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Indications and safety of intravenous and subcutaneous immunoglobulin therapy

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Pages 301-316 | Published online: 10 Jan 2014

References

  • Cunningham-Rundles C. Lung disease, antibodies and other unresolved issues in immune globulin therapy for antibody deficiency. Clin. Exp. Immunol.157(Suppl. 1), S12–S16 (2009).
  • Radosevich M, Burnouf T. Intravenous immunoglobulin G: trends in production methods, quality control and quality assurance. Vox. Sang.98(1), 12–28 (2010).
  • Garcia-Lloret M, McGhee S, Chatila TA. Immunoglobulin replacement therapy in children. Immunol. Allergy Clin. North Am.28(4), 833–849, ix (2008).
  • Berger M. Principles of and advances in immunoglobulin replacement therapy for primary immunodeficiency. Immunol. Allergy Clin. North Am.28(2), 413–437, x (2008).
  • Toubi E, Etzioni A. Intravenous immunoglobulin in immunodeficiency states: state of the art. Clin. Rev. Allergy Immunol.29(3), 167–172 (2005).
  • Eibl MM. History of immunoglobulin replacement. Immunol. Allergy Clin. North Am.28(4), 737–764, viii (2008).
  • Bruton OC. Agammaglobulinemia. Pediatrics9(6), 722–728 (1952).
  • Berger M. A history of immune globulin therapy, from the Harvard crash program to monoclonal antibodies. Curr. Allergy Asthma Rep.2(5), 368–378 (2002).
  • Barandun S, Kistler P, Jeunet F, Isliker H. Intravenous administration of human gamma-globulin. Vox. Sang.7, 157–174 (1962).
  • Looney RJ, Huggins J. Use of intravenous immunoglobulin G (IVIg). Best Pract. Res. Clin. Haematol.19(1), 3–25 (2006).
  • Orange JS, Hossny EM, Weiler CR et al. Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. J. Allergy Clin. Immunol.117(4 Suppl.), S525–S553 (2006).
  • Imbach P, Barandun S, Baumgartner C, Hirt A, Hofer F, Wagner HP. High-dose intravenous gammaglobulin therapy of refractory, in particular idiopathic thrombocytopenia in childhood. Helv. Paediatr. Acta36(1), 81–86 (1981).
  • McDaneld LM, Fields JD, Bourdette DN, Bhardwaj A. Immunomodulatory therapies in neurologic critical care. Neurocrit. Care12(1), 132–143 (2010).
  • Arnson Y, Shoenfeld Y, Amital H. Intravenous immunoglobulin therapy for autoimmune diseases. Autoimmunity42(6), 553–560 (2009).
  • Chouksey A, Duff K, Wasserbauer N, Berger M. Subcutaneous immunoglobulin-G replacement therapy with preparations currently available in the United States for intravenous or intramuscular use: reasons and regimens. Allergy Asthma Clin. Immunol.1(3), 120–130 (2005).
  • Remvig L, Andersen V, Hansen NE, Karle H. Prophylactic effect of self-administered pump-driven subcutaneous IgG infusion in patients with antibody deficiency: a triple-blind cross-over study comparing P-IgG levels of 3 g l-1 versus 6 g l-1. J. Intern. Med.229(1), 73–77 (1991).
  • Shapiro R. Subcutaneous immunoglobulin therapy by rapid push is preferred to infusion by pump: a retrospective analysis. J. Clin. Immunol.30(2), 301–307 (2010).
  • Kazatchkine MD, Bellon B, Kaveri SV. Mechanisms of action of intravenous immunoglobulin (IVIg). Mult. Scler.6(Suppl. 2), S24–S26; discussion S33 (2000).
  • Simon HU, Spath PJ. IVIg – mechanisms of action. Allergy58(7), 543–552 (2003).
  • Terness P, Opelz G. Natural anti-immunoglobulin autoantibodies: irrelevant by-products or immunoregulatory molecules? Int. Arch. Allergy Immunol.115(4), 270–277 (1998).
  • Cukrowska B, Sinkora J, Mandel L et al. Thymic B cells of pig fetuses and germ-free pigs spontaneously produce IgM, IgG and IgA: detection by ELISPOT method. Immunology87(3), 487–492 (1996).
  • Provan D, Nokes TJC, Agrawal S, Winer J, Wood P. Clinical Guidelines for Immunoglobulin Use (2nd Edition). NHS, London, UK (2008).
  • Sewell C. First National Immunoglobulin Database Report (2008–2009). NHS, London, UK (2010).
  • Gurcan HM, Keskin DB, Ahmed AR. Information for healthcare providers on general features of IGIV with emphasis on differences between commercially available products. Autoimmun. Rev.9(8), 553–559 (2010).
  • El-Shanawany T, Sewell WA, Misbah SA, Jolles S. Current clinical uses of intravenous immunoglobulin. Clin. Med.6(4), 356–359 (2006).
  • Hull JZ, Hull JH. Current clinical uses of intravenous immunoglobulin. Clin. Med.6(5), 507; author reply 507–508 (2006).
  • Jolles S, Sewell WA, Misbah SA. Clinical uses of intravenous immunoglobulin. Clin. Exp. Immunol.142(1), 1–11 (2005).
  • Shimoni Z, Bulvik S, Niveni M. Current clinical uses of intravenous immunoglobulin. Clin. Med.6(6), 621; author reply 621–622 (2006).
  • Lucas M, Lee M, Lortan J, Lopez-Granados E, Misbah S, Chapel H. Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years. J. Allergy Clin. Immunol.125(6), 1354–1360; e1354 (2010).
  • Lederman HM, Roifman CM, Lavi S, Gelfand EW. Corticosteroids for prevention of adverse reactions to intravenous immune serum globulin infusions in hypogammaglobulinemic patients. Am. J. Med.81(3), 443–446 (1986).
  • Mouthon L. Indications for intravenous immunoglobulins. Presse. Med.35(4 Pt 2), 714–719 (2006).
