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Review

Extended criteria donors in liver transplantation Part I: reviewing the impact of determining factors

, , , , , , , & show all
Pages 827-839 | Received 04 Aug 2015, Accepted 28 Jan 2016, Published online: 03 Mar 2016

References

  • Mirza DF, Gunson BK, Da Silva RF, et al. Policies in Europe on “marginal quality” donor livers. Lancet. 1994;344(8935):1480–1483.
  • Barshes NR, Horwitz IB, Franzini L, et al. Waitlist mortality decreases with increased use of extended criteria donor liver grafts at adult liver transplant centers. Am J Transplant. 2007;7(5):1265–1270.
  • Nickkholgh A, Weitz J, Encke J, et al. Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature. Nephrol Dial Transplant. 2007;22(Suppl 8):viii29–viii36.
  • Northup PG, Pruett TL, Kashmer DM, et al. Donor factors predicting recipient survival after liver retransplantation: the retransplant donor risk index. Am J Transplant. 2007;7(8):1984–1988.
  • Schemmer P, Nickkholgh A, Hinz U, et al. Extended donor criteria have no negative impact on early outcome after liver transplantation: a single-center multivariate analysis. Transplant Proc. 2007;39(2):529–534.
  • Afonso RC, Hidalgo R, Paes AT, et al. Impact of cumulative risk factors for expanded criteria donors on early survival after liver transplantation. Transplant Proc. 2008;40(3):800–801.
  • Durand F, Renz JF, Alkofer B, et al. Report of the Paris consensus meeting on expanded criteria donors in liver transplantation. Liver Transpl. 2008;14(12):1694–1707.
  • Feng S, Lai JC. Expanded criteria donors. Clin Liver Dis. 2014;18(3):633–649.
  • Chen H, Peng CH, Shen BY, et al. Multi-factor analysis of initial poor graft function after orthotopic liver transplantation. Hepatobiliary Pancreat Dis Int. 2007;6(2):141–146.
  • Nemes B, Gelley F, Zadori G, et al. The role of marginal donors in liver transplantation. The Hungarian experience. Orv Hetil. 2009;150(49):2228–2236.
  • Lucidi V, Lemye AC, Baire L, et al. Use of marginal donors for liver transplantation: a single-center experience within the Eurotransplant patient-driven allocation system. Transplant Proc. 2007;39(8):2668–2671.
  • Silberhumer GR, Pokorny H, Hetz H, et al. Combination of extended donor criteria and changes in the model for end-stage liver disease score predict patient survival and primary dysfunction in liver transplantation: a retrospective analysis. Transplantation. 2007;83(5):588–592.
  • Mullhaupt B, Dimitroulis D, Gerlach JT, et al. Hot topics in liver transplantation: organ allocation–extended criteria donor–living donor liver transplantation. J Hepatol. 2008;48(Suppl 1):S58–67.
  • Gordon Burroughs S, Busuttil RW. Optimal utilization of extended hepatic grafts. Surg Today. 2009;39(9):746–751.
  • Silberhumer GR, Rahmel A, Karam V, et al. The difficulty in defining extended donor criteria for liver grafts: the Eurotransplant experience. Transpl Int. 2013;26(10):990–998.
  • Bruzzone P, Giannarelli D, Adam R. A preliminary European liver and intestine transplant association-European liver transplant registry study on informed recipient consent and extended criteria liver donation. Transplant Proc. 2013;45(7):2613–2615.
  • Wu T-J, Lee C-F, Chou H-S, et al. Suspect the donor with potential infection in the adult deceased donor liver transplantation. Transplant Proc. 2008;40(8):2486–2488.
  • Detry O. Extended criteria donors: the case for liver procurement in donors with a central nervous system malignancy. Liver Transpl. 2009;15(6):670–671.
  • Nafidi O, Marleau D, Roy A, et al. Identification of new donor variables associated with graft survival in a single-center liver transplant cohort. Liver Transpl. 2010;16(12):1393–1399.
  • Hong JC, Yersiz H, Kositamongkol P, et al. Liver transplantation using organ donation after cardiac death: a clinical predictive index for graft failure-free survival. Arch Surg. 2011;146(9):1017–1023.
