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Review

Pituitary-directed medical treatment of Cushing’s disease

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Pages 263-272 | Published online: 10 Jan 2014

References

  • Arnaldi G, Angeli A, Atkinson AB et al. Diagnosis and complications of Cushing’s syndrome: a consensus statement. J. Clin. Endocrinol. Metab.88(12), 5593–5602 (2003).
  • Biller BMK, Grossman AB, Stewart PM et al. Treatment of adrenocorticotropin-dependent Cushing’s syndrome: a consensus statement. J. Clin. Endocrinol. Metab.93, 2454–2462 (2008).
  • Bourdeau I, Bard C, Forget H, Boulanger Y, Cohen H, Lacroix A. Cognitive function and cerebral assessment in patients who have Cushing’s syndrome. Endocrinol. Metab. Clin. North Am.34(2), 357–369 (2005).
  • Mancini T, Doga M, Mazziotti G, Giustina A. Cushing’s syndrome and bone. Pituitary7(4), 249–252 (2004).
  • Pivonello R, De Martino MC, De Leo M, Lombardi G, Colao AM. Cushing’s syndrome. Endocrinol. Metab. Clin. North Am.37, 135–149 (2008).
  • Arnaldi G, Mancini T, Polenta B, Boscaro M. Cardiovascular risk in Cushing’s syndrome. Pituitary7(4), 253–256 (2004).
  • Pivonello R, Faggiano A, Lombardi G et al. The metabolic syndrome and cardiovascular risk in Cushing’s syndrome. Endocrinol. Metab. Clin. North Am.34, 327–339 (2005).
  • Faggiano A, Pivonello R, Spiezia S et al. Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing’s disease during active disease and 1 year after disease remission. J. Clin. Endocrinol. Metab.88, 2527–2533 (2003).
  • Colao A, Pivonello R, Spiezia S et al. Persistence of increased cardiovascular risk in patients with Cushing’s disease after five years of successful cure. J. Clin. Endocrinol. Metab.84, 2664–2672 (1999).
  • Patil CG, Prevedello DM, Lad SP et al. Late recurrences of Cushing’s disease after initial successful transsphenoidalsurgery. J. Clin. Endocrinol. Metab.93, 358–362 (2008).
  • Bochicchio D, Losa M, Buchfelder M. Factors influencing the immediate and late outcome of Cushing’s disease treated by transsphenoidal surgery: a retrospective study by the European Cushing’s Disease Survey Group. J. Clin. Endocrinol. Metab.80(11), 3114–3120 (1995).
  • Hammer GD, Tyrrell JB, Lamborn KR et al. Transsphenoidal microsurgery for Cushing’s disease: initial outcome and long-term results. J. Clin. Endocrinol. Metab.89(12), 6348–6357 (2004).
  • Hofmann BM, Fahlbusch R. Treatment of Cushing’s disease: a retrospective clinical study of the latest 100 cases. Front. Horm. Res.34, 158–184 (2006).
  • Atkinson AB, Kennedy A, Wiggam MI, McCance DR, Sheridan B. Long-term remission rates after pituitary surgery for Cushing’s disease: the need for long-term surveillance. Clin. Endocrinol. (Oxf.)63(5), 549–559 (2005).
  • Mullan KR, Atkinson B. Endocrine clinical update: where are we in the therapeutic management of pituitary-dependent hypercortisolism? Clin. Endocrinol.68, 327–337 (2008).
  • Castinetti F, Nagai M, Dufour H et al. gamma knife radiosurgery is a successful adjunctive treatment in Cushing’s disease. Eur. J. Endocrinol.156(1), 91–98 (2007).
  • Gumbs AA, Gagner M. Laparoscopic adrenalectomy. Best Pract. Res. Clin. Endocrinol. Metab.20(3), 483–499 (2006).
