2,689
Views
95
CrossRef citations to date
0
Altmetric
Review

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

, , , &
Pages 361-373 | Published online: 10 Jan 2014

References

  • Miller FW, Pollard KM, Parks CG et al. Criteria for environmentally associated autoimmune diseases. J. Autoimmun. 39(4), 253–258 (2012).
  • Miller FW, Alfredsson L, Costenbader KH et al. Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J. Autoimmun. 39(4), 259–271 (2012).
  • Germolec D, Kono DH, Pfau JC, Pollard KM. Animal models used to examine the role of the environment in the development of autoimmune disease: findings from an NIEHS Expert Panel Workshop. J. Autoimmun. 39(4), 285–293 (2012).
  • Agmon-Levin N, Hughes GR, Shoenfeld Y. The spectrum of ASIA: ‘autoimmune (auto-inflammatory) syndrome induced by adjuvants’. Lupus 21(2), 118–120 (2012).
  • Vera-Lastra O, Medina G, Cruz-Dominguez Mdel P et al. Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld’s syndrome). Lupus 21(2), 128–135 (2012).
  • Javierre BM, Hernando H, Ballestar E. Environmental triggers and epigenetic deregulation in autoimmune disease. Discov. Med. 12(67), 535–545 (2011).
  • Rigopoulou EI, Smyk DS, Matthews CE et al. Epstein–Barr virus as a trigger of autoimmune liver diseases. Adv. Virol. 2012, 987471 (2012).
  • Costenbader KH, Gay S, Alarcón-Riquelme ME, Iaccarino L, Doria A. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun. Rev. 11(8), 604–609 (2012).
  • Darbre PD. Aluminum, antiperspirants and breast cancer. J. Inorg. Biochem. 99(9), 1912–1919 (2005).
  • Shoenfeld Y, Agmon-Levin N. ‘ASIA’ – autoimmune/inflammatory syndrome induced by adjuvants. J. Autoimmun. 36(1), 4–8 (2011).
  • Bassi N, Luisetto R, Del Prete D et al. Induction of the ‘ASIA’ syndrome in NZB/NZWF1 mice after injection of complete Freund’s adjuvant (CFA). Lupus 21(2), 203–209 (2012).
  • Kool M, Soullié T, van Nimwegen M et al. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J. Exp. Med. 205(4), 869–882 (2008).
  • Demento SL, Eisenbarth SC, Foellmer HG et al. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 27(23), 3013–3021 (2009).
  • Kuroda Y, Akaogi J, Nacionales DC et al. Distinctive patterns of autoimmune response induced by different types of mineral oil. Toxicol. Sci. 78(2), 222–228 (2004).
  • Speil C, Rzepka R. Vaccines and vaccine adjuvants as biological response modifiers. Infect. Dis. Clin. North Am. 25(4), 755–772 (2011).
  • Cabral AR, Alcocer-Varela J, Orozco-Topete R, Reyes E, Fernández-Domínguez L, Alarcón-Segovia D. Clinical, histopathological, immunological and fibroblast studies in 30 patients with subcutaneous injections of modelants including silicone and mineral oils. Rev. Invest. Clin. 46(4), 257–266 (1994).
  • Eymann R, Kim YJ, Bohle RM et al. Microstructural alterations of silicone catheters in an animal experiment: histopathology and SEM findings. Acta Neurochir. Suppl. 113, 87–90 (2012).
  • Malik AF, Hoque R, Ouyang X et al. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc. Natl Acad. Sci. USA 108(50), 20095–20100 (2011).
  • Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Adjuvants and autoimmunity. Lupus 18(13), 1217–1225 (2009).
  • Guis S, Pellissier JF, Nicoli F et al. HLA-DRB1*01 and macrophagic myofasciitis. Arthritis Rheum. 46(9), 2535–2537 (2002).
  • Mackness B, Mackness MI, Arrol S, Turkie W, Durrington PN. Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon. Br. J. Pharmacol. 122(2), 265–268 (1997).
  • O’Hanlon T, Koneru B, Bayat E et al.; Environmental Myositis Study Group. Immunogenetic differences between Caucasian women with and those without silicone implants in whom myositis develops. Arthritis Rheum. 50(11), 3646–3650 (2004).
