Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence

References

• Brown DW, Croft JB, Greenlund KJ, WH Giles. Deaths from chronic obstructive pulmonary disease – United States, 2000–2005. J. Am. Med. Assoc.301(13), 1331–1333 (2009).
   Google Scholar
• Takubo Y, Guerassimov A, Ghezzo H et al. Alpha1-antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human disease. Am. J. Respir. Crit. Care Med.166(12 Pt 1), 1596–1603 (2002).
   PubMed Web of Science ®Google Scholar
• Newell JD Jr. CT of emphysema. Radiol. Clin. North Am.40(1), 31–42, (2002).
   PubMedGoogle Scholar
• Spaggiari E, Zompatori M, Verduri A et al. Early smoking-induced lung lesions in asymptomatic subjects. Correlations between high resolution dynamic CT and pulmonary function testing. Radiol. Med.109(1–2), 27–39 (2005).
   PubMed Web of Science ®Google Scholar
• Hesselbacher SE, Ross R, Schabath MB et al. Cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers. Int. J. Environ. Res. Public Health8(5), 1324–1340 (2011).
   PubMed Web of Science ®Google Scholar
• Spitz MR, Hong WK, Amos CI et al. A risk model for prediction of lung cancer. J. Natl Cancer Inst.99(9), 715–726 (2007).
   PubMed Web of Science ®Google Scholar
• Wilson DO, Weissfeld JL, Balkan A et al. Association of radiographic emphysema and airflow obstruction with lung cancer. Am. J. Respir. Crit. Care Med.178(7), 738–744 (2008).
   PubMed Web of Science ®Google Scholar
• Gregersen PK, Olsson LM. Recent advances in the genetics of autoimmune disease. Annu. Rev. Immunol.27, 363–391 (2009).
   PubMed Web of Science ®Google Scholar
• Laurell CB, Eriksson S. The serum alpha-L-antitrypsin in families with hypo-alpha-L-antitrypsinemia. Clin. Chim. Acta.11, 395–398 (1965).
   PubMed Web of Science ®Google Scholar
• Castaldi PJ, Cho MH, Cohn M et al. The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum. Mol. Genet.19(3), 526–534 (2010).
   PubMed Web of Science ®Google Scholar
• Greene CM, Hassan T, Molloy K, McElvaney NG. The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and alpha-1 anti-trypsin deficiency. Expert Rev. Respir. Med.5(3), 395–411 (2011).
   PubMed Web of Science ®Google Scholar
• Kong X, Cho MH, Anderson W et al. Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am. J. Respir. Crit. Care Med.183(1), 43–49 (2011).
   PubMed Web of Science ®Google Scholar
• Regan EA, Hokanson JE, Murphy JR et al. Genetic epidemiology of COPD (COPDGene) study design. J. Chron. Obstruct. Pulmon. Dis.7(1), 32–43 (2010).
   Google Scholar
• Pillai SG, Ge D, Zhu G et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet.5(3), e1000421 (2009).
   PubMed Web of Science ®Google Scholar
• Thorgeirsson TE, Geller F, Sulem P et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature452(7187), 638–642 (2008).
   PubMed Web of Science ®Google Scholar
• Thorgeirsson TE, Gudbjartsson DF, Surakka I et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat. Genet.42(5), 448–453 (2010).
   PubMed Web of Science ®Google Scholar
• Kaplan PD, Kuhn C, Pierce JA. The induction of emphysema with elastase. I. The evolution of the lesion and the influence of serum. J. Lab. Clin. Med.82(3), 349–356 (1973).
   PubMed Web of Science ®Google Scholar
• Shapiro SD. Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease. Am. J. Respir. Crit. Care Med.150(6 Pt 2), S160–S164 (1994).
   PubMed Web of Science ®Google Scholar
• Senior RM, Connolly NL, Cury JD, Welgus HG, Campbell EJ. Elastin degradation by human alveolar macrophages. A prominent role of metalloproteinase activity. Am. Rev. Respir. Dis.139(5), 1251–1256 (1989).
   PubMed Web of Science ®Google Scholar
• Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu. Rev. Pathol.4, 435–459 (2009).
