Inherited predisposition to chronic lymphocytic leukemia

References

• Caporaso N, Marti GE, Goldin L. Perspectives on familial chronic lymphocytic leukemia: genes and the environment. Semin. Hematol.41(3), 201–206 (2004).
   PubMed Web of Science ®Google Scholar
• Sellick GS, Catovsky D, Houlston RS. Familial chronic lymphocytic leukemia. Semin. Oncol.33(2), 195–201 (2006).
   PubMed Web of Science ®Google Scholar
• Jonsson V, Houlston RS, Catovsky D et al. CLL family ‘Pedigree 14’ revisited: 1947–2004. Leukemia19(6), 1025–1028 (2005).
   PubMedGoogle Scholar
• Mauro FR, Giammartini E, Gentile M et al. Clinical features and outcome of familial chronic lymphocytic leukemia. Haematologica91(8), 1117–1120 (2006).
   PubMedGoogle Scholar
• Capalbo S, Trerotoli P, Ciancio A et al. Increased risk of lymphoproliferative disorders in relatives of patients with B-cell chronic lymphocytic leukemia: relevance of the degree of familial linkage. Eur. J. Haematol.65(2), 114–117 (2000).
   PubMedGoogle Scholar
• Yuille MR, Houlston RS, Catovsky D. Anticipation in familial chronic lymphocytic leukaemia. Leukemia12, 1696–1698 (1998).
   PubMed Web of Science ®Google Scholar
• Pang JWY, Cook LS, Schwartz SM, Weiss NS. Incidence of leukemia in Asian migrants to the United States and their descendants. Cancer Causes Cont.13, 791–795 (2002).
   PubMed Web of Science ®Google Scholar
• Kerber RA, O’Brien E. A cohort study of cancer risk in relation to family histories of cancer in the Utah population database. Cancer103(9), 1906–1915 (2005).
   PubMed Web of Science ®Google Scholar
• Goldin LR, Pfeiffer RM, Li X, Hemminki K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database. Blood104(6), 1850–1854 (2004).
   PubMed Web of Science ®Google Scholar
• Dores G, Anderson W, Curtis R et al. Chronic lymphocytic leukemia and small lymphocytic lymphoma: overview of the descriptive epidemiology. Br. J. Haematol.139, 809–819 (2007).
   PubMed Web of Science ®Google Scholar
• Turesson I, Linet M, Bjorkholm M et al. Ascertainment and diagnostic accuracy for hematopoietic lymphoproliferative malignancies in Sweden 1964–2003. Int. J. Cancer121, 2260–2266 (2007).
   PubMed Web of Science ®Google Scholar
• Zent CS, Kyasa MJ, Evans R, Schichman SA. Chronic lymphocytic leukemia incidence is substantially higher than estimated from tumor registry data. Cancer92(5), 1325–1330 (2001).
   PubMed Web of Science ®Google Scholar
• Chang ET, Smedby KE, Hjalgrim H et al. Family history of hematopoietic malignancy and risk of lymphoma. J. Natl Cancer Inst.97(19), 1466–1474 (2005).
   PubMed Web of Science ®Google Scholar
• Pottern LM, Linet MS, Blair A et al. Familial cancers associated with subtypes of leukemia and non-Hodgkin’s lymphoma. Leukemia Res.15(5), 305–314 (1991).
   PubMed Web of Science ®Google Scholar
• Ishibe N, Sgambati MT, Fontaine L et al. Clinical characteristics of familial B CLL in the National Cancer Institute Familial Registry. Leuk. Lymphoma42(1–2), 99–108 (2001).
   PubMed Web of Science ®Google Scholar
• Landgren O, Pfeiffer RM, Stewart L et al. Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. Intl J. Cancer120, 1099–1102 (2006).
   Google Scholar
• Di Prospero NA, Fischbeck KH. Therapeutics development for triplet repeat expansion diseases. Nat. Rev. Genet.6(10), 756–765 (2005).