  • Miraglia JL, Abdala E, Hoff PM et al. Immunogenicity and reactogenicity of 2009 influenza A (H1N1) inactivated monovalent non-adjuvanted vaccine in elderly and immunocompromised patients. PLoS ONE 6(11), e27214 (2011).
  • Bijl M, Kallenberg CG, van Assen S. Vaccination of the immune-compromised patients with focus on patients with autoimmune-inflammatory diseases. Neth. J. Med. 69(1), 5–13 (2011).
  • Hull JH, Mead SH, Foster OJ, Modarres-Sadeghi H. Severe vasculitic neuropathy following influenza vaccination. J. Neurol. Neurosurg. Psychiatr. 75(10), 1507–1508 (2004).
  • Urso R, Bevilacqua N, Gentile M, Biagioli D, Lauria FN. Pandemic 2009 H1N1 virus infection associated with purpuric skin lesions: a case report. J. Med. Case Reports 1(5), 132 (2011).
  • Uji M, Matsushita H, Iwata S. Microscopic polyangiitis after influenza vaccination. Intern. Med. 44(8), 892–896 (2005).
  • Konishi M, Koarada S, Yamaguchi K et al. Case of microscopic polyangiitis and giant cell arteritis after influenza vaccination. Nihon Rinsho. Meneki. Gakkai Kaishi 34(3), 154–161 (2011).
  • Ulm S, Hummel M, Emig M et al. Leukocytoclastic vasculitis and acute renal failure after influenza vaccination in an elderly patient with myelodysplastic syndrome. Onkologie 29(10), 470–472 (2006).
  • Mormile R, D’Alterio V, Treccagnoli G, Sorrentino P. Henoch-Schonlein purpura with antiphospholipid antibodies after influenza vaccination: how fearful is it in children? Vaccine 23(5), 567–568 (2004).
  • Lambert EM, Liebling A, Glusac E, Antaya RJ. Henoch-Schonlein purpura following a meningococcal vaccine. Pediatrics 112(6 Pt 1), e491 (2003).
  • Courtney PA, Patterson RN, Lee RJ. Henoch-Schönlein purpura following meningitis C vaccination. Rheumatology (Oxford). 40(3), 345–346 (2001).
  • Goodman MJ, Nordin JD, Belongia EA, Mullooly JP, Baggs J. Henoch-Schölein purpura and polysaccharide meningococcal vaccine. Pediatrics 126(2), e325–e329 (2010).
  • Wada M, Asai J, Asai A, Nakai D, Kishimoto S, Katoh N. Giant cell arteritis with polymyalgia rheumatica associated with influenza vaccination. J. Dermatol. 38(11), 1099–1101 (2011).
  • Marti J, Anton E. Polymyalgia rheumatica complicating influenza vaccination. J. Am. Geriatr. Soc. 52(8), 1412 (2004).
  • Soriano A, Verrecchia E, Marinaro A et al. Giant cell arteritis and polymyalgia rheumatica after influenza vaccination: report of 10 cases and review of the literature. Lupus 21(2), 153–157 (2012).
  • Stübgen JP. Neuromuscular disorders associated with hepatitis B vaccination. J. Neurol. Sci. 292(1-2), 1–4 (2010).
  • Begier EM, Langford CA, Sneller MC, Wise RP, Ball R; VAERS Working Group. Polyarteritis nodosa reports to the vaccine adverse event reporting system (VAERS): implications for assessment of suspected vaccine-provoked vasculitis. J. Rheumatol. 31(11), 2181–2188 (2004).
  • Ventura F, Antunes H, Brito C, Pardal F, Pereira T, Vieira AP. Cutaneous polyarteritis nodosa in a child following hepatitis B vaccination. Eur. J. Dermatol. 19(4), 400–401 (2009).
  • de Carvalho JF, Pereira RM, Shoenfeld Y. Systemic polyarteritis nodosa following hepatitis B vaccination. Eur. J. Intern. Med. 19(8), 575–578 (2008).
  • Slade BA, Leidel L, Vellozzi C et al. Postlicensure safety surveillance for quadrivalent human papillomavirus recombinant vaccine. JAMA 302(7), 750–757 (2009).
  • Soldevilla HF, Briones SF, Navarra SV. Systemic lupus erythematosus following HPV immunization or infection? Lupus 21(2), 158–161 (2012).