  • Aghamohammadi A, Farhoudi A, Moin M et al. Adverse effects of intravenous immunoglobulin therapy in patients with antibody deficiency. Iran. J. Allergy Asthma Immunol.2(3), 121–126 (2003).
  • Dashti-Khavidaki S, Aghamohammadi A, Farshadi F et al. Adverse reactions of prophylactic intravenous immunoglobulin; a 13-year experience with 3004 infusions in Iranian patients with primary immunodeficiency diseases. J. Investig. Allergol. Clin. Immunol.19(2), 139–145 (2009).
  • Bednarik J, Kadanka Z. Adverse effects of administration of intravenous human immunoglobulins. Cas. Lek. Cesk.138(21), 647–649 (1999).
  • Schiavotto C, Ruggeri M, Rodeghiero F. Adverse reactions after high-dose intravenous immunoglobulin: incidence in 83 patients treated for idiopathic thrombocytopenic purpura (ITP) and review of the literature. Haematologica78(6 Suppl. 2), 35–40 (1993).
  • Wittstock M, Zettl UK. Adverse effects of treatment with intravenous immunoglobulins for neurological diseases. J. Neurol.253(Suppl. 5), V75–V79 (2006).
  • Wu KH, Wu WM, Lu MY, Chiang BL. Inhibitory effect of pooled human immunoglobulin on cytokine production in peripheral blood mononuclear cells. Pediatr. Allergy Immunol.17(1), 60–68 (2006).
  • Pierce LR, Jain N. Risks associated with the use of intravenous immunoglobulin. Transfus. Med. Rev.17(4), 241–251 (2003).
  • Shah SR. A newer immunoglobulin intravenous (IGIV) – gammagard liquid 10%: evaluation of efficacy, safety, tolerability and impact on patient care. Expert Opin. Biol. Ther.8(6), 799–804 (2008).
  • Katz U, Achiron A, Sherer Y, Shoenfeld Y. Safety of intravenous immunoglobulin (IVIg) therapy. Autoimmun. Rev.6(4), 257–259 (2007).
  • Boger RH, Bode-Boger SM, Frolich JC. Intravenous immunoglobulins. Basic principles, selection criteria and indications for preventive and therapeutic administration. Med. Klin. (Munich)90(9), 520–526 (1995).
  • Nydegger UE. Safety and side effects of i.v. immunoglobulin therapy. Clin. Exp. Rheumatol.14(Suppl. 15), S53–S57 (1996).
  • Aghamohammadi A, Moin M, Farhoudi A et al. Efficacy of intravenous immunoglobulin on the prevention of pneumonia in patients with agammaglobulinemia. FEMS Immunol. Med. Microbiol.40(2), 113–118 (2004).
  • Kanegane H, Nomura K, Futatani T, Miyawaki T. Intravenous immunoglobulin replacement therapy in X-linked agammaglobulinemia. Nihon Rinsho Meneki Gakkai Kaishi25(4), 337–343 (2002).
  • Busse PJ, Razvi S, Cunningham-Rundles C. Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency. J. Allergy Clin. Immunol.109(6), 1001–1004 (2002).
  • Pourpak Z, Aghamohammadi A, Sedighipour L et al. Effect of regular intravenous immunoglobulin therapy on prevention of pneumonia in patients with common variable immunodeficiency. J. Microbiol. Immunol. Infect.39(2), 114–120 (2006).
  • Tcheurekdjian H, Palermo T, Hostoffer R. Quality of life in common variable immunodeficiency requiring intravenous immunoglobulin therapy. Ann. Allergy Asthma Immunol.93(2), 160–165 (2004).
  • Mushiake K, Motoyoshi F, Kondo N, Shimizu H, Orii T. Long-term follow up of patients with common variable immunodeficiency treated with intravenous immunoglobulin: reevaluation of intravenous immunoglobulin replacement therapy. IVIg therapy in CVID. Biotherapy7(2), 101–107 (1993).
  • Davies EG, Thrasher AJ. Update on the hyper immunoglobulin M syndromes. Br. J. Haematol.149(2), 167–180 (2010).
  • McLean GR, Miller KK, Schrader JW, Junker AK. Biased immunoglobulin G (IgG) subclass production in a case of hyper-IgM syndrome. Clin. Diagn. Lab. Immunol.11(6), 1192–1193 (2004).
  • Schwartz HJ, Hostoffer RW, McFadden ER Jr, Berger M. The response to intravenous immunoglobulin replacement therapy in patients with asthma with specific antibody deficiency. Allergy Asthma Proc.27(1), 53–58 (2006).
  • Skoda-Smith S, Torgerson TR, Ochs HD. Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease. Ther. Clin. Risk Manag.6, 1–10 (2010).
  • de Martino M, Galli L, Azzari C, Zammarchi E, Vierucci A. Effect of different intravenous immunoglobulin regimens on hemorrhages, platelet numbers and volume in a child with Wiskott-Aldrich syndrome. Vox. Sang.67(3), 317–319 (1994).
  • Litzman J, Jones A, Hann I, Chapel H, Strobel S, Morgan G. Intravenous immunoglobulin, splenectomy, and antibiotic prophylaxis in Wiskott-Aldrich syndrome. Arch. Dis. Child.75(5), 436–439 (1996).
  • Fontan Casariego G. [Primary immunodeficiencies. Clinical features and variant forms]. Allergol. Immunopathol. (Madr.)29(3), 101–107 (2001).
  • Buckley RH. B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review. J. Allergy Clin. Immunol.125(4), 790–797 (2010).
  • Kobrynski LJ. Combined immune deficiencies in children. J. Infus. Nurs.29(4), 206–213 (2006).
  • Minegishi Y, Saito M, Tsuchiya S et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature448(7157), 1058–1062 (2007).
  • Renner ED, Rylaarsdam S, Anover-Sombke S et al. Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(h)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J. Allergy Clin. Immunol.122(1), 181–187 (2008).
  • Sheerin KA, Buckley RH. Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. J. Allergy Clin. Immunol.87(4), 803–811 (1991).
  • DeWitt CA, Bishop AB, Buescher LS, Stone SP. Hyperimmunoglobulin E syndrome: two cases and a review of the literature. J. Am. Acad. Dermatol.54(5), 855–865 (2006).
