New problems arising from old drugs: second-generation effects of acetaminophen

References

• Lee WM. Acetaminophen toxicity: changing perceptions on a social/medical issue. Hepatology 2007;46(4):966-70
   PubMed Web of Science ®Google Scholar
• Thiele K, Kessler T, Arck P, et al. Acetaminophen and pregnancy: short- and long-term consequences for mother and child. J Reprod Immunol 2013;97(1):128-39
   PubMed Web of Science ®Google Scholar
• US FDA. Protecting and promoting your health. Available from: www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm165107.htm
   Google Scholar
• Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J 1966;2(5512):497-9
   PubMed Web of Science ®Google Scholar
• Lee WM. The case for limiting acetaminophen-related death: smaller doses and unbundling the opioid-acetaminophen compounds. Clin Pharmacol Ther 2010;88(3):289-92
   PubMed Web of Science ®Google Scholar
• Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005;42(6):1364-72
   PubMed Web of Science ®Google Scholar
• McClure CK, Katz KD, Patrick TE, et al. The epidemiology of acute poisonings in women of reproductive age and during pregnancy, California, 2000-2004. Matern Child Health J 2011;15(7):964-73
   PubMed Web of Science ®Google Scholar
• James LP, Alonso EM, Hynan LS, et al. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pedriatrics 2006;118(3):e676-81
   Web of Science ®Google Scholar
• Craig DG, Bates CM, Davidson JS, et al. Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity. Br J Clin Pharmacol 2011;71(2):273-82
   PubMed Web of Science ®Google Scholar
• Watkins PB, Kaplowitz N, Slattery JT, et al. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily. JAMA 2006;296(1):87-93
   PubMed Web of Science ®Google Scholar
• Zimmerman HJ, Maddrey WC. Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology 1995;22(3):767-73
   PubMed Web of Science ®Google Scholar
• Schiodt FV, Rochling FA, Casey DL, Lee WM. Acetaminophen toxicity in an urban county hospital. N Engl J Med 1997;337(16):1112-17
   PubMed Web of Science ®Google Scholar
• Rumack B, Heard K, Green J, et al. Effect of therapeutic doses of acetaminophen (up to 4 g/day) on serum alanine aminotransferase levels in subjects consuming ethanol: systematic review and meta-analysis of randomized controlled trials. Pharmacotherapy 2012;32(9):784-91
   PubMed Web of Science ®Google Scholar
• Dart RC, Green JL, Kuffner EK, et al. The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol – a randomized study. Aliment Pharmacol Ther 2010;32(3):478-86
   PubMed Web of Science ®Google Scholar
• Michaut A, Moreau C, Robin MA, Fromenty B. Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease. Liver Int 2014. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Han D, Dara L, Win S, et al. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci 2013;34(4):243-53
   PubMed Web of Science ®Google Scholar
• McGill MR, Sharpe MR, Williams CD, et al. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest 2012;122(4):1574-83
   PubMed Web of Science ®Google Scholar
• Imaeda AB, Watanabe A, Sohail MA, et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest 2009;119(2):305-14
   PubMed Web of Science ®Google Scholar
• Marques PE, Oliveira AG, Pereira RV, et al. Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice. Hepatology 2014. [Epub ahead of print]
   PubMedGoogle Scholar
• Marques PE, Amaral SS, Pires DA, et al. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. Hepatology 2012;56(5):1971-82
   PubMed Web of Science ®Google Scholar
• Choi DY, Ban JO, Kim SC, Hong JT. CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver. Arch Toxicol 2014. [Epub ahead of print]
   Web of Science ®Google Scholar
• Williams CD, Farhood A, Jaeschke H. Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury. Toxicol Appl Pharmacol 2010;247(3):169-78
   PubMed Web of Science ®Google Scholar
• Williams CD, Bajt ML, Sharpe MR, et al. Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol Appl Pharmacol 2014;275(2):122-33
   PubMed Web of Science ®Google Scholar
