References
- Papers of special note have been highlighted as:
- * Of interest
- ** Of considerable interest
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** The paper is the first demonstration that adaptive immune responses against oxidative stress-derived antigens have a role in the evolution of steatohepatitis in a mice model of nonalcoholic steatohepatitis
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** This paper provides extensive evidence supporting the role of CD8+ T-lymphocytes and natural killer T cells in the evolution of nonalcoholic steatohepatitis and in the development of nonalcoholic steatohepatitis-related hepatocellular carcinoma in mice
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* This paper demonstrates the role of IFN-γ in sustaining the evolution of steatohepatitis in a mice model of nonalcoholic steatohepatitis
- Shimazu Y, Hamaguchi M, Fukuda T, et al. Steatohepatitis as impaired immune metabolism induced by liver resident regulatory T-cell depletion. Hepatology. 2015. DOI:10.1002/hep.27986.
** This paper provides the first demonstration of the importance of regulatory T-cells in the pathogenesis of nonalcoholic steatohepatitis
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* The paper characterizes one of the mechanisms by which natural killer T cells support alcohol-induced hepatic inflammation
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* The paper shows that Kupffer cells have an important role in maintaining immune tolerance within the liver and that Kupffer cell activation abrogates these effects
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- Henning JR, Graffeo CS, Rehman A, et al. Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology. 2013;58:589–602.
* This paper demonstrates that hepatic dendritic cells have a role in the pathogenesis of nonalcoholic steatohepatitis
- Sutti S, Locatelli I, Bruzzì S, et al. CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis. Clin Sci (Lond). 2015;129:797–808.
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- Elinav E, Pappo O, Sklair-Levy M, et al. Amelioration of non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice by oral immune regulation towards liver-extracted proteins is associated with elevated intrahepatic NKT lymphocytes and serum IL-10 levels. J Pathol. 2006;208:74–81.