  • Waldfahrer F, Pahl S, Federspil PA, Iro H. Hyper-IgE syndrome with ENT manifestations. Overview and case report of successful therapy with high dosage i.v. immunoglobulin. HNO47(12), 1063–1068 (1999).
  • Sun JD, Linden KG. Netherton syndrome: a case report and review of the literature. Int. J. Dermatol.45(6), 693–697 (2006).
  • Renner ED, Hartl D, Rylaarsdam S et al. Comel-Netherton syndrome defined as primary immunodeficiency. J. Allergy Clin. Immunol.124(3), 536–543 (2009).
  • Boughton BJ, Jackson N, Lim S, Smith N. Randomized trial of intravenous immunoglobulin prophylaxis for patients with chronic lymphocytic leukaemia and secondary hypogammaglobulinaemia. Clin. Lab. Haematol.17(1), 75–80 (1995).
  • Chapel HM, Hargreaves R, Lee M, Pamphilon D. Intravenous immunoglobulin therapy in patients with multiple myeloma. Immunodeficiency4(1–4), 77–78 (1993).
  • Sokos DR, Berger M, Lazarus HM. Intravenous immunoglobulin: appropriate indications and uses in hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant.8(3), 117–130 (2002).
  • Khouri IF, Ippoliti C, Gajewski J, Przepiorka D, Champlin RE. Neutropenias following allogeneic bone marrow transplantation: response to therapy with high-dose intravenous immunoglobulin. Am. J. Hematol.52(4), 313–315 (1996).
  • Nasman Bjork I, Fesel C, Brissac C, Lundkvist I. Prophylactic intravenous immunoglobulin treatment influences serum immunoglobulin M repertoire development after allogeneic bone marrow transplantation. Scand. J. Immunol.50(1), 73–82 (1999).
  • Sullivan KM, Kansu E, Storer B et al. Intravenous immunoglobulin and the risk of hepatic veno-occlusive disease after bone marrow transplantation. Biol. Blood Marrow Transplant.4(1), 20–26 (1998).
  • Winston DJ, Antin JH, Wolff SN et al. A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation. Bone Marrow Transplant.28(2), 187–196 (2001).
  • Ohlsson A, Lacy J. Intravenous immunoglobulin for suspected or subsequently proven infection in neonates. Cochrane Database Syst. Rev. (3), CD001239 (2010).
  • Cohen-Wolkowiez M, Benjamin DK Jr, Capparelli E. Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr. Opin. Pediatr.21(2), 177–181 (2009).
  • Forsyth BW. Primary care of children with HIV infection. Curr. Opin. Pediatr.7(5), 502–512 (1995).
  • Cikurel K, Schiff L, Simpson DM. Pilot study of intravenous immunoglobulin in HIV-associated myelopathy. AIDS Patient Care STDS23(2), 75–78 (2009).
  • Lindkvist A, Eden A, Norstrom MM et al. Reduction of the HIV-1 reservoir in resting CD4+ T-lymphocytes by high dosage intravenous immunoglobulin treatment: a proof-of-concept study. AIDS Res. Ther.6, 15 (2009).
  • de Sanctis JT, Cumbo-Nacheli G, Dobbie D, Baumgartner D. HIV-associated nemaline rod myopathy: role of intravenous immunoglobulin therapy in two persons with HIV/AIDS. AIDS Read.18(2), 90–94 (2008).
  • Huang LC, Myer L, Jaspan HB. The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: a retrospective cohort study. BMC Infect. Dis.8, 127 (2008).
  • Church JA, Fox S, Gomperts E. Effects of high-dose intravenous immunoglobulin on virus load in HIV-infected children. J. Acquir. Immune Defic. Syndr.22(3), 309–311 (1999).
  • Grisaru-Soen G, Lau W, Arneson C et al. Randomized controlled trial of short-term withdrawal of i.v. immunoglobulin therapy for selected children with human immunodeficiency virus infection. Pediatr. Int.49(6), 972–977 (2007).
  • Coggeshall KM. Inhibitory signaling by B cell Fc γ RIIb. Curr. Opin. Immunol.10(3), 306–312 (1998).
  • Kazatchkine MD, Kaveri SV. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N. Engl. J. Med.345(10), 747–755 (2001).
  • Hurez V, Kaveri SV, Mouhoub A et al. Anti-CD4 activity of normal human immunoglobulin G for therapeutic use. (Intravenous immunoglobulin, IVIg). Ther. Immunol.1(5), 269–277 (1994).
  • Kaveri S, Vassilev T, Hurez V et al. Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use. J. Clin. Invest.97(3), 865–869 (1996).
  • Molgo M, Carreno N, Hoyos-Bachiloglu R, Andresen M, Gonzalez S. Use of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis and Stevens–Johnson/toxic epidermal necrolysis overlap syndrome. Review of 15 cases. Rev. Med. Chil.137(3), 383–389 (2009).
  • Horwitz MS, Sarvetnick N. Viruses, host responses, and autoimmunity. Immunol. Rev.169, 241–253 (1999).
  • Guilpain P, Chanseaud Y, Tamby MC et al. Immunomodulatory effects of intravenous immunoglobulins. Presse Med.33(17), 1183–1194 (2004).
  • Basta M, Kirshbom P, Frank MM, Fries LF. Mechanism of therapeutic effect of high-dose intravenous immunoglobulin. Attenuation of acute, complement-dependent immune damage in a guinea pig model. J. Clin. Invest.84(6), 1974–1981 (1989).
  • Mouthon L, Lacroix-Desmazes S, Pashov A, Kaveri SV, Kazatchkine MD. Immunomodulatory effects of intravenous immunoglobulins in autoimmune diseases. Rev. Med. Interne.20(Suppl. 4), 423S–430S (1999).
  • Sapir T, Blank M, Shoenfeld Y. Immunomodulatory effects of intravenous immunoglobulins as a treatment for autoimmune diseases, cancer, and recurrent pregnancy loss. Ann. NY Acad. Sci.1051, 743–778 (2005).