   PubMed Web of Science ®Google Scholar
• Goldin LR, Sgambati M, Marti GE et al. Anticipation in familial chronic lymphocytic leukemia. Am. J. Hum. Genet.65, 265–269 (1999).
   PubMed Web of Science ®Google Scholar
• Horwitz M, Goode EL, Jarvik GP. Anticipation in familial leukemia. Am. J. Hum. Genet.59(5), 990–998 (1996).
   PubMed Web of Science ®Google Scholar
• Daugherty SE, Pfeiffer RM, Mellemkjaer L, Hemminki K, Goldin LR. No evidence for anticipation in lymphoproliferative tumors in population-based samples. Cancer Epidemiol. Biomarkers Prev.14(5), 1245–1250 (2005).
   PubMed Web of Science ®Google Scholar
• Benzow KA, Koob MD, Condie A et al. Instability of CAG-trinucleotide repeats in chronic lymphocytic leukemia. Leuk. Lymphoma43(10), 1987–1990 (2002).
   PubMed Web of Science ®Google Scholar
• Crowther D, Wild R, Sellick G et al. Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL. Blood111(12), 5691–5693 (2008).
   PubMedGoogle Scholar
• Sellick GS, Allinson R, Matutes E, Catovsky D, Houlston RS. Increased sex concordance of sibling pairs with chronic lymphocytic leukemia. Leukemia18(6), 1162–1163 (2004).
   PubMedGoogle Scholar
• Pritsch O, Troussard X, Magnac C et al. VH gene usage by family members affected with chronic lymphocytic leukaemia. Br. J. Haematol.107(3), 616–624 (1999).
   PubMed Web of Science ®Google Scholar
• Rassenti LZ, Toy TL, Huynh L et al. High similarity between familial and sporadic cases of chronic lymphocytic leukemia. Blood102, 670a (2003).
   Google Scholar
• Sakai A, Marti GE, Caporaso N et al. Analysis of expressed immunoglobulin heavy chain genes in familial B-CLL. Blood95(4), 1413–1419 (2000).
   PubMed Web of Science ®Google Scholar
• Ishibe N, Prieto D, Hosack DA et al. Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia. Leuk. Res.26(9), 791–794 (2002).
   PubMedGoogle Scholar
• Ng D, Toure O, Wei MH et al. Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia. Blood109(3), 916–925 (2007).
   PubMed Web of Science ®Google Scholar
• Goldin LR, Caporaso NE. Family studies in chronic lymphocytic leukemia and other lymphoproliferative tumors. Br. J. Haematol.139, 774–779 (2007).
   PubMed Web of Science ®Google Scholar
• Molica S, Digiesi G, Mauro F et al. Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia. Leuk. Res. DOI: 10.1016/j.leukres.2008.05.004 (2008) (Epub ahead of print).
   PubMedGoogle Scholar
• Novak AJ, Grote DM, Ziesmer SC et al. Elevated serum B-lymphocyte stimulator levels in patients with familial lymphoproliferative disorders. J. Clin. Oncol.24(6), 983–987 (2006).
   PubMed Web of Science ®Google Scholar
• Ishibe N, Albitar M, Jilani IB et al. CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia but CD38 expression is not. Blood100(1), 1100–1101 (2002).
   PubMedGoogle Scholar
• Marti GE, Abbasi F, Raveche E et al. Overview of monoclonal B-cell lymphocytosis. Br. J. Haematol.139, 701–708 (2007).
   PubMed Web of Science ®Google Scholar
• Marti GE, Carter P, Abbasi F et al. B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia. Cytometry B Clin. Cytom.52(1), 1–12 (2003).
   PubMed Web of Science ®Google Scholar
• Vogt RF, Shim YK, Middleton DC et al. Monoclonal B-cell lymphocytosis as a biomarker in environmental health studies. Br. J. Haematol.139(5), 690–700 (2007).
