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Review

Seromarkers in childhood atopic dermatitis

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Pages 299-314 | Published online: 10 Jan 2014

References

  • Leung AKC, Barber KA. Managing childhood atopic dermatitis. Adv. Ther.20(3), 129–137 (2003).
  • Leung AK, Hon KL, Robson WL. Atopic dermatitis. Adv. Pediatr.54, 241–273 (2007).
  • Williams HC. Is the prevalence of atopic dermatitis increasing? Clin. Exp. Dermatol.17(6), 385–391 (1992).
  • Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J. Clin. Invest.113(5), 651–657 (2004).
  • Grillo M, Gassner L, Marshman G, Dunn S, Hudson P. Pediatric atopic eczema: the impact of an educational intervention. Pediatr. Dermatol.23(5), 428–436 (2006).
  • Leung R, Wong G, Lau J et al. Prevalence of asthma and allergy in Hong Kong schoolchildren: an ISAAC study. Eur. Respir. J.10(2), 354–360 (1997).
  • Wong GW, Hui DS, Chan HH et al. Prevalence of respiratory and atopic disorders in Chinese schoolchildren. Clin. Exp. Allergy31(8), 1225–1231 (2001).
  • Leung DY, Nicklas RA, Li JT et al. Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters. Ann. Allergy Asthma Immunol.93(3 Suppl. 2), S1–S21 (2004).
  • Abramovits W. Atopic dermatitis. J. Am. Acad. Dermatol.53(1 Suppl. 1), S86–S93 (2005).
  • Simpson EL, Hanifin JM. Atopic dermatitis. J. Am. Acad. Dermatol.53(1), 115–128 (2005).
  • Roos TC, Geuer S, Roos S, Brost H. Recent advances in treatment strategies for atopic dermatitis. Drugs64(23), 2639–2666 (2004).
  • Hon KL. Skin diseases in Chinese children at a Pediatric Dermatology Center. Pediatr. Dermatol.21(2), 109–112 (2004).
  • Hon KL, Lam MC, Leung TF et al. Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis. Ann. Acad. Med. Singapore34(10), 602–605 (2005).
  • Chamlin SL, Frieden IJ, Williams ML, Chren MM. Effects of atopic dermatitis on young American children and their families. Pediatrics114(3), 607–611 (2004).
  • Hon KL, Leung TF, Wong K et al. Does age or gender influence quality of life in children with atopic dermatitis? Clin. Exp. Dermatol.33(6), 705–709 (2008).
  • Ben Gashir MA, Seed PT, Hay RJ. Are quality of family life and disease severity related in childhood atopic dermatitis? J. Eur. Acad. Dermatol. Venereol.16(5), 455–462 (2002).
  • Ben Gashir MA. Relationship between quality of life and disease severity in atopic dermatitis/eczema syndrome during childhood. Curr. Opin. Allergy Clin. Immunol.3(5), 369–373 (2003).
  • Ben Gashir MA, Seed PT, Hay RJ. Quality of life and disease severity are correlated in children with atopic dermatitis. Br. J. Dermatol.150(2), 284–290 (2004).
  • Charman C, Chambers C, Williams H. Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring? J. Invest. Dermatol.120(6), 932–941 (2003).
  • Williams HC, Johansson SG. Two types of eczema – or are there? J. Allergy Clin. Immunol.116(5), 1064–1066 (2005).
  • Hon KL, Lam MC, Leung TF et al. Are age-specific high serum IgE levels associated with worse symptomatology in children with atopic dermatitis? Int. J. Dermatol.46(12), 1258–1262 (2007).
  • Dohil MA, Eichenfield LF. A treatment approach for atopic dermatitis. Pediatr. Ann.34(3), 201–210 (2005).
  • Rudikoff D, Lebwohl M. Atopic dermatitis. Lancet351(9117), 1715–1721 (1998).
