Cure or cause: opposing roles for zinc in age-related macular degeneration

References

• Bird AC. The Bowman lecture. Towards an understanding of age-related macular disease. Eye17(4), 457–466 (2003).
   PubMed Web of Science ®Google Scholar
• Evans J. Causes of blindness and partial sight in England and Wales. In: Studies on Medical and Population Subjects. HMsS (Ed.). London, UK1990–1991 (1995).
   Google Scholar
• Leibowitz HM, Krueger DE, Maunder LR et al. The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973–1975. Surv. Ophthalmol.24(Suppl.), 335–610 (1980).
   PubMedGoogle Scholar
• Ross RJ, Verma V, Rosenberg KI, Chan CC, Tuo J. Genetic markers and biomarkers for age-related macular degeneration. Expert Rev. Ophthalmol.2(3), 443–457 (2007).
   PubMedGoogle Scholar
• Lengyel I, Tufail A, Hosaini HA, Luthert P, Bird AC, Jeffery G. Association of drusen deposition with choroidal intercapillary pillars in the aging human eye. Invest. Ophthalmol. Vis. Sci.45(9), 2886–2892 (2004).
   PubMed Web of Science ®Google Scholar
• Donati G. Emerging therapies for neovascular age-related macular degeneration: state of the art. Ophthalmologica221(6), 366–377 (2007).
   PubMed Web of Science ®Google Scholar
• DiSilvestro RA. Zinc in relation to diabetes and oxidative disease. J. Nutr.130(5S Suppl.), 1509–1511S (2000).
   PubMed Web of Science ®Google Scholar
• Evans JR, Henshaw K. Antioxidant vitamin and mineral supplementation for preventing age-related macular degeneration. Cochrane Database Syst. Rev.2, CD000253 (2000).
   Google Scholar
• Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ335(7623), 755 (2007).
   PubMed Web of Science ®Google Scholar
• Evans JR. Antioxidant vitamin and mineral supplements for age-related macular degeneration. Cochrane Database Syst. Rev.2, CD000254 (2002).
   PubMedGoogle Scholar
• van Leeuwen R, Boekhoorn S, Vingerling JR et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA294(24), 3101–3107 (2005).
   PubMed Web of Science ®Google Scholar
• Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins c and e, β carotene, and zinc for age-related macular degeneration and vision loss: AREDS Report No. 8. Arch. Ophthalmol.119(10), 1417–1436 (2001).
   PubMedGoogle Scholar
• Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J. Trace Elem. Med. Biol.20(1), 3–18 (2006).
   PubMed Web of Science ®Google Scholar
• Johnson AR, Munoz A, Gottlieb JL, Jarrard DF. High dose zinc increases hospital admissions due to genitourinary complications. J. Urol.177(2), 639–643 (2007).
   PubMed Web of Science ®Google Scholar
• Hyun HJ, Sohn JH, Ha DW, Ahn YH, Koh JY, Yoon YH. Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci.42(2), 460–465 (2001).
   PubMed Web of Science ®Google Scholar
• Song J, Lee SC, Kim SS et al. Zn2+-induced cell death is mediated by the induction of intracellular ROS in ARPE-19 cells. Curr. Eye Res.28(3), 195–201 (2004).
   PubMed Web of Science ®Google Scholar
• Newsome DA, Miceli MV, Tate DJ, Alcock NW, Oliver PD. Zinc content of human retinal pigment epithelium decreases with age and macular degeneration, but superoxide dismutase activity increases. The Journal of Trace Elements in Experimental Medicine,8(4), 193–199 (1996).
   Google Scholar
• Miceli MV, Tate DJ Jr, Alcock NW, Newsome DA. Zinc deficiency and oxidative stress in the retina of pigmented rats. Invest. Ophthalmol. Vis. Sci.40(6), 1238–1244 (1999).
