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The role of immune mechanisms in alcoholic and nonalcoholic steatohepatitis: a 2015 update

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Pages 243-253 | Received 27 Aug 2015, Accepted 20 Oct 2015, Published online: 03 Dec 2015

References

  • Papers of special note have been highlighted as:
  • * Of interest
  • ** Of considerable interest
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** The paper is the first demonstration that adaptive immune responses against oxidative stress-derived antigens have a role in the evolution of steatohepatitis in a mice model of nonalcoholic steatohepatitis

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** This paper provides extensive evidence supporting the role of CD8+ T-lymphocytes and natural killer T cells in the evolution of nonalcoholic steatohepatitis and in the development of nonalcoholic steatohepatitis-related hepatocellular carcinoma in mice

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* This paper demonstrates the role of IFN-γ in sustaining the evolution of steatohepatitis in a mice model of nonalcoholic steatohepatitis

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** This paper provides the first demonstration of the importance of regulatory T-cells in the pathogenesis of nonalcoholic steatohepatitis

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* The paper characterizes one of the mechanisms by which natural killer T cells support alcohol-induced hepatic inflammation

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* The paper shows that Kupffer cells have an important role in maintaining immune tolerance within the liver and that Kupffer cell activation abrogates these effects

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* This paper demonstrates that hepatic dendritic cells have a role in the pathogenesis of nonalcoholic steatohepatitis

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