423
Views
1
CrossRef citations to date
0
Altmetric
Editorial

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

, &
Pages 105-109 | Published online: 10 Jan 2014

References

  • Xia CQ, Milton MN, Gan LS. Evaluation of drug-transporter interactions using in vitro and in vivo models. Curr. Drug Metab.8(4), 341–363 (2007).
  • Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. Impact of drug transporter studies on drug discovery and development. Pharmacol. Rev.55(3), 425–461 (2003).
  • Constan AA, Sprankle CS, Peters JM et al. Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. Toxicol. Appl. Pharmacol.160(2), 120–126 (1999).
  • Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J. Biol. Chem.271(20), 12063–12067 (1996).
  • Wong FW, Chan WY, Lee SS. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol. Appl. Pharmacol.153, 109–118 (1998).
  • Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature407(6806), 920–923 (2000).
  • Henderson CJ, Otto DM, McLaren AW, Carrie D, Wolf CR. Knockout mice in xenobiotic metabolism. Drug Metab. Rev.35(4), 385–392 (2003).
  • Henderson CJ, Wolf CR. Transgenic analysis of human drug-metabolizing enzymes: preclinical drug development and toxicology. Mol. Interventions3(6), 331–343 (2003).
  • Otto DM, Henderson CJ, Carrie D et al. Identification of novel roles of the cytochrome P450 system in early embryogenesis: effects on vasculogenesis and retinoic acid homeostasis. Mol. Cell Biol.23(17), 6103–6116 (2003).
  • Shen AL, O’Leary KA, Kasper CB. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. J. Biol. Chem.277(8), 6536–6541 (2002).
  • Gu J, Weng Y, Zhang QY et al. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J. Biol. Chem.278(28), 25895–25901 (2003).
  • Henderson CJ, Otto DM, Carrie D et al. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J. Biol. Chem.278(15), 13480–13486 (2003).
  • Gu J, Chen CS, Wei Y et al. A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition. J. Pharmacol. Exp. Ther.321(1), 9–17 (2007).
  • Pass GJ, Carrie D, Boylan M et al. Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse. Cancer Res.65(10), 4211–4217 (2005).
  • Finn RD, McLaughlin LA, Ronseaux S et al. Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J. Biol. Chem.283(46), 31385–31393 (2008).
  • Herold MJ, van den Brandt J, Seibler J, Reichardt HM. Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. Proc. Natl Acad. Sci. USA105(47), 18507–18512 (2008).
  • Cheung C, Gonzalez FJ. Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. J. Pharmacol. Exp. Ther.327(2), 288–299 (2008).
  • Ma X, Shah Y, Cheung C et al. The PREgnane X receptor gene-humanized mouse: a model for investigating drug–drug interactions mediated by cytochromes P450 3A. Drug Metab. Dispos.35(2), 194–200 (2007).
  • Scheer N, Ross J, Rode A et al. A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J. Clin. Invest.118(9), 3228–3239 (2008).
  • Cheung C, Akiyama TE, Ward JM et al. Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor α. Cancer Res.64(11), 3849–3854 (2004).
  • Yang Q, Nagano T, Shah Y, Cheung C, Ito S, Gonzalez FJ. The PPAR α-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR α. Toxicol. Sci.101(1), 132–139 (2008).
  • Moriguchi T, Motohashi H, Hosoya T et al. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc. Natl Acad. Sci. USA100(10), 5652–5657 (2003).
  • Gonzalez FJ, Yu AM. Cytochrome P450 and xenobiotic receptor humanized mice. Ann. Rev. Pharmacol. Toxicol.46, 41–64 (2006).
  • Corchero J, Granvil CP, Akiyama TE et al. The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4α on the disposition of debrisoquine in the mouse. Mol. Pharmacol.60(6), 1260–1267 (2001).
  • Granvil CP, Yu AM, Elizondo G et al. Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Drug Metab. Dispos.31(5), 548–558 (2003).
  • Dragin N, Uno S, Wang B, Dalton TP, Nebert DW. Generation of ‘humanized’ hCYP1A1_1A2_Cyp1a1/1a2-/- mouse line. Biochem. Biophys. Res. Commun.359(3), 635–642 (2007).
  • van Herwaarden AE, Wagenaar E, van der Kruijssen CM et al. Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J. Clin. Invest.117(11), 3583–3592 (2007).
  • van Waterschoot RA, van Herwaarden AE, Lagas JS et al. Midazolam metabolism in Cytochrome P450 3A knockout mice can be attributed to upregulated CYP2C enzymes. Mol. Pharmacol.73(3), 1029–1036 (2008).
  • Chen S, Beaton D, Nguyen N et al. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J. Biol. Chem.280(45), 37547–37557 (2005).
  • Azuma H, Paulk N, Ranade A et al. Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat. Biotechnol.25(8), 903–910 (2007).
  • Tateno C, Yoshizane Y, Saito N et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am. J. Pathol.165(3), 901–912 (2004).
  • Katoh M, Yokoi T. Application of chimeric mice with humanized liver for predictive ADME. Drug Metab. Rev.39(1), 145–157 (2007).
  • Campbell SJ, Carlotti F, Hall PA, Clark AJ, Wolf CR. Regulation of the CYP1A1 promoter in transgenic mice: an exquisitely sensitive on–off system for cell specific gene regulation. J. Cell. Sci.109(11), 2619–2625 (1996).
  • Campbell SJ, Henderson CJ, Anthony DC, Davidson D, Clark AJ, Wolf CR. The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development. J. Biol. Chem.280(7), 5828–5835 (2005).
  • Zhang W, Purchio AF, Chen K et al. A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. Drug Metab. Dispos.31(8), 1054–1064 (2003).
  • Stedman C, Robertson G, Coulter S, Liddle C. Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice. J. Biol. Chem.279(12), 11336–11343 (2004).
  • Zhang W, Moorthy B, Chen M et al. A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice. Toxicol. Sci.82(1), 297–307 (2004).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.