  • Kristal L, Klein PA. Atopic dermatitis in infants and children. An update. Pediatr. Clin. North Am.47(4), 877–895 (2000).
  • Eigenmann PA. Clinical features and diagnostic criteria of atopic dermatitis in relation to age. Pediatr. Allergy Immunol.12(Suppl. 14), 69–74 (2001).
  • Hanifin JM. Atopic dermatitis. J. Am. Acad. Dermatol.6(1), 1–13 (1982).
  • Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm. Venereol. (Stockh.)2, 44–47 (1980).
  • Charman C, Williams H. Outcome measures of disease severity in atopic eczema. Arch. Dermatol.136(6), 763–769 (2000).
  • Leung DY, Jain N, Leo HL. New concepts in the pathogenesis of atopic dermatitis. Curr. Opin. Immunol.15(6), 634–638 (2003).
  • Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean WH, Shimizu H. Clinical severity correlates with impaired barrier in filaggrin-related eczema. J. Invest. Dermatol.129(3), 682–689 (2009).
  • Ong PY, Ohtake T, Brandt C et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med.347(15), 1151–1160 (2002).
  • Beltrani VS. Suggestions regarding a more appropriate understanding of atopic dermatitis. Curr. Opin. Allergy Clin. Immunol.5(5), 413–418 (2005).
  • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol.7, 145–173 (1989).
  • Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell101(5), 455–458 (2000).
  • Luster AD. Chemokines – chemotactic cytokines that mediate inflammation. N. Engl. J. Med.338(7), 436–445 (1998).
  • Borish LC, Steinke JW. 2. Cytokines and chemokines. J. Allergy Clin. Immunol.111(2 Suppl.), S460–S475 (2003).
  • Niwa Y. Elevated RANTES levels in plasma or skin and decreased plasma IL-10 levels in subsets of patients with severe atopic dermatitis. Arch. Dermatol.136(1), 125–126 (2000).
  • Taha RA, Minshall EM, Leung DY et al. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis. J. Allergy Clin. Immunol.105(5), 1002–1007 (2000).
  • Nakayama T, Fujisawa R, Yamada H et al. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 a/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int. Immunol.13(1), 95–103 (2001).
  • Kakinuma T, Nakamura K, Wakugawa M et al. Thymus and activation-regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity. J. Allergy Clin. Immunol.107(3), 535–541 (2001).
  • Nakatani T, Kaburagi Y, Shimada Y et al. CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis. J. Allergy Clin. Immunol.107(2), 353–358 (2001).
  • Vestergaard C, Yoneyama H, Murai M et al. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J. Clin. Invest.104(8), 1097–1105 (1999).
  • Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European Task Force on Atopic Dermatitis. Dermatology186(1), 23–31 (1993).
  • Kunz B, Oranje AP, Labreze L, Stalder JF, Ring J, Taieb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology195(1), 10–19 (1997).
  • Emerson RM, Charman CR, Williams HC. The Nottingham Eczema Severity Score: preliminary refinement of the Rajka and Langeland grading. Br. J. Dermatol.142(2), 288–297 (2000).
  • Hon KL, Ma KC, Wong E et al. Validation of a self-administered questionnaire in Chinese in the assessment of eczema severity. Pediatr. Dermatol.20(6), 465–469 (2003).
  • Sturgill S. Atopic dermatitis update. Curr. Opin. Pediatr.16(4), 396–401 (2004).
  • Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp. Dermatol.10(1), 11–18 (2001).
  • Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm. Venereol. Suppl.144, 13–14 (1989).
  • Charman CR, Venn AJ, Williams HC. Measurement of body surface area involvement in atopic eczema: an impossible task? Br. J. Dermatol.140(1), 109–111 (1999).
  • Hon KL, Leung TF, Wong Y, Fok TF. Lesson from performing SCORADs in children with atopic dermatitis: subjective symptoms do not correlate well with disease extent or intensity. Int. J. Dermatol.45(6), 728–730 (2006).