  • Gullestad L, Aukrust P. Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches. Am. J. Cardiol.95(11A), 17C–23C; discussion 38C–40C (2005).
  • Udi N, Yehuda S. Intravenous immunoglobulin – indications and mechanisms in cardiovascular diseases. Autoimmun. Rev.7(6), 445–452 (2008).
  • Wolf HH, Davies SV, Borte M et al. Efficacy, tolerability, safety and pharmacokinetics of a nanofiltered intravenous immunoglobulin: studies in patients with immune thrombocytopenic purpura and primary immunodeficiencies. Vox. Sang.84(1), 45–53 (2003).
  • Tellier Z, Mouthon L. Therapeutic indications of intravenous immunoglobulins. Transfus. Clin. Biol.10(3), 179–184 (2003).
  • Grenouillet-Delacrea M, Longy-Boursier M. Human immunoglobulins, adverse drug reaction, prevention. Rev. Med. Interne29(2), 24–28 (2008).
  • Howman RA, Barr AL, Shand AW, Dickinson JE. Antenatal intravenous immunoglobulin in chronic immune thrombocytopenic purpura: case report and literature review. Fetal Diagn. Ther.25(1), 93–97 (2009).
  • Robak T, Salama A, Kovaleva L et al. Efficacy and safety of PrIVIgen, a novel liquid intravenous immunoglobulin formulation, in adolescent and adult patients with chronic immune thrombocytopenic purpura. Hematology14(4), 227–236 (2009).
  • Tavil B, Unal S, Aytac-Elmas S, Yetgin S. Weekly long-term intravenous immunoglobulin for refractory parvovirus B19 and Epstein–Barr virus-induced immune thrombocytopenic purpura. Turk. J. Pediatr.50(1), 74–77 (2008).
  • Gereige RS, Barrios NJ. Treatment of childhood acute immune thrombocytopenic purpura with high-dose methylprednisolone, intravenous immunoglobulin, or the combination of both. P. R. Health Sci. J.19(1), 15–18 (2000).
  • Kocak U, Gursel T, Ozturk G. The effect of steroid and intravenous immunoglobulin on thrombopoietin levels in pediatric patients with immune thrombocytopenic purpura. Blood Coagul. Fibrinolysis11(2), 121–125 (2000).
  • Kierzkowska B, Lipinska J, Baranska D et al. Takayasu’s arteritis mimicking Kawasaki disease in 7-month-old infant, successfully treated with glucocorticosteroids and intravenous immunoglobulins. Rheumatol. Int. DOI: 10.1007/s00296-010-1518-yOnline First™ (2010) (Epub ahead of print).
  • Khan S, Dore PC, Sewell WA. Both patient characteristics and IVIg product-specific mechanisms may affect eosinophils in immunoglobulin-treated Kawasaki disease. Pediatr. Allergy Immunol.19(2), 186–187 (2008).
  • Morgan GJ, MacLeod C, Jenkins J, Stewart C, Craig B. IVIg, aspirin, and Kawasaki disease. J. Pediatr.143(2), 280–281; author reply 281 (2003).
  • Sakata K, Hamaoka K, Ozawa S et al. A randomized prospective study on the use of 2 g-IVIg or 1 g-IVIg as therapy for Kawasaki disease. Eur. J. Pediatr.166(6), 565–571 (2007).
  • Soltner E, Neel A, Tiab M et al. Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIg therapy. Joint Bone Spine76(5), 559–561 (2009).
  • Takatsuki S, Ito Y, Takeuchi D et al. IVIg reduced vascular oxidative stress in patients with Kawasaki disease. Circ. J.73(7), 1315–1318 (2009).
  • Suzuki H, Uemura S, Tone S et al. Effects of immunoglobulin and γ-interferon on the production of tumour necrosis factor-α and interleukin-1 β by peripheral blood monocytes in the acute phase of Kawasaki disease. Eur. J. Pediatr.155(4), 291–296 (1996).
  • Bril V, Ilse WK, Pearce R, Dhanani A, Sutton D, Kong K. Pilot trial of immunoglobulin versus plasma exchange in patients with Guillain–Barré syndrome. Neurology46(1), 100–103 (1996).
  • Diener HC, Haupt WF, Kloss TM et al. A preliminary, randomized, multicenter study comparing intravenous immunoglobulin, plasma exchange, and immune adsorption in Guillain–Barré syndrome. Eur. Neurol.46(2), 107–109 (2001).
  • Kleyweg RP, van der Meche FG, Schmitz PI. A randomized trial comparing intravenous immunoglobulin and plasma exchange in Guillain–Barré syndrome. Transfus. Sci.15(4), 389–392 (1994).
  • Hughes RA, Raphael JC, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain–Barré syndrome. Cochrane Database Syst. Rev. (1), CD002063 (2006).
  • Buzzigoli SB, Genovesi M, Lambelet P, Logi C, Raffaelli S, Cattano D. Plasmapheresis treatment in Guillain–Barré syndrome: potential benefit over intravenous immunoglobulin. Anaesth. Intensive Care38(2), 387–389 (2010).
  • Hughes RA, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain–Barré syndrome. Cochrane Database Syst. Rev. (6), CD002063 (2010).
  • Matsuzawa Y, Sakakibara R, Shoda T, Kishi M, Ogawa E. Good maternal and fetal outcomes of predominantly sensory Guillain–Barré syndrome in pregnancy after intravenous immunoglobulin. Neurol. Sci.31(2), 201–203 (2010).
  • Mori I, Parizot C, Dorgham K et al. Prominent plasmacytosis following intravenous immunoglobulin correlates with clinical improvement in Guillain–Barré syndrome. PLoS ONE3(5), e2109 (2008).
  • Rhee DY, Park GH, Chang SE et al. Pompholyx after intravenous immunoglobulin therapy for treatment of Guillain–Barré syndrome. J. Eur. Acad. Dermatol. Venereol.23(5), 602–604 (2009).
