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Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

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References

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  • Ibrutinib and rituximab compared with fludarabine phosphate, cyclophosphamide, and rituximab in treating patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT02048813
  • Fludarabine/rituximab combined with escalating doses of lenalidomide in untreated CLL. Available from: https://clinicaltrials.gov/ct2/show/NCT01703364
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  • Vorinostat, fludarabine phosphate, cyclophosphamide, and rituximab in treating patients with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT00918723
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  • BR in patients with CLL with comorbidities and/or renal dysfunction. Available from: https://clinicaltrials.gov/ct2/show/NCT01832922
  • A Phase 1b study evaluating the safety and tolerability of ABT-199 in combination with rituximab in subjects with relapsed chronic lymphocytic leukemia and small lymphocytic lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT01682616
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  • Rituximab in Pretreated Elderly or Unfit B-CLL Patients. Available from: https://clinicaltrials.gov/ct2/show/NCT01576588
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  • A Phase II Study of Ibrutinib Plus FCR in Previously Untreated, Younger Patients With Chronic Lymphocytic Leukemia (iFCR). Available from: https://clinicaltrials.gov/ct2/show/NCT02251548
  • Combination of Lenalidomide and Rituximab in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL-SLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01446133
  • Phase 2 Study of the Combination of Bruton’s Tyrosine Kinase Inhibitor PCI-32765 and Rituximab in High-Risk Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Patients. Available from: https://clinicaltrials.gov/ct2/show/NCT01520519
  • CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b). Available from: https://clinicaltrials.gov/ct2/show/NCT01998880
  • Efficacy and Safety of Idelalisib in Combination With Bendamustine and Rituximab in Subjects With Previously Untreated Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01980888
  • Vorinostat, Cladribine, and Rituximab in Treating Patients With Mantle Cell Lymphoma, Relapsed Chronic Lymphocytic Leukemia, or Relapsed B Cell Non-Hodgkin’s Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT00764517
  • A Study of GDC-0199 (ABT-199) Plus MabThera/Rituxan (Rituximab) Compared With Bendamustine Plus MabThera/Rituxan (Rituximab) in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT02005471
  • Study of IPI-145 in Combination With Rituximab or Bendamustine/Rituximab in Hematologic Malignancies. Available from: https://clinicaltrials.gov/ct2/show/NCT01871675
  • Pentostatin, Cyclophosphamide, and Rituximab With or Without Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT00816595
  • Rituximab, Pentostatin, Cyclophosphamide, and Lenalidomide in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT00602836
  • Rituximab Plus Sargramostim (GM-CSF) In Patients With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT00940342
  • Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors. Available from: https://clinicaltrials.gov/ct2/show/NCT01326702
  • CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT02168907
  • Lenalidomide With or Without Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT00096044
  • Rituximab, Alemtuzumab, and GM-CSF As First-Line Therapy in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT00562328
  • Rituximab and Alemtuzumab in Treating Older Patients With Progressive Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01013961
  • Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Low-Grade Follicular Lymphoma, Waldenstrom Macroglobulinemia, or Mantle Cell Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT00711828
  • Safety Study of ABT-263 in Combination With Rituximab in Lymphoid Cancers. Available from: https://clinicaltrials.gov/ct2/show/NCT00788684
  • FCR or BR in Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia (CLL10). Available from: https://clinicaltrials.gov/ct2/show/NCT00769522
  • A Study of MabThera (Rituximab) in Combination With Fludarabine and Cyclophosphamide in Patients With Chronic Lymphocytic Leukemia And Favorable Somatic Status. Available from: https://clinicaltrials.gov/ct2/show/NCT01271010
  • A Study of GDC-0199 (ABT-199) in Combination With Bendamustine And MabThera/Rituxan in Patients With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01671904