   PubMed Web of Science ®Google Scholar
• Kennedy CJ, Rakoczy PE, Robertson TA, Papadimitriou JM, Constable IJ. Kinetic studies on phagocytosis and lysosomal digestion of rod outer segments by human retinal pigment epithelial cells in vitro. Exp. Cell Res.210(2), 209–214 (1994).
   PubMed Web of Science ®Google Scholar
• Schraermeyer U, Peters S, Thumann G, Kociok N, Heimann K. Melanin granules of retinal pigment epithelium are connected with the lysosomal degradation pathway. Exp. Eye Res.68(2), 237–245 (1999).
   PubMed Web of Science ®Google Scholar
• Ames BN. Micronutrient deficiencies. A major cause of DNA damage. Ann. NY Acad. Sci.889, 87–106 (1999).
   PubMed Web of Science ®Google Scholar
• Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE–Bruch’s membrane interface in aging and age-related macular degeneration. Prog. Retin. Eye Res.20(6), 705–732 (2001).
   PubMed Web of Science ®Google Scholar
• Rink L, Gabriel P. Zinc and the immune system. Proc. Nutr. Soc.59, 541–552 (2000).
   PubMed Web of Science ®Google Scholar
• Clemons TE, Kurinij N, Sperduto RD. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. Arch. Ophthalmol.122(5), 716–726 (2004).
   PubMed Web of Science ®Google Scholar
• Lengyel I, Flinn JM, Peto T et al. High concentration of zinc in sub-retinal pigment epithelial deposits. Exp. Eye Res.84(4), 772–780 (2007).
   PubMed Web of Science ®Google Scholar
• Magnusson KP, Duan S, Sigurdsson H et al. CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med.3(1), e5 (2005).
   Google Scholar
• Hageman GS, Anderson DH, Johnson LV et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc. Natl. Acad. Sci. USA102(20), 7227–7232 (2005).
   PubMed Web of Science ®Google Scholar
• Klein RJ, Zeiss C, Chew EY et al. Complement factor H polymorphism in age-related macular degeneration. Science308(5720), 385–389 (2005).
   PubMed Web of Science ®Google Scholar
• Haines JL, Hauser MA, Schmidt S et al. Complement factor H variant increases the risk of age-related macular degeneration. Science308(5720), 419–421 (2005).
   PubMed Web of Science ®Google Scholar
• Edwards AO, Ritter R 3rd, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and age-related macular degeneration. Science308(5720), 421–424 (2005).
   PubMed Web of Science ®Google Scholar
• Crossley LG, Porter RR. Purification of the human complement control protein C3b inactivator. Biochem. J.191(1), 173–182 (1980).
   PubMedGoogle Scholar
• Perkins SJ, Nealis AS, Sim RB. Oligomeric domain structure of human complement factor H by X-ray and neutron solution scattering. Biochemistry30(11), 2847–2857 (1991).
   PubMedGoogle Scholar
• Saunders RE, Goodship TH, Zipfel PF, Perkins SJ. An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations. Hum. Mutat.27(1), 21–30 (2006).
   PubMed Web of Science ®Google Scholar
• Turnberg D, Botto M. The regulation of the complement system: insights from genetically-engineered mice. Mol. Immunol.40(2–4), 145–153 (2003).
   PubMedGoogle Scholar
• Frederickson CJ, Koh JY, Bush AI. The neurobiology of zinc in health and disease. Nat. Rev. Neurosci.6(6), 449–462 (2005).
   PubMed Web of Science ®Google Scholar
• Suh SW, Jensen KB, Jensen MS et al. Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer’s diseased brains. Brain Res.852(2), 274–278 (2000).
   PubMed Web of Science ®Google Scholar
• Bush AI. Metal complexing agents as therapies for Alzheimer’s disease. Neurobiol. Aging23(6), 1031–1038 (2002).
   PubMed Web of Science ®Google Scholar
• Ugarte M, Osborne NN. Zinc in the retina. Prog. Neurobiol.64(3), 219–249 (2001).
   PubMed Web of Science ®Google Scholar