  • Leung TF, Ma KC, Hon KL et al. Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children. Pediatr. Allergy Immunol.14(4), 296–301 (2003).
  • Hon K, Leung T, Ma K, Li A, Wong Y, Fok TF. Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Clin. Exp. Dermatol.29(3), 293–296 (2004).
  • Hon KL, Leung TF, Ma KC et al. Serum concentration of IL-18 correlates with disease extent in young children with atopic dermatitis. Pediatr. Dermatol.21(6), 619–622 (2004).
  • Leung TF, Wong CK, Chan IH, Ip WK, Lam CW, Wong GW. Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma. J. Allergy Clin. Immunol.110(3), 404–409 (2002).
  • Leung TF, Wong CK, Lam CW et al. Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children. Eur. Respir. J.21, 616–620 (2003).
  • Fujisawa T, Fujisawa R, Kato Y et al. Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. J. Allergy Clin. Immunol.110(1), 139–146 (2002).
  • Sugawara N, Yamashita T, Ote Y, Miura M, Terada N, Kurosawa M. TARC in allergic disease. Allergy57(2), 180–181 (2002).
  • Adema GJ, Hartgers F, Verstraten R et al. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature387(6634), 713–717 (1997).
  • Hieshima K, Imai T, Baba M et al. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 a/LD78 a and chemotactic for T lymphocytes, but not for monocytes. J. Immunol.159(3), 1140–1149 (1997).
  • Tasaki Y, Fukuda S, Iio M et al. Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1a/LD78a-like genes. Genomics55(3), 353–357 (1999).
  • Gunther C, Bello-Fernandez C, Kopp T et al. CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J. Immunol.174(3), 1723–1728 (2005).
  • Hon KL, Ching GK, Wong KY, Leung TF, Leung AK. A pilot study to explore the usefulness of antibody array in childhood atopic dermatitis. J. Nat. Med. Assoc.100(5), 500–504 (2008).
  • Hon KL, Ching G, Ng PC, Leung TF. Exploring CCL18, eczema severity and atopy. Pediatr. Allergy Immunol. (2010) (In press).
  • Gunther C, Kopp T, Carballido JM, Pfeiffer C. CCL18 is expressed in patients with bullous pemphigoid and parallels disease course. Br. J. Dermatol.160(4), 747–755 (2009).
  • Kodelja V, Muller C, Politz O, Hakij N, Orfanos CE, Goerdt S. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 a with a Th2-associated expression pattern. J. Immunol.160(3), 1411–1418 (1998).
  • Vulcano M, Struyf S, Scapini P et al. Unique regulation of CCL18 production by maturing dendritic cells. J. Immunol.170(7), 3843–3849 (2003).
  • de Nadai P. Involvement of CCL18 in inflammatory allergic diseases. J. Allergy Clin. Immunol.113(2), S262 (2004).
  • Hon KL, Lam MC, Leung TF et al. Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitis. Br. J. Dermatol.154(4), 629–635 (2006).
  • Hon KL, Lam MC, Wong KY, Leung TF, Ng PC. Pathophysiology of nocturnal scratching in childhood atopic dermatitis: the role of brain-derived neurotrophic factor and substance P. Br. J. Dermatol.157(5), 922–925 (2007).
  • Kakinuma T, Saeki HM, Tsunemi YM et al. Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. J. Allergy Clin. Immunol.111(3), 592–597 (2003).
  • Morales J, Homey B, Vicari AP et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl Acad. Sci. USA96(25), 14470–14475 (1999).
  • Kunkel EJ, Butcher EC. Chemokines and the tissue-specific migration of lymphocytes. Immunity16(1), 1–4 (2002).
  • Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC. CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J. Exp. Med.194(10), 1541–1547 (2001).
  • Hon KL, Leung TF, Wong Y et al. A pentaherbs capsule as a treatment option for atopic dermatitis in children: an open-labeled case series. Am. J. Chin. Med.32(6), 941–950 (2004).