• Liew Z, Ritz B, Rebordosa C, et al. Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. JAMA 2014;168(4):313-20
   Google Scholar
• Schoenfeld A, Bar Y, Merlob P, Ovadia Y. NSAIDs: maternal and fetal considerations. Am J Reprod Immunol 1992;28(3-4):141-7
   PubMed Web of Science ®Google Scholar
• Brandlistuen RE, Ystrom E, Nulman I, et al. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study. Int J Epidemiol 2013;42(6):1702-13
   PubMed Web of Science ®Google Scholar
• Henderson AJ, Shaheen SO. Acetaminophen and asthma. Paediatr Respir Rev 2013;14(9):9-16
   PubMedGoogle Scholar
• McBride JT. The association of acetaminophen and asthma prevalence and severity. Pediatrics 2011;128(6):1181-5
   PubMed Web of Science ®Google Scholar
• Jensen MS, Rebordosa C, Thulstrup AM, et al. Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism. Epidemiology 2010;21(6):779-85
   PubMed Web of Science ®Google Scholar
• Snijder CA, Kortenkamp A, Steegers EA, et al. Intraauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study. Hum Reprod 2012;27(4):1191-201
   PubMed Web of Science ®Google Scholar
• Shaheen SO, Newson RB, Smith GD, Henderson AJ. Prenatal paracetamol exposure and asthma: further evidence against confounding. Int J Epidemiol 2010;39(3):790-4
   PubMed Web of Science ®Google Scholar
• Heintze K, Petersen KU. The case of drug causation of childhood asthma: antibiotics and paracetamol. Eur J Clin Pharmacol 2013;69(6):1197-209
   PubMed Web of Science ®Google Scholar
• Larrey D, Letteron P, Foliot A, et al. Effects of pregnancy on the toxicity and metabolism of acetaminophen in mice. J Pharmacol Exp Ther 1986;237(1):283-91
   PubMed Web of Science ®Google Scholar
• Byer AJ, Traylor TR, Semmer JR. Acetaminophen overdose in the third trimester of pregnancy. J Am Med Assoc 1982;247(22):3114-15
   Web of Science ®Google Scholar
• Rollins DE, von Bahr C, Glaumann H, et al. Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells. Science 1979;205(4413):1414-16
   PubMed Web of Science ®Google Scholar
• Davern TJ, James LP, Hinson JA, et al. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology 2006;130(3):687-94
   PubMed Web of Science ®Google Scholar
• Nassini R, Materazzi S, Andrè E, et al. Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 2010;24(12):4904-16
   PubMed Web of Science ®Google Scholar
• Hitchler MJ, Domann FE. An epigenetic perspective on the free radical theory of development. Free Radic Biol Med 2007;43(7):1023-36
   PubMed Web of Science ®Google Scholar
• de Planell-Saguer M, Lovinsky-Desir S, Miller RL. Epigenetic regulation: the interface between prenatal and early-life exposure and asthma susceptibility. Environ Mol Mutagen 2014;55(3):231-43
   PubMed Web of Science ®Google Scholar
• Kennedy TG, Gillio-Meina C, Phang SH. Prostaglandins and the initiation of blastocyst implantation and decidualization. Reproduction 2007;134(5):635-43
   PubMed Web of Science ®Google Scholar
• Chakraborty I, Das SK, Wang J, Dey SK. Developmental expression of the cyclooxygenase-1 and cyclooxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids. J Mol Endocrinol 1996;16(2):107-22
   PubMed Web of Science ®Google Scholar
• Narayanankutty A, Reséndiz-Hernández JM, Falfán-Valencia R, Teran LM. Biochemical pathogenesis of aspirin exacerbated respiratory disease (AERD). Clin Biochem 2013;46(7-8):566-78
   PubMed Web of Science ®Google Scholar
• Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006;355(21):2226-35
   PubMed Web of Science ®Google Scholar
• Hinz B, Cheremina O, Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2007;22(2):383-90
   PubMed Web of Science ®Google Scholar
• Lesko SM, Louik C, Vezina RM, Mitchell AA. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002;109(2):1-4
   PubMed Web of Science ®Google Scholar
• Kanabar D, Dale S, Rawat M. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Therapeut 2007;29(12):2716-23
   PubMed Web of Science ®Google Scholar
• Arck PC, Hecher K. Fetomaternal immune cross-talk and its consequences for maternal and offspring’s health. Nat Med 2013;19(5):548-56