   PubMed Web of Science ®Google Scholar
• Shim YK, Vogt RF, Middleton D et al. Prevalence and natural history of monoclonal and polyclonal B-cell lymphocytosis in a residential adult population. Cytometry B Clin. Cytom.72(5), 344–353 (2007).
   PubMed Web of Science ®Google Scholar
• Ghia P, Prato G, Scielzo C et al. Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood103(6), 2337–2342 (2004).
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Green MJ, Kuzmicki A et al. Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood100(2), 635–639 (2002).
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Yuille MR, Fuller J et al. Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood100(7), 2289–2290 (2002).
   PubMed Web of Science ®Google Scholar
• de Tute R, Yuille M, Catovsky D et al. Monoclonal B-cell lymphocytosis (MBL) in CLL families: substantial increase in relative risk for young adults. Leukemia20(4), 728–729 (2006).
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Bennett FL, O’Connor SJ et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N. Engl. J. Med.359(6), 575–583 (2008).
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Bennett F, Hillmen P. The biological and clinical relationship between CD5+23+ monoclonal B cell lymphocytosis and chronic lymphocytic leukemia. Br. J. Haematol.139, 724–729 (2007).
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Fenton JAL, Plummer M et al. Monoclonal B cell lymphocytosis (MBL) and CLL show intraclonal variation: cases classified as “unmutated” have the greatest clonal diversity. Blood108(11), 13a (2006).
   Google Scholar
• Bennett FL, Fenton JAL, O’Connor SJM, Hillmen P, Rawstron AC. Disease progression in monoclonal B-cell lymphocytosis is independent of VH mutation status. Blood108(11), 13a (2006).
   Google Scholar
• Faguet GB, Agee JF, Marti GE. Clone emergence and evolution in chronic lymphocytic leukemia: characterization of clinical, laboratory, and immunophenotypic profiles of 25 patients. Leuk. Lymphoma6, 345–356 (1992).
   Web of Science ®Google Scholar
• Cheson BD, Bennett JM, Grever M et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood87(12), 4990–4997 (1996).
   PubMed Web of Science ®Google Scholar
• Hallek M, Cheson BD, Catovsky D et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines. Blood111(12), 5446–5456 (2008).
   PubMed Web of Science ®Google Scholar
• Fung SS, Hillier KL, Leger CS et al. Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis. Leuk. Lymphoma48(6), 1087–1091 (2007).
   PubMed Web of Science ®Google Scholar
• Marti GE, Rawstron AC, Ghia P et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br. J. Haematol.130, 325–332 (2005).
   PubMed Web of Science ®Google Scholar
• Goldin LR, Ishibe N, Sgambati M et al. A genome scan of 18 families with chronic lymphocytic leukaemia. Br. J. Haematol.121(6), 866–873 (2003).
   PubMed Web of Science ®Google Scholar
• Ng D, Marti GE, Fontaine L et al. High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia. Br. J. Haematol.133(1), 59–61 (2006).
   PubMed Web of Science ®Google Scholar
• Sellick GS, Webb EL, Allinson R et al. A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. Am. J. Hum. Genet.77(3), 420–429 (2005).
   PubMed Web of Science ®Google Scholar
• Sellick GS, Goldin LR, Wild RW et al. A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. Blood110(9), 3326–3333 (2007).
   PubMed Web of Science ®Google Scholar
• Theodorou I, Abel L, Mauro F et al. High occurence of DRB1 11 in chronic lymphocytic leukaemia families. Br. J. Haematol.119(3), 713–715 (2002).
   PubMedGoogle Scholar
• Machulla HKG, Mueller LP, Schaaf A et al. Association of chronic lymphocytic leukemia with specific alleles of the HLA-DR4:DR53:DQ8 haplotype in German patients. Int. J. Cancer92, 203–207 (2001).
   PubMed Web of Science ®Google Scholar
• Plass C, Byrd JC, Raval A, Tanner SM, de la Chapelle A. Molecular profiling of chronic lymphocytic leukemia: genetics meets epigenetics to identify predisposing genes. Br. J. Haematol.139, 744–752 (2007).