   PubMed Web of Science ®Google Scholar
• Churg A, Zay K, Shay S et al. Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am. J. Respir. Cell Mol. Biol.27(3), 368–374 (2002).
   PubMed Web of Science ®Google Scholar
• Lee SH, Goswami S, Grudo A et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat. Med.13(5), 567–569 (2007).
   PubMed Web of Science ®Google Scholar
• Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N. Engl. J. Med.360(23), 2445–2454 (2009).
   PubMed Web of Science ®Google Scholar
• Senior RM, Griffin GL, Mecham RP et al. Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes. J. Cell Biol.99(3), 870–874 (1984).
   PubMed Web of Science ®Google Scholar
• van Houwelingen AH, Weathington NM, Verweij V et al. Induction of lung emphysema is prevented by L-arginine-threonine-arginine. FASEB Journal.22(9), 3403–3408 (2008).
   PubMedGoogle Scholar
• Weathington NM, van Houwelingen AH, Noerager BD et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat. Med.12(3), 317–323 (2006).
   PubMed Web of Science ®Google Scholar
• Saetta M, Baraldo S, Corbino L et al. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.160(2), 711–717 (1999).
   PubMed Web of Science ®Google Scholar
• Anthonisen NR, Connett JE, Murray RP. Smoking and lung function of lung health study participants after 11 years. Am. J. Respir. Crit. Care Med.166(5), 675–679 (2002).
   PubMed Web of Science ®Google Scholar
• Cosio MG, Guerassimov A. Chronic obstructive pulmonary disease. Inflammation of small airways and lung parenchyma. Am. J. Respir. Crit. Care Med.160(5 Pt 2), S21–S25 (1999).
   PubMed Web of Science ®Google Scholar
• Palmer MT, Weaver CT. Autoimmunity: increasing suspects in the CD4+ T cell lineup. Nature Immunology.11(1), 36–40 (2010).
   PubMed Web of Science ®Google Scholar
• Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu. Rev. Immunol.27, 485–517 (2009).
   PubMed Web of Science ®Google Scholar
• Fletcher JM, Lalor SJ, Sweeney CM, Tubridy N, Mills KH. T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin. Exp. Immunol.162(1), 1–11 (2010).
   PubMed Web of Science ®Google Scholar
• Shan M, Yuan X, Song L et al. Cigarette smoke induction of osteopontin (SPP1) mediates Th17 inflammation in human and experimental emphysema. Sci. Transl. Med. (4), 117 (2012).
   Google Scholar
• Hanauer SB, Cohen RD, Becker RV 3rd, Larson LR, Vreeland MG. Advances in the management of Crohn’s disease: economic and clinical potential of infliximab. Clin. Ther.20(5), 1009–1028 (1998).
   PubMedGoogle Scholar
• D’Hulst AI, Maes T, Bracke KR et al. Cigarette smoke-induced pulmonary emphysema in SCID-mice. Is the acquired immune system required? Respiratory Research.6, 147 (2005).
   PubMedGoogle Scholar
• Guerassimov A, Hoshino Y, Takubo Y et al. The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am. J. Respir. Crit. Care Med.170(9), 974–980 (2004).
   PubMed Web of Science ®Google Scholar
• Grumelli S, Corry DB, Song LZ et al. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med.1(1), e8 (2004).
   PubMed Web of Science ®Google Scholar
• Panina-Bordignon P, Papi A, Mariani M et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J. Clin. Invest.107(11), 1357–1364 (2001).
   PubMed Web of Science ®Google Scholar
• Shan M, Han-Fang Cheng HF, Song LZ et al. Lung myeloid dendritic cells coordinately induce Th1 and Th17 responses in human emphysema. Sci. Transl. Med.1, 132–140 (2009).
   Google Scholar
• Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity24(6), 677–688 (2006).
   PubMed Web of Science ®Google Scholar
• Feghali-Bostwick C, Gadgil A, Otterbein L et al. Autoantibodies in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.177(2), 156–163 (2008).
   PubMed Web of Science ®Google Scholar
• Nunez B, Sauleda J, Anto JM et al. Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.1183(8), 1025–1031 (2011).
   Google Scholar
• Greene CM, Low TB, O’Neill SJ, McElvaney NG. Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease. Am. J. Respir. Crit. Care Med.181(1), 31–35 (2009).