  • Blok JJ, Braat AE, Adam R, et al. Validation of the donor risk index in orthotopic liver transplantation within the Eurotransplant region. Liver Transpl. 2012;18(1):112–119.
  • Arjona-Sanchez A, Sanchez-Hidalgo JM, Ciria-Bru R, et al. Prediction model to discard a priori liver allografts. Transplant Proc. 2014;46(9):3076–3078.
  • Zeeh J, Platt D. The aging liver: structural and functional changes and their consequences for drug treatment in old age. Gerontology. 2002;48(3):121–127.
  • Nardo B, Masetti M, Urbani L, et al. Liver transplantation from donors aged 80 years and over: pushing the limit. Am J Transplant. 2004;4(7):1139–1147.
  • Serrano MT, Garcia-Gil A, Arenas J, et al. Outcome of liver transplantation using donors older than 60 years of age. Clin Transplant. 2010;24(4):543–549.
  • Fruhauf NR, Fischer-Frohlich CL, Kutschmann M, et al. Joint impact of donor and recipient parameters on the outcome of liver transplantation in Germany. Transplantation. 2011;92(12):1378–1384.
  • Kim DY, Moon J, Island ER, et al. Liver transplantation using elderly donors: a risk factor analysis. Clin Transplant. 2011;25(2):270–276.
  • Saidi RF. Utilization of expanded criteria donors in liver transplantation. Int J Organ Transplant Med. 2013;4(2):46–59.
  • Ghinolfi D, Marti J, De Simone P, et al. Use of octogenarian donors for liver transplantation: a survival analysis. Am J Transplant. 2014;14(9):2062–2071.
  • Radunz S, Paul A, Nowak K, et al. Liver transplantation using donor organs with markedly elevated liver enzymes: how far can we go? Liver Int. 2011;31(7):1021–1027.
  • Hoyer DP, Paul A, Saner F, et al. Safely expanding the donor pool: brain dead donors with history of temporary cardiac arrest. Liver Int. 2015; 35(6):1756–1763.
  • Mangus RS, Kubal CA, Fridell JA, et al. Alcohol abuse in deceased liver donors: impact on post-transplant outcomes. Liver Int. 2015;35(1):171–175.
  • Avolio AW, Agnes S, Magalini SC, et al. Importance of donor blood chemistry data (AST, serum sodium) in predicting liver transplant outcome. Transplant Proc. 1991;23(5):2451–2452.
  • Gonzalez FX, Rimola A, Grande L, et al. Predictive factors of early postoperative graft function in human liver transplantation. Hepatology. 1994;20(3):565–573.
  • Figueras J, Busquets J, Grande L, et al. The deleterious effect of donor high plasma sodium and extended preservation in liver transplantation. A multivariate analysis. Transplantation. 1996;61(3):410–413.
  • Totsuka E, Fung U, Hakamada K, et al. Analysis of clinical variables of donors and recipients with respect to short-term graft outcome in human liver transplantation. Transplant Proc. 2004;36(8):2215–2218.
  • Powner DJ. Factors during donor care that may affect liver transplantation outcome. Prog Transplant. 2004;14(3):241–247. quiz 248–249.
  • Tector AJ, Mangus RS, Chestovich P, et al. Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival. Ann Surg. 2006;244(3):439–450.
  • Totsuka E, Dodson F, Urakami A, et al. Influence of high donor serum sodium levels on early postoperative graft function in human liver transplantation: effect of correction of donor hypernatremia. Liver Transpl Surg. 1999;5(5):421–428.
  • Renz JF, Kin C, Kinkhabwala M, et al. Utilization of extended donor criteria liver allografts maximizes donor use and patient access to liver transplantation. Ann Surg. 2005;242(4):556–563. discussion 563–555.
  • Akoad M, Wagener M, Francis F, et al. Outcome of imported liver allografts and impact on patient access to liver transplantation. Transplant Proc. 2006;38(10):3564–3566.
  • Cywinski JB, Mascha E, Miller C, et al. Association between donor-recipient serum sodium differences and orthotopic liver transplant graft function. Liver Transpl. 2008;14(1):59–65.