   PubMed Web of Science ®Google Scholar
• Arck P, Solano ME, Walecki M, Meinhardt A. The immune privilege of testis and gravid uterus: same difference? Mol Cell Endocrinol 2013;382(1):509-20
   PubMed Web of Science ®Google Scholar
• Chazara O, Xiong S, Moffett A. Maternal KIR and fetal HLA-C: a fine balance. J Leukoc Biol 2011;90(4):703-16
   PubMed Web of Science ®Google Scholar
• Karimi K, Solano ME, Ashkar AA, et al. Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells. J Mol Med 2013;90(9):1047-57
   Web of Science ®Google Scholar
• Blois SM, Ilarregui JM, Tometten M, et al. A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 2007;13(12):1450-7
   PubMed Web of Science ®Google Scholar
• Blois SM, Kammerer U, Alba Soto C, et al. Dendritic cells: key to fetal tolerance? Biol Reprod 2007;77(4):590-8
   PubMed Web of Science ®Google Scholar
• Moldenhauer LM, Hayball JD, Robertson SA. Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancy. J Reprod Immunol 2010;87(1-2):1-13
   PubMed Web of Science ®Google Scholar
• Vacca P, Cantoni C, Vitale M, et al. Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression. Proc Natl Acad Sci USA 2010;107(26):11918-23
   PubMed Web of Science ®Google Scholar
• Kopcow HD, Rosetti F, Leung Y, et al. T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1. Proc Natl Acad Sci USA 2008;105(47):18472-7
   PubMed Web of Science ®Google Scholar
• Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 2004;5(3):266-71
   PubMed Web of Science ®Google Scholar
• Clark DA, Chaouat G, Arck PC, et al. Cytokine-dependent abortion in CBA × DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase. J Immunol 1998;160(2):545-9
   PubMed Web of Science ®Google Scholar
• Prymula R, Siegrist CA, Chlibek R, et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet 2009;374(9698):1339-50
   PubMed Web of Science ®Google Scholar
• Yamaura K, Ogawa K, Yonekawa T, et al. Inhibition od the antibody production by acetaminophen independent of liver injury in mice. Biol Pharm Bull 2002;25(2):201-5
   PubMed Web of Science ®Google Scholar
• Masson MJ, Peterson RA, Chung CJ, et al. Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance. Chem Res Toxicol 2007;20(1):20-6
   PubMed Web of Science ®Google Scholar
• Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov 2005;4(6):489-99
   PubMed Web of Science ®Google Scholar
• Crispe IN. Liver antigen-presenting cells. J Hepatol 2011;54(2):357-65
   PubMed Web of Science ®Google Scholar
• Tiegs G, Lohse AW. Immune tolerance: what is unique about the liver. J Autoimmun 2010;34(1):1-6
   PubMed Web of Science ®Google Scholar
• Connolly MK, Ayo D, Malhotra A, et al. Dendritic cell depletion exacerbates acetaminophen hepatotoxicity. Hepatology 2011;54(3):959-68
   PubMed Web of Science ®Google Scholar
• Remoli ME, Gafa V, Giacomini E, et al. IFN-β modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur J Immunol 2007;37(12):3499-508
   PubMed Web of Science ®Google Scholar
• Kessler T, Thiele K, Solano ME, et al. Acetaminophen application during murine pregnancy triggers metabolic and immunologic changes in dams and impairs fetal development. J Reprod Immunol 2012;94(1):20
   Web of Science ®Google Scholar
• Brandlistuen RE, Ystrom E, Nulman I, et al. Author’s response: more research on paracetamol is required. Int J Epidemiol 2014;43(3):975-6
   PubMed Web of Science ®Google Scholar
• Kushwah R, Hu J. Role of dendritic cells in the induction of regulatory T cells. Cell Biosci 2011;1(1):20
   PubMedGoogle Scholar
• Beasley R, Clayton T, Crane J, et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008;372(9643):1039-48
   PubMed Web of Science ®Google Scholar
• McGill MR, Jaeschke H. Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opin Drug Metab Toxicol 2014;10(7):1005-17
   PubMed Web of Science ®Google Scholar
• Solano ME, Jago C, Pincus MK, Arck P. Highway to health; or how prenatal factors determine disease risks in the later life of the offspring. J Reprod Immunol 2011;90(1):3-8
   PubMed Web of Science ®Google Scholar