  • Korinthenberg R, Schessl J, Kirschner J, Monting JS. Intravenously administered immunoglobulin in the treatment of childhood Guillain–Barré syndrome: a randomized trial. Pediatrics116(1), 8–14 (2005).
  • Elovaara I, Apostolski S, van Doorn P et al. EFNS guidelines for the use of intravenous immunoglobulin in treatment of neurological diseases: EFNS task force on the use of intravenous immunoglobulin in treatment of neurological diseases. Eur. J. Neurol.15(9), 893–908 (2008).
  • Comi G, Quattrini A, Fazio R, Roveri L. Immunoglobulins in chronic inflammatory demyelinating polyneuropathy. Neurol. Sci.24(Suppl. 4), S246–S250 (2003).
  • Blackhouse G, Gaebel K, Xie F et al. Cost-utility of intravenous immunoglobulin (IVIg) compared with corticosteroids for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) in Canada. Cost Eff. Resour. Alloc.8, 14 (2010).
  • Kubori T, Mezaki T, Kaji R et al. The clinical usefulness of high-dose intravenous immunoglobulin therapy for chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. No To Shinkei51(2), 127–135 (1999).
  • Jann S, Bramerio MA, Facchetti D, Sterzi R. Intravenous immunoglobulin is effective in patients with diabetes and with chronic inflammatory demyelinating polyneuropathy: long term follow-up. J. Neurol. Neurosurg. Psychiatry80(1), 70–73 (2009).
  • Sladky JT. What is the best initial treatment for childhood chronic inflammatory demyelinating polyneuropathy: corticosteroids or intravenous immunoglobulin? Muscle Nerve38(6), 1638–1643 (2008).
  • Nobile-Orazio E, Gallia F, Tuccillo F, Terenghi F. Chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy: treatment update. Curr. Opin. Neurol.23(5), 519–523 (2010).
  • Donofrio PD, Bril V, Dalakas MC et al. Safety and tolerability of immune globulin intravenous in chronic inflammatory demyelinating polyradiculoneuropathy. Arch. Neurol.67(9), 1082–1088 (2010).
  • Kuitwaard K, van den Berg LH, Vermeulen M et al. Randomised controlled trial comparing two different intravenous immunoglobulins in chronic inflammatory demyelinating polyradiculoneuropathy. J. Neurol. Neurosurg. Psychiatry81(12), 1374–1379 (2010).
  • Latov N, Deng C, Dalakas MC et al. Timing and course of clinical response to intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy. Arch. Neurol.67(7), 802–807 (2010).
  • Boerio D, Creange A, Hogrel JY, Gueguen A, Bertrand D, Lefaucheur JP. Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy. J. Neurol. Sci.292(1–2), 63–71 (2010).
  • van der Pol WL, Cats EA, van den Berg LH. Intravenous immunoglobulin treatment in multifocal motor neuropathy. J. Clin. Immunol.30(Suppl. 1), S79–S83 (2010).
  • Harbo T, Andersen H, Hess A, Hansen K, Sindrup SH, Jakobsen J. Subcutaneous versus intravenous immunoglobulin in multifocal motor neuropathy: a randomized, single-blinded cross-over trial. Eur. J. Neurol.16(5), 631–638 (2009).
  • Leger JM, Viala K, Cancalon F et al. Intravenous immunoglobulin as short- and long-term therapy of multifocal motor neuropathy: a retrospective study of response to IVIg and of its predictive criteria in 40 patients. J. Neurol. Neurosurg. Psychiatry79(1), 93–96 (2008).
  • Eftimov F, Vermeulen M, de Haan RJ, van den Berg LH, van Schaik IN. Subcutaneous immunoglobulin therapy for multifocal motor neuropathy. J. Peripher. Nerv. Syst.14(2), 93–100 (2009).
  • Bayry J, Lacroix-Desmazes S, Kaveri SV. Novel therapeutic strategies for multiple sclerosis: potential of intravenous immunoglobulin. Nat. Rev. Drug Discov.8(7), 594 (2009).
  • Cohen JA. How effective is intravenous immunoglobulin for the treatment of relapsing–remitting multiple sclerosis? Nat. Clin. Pract. Neurol.4(11), 588–589 (2008).
  • Pohlau D, Przuntek H, Sailer M et al. Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre study. Mult. Scler.13(9), 1107–1117 (2007).
  • Schwarz S, Meinck HM, Storch-Hagenlocher B. Intravenous immunoglobulins in multiple sclerosis. An update. Nervenarzt80(8), 918–928 (2009).
  • Liu JF, Wang WX, Xue J et al. Comparing the autoantibody levels and clinical efficacy of double filtration plasmapheresis, immunoadsorption, and intravenous immunoglobulin for the treatment of late-onset myasthenia gravis. Ther. Apher. Dial.14(2), 153–160 (2010).
  • Pittayanon R, Treeprasertsuk S, Phanthumchinda K. Plasmapheresis or intravenous immunoglobulin for myasthenia gravis crisis in King Chulalongkorn Memorial Hospital. J. Med. Assoc. Thai.92(4), 478–482 (2009).
  • Gajdos P, Chevret S. Treatment of myasthenia gravis acute exacerbations with intravenous immunoglobulin. Ann. NY Acad. Sci.1132, 271–275 (2008).
  • Gajdos P, Chevret S, Toyka K. Intravenous immunoglobulin for myasthenia gravis. Cochrane Database Syst. Rev. (1), CD002277 (2008).
  • Jensen P, Bril V. A comparison of the effectiveness of intravenous immunoglobulin and plasma exchange as preoperative therapy of myasthenia gravis. J. Clin. Neuromuscul. Dis.9(3), 352–355 (2008).
  • Buchwald B, Ahangari R, Weishaupt A, Toyka KV. Presynaptic effects of immunoglobulin G from patients with Lambert–Eaton myasthenic syndrome: their neutralization by intravenous immunoglobulins. Muscle Nerve31(4), 487–494 (2005).
  • Peterlin BL, Flood W, Kothari MJ. Use of intravenous immunoglobulin in Lambert–Eaton myasthenic syndrome. J. Am. Osteopath. Assoc.102(12), 682–684 (2002).