  • Homey B, Alenius H, Muller A et al. CCL27–CCR10 interactions regulate T cell-mediated skin inflammation. Nat. Med.8(2), 157–165 (2002).
  • Homey B, Wang W, Soto H et al. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol.164(7), 3465–3470 (2000).
  • Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol. Rev.223, 87–113 (2008).
  • Schmidt-Weber CB, Akdis M, Akdis CA. TH17 cells in the big picture of immunology. J. Allergy Clin. Immunol.120(2), 247–254 (2007).
  • Koga C, Kabashima K, Shiraishi N, Kobayashi M, Tokura Y. Possible pathogenic role of Th17 cells for atopic dermatitis. J. Invest. Dermatol.128(11), 2625–2630 (2008).
  • Hamid Q, Boguniewicz M, Leung DY. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J. Clin. Invest.94(2), 870–876 (1994).
  • Boguniewicz M. Advances in the understanding and treatment of atopic dermatitis. Curr. Opin. Pediatr.9(6), 577–581 (1997).
  • Furue M, Ohtsuki M, Ogata F, Ishibashi Y. Responsiveness to interleukin 4 and interleukin 2 of peripheral blood mononuclear cells in atopic dermatitis. J. Invest. Dermatol.96(4), 468–472 (1991).
  • Okamura H, Tsutsui H, Komatsu T et al. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature378(6552), 88–91 (1995).
  • Hoshino T, Wiltrout RH, Young HA. IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response. J. Immunol.162(9), 5070–5077 (1999).
  • Wild JS, Sigounas A, Sur N et al. IFN-γ-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. J. Immunol.164(5), 2701–2710 (2000).
  • Yoshizawa Y, Nomaguchi H, Izaki S, Kitamura K. Serum cytokine levels in atopic dermatitis. Clin. Exp. Dermatol.27(3), 225–229 (2002).
  • El Mezzein RE, Matsumoto T, Nomiyama H, Miike T. Increased secretion of IL-18 in vitro by peripheral blood mononuclear cells of patients with bronchial asthma and atopic dermatitis. Clin. Exp. Dermatol.126(2), 193–198 (2001).
  • Higashi NM, Gesser BP, Kawana SM, Thestrup-Pedersen KMP. Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic dermatitis. J. Allergy Clin. Immunol.108(4), 607–614 (2001).
  • Urushihara N, Iwagaki H, Yagi T et al. Elevation of serum interleukin-18 levels and activation of Kupffer cells in biliary atresia. J. Pediatr. Surg.35(3), 446–449 (2000).
  • Sonkoly E, Muller A, Lauerma AI et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J. Allergy Clin. Immunol.117(2), 411–417 (2006).
  • Bilsborough J, Leung DY, Maurer M et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis.[Erratum in J. Allergy Clin. Immunol.117(5) 1124 (2006)]. J. Allergy Clin. Immunol.117(2), 418–425 (2006).
  • Laske N, Bunikowski R, Niggemann B. Extraordinarily high serum IgE levels and consequences for atopic phenotypes. Ann. Allergy Asthma Immunol.91(2), 202–204 (2003).
  • Laske N, Niggemann B. Does the severity of atopic dermatitis correlate with serum IgE levels? Pediatr. Allergy Immunol.15(1), 86–88 (2004).
  • Lasko TA, Bhagwat JG, Zou KH, Ohno-Machado L. The use of receiver operating characteristic curves in biomedical informatics. J. Biomed. Inform.38(5), 404–415 (2005).
  • Kulig M, Tacke U, Forster J et al. Serum IgE levels during the first 6 years of life. J. Pediatr.134(4), 453–458 (1999).
  • Wittig HJ, Belloit J, De Fillippi I, Royal G. Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease. J. Allergy Clin. Immunol.66(4), 305–313 (1980).