  • Orbach H, Agmon-Levin N, Zandman-Goddard G. Vaccines and autoimmune diseases of the adult. Discov. Med. 9(45), 90–97 (2010).
  • Schattner A. Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines. Vaccine 23(30), 3876–3886 (2005).
  • Conti F, Rezai S, Valesini G. Vaccination and autoimmune rheumatic diseases. Autoimmun. Rev. 8(2), 124–128 (2008).
  • Agmon-Levin N, Zafrir Y, Paz Z, Shilton T, Zandman-Goddard G, Shoenfeld Y. Ten cases of systemic lupus erythematosus related to hepatitis B vaccine. Lupus 18(13), 1192–1197 (2009).
  • Geier DA, Geier MR. A case-control study of serious autoimmune adverse events following hepatitis B immunization. Autoimmunity 38(4), 295–301 (2005).
  • Vista ES, Crowe SR, Thompson LF et al. Influenza vaccination can induce new-onset anticardiolipins but not β2-glycoprotein-I antibodies among patients with systemic lupus erythematosus. Lupus 21(2), 168–174 (2012).
  • Urowitz MB, Anton A, Ibanez D, Gladman DD. Autoantibody response to adjuvant and nonadjuvant H1N1 vaccination in systemic lupus erythematosus. Arthritis Care Res. (Hoboken) 63(11), 1517–1520 (2011).
  • Blank M, Israeli E, Shoenfeld Y. When APS (Hughes syndrome) met the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Lupus 21(7), 711–714 (2012).
  • Cruz-Tapias P, Blank M, Anaya JM, Shoenfeld Y. Infections and vaccines in the etiology of antiphospholipid syndrome. Curr. Opin. Rheumatol. 24(4), 389–393 (2012).
  • Altman A, Szyper-Kravitz M, Shoenfeld Y. HBV vaccine and dermatomyositis: is there an association? Rheumatol. Int. 28(6), 609–612 (2008).
  • Ramírez-Rivera J, Vega-Cruz AM, Jaume-Anselmi F. Polymyositis: rare complication of hepatitis B vaccination. An unusual cause of toxic shock syndrome. Bol. Asoc. Med. P. R. 95(6), 13–16 (2003).
  • Orbach H, Tanay A. Vaccines as a trigger for myopathies. Lupus 18(13), 1213–1216 (2009).
  • Sibilia J, Maillefert JF. Vaccination and rheumatoid arthritis. Ann. Rheum. Dis. 61(7), 575–576 (2002).
  • Harrison BJ, Thomson W, Pepper L et al. Patients who develop inflammatory polyarthritis (IP) after immunization are clinically indistinguishable from other patients with IP. Br. J. Rheumatol. 36(3), 366–369 (1997).
  • Pope JE, Stevens A, Howson W, Bell DA. The development of rheumatoid arthritis after recombinant hepatitis B vaccination. J. Rheumatol. 25(9), 1687–1693 (1998).
  • Geier DA, Geier MR. A case-control study of serious autoimmune adverse events following hepatitis B immunization. Autoimmunity 38(4), 295–301 (2005).
  • Elkayam O, Yaron M, Caspi D. Safety and efficacy of vaccination against hepatitis B in patients with rheumatoid arthritis. Ann. Rheum. Dis. 61(7), 623–625 (2002).
  • Elkayam O, Paran D, Caspi D et al. Immunogenicity and safety of pneumococcal vaccination in patients with rheumatoid arthritis or systemic lupus erythematosus. Clin. Infect. Dis. 34(2), 147–153 (2002).
  • Stratton KR, Howe CJ, Johnston RB Jr (Eds). Adverse events associated with childhood vaccines: evidence bearing on causality. National Academy Press, Washington, DC, USA, 464 (1994).
  • Lasky T, Terracciano GJ, Magder L et al. The Guillain–Barré syndrome and the 1992–1993 and 1993–1994 influenza vaccines. N. Engl. J. Med. 339(25), 1797–1802 (1998).
  • Roscelli JD, Bass JW, Pang L. Guillain–Barré syndrome and influenza vaccination in the US Army, 1980–1988. Am. J. Epidemiol. 133(9), 952–955 (1991).
  • Nachamkin I, Shadomy SV, Moran AP et al. Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain–Barré syndrome. J. Infect. Dis. 198(2), 226–233 (2008).