  • Gerschlager W, Brown P. Effect of treatment with intravenous immunoglobulin on quality of life in patients with stiff-person syndrome. Mov. Disord.17(3), 590–593 (2002).
  • Mikaeloff Y, Jambaque I, Mayer M, Ponsot G, Kalifa G, Carel JC. Benefit of intravenous immunoglobulin in autoimmune stiff-person syndrome in a child. J. Pediatr.139(2), 340 (2001).
  • Shiraishi H, Motomura M, Iwanaga H et al. Successful treatment in a patient with a focal form of stiff-person syndrome using plasma exchange and intravenous immunoglobulin therapy. Rinsho Shinkeigaku42(8), 766–770 (2002).
  • Overell JR, Hsieh ST, Odaka M, Yuki N, Willison HJ. Treatment for Fisher syndrome, Bickerstaff’s brainstem encephalitis and related disorders. Cochrane Database Syst. Rev. (1), CD004761 (2007).
  • Mori M, Kuwabara S, Fukutake T, Hattori T. Intravenous immunoglobulin therapy for Miller Fisher syndrome. Neurology68(14), 1144–1146 (2007).
  • Bennetto LP, Lyons P. Miller Fisher syndrome associated with pasteurella multocida infection. J. Neurol. Neurosurg. Psychiatry75(12), 1786–1787 (2004).
  • Kaushik P, Cohen AJ, Zuckerman SJ et al. Miller fisher variant of Guillain–Barré syndrome requiring a cardiac pacemaker in a patient on tacrolimus after liver transplantation. Ann. Pharmacother.39(6), 1124–1127 (2005).
  • Comi G, Roveri L, Swan A et al. A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy. J. Neurol.249(10), 1370–1377 (2002).
  • Gorson KC, Ropper AH, Weinberg DH, Weinstein R. Efficacy of intravenous immunoglobulin in patients with IgG monoclonal gammopathy and polyneuropathy. Arch. Neurol.59(5), 766–772 (2002).
  • Kizawa M, Mori K, Iijima M, Koike H, Hattori N, Sobue G. Intravenous immunoglobulin treatment in painful sensory neuropathy without sensory ataxia associated with Sjogren’s syndrome. J. Neurol. Neurosurg. Psychiatry77(8), 967–969 (2006).
  • Taguchi Y, Takashima S, Takata M, Dougu N, Asaoka E, Inoue H. High-dose intravenous immunoglobulin in the treatment of sensory ataxic neuropathy with Sjogren’s syndrome: a case report. No To Shinkei56(5), 421–424 (2004).
  • Levy Y, Uziel Y, Zandman GG et al. Intravenous immunoglobulins in peripheral neuropathy associated with vasculitis. Ann. Rheum. Dis.62(12), 1221–1223 (2003).
  • Tsurikisawa N, Taniguchi M, Saito H et al. Treatment of Churg–Strauss syndrome with high-dose intravenous immunoglobulin. Ann. Allergy Asthma Immunol.92(1), 80–87 (2004).
  • Nobuhara Y, Saito M, Goto R et al. Chronic progressive sensory ataxic neuropathy associated with limited systemic sclerosis. J. Neurol. Sci.241(1–2), 103–106 (2006).
  • Carpo M, Meucci N, Allaria S et al. Anti-sulfatide IgM antibodies in peripheral neuropathy. J. Neurol. Sci.176(2), 144–150 (2000).
  • Heaney D, Geddes JF, Nagendren K, Swash M. Sarcoid polyneuropathy responsive to intravenous immunoglobulin. Muscle Nerve29(3), 447–450 (2004).
  • Ponsford S, Willison H, Veitch J, Morris R, Thomas PK. Long-term clinical and neurophysiological follow-up of patients with peripheral, neuropathy associated with benign monoclonal gammopathy. Muscle Nerve23(2), 164–174 (2000).
  • Gondim FA, Brannagan TH 3rd, Sander HW, Chin RL, Latov N. Peripheral neuropathy in patients with inflammatory bowel disease. Brain128(Pt 4), 867–879 (2005).
  • Caporale CM, Capasso M, Ragno M, Di Muzio A, Uncini A. Lewis–Sumner syndrome in hepatitis C virus infection: a possible pathogenetic association with therapeutic problems. Muscle Nerve34(1), 116–121 (2006).
  • Odum J, D’Costa D, Freeth M, Taylor D, Smith N, MacWhannell A. Cryoglobulinaemic vasculitis caused by intravenous immunoglobulin treatment. Nephrol. Dial. Transplant16(2), 403–406 (2001).
  • Vrancken AF, Notermans NC, Jansen GH, Wokke JH, Said G. Progressive idiopathic axonal neuropathy – a comparative clinical and histopathological study with vasculitic neuropathy. J. Neurol.251(3), 269–278 (2004).
  • Gorson KC, Ropper AH. Idiopathic distal small fiber neuropathy. Acta Neurol. Scand.92(5), 376–382 (1995).
  • Dalakas MC, Sonies B, Dambrosia J, Sekul E, Cupler E, Sivakumar K. Treatment of inclusion-body myositis with IVIg: a double-blind, placebo-controlled study. Neurology48(3), 712–716 (1997).
  • Nakajima M, Fujioka S, Ohno H, Iwamoto K. Partial but rapid recovery from paralysis after immunomodulation during early stage of neuralgic amyotrophy. Eur. Neurol.55(4), 227–229 (2006).
  • Takakura Y, Murai H, Furuya H, Ochi H, Kira J. A case of brachial amyotrophic diplegia accompanied with Sjogren’s syndrome presenting good response to immunotherapies in the early course of the disease. Rinsho Shinkeigaku45(5), 346–350 (2005).
  • Pascoe MK, Low PA, Windebank AJ, Litchy WJ. Subacute diabetic proximal neuropathy. Mayo Clin. Proc.72(12), 1123–1132 (1997).
  • Fernandes Filho JA, Nathan BM, Palmert MR, Katirji B. Diabetic amyotrophy in an adolescent responsive to intravenous immunoglobulin. Muscle Nerve32(6), 818–820 (2005).