   PubMed Web of Science ®Google Scholar
• Raval A, Tanner SM, Byrd JC et al. Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell129(5), 879–890 (2007).
   PubMed Web of Science ®Google Scholar
• Swift M, Reitnauer PJ, Morrell D, Chase CL. Breast and other cancers in families with ataxia-telangiectasia. N. Engl. J. Med.316(21), 1289–1294 (1987).
   PubMed Web of Science ®Google Scholar
• Dohner H, Stilgenbauer S, Benner A et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N. Engl. J. Med.343(26), 1910–1916 (2000).
   PubMed Web of Science ®Google Scholar
• Austen B, Skowronska A, Baker C et al. Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J. Clin. Oncol.25(34), 5448–5457 (2007).
   PubMed Web of Science ®Google Scholar
• Bevan S, Catovsky D, Marossy A et al. Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia. Leukemia13(10), 1497–1500 (1999).
   PubMed Web of Science ®Google Scholar
• Ishibe N, Goldin LR, Caporaso NE et al. ATM mutations and protein expression are not associated with familial B-CLL cases. Leuk. Res.27(10), 973–975 (2003).
   PubMed Web of Science ®Google Scholar
• Yuille MR, Condie A, Hudson CD et al. ATM mutations are rare in familial chronic lymphocytic leukemia. Blood100(2), 603–609 (2002).
   PubMed Web of Science ®Google Scholar
• Bevan S, Catovsky D, Matutes E et al. Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia. Blood96(12), 3982–3984 (2000).
   PubMed Web of Science ®Google Scholar
• Moshynska O, Sankaran K, Pahwa P, Saxena A. Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. J. Natl Cancer Inst.96(9), 673–682 (2004).
   PubMed Web of Science ®Google Scholar
• Dicker F, Rauhut S, Kohlmann A et al. Re: prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. J. Natl Cancer Inst.97(14), 1092–1093; author reply 1093–1095 (2005).
   PubMedGoogle Scholar
• Freeman SN, Bepler G, Haura E, Sutphen R, Cress WD. Re: prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. J. Natl Cancer Inst.97(14), 1088–1089; author reply 1093–1095 (2005).
   PubMedGoogle Scholar
• Vargas RL, Felgar RE, Rothberg PG. Re: prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. J. Natl Cancer Inst.97(14), 1089–1090; author reply 1093–1095 (2005).
   PubMedGoogle Scholar
• Iglesias-Serret D, Coll-Mulet L, Santidrian AF et al. Re: prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. J. Natl Cancer Inst.97(14), 1090–1091; author reply 1093–1095 (2005).
   PubMedGoogle Scholar
• Nenning UC, Eckert C, Wellmann S et al. Re: prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. J. Natl Cancer Inst.97(14), 1091–1092; author reply 1093–1095 (2005).
   PubMedGoogle Scholar
• Wiley JS, Dao-Ung LP, Gu BJ et al. A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. Lancet359(9312), 1114–1119 (2002).
   PubMed Web of Science ®Google Scholar
• Sellick GS, Rudd M, Eve P et al. The P2X7 receptor gene A1513C polymorphism does not contribute to risk of familial or sporadic chronic lymphocytic leukemia. Cancer Epidemiol. Biomarkers Prev.13(6), 1065–1067 (2004).
   PubMed Web of Science ®Google Scholar
• Rothman N, Skibola CF, Wang SS et al. Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncol.7(1), 27–38 (2006).
   PubMed Web of Science ®Google Scholar
• Demeter J, Porzsolt F, Ramisch S et al. Polymorphism of the tumor necrosis factor-α and lymphotoxin-α genes in chronic lymphocytic leukemia. Br. J. Haematol.97, 107–112 (1997).
   PubMed Web of Science ®Google Scholar
• Bogunia-Kubik K, Mazur G, Urbanowicz I et al. Lack of association between the TNF-α promoter gene polymorphism and susceptibility to B-cell chronic lymphocytic leukemia. Int. J. Immunogenet.33, 21–24 (2006).
