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Expert Review of Gastroenterology & Hepatology Volume 7, 2013 - Issue 6
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Key Paper Evaluation

Predicting risk in patients with acetaminophen overdose

Laura P James Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital Research Institute, Little Rock, AR, USA; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital Research Institute, Little Rock, AR, USA
,
Prit Gill Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital Research Institute, Little Rock, AR, USA; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital Research Institute, Little Rock, AR, USA
&
Pippa Simpson Department of Pediatrics, Medical College of Wisconsin, Madison, WI, USA; Department of Pediatrics, Medical College of Wisconsin, Madison, WI, USA
Pages 509-512 | Published online: 10 Jan 2014

References

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  • Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N. Engl. J. Med. 319(24), 1557–1562 (1988).
  • Heard KJ. Acetylcysteine for acetaminophen poisoning. N. Engl. J. Med. 359(3), 285–292 (2008).
  • Fontana RJ. Acute liver failure including acetaminophen overdose. Med. Clin. North Am. 92(4), 761–794, viii (2008).
  • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44(1), 27–33 (2006).
  • Starkey Lewis PJ, Dear J, Platt V et al. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 54(5), 1767–1776 (2011).
  • James LP, Simon MT, Capparelli EV et al. Pharmacokinetic analysis of acetaminophen protein adducts in adults with acute liver failure. Clin. Pharmacol. Ther. 81, 2 (2007).

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