  • Morii T, Fujita H, Toyoshima I, Sageshima M, Ito S. Efficacy of immunoglobulin and prednisolone in diabetic amyotrophy. Endocr. J.50(6), 831–832 (2003).
  • Tellier Z, Andre MH, Polack B. Management of haemophilia A-inhibitor patients: clinical and regulatory perspectives. Clin. Rev. Allergy Immunol.37(2), 125–134 (2009).
  • Gianella-Borradori A, Hirt A, Luthy A, Wagner HP, Imbach P. Haemophilia due to factor VIII inhibitors in a patient suffering from an autoimmune disease: treatment with intravenous immunoglobulin. A case report. Blut48(6), 403–407 (1984).
  • Seifried E, Gaedicke G, Pindur G, Rasche H. The treatment of haemophilia A inhibitor with high dose intravenous immunoglobulin. Blut48(6), 397–401 (1984).
  • Hoppe B, Gaedicke G, Kiesewetter H, Salama AR. Response to intravenous immunoglobulin G in an infant with immunoglobulin A-associated autoimmune haemolytic anaemia. Vox. Sang.86(2), 151–153 (2004).
  • Macintyre EA, Linch DC, Macey MG, Newland AC. Successful response to intravenous immunoglobulin in autoimmune haemolytic anaemia. Br. J. Haematol.60(2), 387–388 (1985).
  • Majer RV, Hyde RD. High-dose intravenous immunoglobulin in the treatment of autoimmune haemolytic anaemia. Clin. Lab. Haematol.10(4), 391–395 (1988).
  • Murakami H, Kikuchi M, Toyama K, Ikeda Y. A case of autoimmune neutropenia and thrombocytopenia – effect of high-dose intravenous immunoglobulin. Keio J. Med.34(4), 227–232 (1985).
  • Baum S, Scope A, Barzilai A, Azizi E, Trau H. The role of IVIg treatment in severe pemphigus vulgaris. J. Eur. Acad. Dermatol. Venereol.20(5), 548–552 (2006).
  • Bystryn JC, Jiao D. IVIg selectively and rapidly decreases circulating pathogenic autoantibodies in pemphigus vulgaris. Autoimmunity39(7), 601–607 (2006).
  • Ishii N, Hashimoto T, Zillikens D, Ludwig RJ. High-dose intravenous immunoglobulin (IVIg) therapy in autoimmune skin blistering diseases. Clin. Rev. Allergy Immunol.38(2–3), 186–195 (2010).
  • Kasperkiewicz M, Schmidt E. Current treatment of autoimmune blistering diseases. Curr. Drug Discov. Technol.6(4), 270–280 (2009).
  • Roujeau JC, Ingen-Housz-Oro S, Leroux C, Joly P. Treatment of bullous pemphigoid and pemphigus. The French experience, 2009 update. G. Ital. Dermatol. Venereol.144(4), 333–338 (2009).
  • Cherin P. Intravenous immunoglobulins in the treatment of polymyositis and dermatomyositis. Ann. Med. Interne (Paris)151(Suppl. 1), 1S48–1S50 (2000).
  • Cherin P, Herson S. Intravenous immunoglobulins in polymyositis and dermatomyositis. Rev. Med. Interne20(Suppl. 4), 436S–439S (1999).
  • Luzi G, Diamanti AP, Germano V et al. Successful treatment with intravenous immunoglobulins in a patient affected by dermatomyositis/systemic lupus erythematosus overlap syndrome and tuberculosis. Clin. Immunol.125(2), 127–130 (2007).
  • Marie I, Hachulla E, Levesque H et al. Intravenous immunoglobulins as treatment of life threatening esophageal involvement in polymyositis and dermatomyositis. J. Rheumatol.26(12), 2706–2709 (1999).
  • Mouthon L. Physiopathology of polymyositis and dermatomyositis, mechanism of action of intravenous immunoglobulins. Rev. Med. Interne 25 Spec. No 3, 10–12 (2004).
  • Danieli MG, Pettinari L, Moretti R, Logullo F, Gabrielli A. Subcutaneous immunoglobulin in polymyositis and dermatomyositis: a novel application. Autoimmun. Rev.10(3), 144–149 (2010).
  • O’Neil KM. Progress in pediatric vasculitis. Curr. Opin. Rheumatol.21(5), 538–546 (2009).
  • Yazici Y. Systemic vasculitis treatment and monitoring update, 2008. Bull. NYU Hosp. Jt. Dis.66(3), 228–230 (2008).
  • Zandman-Goddard G, Blank M, Shoenfeld Y. Intravenous immunoglobulins in systemic lupus erythematosus: from the bench to the bedside. Lupus18(10), 884–888 (2009).
  • Karim MY, Pisoni CN, Khamashta MA. Update on immunotherapy for systemic lupus erythematosus – what’s hot and what’s not! Rheumatology (Oxford)48(4), 332–341 (2009).
  • LeHoang P, Cassoux N, George F, Kullmann N, Kazatchkine MD. Intravenous immunoglobulin (IVIg) for the treatment of birdshot retinochoroidopathy. Ocul. Immunol. Inflamm.8(1), 49–57 (2000).
  • Tellier Z. Human immunoglobulins in intraocular inflammation. Ann. NY Acad. Sci.1110, 337–347 (2007).
  • Phan TG, Wong RC, Crotty K, Adelstein S. Toxic epidermal necrolysis in acquired immunodeficiency syndrome treated with intravenous gammaglobulin. Australas. J. Dermatol.40(3), 153–157 (1999).
  • Andresen M, Boghero Y, Molgo M, Dougnao A, Diaz O. Toxic epidermal necrolysis. Therapy in ICU with intravenous immunoglobulins in a case. Rev. Med. Chil.128(12), 1343–1348 (2000).
  • Lissia M, Figus A, Rubino C. Intravenous immunoglobulins and plasmapheresis combined treatment in patients with severe toxic epidermal necrolysis: preliminary report. Br. J. Plast. Surg.58(4), 504–510 (2005).
