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Drug Profiles

Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomes

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References

• Thorough review outlining mechanistic insights into the synergistic antimyeloma activity of proteasome inhibitors and deacetylase inhibitors.

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• Important preclinical work examining the mechanistic basis of synergy between bortezomib and panobinostat.

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•• Comprehensive study examining the pharmacokinetics and metabolism of panobinostat.

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•• Key Phase 1b trial establishing the MTD for PAN-BTZ-Dex in patients with relapsed or refractory multiple myeloma. This trial was the basis for the PANORAMA program.

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•• Key Phase 2 trial showing promising efficacy of PAN-BTZ-Dex in patients with bortezomib-refractory myeloma.

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•• Pivotal Phase 3 trial demonstrating that PAN-BTZ-Dex prolonged median PFS in patients with relapsed or relapsed and refractory multiple myeloma by nearly 4 months when compared with Pb0-BTZ-Dex.

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• Preclinical study showing that panobinostat-induced thrombocytopenia is mediated through reversible inhibition of megakaryocytes.

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•• Important preclinical study documenting panobinostat antimyeloma synergy with both proteasome inhibitors (bortezomib) and immunomodulatory drugs (lenalidomide).

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