270
Views
34
CrossRef citations to date
0
Altmetric
Drug Profile

Treatment of knee osteoarthritis with Orthokine®-derived autologous conditioned serum

&
Pages 335-345 | Published online: 10 Jan 2014

References

  • Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull. World Health Organ.81, 646–656 (2003).
  • Keenan AM, Tennant A, Fear J et al. Impact of multiple joint problems on daily living tasks in people in the community over age fifty-five. Arthritis Rheum.55, 757–764 (2006).
  • Sprangers MA, de Regt EB, Andries F et al. Which chronic conditions are associated with better or poorer quality of life? J. Clin. Epidemiol.53, 895–907 (2000).
  • Reginster J-Y. The prevalence and burden of arthritis. Rheumatology42(Suppl. 1), 3–6 (2002).
  • Hannan MT, Felson DT, Pincus T. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J. Rheumatol.27, 1513–1517 (2000).
  • Hootman JM, Helmick DG. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum.54, 226–229 (2006).
  • Ethgen O, Reginster J-Y. Degenerative musculoskeletal disease. Ann. Rheum. Dis.63, 1–3 (2004).
  • Lawrence RC, Felson DT, Helmick CG et al. Estimates of prevalence of arthritis and other rheumatic conditions in the United States. Arthritis Rheum.58(1), 26–35 (2008).
  • Felson DT. Clinical practice: osteoarthritis of the knee. N. Engl. J. Med.354, 841–848 (2006).
  • Ricci JA, Stewart WF, Chee E, Leotta C, Foley K, Hochberg MC. Pain exacerbation as a major source of lost productive time in US workers with arthritis. Arthritis Rheum.53, 673–681 (2005).
  • Mapel DW, Shainline M, Paez K, Gunter M. Hospital, pharmacy, and outpatient costs for osteoarthritis and chronic back pain. J. Rheumatol.31, 573–583 (2004).
  • Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum.41(8), 1343–1355 (1998).
  • Hunter DJ, Niu J, Zhang Y et al. Knee height, knee pain, and knee osteoarthritis: the Beijing Osteoarthritis Study. Arthritis Rheum.52(5), 1418–1423 (2005).
  • Rapp SR, Rejeski WJ, Miller ME. Physical function among older adults with knee pain: the role of pain coping skills. Arthritis Care Res.13(5), 270–279 (2000).
  • Gabriel SE, Crowson CS, Campion ME, O’Fallon WM. Direct medical costs unique to people with arthritis. J. Rheumatol.24, 719–725 (1997).
  • Gupta S, Hawker GA, Laporte A, Croxford R, Coyte PC. The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of individuals living with this condition. Rheumatology44, 1531–1537 (2005).
  • Maetzel A, Li LC, Pencharz J et al. The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann. Rheum. Dis.63, 395–401 (2004).
  • CDC. National and state medical expenditures and lost earnings attributable to arthritis and other rheumatic conditions – United States, 2003. MMWR Morb. Mortal. Wkly Rep.56(1), 4–7 (2007).
  • Jordan KM, Arden NK, Doherty M et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT). Ann. Rheum. Dis.62, 1145–1155 (2003).
  • Zhang W, Moskowitz RW, Nuki G et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part 1: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage15, 981–1000 (2007).
  • Zhang W, Moskowitz RW, Nuki G et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage16(2), 137–162 (2008).
  • Watkins PB, Kaplowitz N, Slattery JT et al. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA296(1), 87–93 (2006).
  • Bellamy N, Campbell J, Robinson V et al. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst. Rev.2(2), CD005328 (2005).
  • Towheed TE, Maxwell L, Anastassiades TP et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst. Rev.2(2), CD002946 (2005).
  • Fox BA, Stephens MM. Glucosamine hydrochloride for the treatment of osteoarthritis symptoms. Clin. Interv. Aging2(4), 599–604 (2007).
  • Fajardo M, Di Cesare PE. Disease-modifying therapies for osteoarthritis. Drugs Aging22(2), 141–161 (2005).
  • Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology39(1–2), 237–246 (2002).
  • Pelletier JP, McCollum R, Cloutier JM, Martel-Pelletier J. Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J. Rheumatol.22(Suppl. 43), 109–114 (1995).
  • Krasnokutsky S, Attur M, Palmer G, Samuels J, Abramson SB. Current concepts in the pathogenesis of osteoarthritis. Osteoarthritis Cartilage16, S1–S3 (2008).
  • Abramson SB, Attur M. Developments in the scientific understanding of osteoarthritis. Arthritis Res. Ther.11, 227 (2009).
  • Dinarello C. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol.27, 519–550 (2009).
  • Fukui N, Purple CR, Sandell LJ. Cell biology of osteoarthritis: the chondrocyte’s response to injury. Curr. Rheumatol. Rep.3(6), 496–505 (2001).
  • Goldring MB. Osteoarthritis and cartilage: the role of cytokines. Curr. Rheumatol. Rep.2(6), 459–465 (2000).
  • Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res. Ther.8(Suppl. 2), S3 (2006).
  • Arend WP, Leung DYM. IgG induction of IL-1 receptor antagonist production by human monocytes. Immunol. Rev.139, 71–78 (1994).
  • Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu. Rev. Immunol.16, 27–35 (1998).
  • Arend WP. Interleukin 1 receptor antagonist. A new member of the interleukin 1 family. J. Clin. Invest.88, 1445–1451 (1991).
  • Firestein GS, Berger AE, Tracey DE et al. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. J. Immunol.149(3), 1054–1062 (1992).
  • Bandara G, Robbins PD, Georgescu HI, Mueller GM, Glorioso JC, Evans CH. Gene transfer synoviocytes: prospects for gene treatment of arthritis. DNA Cell Biol.11(3), 227–231 (1992).
  • Bander G, Mueller GM, Galea-Lauri J et al. Intraarticular expression of biologically active interleukin-1 receptor-antagonist protein by ex vivo gene transfer. Proc. Natl Acad. Sci.99, 10764–10768 (1993).
  • Goldring MB. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect. Tissue Res.40(1), 1–11 (1999).
  • Fernandes J, Tardiff, G, Martel-Pelletier J et al.In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritis rabbit knee joints. Am. J. Pathol.154(4), 1159–1169 (1999).
  • Frisbee DD, Ghivizzani SC, Robbins PD et al. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther.9(1), 12–20 (2002).
  • Zhang X, Mao Z, Yu C. Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J. Orthop. Res.22(4), 742–750 (2004).
  • Pelletier JP, Canon JP, Evans D et al.In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum.40(6), 1012–1029 (1997).
  • Chevalier X, Giraudeau B, Conrozier T et al. Safety study of intra-articular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. J. Rheumatol.32(7), 1317–1323 (2005).
  • Chevalier X, Gopille P, Beaulieu AD et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum.61(3), 344–352 (2009).
  • Meijer H, Reinecke J, Becker C, Tholen G, Wehling P. The production of anti-inflammatory cytokines in whole blood by physico-chemical induction. Inflamm. Res.52(10), 404–407 (2003).
  • Evans CH. Novel biological approaches to the intra-articular treatment of osteoarthritis. BioDrugs19(6), 355–362 (2005).
  • Wehling P, Moser C, Frisbee D et al. Autologous conditioned serum in the treatment of orthopedic diseases: the orthokine therapy. BioDrugs21(5), 323–332 (2007).
  • Wright-Carpenter T, Opolon P, Appell HJ, Meijer H, Wehling P, Mir LM. Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model. Int. J. Sports Med.25, 582–587 (2004).
  • Wright-Carpenter T, Klein P, Schäferhoff P, Appell HJ, Mir LM, Wehling P. Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains. Int. J. Sports Med.25, 588–593 (2004).
  • Frisbee DD, Kawcak CE, McIlwraith CW. Evaluation of autologous conditioned serum using an experimental model of equine osteoarthritis. AAEP Proc. Lame. Perform. Horse51, 374–375 (2005).
  • Frisbee DD, Kawcak CE, Werpy NM, Park RD, Mcllwraith CW. Clinical, biochemical, histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am. J. Vet. Res.68, 290–296 (2007).
  • Weinberger T. Clinical experience with ACS/Orthokine/IRAP in horses. Equine Sports Med. Reprint3, 1–5 (2008).
  • Osterdahl J. Evaluation of autologous conditioned serum. Swedish Uni. Agricultural Sci.67, 1–16 (2008).
  • Baltzer AW, Moser C, Jansen SA, Krauspe R. Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis Cartilage17, 152–160 (2009).
  • Yang KGA, Raijmakers NJH, van Arkel ERA et al. Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis Cartilage16, 498–505 (2008).
  • Moser C, Baltzer AW, Jansen SA, Krauspe R. Efficacy of autologous conditioned serum (ACS-Orthokine) in osteoarthritis of the knee at two year follow-up. The German Orthokine Osteoarthritis Trial-GOAT. Osteoarthritis Cartilage15(Suppl. C), C233 (2007).
  • Goldring MB, Goldring SR. Osteoarthritis. J. Cell. Physiol.213, 626–634 (2007).
  • Polisson R. Innovative therapies in osteoarthritis. Curr. Rheumatol. Rep.3(6), 489–496 (2001).
  • Fidelis TS, Soares B, Trevisani FV. Diacerein for osteoarthritis. Cochrane Database Syst Rev.1(1), CD005117 (2006).
  • Brandt KD, Mazzuca SA, Katz BP et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum.52(7), 2015–2015 (2005).
  • Nüesch E, Rutjes AW, Trelle S, Reichenbach S, Jüni P. Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst. Rev.4(4), CD007323 (2009).
  • Evans CH, Ghivizzani SC, Robbins PD. Progress and prospects: genetic treatments for disorders of bones and joints. Gene Ther.16(8), 944–952 (2009).
  • Blaney Davidson EN, van der Kraan PM, van den Berg WB. TGF-β and osteoarthritis. Osteoarthritis Cartilage15(6), 597–604 (2007).
  • Scharstuhl A, Glansbeek HL, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB.Inhibition of endogenous TGF-β during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. J. Immunol.169, 507–514 (2002).
  • Baragi VM, Becher G, Bendele AM et al. A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis. Arthritis Rheum.60(7), 2008–2018 (2009).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.