophthalmology Annual Meeting; November 10-13 2012. Chicago, IL
  • Whitaker S, Ng E, Demopulous G, Crandall A. Two phase 3 trials of OMS302 in irrigation solution for maintenance of mydriasis in intraocular lens replacement. Poster presented at: American Academy of Ophthalmology Annual Meeting; November 16-17 2013. New Orleans, LA
  • Lundstrom M, Stenevi U, Thorburn W. The Swedish National Cataract Register: a 9-year review. Acta Ophthalmol Scand 2002;80:248-57
  • Arshinoff SA. Ophthalmic viscosurgical devices. In: Kohnen T, Koch DD, editors. Essentials in Ophthalmology: Cataract and Refractive Surgery. Berlin Heidelberg, Springer, Germany; 2005. p. 37-62
  • Erie JC, Baratz KH, Hodge DO, et al. Incidence of cataract surgery from 1980 through 2004: 25-year population-based study. J Cataract Refract Surg 2007;33:1273-7
  • Emery J, Steinert RF. Extracapsular Cataract Surgery: Indications and Techniques. In: Steinert RF, editor. Cataract Surgery. 3rd edition. Saunders Elsevier; Irvine: 2010. p. 113-24
  • Ascaso FJ, Huerva V. The History of Cataract Surgery. Cataract. Surgery. 2013. p. 75-90
  • Hovanesian JA, Mitchell JA, Gayton JL. Systemic pharmacokinetics (PK) of OMS302 (phenylephrine and ketorolac injection) used in irrigation solution during intraocular lens replacement procedures. Poster presented at American Academy of Ophthalmology Annual Meeting; October 18-21 2014. Chicago, IL
  • Conrad-Hengerer I, Hengerer FH, Schultz T, Dick HB. Femtosecond laser-assisted cataract surgery in eyes with a small pupil. J Cataract Refract Surg 2013;39:1314-20
  • Fry L. Pupil stretching. Video J Cataract Refract Surg 1995;XI:1
  • Osher R. Peripupillary membranectomy. Video J Cataract Refract Surg 1991;VII:3
  • Graether JM. Graether pupil expander for managing the small pupil during surgery. J Cataract Refract Surg 1996;22:530-5
  • Kershner RM. Management of the small pupil for clear corneal cataract surgery. J Cataract Refract Surg 2002;28:1826-31
  • Wilczynski M, Wierzchowski T, Synder A, Omulecki W. Results of phacoemulsification with Malyugin Ring in comparison with manual iris stretching with hooks in eyes with narrow pupil. Eur J Ophthalmol 2013;23:196-201
  • Bhattacharjee S. Pupil-expansion ring implantation through a 0.9 mm incision. J Cataract Refract Surg 2014;40:1061-7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.