   PubMed Web of Science ®Google Scholar
• Yuille M, Condie A, Hudson C et al. Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. Blood99(11), 4216–4218 (2002).
   PubMed Web of Science ®Google Scholar
• Wolf S, Mertens D, Pscherer A et al. Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. Int. J. Cancer118(7), 1831–1835 (2006).
   PubMed Web of Science ®Google Scholar
• Rudd MF, Sellick GS, Webb EL, Catovsky D, Houlston RS. Variants in the ATM–BRCA2–CHEK2 axis predispose to chronic lymphocytic leukemia. Blood108(2), 638–644 (2006).
   PubMed Web of Science ®Google Scholar
• Slager SL, Kay NE, Fredericksen ZS et al. Susceptibility genes and B-chronic lymphocytic leukaemia. Br. J. Haematol.139, 762–771 (2007).
   PubMed Web of Science ®Google Scholar
• Calin GA, Dumitru CD, Shimizu M et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA99(24), 15524–15529 (2002).
   PubMed Web of Science ®Google Scholar
• Cimmino A, Calin GA, Fabbri M et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl Acad. Sci. USA102(39), 13944–13949 (2005).
   PubMed Web of Science ®Google Scholar
• Calin GA, Ferracin M, Cimmino A et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N. Engl. J. Med.353(17), 1793–1801 (2005).
   PubMed Web of Science ®Google Scholar
• Dalla-Favera R, Siegel R, Lia M, Klein U. New insights into the pathogenesis of CLL by in vitro and in vivo models. Leuk. Lymph48(Suppl. 1), S7 (2007).
   PubMedGoogle Scholar
• Migliazza A, Bosch F, Komatsu H et al. Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood97(7), 2098–2104 (2001).
   PubMed Web of Science ®Google Scholar
• Tyybakinoja A, Vilpo J, Knuutila S. High-resolution oligonucleotide array-CGH pinpoints genes involved in cryptic losses in chronic lymphocytic leukemia. Cytogenet. Genome Res.118(1), 8–12 (2007).
   PubMed Web of Science ®Google Scholar
• Calin GA, Trapasso F, Shimizu M et al. Familial cancer associated with a polymorphism in ARLTS1. N. Engl. J. Med.352(16), 1667–1676 (2005).
   PubMed Web of Science ®Google Scholar
• Sellick GS, Catovsky D, Houlston RS. Relationship between ARLTS1 polymorphisms and risk of chronic lymphocytic leukemia. Leuk. Res.30(12), 1573–1576 (2006).
   PubMedGoogle Scholar
• Ng D, Toure O, Fontaine L et al. No association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukemia. Br. J. Haematol.137, 170–175 (2007).
   PubMedGoogle Scholar
• Summersgill B, Thornton P, Atkinson S et al. Chromosomal imbalances in familial chronic lymphocytic leukaemia: a comparative genomic hybridisation analysis. Leukemia16(7), 1229–1232 (2002).
   PubMed Web of Science ®Google Scholar
• Sellick GS, Coleman RJ, Talaban RV et al. Germline mutations in Dok1 do not predispose to chronic lymphocytic leukemia. Leuk. Res.29(1), 59–61 (2005).
   PubMedGoogle Scholar
• Pfeifer D, Pantic M, Skatulla I et al. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood109(3), 1202–1210 (2007).
   PubMed Web of Science ®Google Scholar
• Scaglione BJ, Salerno E, Balan M et al. Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br. J. Haematol.139(5), 645–657 (2007).
   PubMed Web of Science ®Google Scholar
• Phillips JA, Mehta K, Fernandez C, Raveche ES. The NZB mouse as a model for chronic lymphocytic leukemia. Cancer Res.52(2), 437–443 (1992).
   PubMed Web of Science ®Google Scholar
• Raveche ES, Salerno E, Scaglione BJ et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood109(12), 5079–5086 (2007).