  • Mangla K, Rastogi S, Goyal P, Solanki RB, Rawal RC. Efficacy of low dose intravenous immunoglobulins in children with toxic epidermal necrolysis: an open uncontrolled study. Indian J. Dermatol. Venereol. Leprol.71(6), 398–400 (2005).
  • Stella M, Clemente A, Bollero D, Risso D, Dalmasso P. Toxic epidermal necrolysis (TEN) and Stevens–Johnson syndrome (SJS): experience with high-dose intravenous immunoglobulins and topical conservative approach. A retrospective analysis. Burns33(4), 452–459 (2007).
  • Tan AW, Thong BY, Yip LW, Chng HH, Ng SK. High-dose intravenous immunoglobulins in the treatment of toxic epidermal necrolysis: an Asian series. J. Dermatol.32(1), 1–6 (2005).
  • Yuste M, Sanchez-Estella J, Santos JC et al. Stevens–Johnson syndrome/toxic epidermal necrolysis treated with intravenous immunoglobulins. Actas Dermosifiliogr.96(9), 589–592 (2005).
  • Constantinescu D, Cozmei C, Dumitrascu I, Carasevici E. The management of unexplained recurrent abortions. Is immunotherapy an option? Rev. Med. Chir. Soc. Med. Nat. Iasi.112(2), 371–378 (2008).
  • Carp HJ. Intravenous immunoglobulin: effect on infertility and recurrent pregnancy loss. Isr. Med. Assoc. J.9(12), 877–880 (2007).
  • Wegmann M, Hauber HP. Experimental approaches towards allergic asthma therapy-murine asthma models. Recent Pat. Inflamm. Allergy Drug Discov.4(1), 37–53 (2010).
  • Kovalev IE, Kovaleva VL, Rumiantseva EI. Mechanisms of the therapeutic effect of immunoglobulins in the treatment of bronchial asthma. Eksp. Klin. Farmakol.71(5), 48–51 (2008).
  • Burnett AM, Domachowske JB. Therapeutic considerations for children with invasive group A streptococcal infections: a case series report and review of the literature. Clin. Pediatr. (Phila.)46(6), 550–555 (2007).
  • Schwartz-Albiez R, Monteiro RC, Rodriguez M, Binder CJ, Shoenfeld Y. Natural antibodies, intravenous immunoglobulin and their role in autoimmunity cancer and inflammation. Clin. Exp. Immunol.158(Suppl. 1), S43–S50 (2009).
  • Berger M, Cupps TR, Fauci AS. Immunoglobulin replacement therapy by slow subcutaneous infusion. Ann. Intern. Med.93(1), 55–56 (1980).
  • Cunningham-Rundles C, Siegal FP, Smithwick EM et al. Efficacy of intravenous immunoglobulin in primary humoral immunodeficiency disease. Ann. Intern. Med.101(4), 435–439 (1984).
  • Quartier P, Debre M, De Blic J et al. Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients. J. Pediatr.134(5), 589–596 (1999).
  • Webb DB, Kendra JR, Gross E, Stamatakis JD. Infusion of intravenous immunoglobulin via implantable subcutaneous catheter. Lancet337(8757), 1617–1618 (1991).
  • Gaspar J, Gerritsen B, Jones A. Immunoglobulin replacement treatment by rapid subcutaneous infusion. Arch. Dis. Child.79(1), 48–51 (1998).
  • Arora R, Newton TC, Nelson MR. Subcutaneous immunoglobulin therapy in an 11-year-old patient with common variable immunodeficiency and von Willebrand disease. Ann. Allergy Asthma Immunol.99(4), 367–370 (2007).
  • Gardulf A, Hammerstrom L, Smith CI. Hometreatment of hypogammaglobulinaemia with subcutaneous gammaglobulin by rapid infusion. Lancet338, 162–166 (1991).
  • Thomas MJ, Brennan VM, Chapel HH. Rapid subcutaneous immunoglobulin infusions in children. Lancet342(8884), 1432–1433 (1993).
  • Abrahamsen TG, Sandersen H, Bustnes A. Home therapy with subcutaneous immunoglobulin infusions in children with congenital immunodeficiencies. Pediatrics98(6 Pt 1), 1127–1131 (1996).
  • Chapel HM, Spickett GP, Ericson D, Engl W, Eibl MM, Bjorkander J. The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy. J. Clin. Immunol.20(2), 94–100 (2000).
  • Nicolay U, Kiessling P, Berger M et al. Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. J. Clin. Immunol.26(1), 65–72 (2006).
  • Gardulf A, Nicolay U. Replacement IgG therapy and self-therapy at home improve the health-related quality of life in patients with primary antibody deficiencies. Curr. Opin. Allergy Clin. Immunol.6(6), 434–442 (2006).
  • Moore ML, Quinn JM. Subcutaneous immunoglobulin replacement therapy for primary antibody deficiency: advancements into the 21st Century. Ann. Allergy Asthma Immunol.101(2), 114–121; quiz 122–113, 178 (2008).
  • Membe SK, Ho C, Cimon K, Morrison A, Kanani A, Roifman CM. Economic assessment of different modalities of immunoglobulin replacement therapy. Immunol. Allergy Clin. North Am.28(4), 861–874, x (2008).
  • Gardulf A, Andersen V, Bjorkander J et al. Subcutaneous immunoglobulin replacement in patients with primary antibody deficiencies: safety and costs. Lancet345(8946), 365–369 (1995).
  • Hogy B, Keinecke HO, Borte M. Pharmacoeconomic evaluation of immunoglobulin treatment in patients with antibody deficiencies from the perspective of the German statutory health insurance. Eur. J. Health Econ.6(1), 24–29 (2005).
  • Haddad L, Perrinet M, Parent D et al. Economic evaluation of at home subcutaneous and intravenous immunoglobulin substitution. Rev. Med. Interne.27(12), 924–926 (2006).
  • Misbah S, Sturzenegger MH, Borte M et al. Subcutaneous immunoglobulin: opportunities and outlook. Clin. Exp. Immunol.158(Suppl. 1), S51–S59 (2009).

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