  • Hetman S, Kivity S, Greif J, Fireman EM, Topilsky M. IgE values in the allergic and healthy Israeli population. Ann. Allergy61(2), 123–128 (1988).
  • Hon KL, Leung T, Ma K et al. Urinary leukotriene E4 correlates with severity of atopic dermatitis in children. Clin. Exp. Dermatol.29(3), 277–281 (2004).
  • Hon KL, Lam MC, Kam WY et al. Non-invasive home-based assessment of itch in children with atopic dermatitis: PA-21. Br. J. Dermatol. Suppl.153(Suppl. 1), 89 (2005).
  • Ebata T, Iwasaki S, Kamide R, Niimura M. Use of a wrist activity monitor for the measurement of nocturnal scratching in patients with atopic dermatitis. Br. J. Dermatol.144(2), 305–309 (2001).
  • Benjamin KP, Waterston K, Russell M, Schofield O, Diffey B, Rees JL. The development of an objective method for measuring scratch in children with atopic dermatitis suitable for clinical use. J. Am. Acad. Dermatol.50(1), 33–40 (2004).
  • Rees JL, Laidlaw A. Pruritus: more scratch than itch. Clin. Exp. Dermatol.24(6), 490–493 (1999).
  • Steinhoff M, Stander S, Seeliger S, Ansel JC, Schmelz M, Luger T. Modern aspects of cutaneous neurogenic inflammation. Arch. Dermatol.139(11), 1479–1488 (2003).
  • Raap U, Goltz C, Deneka N et al. Brain-derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects. J. Allergy Clin. Immunol.115(6), 1268–1275 (2005).
  • Raap U, Werfel T, Goltz C et al. Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Allergy61(12), 1416–1418 (2006).
  • Noga O, Englmann C, Hanf G, Grutzkau A, Seybold J, Kunkel G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin. Exp. Allergy33(5), 649–654 (2003).
  • Toyoda M, Nakamura M, Makino T, Hino T, Kagoura M, Morohashi M. Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis. Br. J. Dermatol.147(1), 71–79 (2002).
  • Hon KL, Leung T, Wong Y, Li A, Fok T et al. A survey of bathing and showering practices in children with atopic eczema. Clin. Exp. Dermatol.30(4), 351–354 (2005).
  • Hon KL, Kam WY, Leung TF et al. Steroid fears in children with eczema. Acta Paediatr.95(11), 1451–1455 (2006).
  • Hon KL, Leung TF, Kam WY, Lam MC, Fok TF, Ng PC. Dietary restriction and supplementation in children with atopic eczema. Clin. Exp. Dermatol.31(2), 187–191 (2006).
  • Hon KL, Leung TF, Ma KC, Wong Y, Fok TF. Brief case series: montelukast, at doses recommended for asthma treatment, reduces disease severity and increases soluble CD14 in children with atopic dermatitis. J. Dermatol. Treat.16(1), 15–18 (2005).
  • Hon KL, Lam MC, Leung TF, Chow CM, Wong E, Leung AK. Assessing itch in children with atopic dermatitis treated with tacrolimus: objective versus subjective assessment. Adv. Ther.24(1), 23–28 (2007).
  • Hon KL, Wong KY, Cheung LK et al. Efficacy and problems associated with using a wet-wrap garment for children with severe atopic dermatitis. J. Dermatol. Treat.18(5), 301–305 (2007).
  • Hon KL, Leung TF, Ng PC et al. Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study. Br. J. Dermatol.157(2), 357–363 (2007).
  • Hon KL, Leung TF, Lam MC et al. Which aeroallergens are associated with eczema severity? Clin. Exp. Dermatol.32(4), 401–404 (2007).
  • Hon KL, Leung TF, Lam MC et al. Eczema exacerbation and food atopy beyond infancy: how should we advise Chinese parents about dietary history, eczema severity, and skin prick testing? Adv. Ther.24(2), 223–230 (2007).

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