   PubMed Web of Science ®Google Scholar
• Wither JE, Loh C, Lajoie G et al. Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval. J. Immunol.175(7), 4309–4319 (2005).
   PubMedGoogle Scholar
• Virgilio L, Narducci MG, Isobe M et al. Identification of the TCL1 gene involved in T-cell malignancies. Proc. Natl Acad. Sci. USA91(26), 12530–12534 (1994).
   PubMed Web of Science ®Google Scholar
• Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell6(2), 395–407 (2000).
   PubMed Web of Science ®Google Scholar
• Pekarsky Y, Koval A, Hallas C et al. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc. Natl Acad. Sci. USA97(7), 3028–3033 (2000).
   PubMed Web of Science ®Google Scholar
• Herling M, Patel KA, Khalili J et al.TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia20(2), 280–285 (2006).
   PubMed Web of Science ®Google Scholar
• Bichi R, Shinton SA, Martin ES et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc. Natl Acad. Sci. USA99(10), 6955–6960 (2002).
   PubMed Web of Science ®Google Scholar
• Johnson AJ, Lucas DM, Muthusamy N et al. Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Blood108(4), 1334–1338 (2006).
   PubMed Web of Science ®Google Scholar
• Katsumata M, Siegel RM, Louie DC et al. Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc. Natl Acad. Sci. USA89(23), 11376–11380 (1992).
   PubMed Web of Science ®Google Scholar
• Lee SY, Reichlin A, Santana A et al. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity7(5), 703–713 (1997).
   PubMed Web of Science ®Google Scholar
• Zapata JM, Krajewska M, Morse HC 3rd, Choi Y, Reed JC. TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. Proc. Natl Acad. Sci. USA101(47), 16600–16605 (2004).
   PubMedGoogle Scholar
• Planelles L, Carvalho-Pinto CE, Hardenberg G et al. APRIL promotes B-1 cell-associated neoplasm. Cancer Cell6(4), 399–408 (2004).
   PubMed Web of Science ®Google Scholar
• Rush LJ, Raval A, Funchain P et al. Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets. Cancer Res.64(7), 2424–2433 (2004).
   PubMed Web of Science ®Google Scholar
• Barrett JC, Cardon LR. Evaluating coverage of genome-wide association studies. Nat. Genet.38(6), 659–662 (2006).
   PubMed Web of Science ®Google Scholar
• Broderick P, Carvajal-Carmona L, Pittman AM et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat. Genet.39(11), 1315–1317 (2007).
   PubMed Web of Science ®Google Scholar
• Tenesa A, Farrington SM, Prendergast JG et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat. Genet.40(5), 631–637 (2008).
   PubMed Web of Science ®Google Scholar
• Tomlinson I, Webb E, Carvajal-Carmona L et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat. Genet.39(8), 984–988 (2007).
   PubMed Web of Science ®Google Scholar
• Tomlinson IP, Webb E, Carvajal-Carmona L et al. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat. Genet.40(5), 623–630 (2008).
   PubMed Web of Science ®Google Scholar
• Easton DF, Pooley KA, Dunning AM et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature447(7148), 1087–1093 (2007).
   PubMed Web of Science ®Google Scholar
• Gudmundsson J, Sulem P, Steinthorsdottir V et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat. Genet.39(8), 977–983 (2007).
   PubMed Web of Science ®Google Scholar
• Gudmundsson J, Sulem P, Manolescu A et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat. Genet.39(5), 631–637 (2007).
   PubMed Web of Science ®Google Scholar
• Gudmundsson J, Sulem P, Rafnar T et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat. Genet.40(3), 281–283 (2008).
   PubMed Web of Science ®Google Scholar
• Yeager M, Orr N, Hayes RB et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat. Genet.39(5), 645–649 (2007).
   PubMed Web of Science ®Google Scholar
• Amos CI, Wu X, Broderick P et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat. Genet.40(5), 616–622 (2008).
   PubMed Web of Science ®Google Scholar