  • A Study of MabThera/Rituxan (Rituximab) in Combination With Fludarabine And Cyclophosphamide as Primary Therapy in Elderly Patients With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01263704
  • A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status. Available from: https://clinicaltrials.gov/ct2/show/NCT01283386
  • A Study of MabThera (Rituximab) in First Line Treatment of Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT00545714
  • Chemotherapy, Total-Body Irradiation, Rituximab, and Donor Stem Cell Transplant in Treating Patients With B-Cell Non-Hodgkin’s Lymphoma or Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT00425802
  • Pilot Study of Autologous T Lymphocytes With ADCC in Patients With CD20-Positive B-Cell Malignancies. Available from: https://clinicaltrials.gov/ct2/show/NCT02315118
  • A Study of Idelalisib (GS1101, CAL101) + Ofatumumab in Previously Untreated CLL/SLL. Available from: https://clinicaltrials.gov/ct2/show/NCT02135133
  • Lenalidomide and Ofatumumab in Previously Treated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (CLL/SLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01002755
  • Phase II Ofatumumab/Methylprednisolone Followed by Ofatumumab/Lenalidomide for Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01496976
  • Ofatumumab/Methylprednisolone Followed by Ofatumumab/Lenalidomide for Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01497496
  • Ofatumumab With High Dose Methylprednisone Followed by Ofatumumab and Alemtuzumab in 17p CLL. Available from: https://clinicaltrials.gov/ct2/show/NCT01465334
  • Treatment With Bendamustine, Ofatumumab and MethylPrednisolone in Relapsed B-CLL (BOMP). Available from: https://clinicaltrials.gov/ct2/show/NCT01612988
  • Ofatumumab Induction and Maintenance in Elderly Patients With Poor Risk CLL in the Context of Allogeneic Transplantation. Available from: https://clinicaltrials.gov/ct2/show/NCT01809847
  • A Phase II Study of Ofatumumab-Based Induction Chemoimmunotheraphy Followed by Consolidation Ofatumumab Immunotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT01145209
  • Ofatumumab for High-Risk Chronic Lymphocytic Leukemia (CLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01243190
  • Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT01024010
  • Ofatumumab and Dinaciclib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-Cell Prolymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01515176
  • Ofatumumab for Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT01113632
  • A Trial Looking at Ofatumumab for People With Chronic Lymphocytic Leukaemia Who Cannot Have More Intensive Treatment (RIAltO). Available from: https://clinicaltrials.gov/ct2/show/NCT01678430
  • An Open-Label Phase 2 Study of Ofatumumab (Arzerra) in Combination With Oral GSK2110183 in the Treatment of Relapsed and Refractory Chronic Lymphocytic Leukemia (CLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01532700
  • Alemtuzumab-Ofatumumab in Previously Untreated Symptomatic Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01361711
  • Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT01352312
  • Efficacy and Safety of Idelalisib (GS-1101; CAL-101) in Combination With Ofatumumab for Previously Treated Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01659021
  • Phase II Study of Ofatumumab in Elderly Patients With Chronic Lymphocytic Leukemia (CLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01444716
  • Rapid Infusion of Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01848145
  • Trial of Pentostatin Plus Cyclophosphamide With Ofatumumab (PCO) in Older Patients With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01681563
  • Ofatumumab and Fresh Frozen Plasma in Patients With Chronic Lymphocytic Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT01716208
  • Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapy (PROLONG). Available from: https://clinicaltrials.gov/ct2/show/NCT01039376
  • Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01520922
  • Assessment of Efficacy and Safety of Front-line Fludarabine, Cyclophoshamide and Ofatumumab Chemoimmunotherapy in Young Patients With Chronic Lymphocytic Leukemia. (CLL0911). Available from: https://clinicaltrials.gov/ct2/show/NCT01762202
  • Ofatumumab vs Physician’s Choice in Subjects With Bulky Fludarabine-Refractory Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01313689
  • Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia (COMPLEMENT 1). Available from: https://clinicaltrials.gov/ct2/show/NCT00748189
  • Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT00824265
  • A Study of Obinutuzumab (GA101) in Combination With High-Dose Methylprednisolone (HDMP) in Chronic Lymphocytic Leukemia (CLL) Patients (GA101 & HDMP). Available from: https://clinicaltrials.gov/ct2/show/NCT02229422