  • Lei T, Siu KL, Kok KH et al. Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus. Vaccine 30(16), 2605–2610 (2012).
  • Hartung HP, Keller-Stanislawski B, Hughes RA, Lehmann HC. Guillain–Barré syndrome after exposure to influenza. Nervenarzt 83(6), 714–730 (2012).
  • Shaikh AG, Termsarasab P, Nwankwo C, Rao-Frisch A, Katirji B. Atypical forms of Guillain–Barré syndrome and H1N1-influenza vaccination. Vaccine 30(22), 3251–3254 (2012).
  • Bardage C, Persson I, Ortqvist A, Bergman U, Ludvigsson JF, Granath F. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. BMJ 343, d5956 (2011).
  • Mendes MF, Valladares Neto Dde C, Azevedo RA, Caramelli P. Narcolepsy after A/H1N1 vaccination. Clinics (Sao Paulo) 67(1), 77–78 (2012).
  • Zaracostas J. WHO backs further probes info possible link between H1N1 vaccine and narcolepsy in children. BMJ 342, d909 (2011).
  • Dauvilliers Y, Montplaisir J, Cochen V et al. Post-H1N1 narcolepsy-cataplexy. Sleep 33(11), 1428–1430 (2010).
  • Swedish Medical Agency. Swedish Medical Products Agency publishes report from a case inventory study on Pandemrix vaccination and development of narcolepsy with cataplexy. Euro Surveill. 16(26) (2011).
  • Han F, Lin L, Warby SC et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann. Neurol. 70(3), 410–417 (2011).
  • Erälinna JP. Vaccinations and neurological disease. Duodecim. 126(7), 803–809 (2010).
  • Farez MF, Correale J. Immunizations and risk of multiple sclerosis: systematic review and meta-analysis. J. Neurol. 258(7), 1197–1206 (2011).
  • Huynh W, Cordato DJ, Kehdi E, Masters LT, Dedousis C. Post-vaccination encephalomyelitis: literature review and illustrative case. J. Clin. Neurosci. 15(12), 1315–1322 (2008).
  • Agmon-Levin N, Kivity S, Szyper-Kravitz M, Shoenfeld Y. Transverse myelitis and vaccines: a multi-analysis. Lupus 18(13), 1198–1204 (2009).
  • Hansen TS, Jess T, Vind I et al. Environmental factors in inflammatory bowel disease: a case-control study based on a Danish inception cohort. J. Crohns. Colitis 5(6), 577–584 (2011).
  • Guan Q, Ma Y, Hillman CL et al. Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis. Mol. Med. 17(7–8), 646–656 (2011).
  • Lerner A. Aluminum as an adjuvant in Crohn’s disease induction. Lupus 21(2), 231–238 (2012).
  • Gherardi RK, Coquet M, Cherin P et al. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle. Brain 124(Pt 9), 1821–1831 (2001).
  • Authier FJ, Cherin P, Creange A et al. Central nervous system disease in patients with macrophagic myofasciitis. Brain 124(Pt 5), 974–983 (2001).
  • Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Macrophagic myofaciitis a vaccine (alum) autoimmune-related disease. Clin. Rev. Allergy Immunol. 41(2), 163–168 (2011).
  • Gherardi RK, Authier FJ. Macrophagic myofasciitis: characterization and pathophysiology. Lupus 21(2), 184–189 (2012).
  • Israeli E. Gulf War syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA). Lupus 21(2), 190–194 (2012).
  • Steele L, Sastre A, Gerkovich MM, Cook MR. Complex factors in the etiology of Gulf War illness: wartime exposures and risk factors in veteran subgroups. Environ. Health Perspect. 120(1), 112–118 (2012).
  • Asa PB, Cao Y, Garry RF. Antibodies to squalene in Gulf War syndrome. Exp. Mol. Pathol. 68(1), 55–64 (2000).
  • Hajdu SD, Agmon-Levin N, Shoenfeld Y. Silicone and autoimmunity. Eur. J. Clin. Invest. 41(2), 203–211 (2011).
  • Rosenbaum J. The American College of Rheumatology statement on silicone breast implants represents a consensus. Arthritis Rheum. 39(10), 1765 (1996).
  • Janowsky EC, Kupper LL, Hulka BS. Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases. N. Engl. J. Med. 342(11), 781–790 (2000).