  • Mangus RS, Fridell JA, Vianna RM, et al. Severe hypernatremia in deceased liver donors does not impact early transplant outcome. Transplantation. 2010;90(4):438–443.
  • Goldaracena N, Quinonez E, Mendez P, et al. Extremely marginal liver grafts from deceased donors have outcome similar to ideal grafts. Transplant Proc. 2012;44(7):2219–2222.
  • Khosravi MB, Firoozifar M, Ghaffaripour S, et al. Early outcomes of liver transplants in patients receiving organs from hypernatremic donors. Exp Clin Transplant. 2013;11(6):537–540.
  • Kaseje N, Luthold S, Mentha G, et al. Donor hypernatremia influences outcomes following pediatric liver transplantation. Eur J Pediatr Surg. 2013;23(1):8–13.
  • Uribe M, Alba A, Gonzalez G, et al. Pediatric liver transplant outcome using severe hypernatremic donors. Transplant Proc. 2013;45(10):3726–3727.
  • Busuttil RW, Tanaka K. The utility of marginal donors in liver transplantation. Liver Transpl. 2003;9(7):651–663.
  • Cucchetti A, Vivarelli M, Ravaioli M, et al. Assessment of donor steatosis in liver transplantation: is it possible without liver biopsy? Clin Transplant. 2009;23(4):519–524.
  • Pichon N, Loustaud-Ratti V, Clavel M, et al. Value of liver stiffness measured by transient elastography in the liver transplant pre-operative evaluation of the potential deceased liver donors: preliminary study. Clin Transplant. 2011;25(2):E205–210.
  • Yersiz H, Lee C, Kaldas FM, et al. Assessment of hepatic steatosis by transplant surgeon and expert pathologist: a prospective, double-blind evaluation of 201 donor livers. Liver Transpl. 2013;19(4):437–449.
  • Martins AM, Coelho GR, Marques GA, et al. Hepatic steatosis assessment: a comparative study between surgeon evaluation and forward histopathologic findings. Arq Gastroenterol. 2013;50(1):15–18.
  • Lo IJ, Lefkowitch JH, Feirt N, et al. Utility of liver allograft biopsy obtained at procurement. Liver Transpl. 2008;14(5):639–646.
  • Fiorentino M, Vasuri F, Ravaioli M, et al. Predictive value of frozen-section analysis in the histological assessment of steatosis before liver transplantation. Liver Transpl. 2009;15(12):1821–1825.
  • Biesterfeld S, Knapp J, Bittinger F, et al. Frozen section diagnosis in donor liver biopsies: observer variation of semiquantitative and quantitative steatosis assessment. Virchows Arch. 2012;461(2):177–183.
  • Oliver JB, Peters S, Bongu A, et al. Prerecovery liver biopsy in the brain-dead donor: a case-control study of logistics, safety, precision, and utility. Liver Transpl. 2014;20(2):237–244.
  • El-Badry AM, Breitenstein S, Jochum W, et al. Assessment of hepatic steatosis by expert pathologists: the end of a gold standard. Ann Surg. 2009;250(5):691–697.
  • Spitzer AL, Lao OB, Dick AA, et al. The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment. Liver Transpl. 2010;16(7):874–884.
  • Angele MK, Rentsch M, Hartl WH, et al. Effect of graft steatosis on liver function and organ survival after liver transplantation. Am J Surg. 2008;195(2):214–220.
  • Briceno J, Ciria R, Pleguezuelo M, et al. Impact of donor graft steatosis on overall outcome and viral recurrence after liver transplantation for hepatitis C virus cirrhosis. Liver Transpl. 2009;15(1):37–48.
  • Botha JF, Thompson E, Gilroy R, et al. Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation. Liver Int. 2007;27(6):758–763.
  • Burra P, Loreno M, Russo FP, et al. Donor livers with steatosis are safe to use in hepatitis C virus-positive recipients. Liver Transpl. 2009;15(6):619–628.
  • Baccarani U, Isola M, Adani GL, et al. Steatosis of the hepatic graft as a risk factor for post-transplant biliary complications. Clin Transplant. 2010;24(5):631–635.