  • Bcl-2 Inhibitor GDC-0199 in Combination With Obinutuzumab and Ibrutinib in Treating Patients With Relapsed, Refractory, or Previously Untreated Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT02427451
  • TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL). Available from: https://clinicaltrials.gov/ct2/show/NCT02100852
  • Study of Obinutuzumab + Chlorambucil, ACP-196 + Obinutuzumab, and ACP-196 in Subjects With Previously Untreated CLL. Available from: https://clinicaltrials.gov/ct2/show/NCT02475681
  • A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve CLL or SLL. Available from: https://clinicaltrials.gov/ct2/show/NCT02264574
  • Lenalidomide and Obinutuzumab for Previously Untreated CLL. Available from: https://clinicaltrials.gov/ct2/show/NCT02371590
  • Sequential Regimen of Bendamustine-Debulking Followed by CAL-101 and GA101-Induction and Maintenance in CLL (CLL2-BCG). Available from: https://clinicaltrials.gov/ct2/show/NCT02445131
  • Duvelisib With Obinutuzumab in Patients With CLL/SLL Previously Treated With a BTKi (SYNCHRONY). Available from: https://clinicaltrials.gov/ct2/show/NCT02292225
  • ACP-196 in Combination With Obinutuzumab in Relapsed/Refractory or Untreated CLL/SLL/PLL. Available from: https://clinicaltrials.gov/ct2/show/NCT02296918
  • CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1a). Available from: https://clinicaltrials.gov/ct2/show/NCT01010061
  • Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01980875
  • A Safety Study of Obinutuzumab Alone or in Combination With Chemotherapy in Patients With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01905943
  • An Expanded Access, Open-Label Study of Obinutuzumab (GA101) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01868893
  • A Study Evaluating the Efficacy of Obinutuzumab and Bendamustine Treatment in Patients With Refractory or Relapsed Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT02071225
  • A Study of GA101 (RO5072759) in Combination With Chemotherapy in Patients With Previously Untreated Chronic Lymphocytic Leukemia (GALTON). Available from: https://clinicaltrials.gov/ct2/show/NCT01300247
  • CLLR3: FC + GA101 and B + GA101 in Relapsed or Refractory CLL Followed by GA101 Maintenance for Responding Patients. Available from: https://clinicaltrials.gov/ct2/show/NCT02320383
  • Sequential Regimen of Bendamustine-Debulking Followed by ABT-199 and GA101-Induction and -Maintenance in CLL (CLL2-BAG). Available from: https://clinicaltrials.gov/ct2/show/NCT02401503
  • A Study of Obinutuzumab + Bendamustine in Patients With Previously Untreated Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT02320487
  • Sequential Regimen of Bendamustin [B] Followed by GA101 and Ibrutinib [I] in CLL Patients. Available from: https://clinicaltrials.gov/ct2/show/NCT02345863
  • A Study of GDC-0199 (ABT-199) in Combination With Obinutuzumab in Patients With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01685892
  • A Study Comparing RO5072759 (GA101) 1000 mg Versus 2000 mg in Patients With Previously Untreated Chronic Lymphocytic Leukemia (GAGE). Available from: https://clinicaltrials.gov/ct2/show/NCT01414205
  • A Study to Compare the Efficacy and Safety of Obinutuzumab + GDC-0199 Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT02242942
  • BI836826 Dose Escalation in Relapsed Chronic Lymphocytic Leukaemia (CLL). Available from: https://clinicaltrials.gov/ct2/show/NCT01296932
  • Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia. Available from: https://clinicaltrials.gov/ct2/show/NCT01188681
  • Subcutaneous Alemtuzumab Combined With Oral Dexamethasone, Followed by Alemtuzumab Maintenance or Allo-SCT in CLL With 17p- or Refractory to Fludarabine. Available from: https://clinicaltrials.gov/ct2/show/NCT01392079
  • Bendamustine Combined With Alemtuzumab in Pretreated Chronic Lymphocytic Leukemia (CLL). Available from: https://clinicaltrials.gov/ct2/show/NCT00951457
  • Phase II Clinical Trial of Alemtuzumab to Treat B-cell Chronic Lymphocytic Leukemia (CLL004). Available from: https://clinicaltrials.gov/ct2/show/NCT01982175
  • Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies. Available from: https://clinicaltrials.gov/ct2/show/NCT00040846
  • Everolimus and Alemtuzumab in Treating Patients With Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. Available from: https://clinicaltrials.gov/ct2/show/NCT00935792
  • Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer. Available from: https://clinicaltrials.gov/ct2/show/NCT00118352
  • T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies. Available from: https://clinicaltrials.gov/ct2/show/NCT00683046

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