  • Hennekens CH, Lee IM, Cook NR et al. Self-reported breast implants and connective-tissue diseases in female health professionals. A retrospective cohort study. JAMA 275(8), 616–621 (1996).
  • Bassetto F, Vindigni V, Scarpa C, Doria A. Breast prostheses and connective tissue disease (CTD): myth or reality? Aesthetic Plast. Surg. 34(3), 257–263 (2010).
  • Bridges AJ. Rheumatic disorders in patients with silicone implants: a critical review. J. Biomater. Sci. Polym. Ed. 7(2), 147–157 (1995).
  • Ueki A, Isozaki Y, Tomokuni A et al. Different distribution of HLA class II alleles in anti-topoisomerase I autoantibody responders between silicosis and systemic sclerosis patients, with a common distinct amino acid sequence in the HLA-DQB1 domain. Immunobiology 204(4), 458–465 (2001).
  • Di Lorenzo G, Mansueto P, Melluso M et al. Morphea after silicone gel breast implantation for cosmetic reasons in an HLA-B8, DR3-positive woman. Int. Arch. Allergy Immunol. 112(1), 93–95 (1997).
  • Spiera H, Kerr LD. Scleroderma following silicone implantation: a cumulative experience of 11 cases. J. Rheumatol. 20(6), 958–961 (1993).
  • Claman HN, Robertson AD. Antinuclear antibodies and breast implants. West. J. Med. 160(3), 225–228 (1994).
  • Kivity S, Katz M, Langevitz P, Eshed I, Olchovski D, Barzilai A. Autoimmune syndrome induced by adjuvants (ASIA) in the Middle East: morphea following silicone implantation. Lupus 21(2), 136–139 (2012).
  • Lidar M, Agmon-Levin N, Langevitz P, Shoenfeld Y. Silicone and scleroderma revisited. Lupus 21(2), 121–127 (2012).
  • Levy Y, Rotman-Pikielny P, Ehrenfeld M, Shoenfeld Y. Silicone breast implantation-induced scleroderma: description of four patients and a critical review of the literature. Lupus 18(13), 1226–1232 (2009).
  • Zandman-Goddard G, Blank M, Ehrenfeld M, Gilburd B, Peter J, Shoenfeld Y. A comparison of autoantibody production in asymptomatic and symptomatic women with silicone breast implants. J. Rheumatol. 26(1), 73–77 (1999).
  • Iannello S, Belfiore F. Silicone breast prosthesis and rheumatoid arthritis: a new systemic disease: siliconosis. A case report and a critical review of the literature. Minerva Med. 89(4), 117–130 (1998).
  • Wolfe F, Anderson J. Silicone filled breast implants and the risk of fibromyalgia and rheumatoid arthritis. J. Rheumatol. 26(9), 2025–2028 (1999).
  • Jara LJ, Medina G, Gómez-Bañuelos E, Saavedra MA, Vera-Lastra O. Still’s disease, lupus-like syndrome, and silicone breast implants. A case of ‘ASIA’ (Shoenfeld’s syndrome). Lupus 21(2), 140–145 (2012).
  • Brown SL, Pennello G, Berg WA, Soo MS, Middleton MS. Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. J. Rheumatol. 28(5), 996–1003 (2001).
  • Caldeira M, Ferreira AC. Siliconosis: autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Isr. Med. Assoc. J. 14(2), 137–138 (2012).
  • Alijotas-Reig J, Garcia-Gimenez V, Llurba E, Vilardell-Tarrés M. Autoimmune/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade. Lupus 21(12), 1326–1334 (2012).
  • Alijotas-Reig J, Hindié M, Kandhaya-Pillai R, Miro-Mur F. Bioengineered hyaluronic acid elicited a nonantigenic T-cell activation: implications from cosmetic medicine and surgery to nanomedicine. J. Biomed. Mater. Res. A 95(1), 180–190 (2010).
  • Christensen L, Breiting V, Janssen M, Vuust J, Hogdall E. Adverse reactions to injectable soft tissue permanent fillers. Aesthetic Plast. Surg. 29(1), 34–48 (2005).
  • Cruz Dominguez MP, Vera-Lastra OL, Deras-Quiñones A et al. Mercury tissue deposits: a new adjuvant in autoimmune/inflammatory syndrome (ASIA). Isr. Med. Assoc. J. (2013) (In Press).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.