  • Lattanzi B, Lai Q, Guglielmo N, et al. Graft macrosteatosis and time of T-tube removal as risk factors for biliary strictures after liver transplantation. Clin Transplant. 2013;27(3):E332–E338.
  • Subramanian V, Seetharam AB, Vachharajani N, et al. Donor graft steatosis influences immunity to hepatitis C virus and allograft outcome after liver transplantation. Transplantation. 2011;92(11):1259–1268.
  • Adam R, Cailliez V, Majno P, et al. Normalised intrinsic mortality risk in liver transplantation: European liver transplant registry study. Lancet. 2000;356(9230):621–627.
  • Burroughs AK, Sabin CA, Rolles K, et al. 3-month and 12-month mortality after first liver transplant in adults in Europe: predictive models for outcome. Lancet. 2006;367(9506):225–232.
  • European Liver Transplant Registry. [ cited 2008 Sep]. Available from: http://www.eltr.org
  • Ballarin R, Cucchetti A, Spaggiari M, et al. Long-term follow-up and outcome of liver transplantation from anti-hepatitis C virus-positive donors: a European multicentric case-control study. Transplantation. 2011;91(11):1265–1272.
  • Berenguer M. Risk of extended criteria donors in hepatitis C virus-positive recipients. Liver Transpl. 2008;14(Suppl 2):S45–50.
  • Burr AT, Li Y, Tseng JF, et al. Survival after liver transplantation using hepatitis C virus-positive donor allografts: case-controlled analysis of the UNOS database. World J Surg. 2011;35(7):1590–1595.
  • Northup PG, Argo CK, Nguyen DT, et al. Liver allografts from hepatitis C positive donors can offer good outcomes in hepatitis C positive recipients: a US National Transplant Registry analysis. Transpl Int. 2010;23(10):1038–1044.
  • O’Leary JG, Neri MA, Trotter JF, et al. Utilization of hepatitis C antibody-positive livers: genotype dominance is virally determined. Transpl Int. 2012;25(8):825–829.
  • Cholongitas E, Papatheodoridis GV, Burroughs AK. Liver grafts from anti-hepatitis B core positive donors: a systematic review. J Hepatol. 2010;52(2):272–279.
  • Prieto M. Antibody to hepatitis B core antigen-positive grafts: not perfect but no longer marginal. Liver Transpl. 2009;15(10):1164–1168.
  • Loggi E, Bihl F, Chisholm JV 3rd, et al. Anti-HBs re-seroconversion after liver transplantation in a patient with past HBV infection receiving a HBsAg positive graft. J Hepatol. 2009;50(3):625–630.
  • Yu L, Koepsell T, Manhart L, et al. Survival after orthotopic liver transplantation: the impact of antibody against hepatitis B core antigen in the donor. Liver Transpl. 2009;15(10):1343–1350.
  • Angelico M, Nardi A, Marianelli T, et al. Hepatitis B-core antibody positive donors in liver transplantation and their impact on graft survival: evidence from the liver match cohort study. J Hepatol. 2013;58(4):715–723.
  • MacConmara MP, Vachharajani N, Wellen JR, et al. Utilization of hepatitis B core antibody-positive donor liver grafts. HPB (Oxford). 2012;14(1):42–48.
  • Brock GN, Mostajabi F, Ferguson N, et al. Prophylaxis against de novo hepatitis B for liver transplantation utilizing hep B core (+) donors: does hepatitis B immunoglobulin provide a survival advantage? Transpl Int. 2011;24(6):570–581.
  • Skagen CL, Jou JH, Said A. Risk of de novo hepatitis in liver recipients from hepatitis-B core antibody-positive grafts - a systematic analysis. Clin Transplant. 2011;25(3):E243–249.
  • Calne RY, Williams R. Liver transplantation in man. I: observations on technique and organization in five cases. Br Med J. 1968;4(5630):535–540.
  • Broomhead RH, Patel S, Fernando B, et al. Resource implications of expanding the use of donation after circulatory determination of death in liver transplantation. Liver Transpl. 2012;18(7):771–778.
  • Wells M, Croome KM, Janik T, et al. Comparing outcomes of donation after cardiac death versus donation after brain death in liver transplant recipients with hepatitis C: a systematic review and meta-analysis. Can J Gastroenterol Hepatol. 2014;28(2):103–108.
