Pharmacological approaches to CNS vasculitis: where are we at now?

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•The analysis of a pediatric cohort of PACNS suggests the existence of different clinical patterns. Patients with angiography-negative disease and seizures at presentation experience higher disease activity.

• Salvarani C, Hunder GG, Morris JM, et al. A-beta-related angiitis: comparison with CAA without inflammation and primary CNS vasculitis. Neurology. 2013;81(18):1596–1603.
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•This report compared the characteristics and outcomes of 78 patients with cerebral vascular Abeta deposition and 118 with PACNS without such deposits. Patients with Abeta-related angiitis (ABRA) were older, had more frequent altered cognition, seizures, gadolinium leptomeningeal enhancement, intracerebral hemorrhage, but a lower rate of MRI evidence of cerebral infarction. Their treatments and outcomes, however, were similar.