   PubMedGoogle Scholar
• Cottin V, Fabien N, Khouatra C, Moreira A, Cordier JF. Anti-elastin autoantibodies are not present in combined pulmonary fibrosis and emphysema. Eur. Respir. J.33(1), 219–221 (2009).
   PubMedGoogle Scholar
• Lacroix-Desmazes S, Kaveri SV, Mouthon L et al. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J. Immunol. Methods216(1–2), 117–137 (1998).
   PubMed Web of Science ®Google Scholar
• Zelenay S, Moraes Fontes MF, Fesel C, Demengeot J, Coutinho A. Physiopathology of natural auto-antibodies: the case for regulation. J. Autoimmun.29(4), 229–235 (2007).
   PubMedGoogle Scholar
• da Mota LM, dos Santos Neto LL, de Carvalho JF. Autoantibodies and other serological markers in rheumatoid arthritis: predictors of disease activity? Clin. Rheumatol.28(10), 1127–1134 (2009).
   PubMedGoogle Scholar
• Jacob N, Stohl W. Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future. Autoimmunity43(1), 84–97 (2010).
   PubMed Web of Science ®Google Scholar
• GeurtsvanKessel CH, Lambrecht BN. Division of labor between dendritic cell subsets of the lung. Mucosal Immunol.1(6), 442–450 (2008).
   PubMed Web of Science ®Google Scholar
• Mahnke K, Guo M, Lee S et al. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J. Cell Biol.151(3), 673–684 (2000).
   PubMed Web of Science ®Google Scholar
• Campbell DJ, Koch MA. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat. Rev. Immunol.11(2), 119–130 (2011).
   PubMed Web of Science ®Google Scholar
• Tsoumakidou M, Zhu J, Wang Z et al. Immunohistochemical detection of dendritic cells in human lung tissue. Histopathology51(4), 565–568 (2007).
   PubMedGoogle Scholar
• Demedts IK, Bracke KR, Van Pottelberge G et al. Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.175(10), 998–1005 (2007).
   PubMed Web of Science ®Google Scholar
• Singh M, Lee S-H, Porter P et al. Human Rhinovirus proteinase 2A induces Th1 and Th2 immunity in COPD. J. Allergy Clin. Immunol.125, 1369–1378 (2010).
   PubMed Web of Science ®Google Scholar
• Bandi V, Jakubowycz M, Kinyon C et al. Infectious exacerbations of chronic obstructive pulmonary disease associated with respiratory viruses and non-typeable Haemophilus influenzae. FEMS Immunol. Med. Microbiol.37(1), 69–75 (2003).
   PubMed Web of Science ®Google Scholar
• Seemungal T, Harper-Owen R, Bhowmik A et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.164(9), 1618–1623 (2001).
   PubMed Web of Science ®Google Scholar
• Seemungal TA, Donaldson GC, Bhowmik A, Jeffries DJ, Wedzicha JA. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.161(5), 1608–1613 (2000).
   PubMed Web of Science ®Google Scholar
• Wilkinson TMA, Donaldson GC, Johnston SL, Openshaw PJM, Wedzicha JA. Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med.173(8), 871–876 (2006).
   PubMed Web of Science ®Google Scholar
• Takeuchi O, Hoshino K, Kawai T et al. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity11(4), 443–451 (1999).
   PubMed Web of Science ®Google Scholar
• Doz E, Noulin N, Boichot E et al. Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J. Immunol.180(2), 1169–1178 (2008).
   PubMed Web of Science ®Google Scholar
• Knobloch J, Schild K, Jungck D et al. The T-helper cell type 1 immune response to Gram-negative bacterial infections is impaired in COPD. Am. J. Respir. Crit. Care Med.183(2), 204–214 (2011).
   PubMed Web of Science ®Google Scholar
• Shapiro SD, Campbell EJ, Welgus HG, Senior RM. Elastin degradation by mononuclear phagocytes. Ann. NY Acad. Sci.624, 69–80 (1991).
   PubMedGoogle Scholar
• Shapiro SD. End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on. Am. J. Respir. Crit. Care Med.164(3), 339–340 (2001).
   PubMed Web of Science ®Google Scholar