  • Nguyen JH, Bonatti H, Dickson RC, et al. Long-term outcomes of donation after cardiac death liver allografts from a single center. Clin Transplant. 2009;23(2):168–173.
  • Skaro AI, Jay CL, Baker TB, et al. The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story. Surgery. 2009;146(4):543–552. discussion 552–543.
  • Mathur AK, Heimbach J, Steffick DE, et al. Donation after cardiac death liver transplantation: predictors of outcome. Am J Transplant. 2010;10(11):2512–2519.
  • Abou Abbass A, Abouljoud M, Yoshida A, et al. Biliary complications after orthotopic liver transplantation from donors after cardiac death: broad spectrum of disease. Transplant Proc. 2010;42(9):3392–3398.
  • Bartlett A, Vara R, Muiesan P, et al. A single center experience of donation after cardiac death liver transplantation in pediatric recipients. Pediatr Transplant. 2010;14(3):388–392.
  • Yagci G, Fernandez LA, Knechtle SJ, et al. The impact of donor variables on the outcome of orthotopic liver transplantation for hepatitis C. Transplant Proc. 2008;40(1):219–223.
  • Tao R, Ruppert K, Cruz RJ Jr., et al. Hepatitis C recurrence is not adversely affected by the use of donation after cardiac death liver allografts. Liver Transpl. 2010;16(11):1288–1295.
  • Mawardi M, Aba Alkhail F, Katada K, et al. The clinical consequences of utilizing donation after cardiac death liver grafts into hepatitis C recipients. Hepatol Int. 2011;5(3):830–833.
  • Hernandez-Alejandro R, Croome KP, Quan D, et al. Increased risk of severe recurrence of hepatitis C virus in liver transplant recipients of donation after cardiac death allografts. Transplantation. 2011;92(6):686–689.
  • Taner CB, Bulatao IG, Keaveny AP, et al. Use of liver grafts from donation after cardiac death donors for recipients with hepatitis C virus. Liver Transpl. 2011;17(6):641–649.
  • Uemura T, Ramprasad V, Hollenbeak CS, et al. Liver transplantation for hepatitis C from donation after cardiac death donors: an analysis of OPTN/UNOS data. Am J Transplant. 2012;12(4):984–991.
  • Tariciotti L, Rocha C, Perera MT, et al. Is it time to extend liver acceptance criteria for controlled donors after cardiac death? Transplantation. 2011;92(10):1140–1146.
  • Monbaliu D, Pirenne J, Talbot D. Liver transplantation using donation after cardiac death donors. J Hepatol. 2012;56(2):474–485.
  • Fondevila C, Hessheimer AJ, Flores E, et al. Applicability and results of maastricht type 2 donation after cardiac death liver transplantation. Am J Transplant. 2012;12(1):162–170.
  • Harring TR, Nguyen NT, Cotton RT, et al. Liver transplantation with donation after cardiac death donors: a comprehensive update. J Surg Res. 2012;178(1):502–511.
  • Jay CL, Skaro AI, Ladner DP, et al. Comparative effectiveness of donation after cardiac death versus donation after brain death liver transplantation: recognizing who can benefit. Liver Transpl. 2012;18(6):630–640.
  • Mccormack L, Petrowsky H, Jochum W, et al. Use of severely steatotic grafts in liver transplantation: a matched case-control study. Ann Surg. 2007;246(6):940–948. discussion 946–948.
  • Dutkowski P, Schlegel A, Slankamenac K, et al. The use of fatty liver grafts in modern allocation systems: risk assessment by the balance of risk (BAR) score. Ann Surg. 2012;256(5):861–869. discussion 868–869.
  • Scalea JR, Barth RN, Munivenkatappa R, et al. Shorter waitlist times and improved graft survivals are observed in patients who accept hepatitis C virus+ renal allografts. Transplantation. 2015;99(6):1192–1196.
  • Aubert O, Kamar N, Vernerey D, et al. Long term outcomes of transplantation using kidneys from expanded criteria donors: prospective, population based cohort study. BMJ. 2015;351:h3557. doi:10.1136/bmj.h3557

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