  • Assie G, Bahurel H, Coste J et al. Corticotroph tumor progression after adrenalectomy in Cushing’s disease: a reappraisal of Nelson’s syndrome. J. Clin. Endocrinol. Metab.92(1), 172–179 (2007).
  • Blevins LS Jr, Christy JH, Khajavi M, Tindall GT. Outcomes of therapy for Cushing’s disease due to adrenocorticotropin-secreting pituitary macroadenomas. J. Clin. Endocrinol. Metab.83, 63–67 (1998).
  • Miller JW, Crapo L. The medical treatment of Cushing’s syndrome. Endocr. Rev.14(4), 443–458 (1993).
  • Sonino N, Boscaro M. Medical therapy for Cushing’s disease. Endocrinol. Metab. Clin. North Am.28, 211–222 (1999).
  • Nieman LK. Medical therapy of Cushing’s Disease. Pituitary5(2), 77–82 (2002).
  • Morris D, Grossman A. The medical management of Cushing’s syndrome. Ann. NY Acad. Sci.970, 119–133 (2002).
  • Arnaldi G, Cardinaletti M, Boscaro M Advances in medical treatment of Cushing’s disease. Expert Rev. Endocrinol Metab.2(6), 735–743 (2007).
  • Alexandraki KI, Grossman AB. Pituitary-targeted medical therapy of Cushing’s disease. Expert Opin. Investig. Drugs17(5), 669–677 (2008).
  • Krieger DT, Amorosa L, Linick F. Cyproheptadine-induced remission of Cushing’s disease. N. Engl. J. Med.293(18), 893–896 (1975).
  • Sonino N, Fava GA, Fallo F, Franceschetto A, Belluardo P, Boscaro M. Effect of the serotonin antagonists ritanserin and ketanserin in Cushing’s disease. Pituitary3(2), 55–59 (2000).
  • Kristiansen K, Dahl SG. Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2C receptor interactions. Eur. J. Pharmacol.306(1–3), 195–210 (1996).
  • Tepavcevic D, Giljevic Z, Aganovic I et al. Effects of ritanserin, a specific serotonin-S2 receptor antagonist, on the release of anterior pituitary hormones during insulin-induced hypoglycemia in normal humans. J. Endocrinol. Invest.18(6), 427–430 (1995).
  • Seibyl JP, Krystal JH, Price LH et al. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects Psychiatry Res.38(3), 227–236 (1991).
  • Heaney AP, Fernando M, Yong WH, Melmed S. Functional PPAR-γ receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat. Med.8(11), 1281–1287 (2002).
  • Heaney AP. Novel medical approaches for the treatment of Cushing’s disease. J. Endocrinol. Invest.27(6), 591–595 (2004).
  • Ambrosi B, Dall’Asta C, Cannavo S et al. Effects of chronic administration of PPAR-γ ligand rosiglitazone in Cushing’s disease. Eur. J. Endocrinol.151(2), 173–178 (2004).
  • Giraldi FP, Scaroni C, Arvat E et al. Effect of protracted treatment with rosiglitazone, a PPAR-γ agonist, in patients with Cushing’s disease. Clin. Endocrinol.64(2), 219–224 (2006).
  • Cannavo S, Arosio M, Almoto B, Dall’Asta C, Ambrosi B. Effectiveness of long-term rosiglitazone administration in patients with Cushing’s disease. Clin. Endocrinol. (Oxf.)63(1), 118–119 (2005).
  • Cannavo S, Ambrosi B, Chiodini I et al. Baseline and CRH-stimulated ACTH and cortisol levels after administration of the peroxisome proliferator-activated receptor-γ ligand, rosiglitazone, in Cushing’s disease. J. Endocrinol. Invest.27(5), RC8–RC11 (2005).
  • Suri D, Weiss RE. Effect of pioglitazone on adrenocorticotropic hormone and cortisol secretion in Cushing’s disease. J. Clin. Endocrinol. Metab.90(3), 1340–1346 (2005).
  • Morcos M, Fohr B, Tafel J et al. Long-term treatment of central Cushing’s syndrome with rosiglitazone. Exp. Clin. Endocrinol. Diabetes115, 292– 297 (2007).
  • Mullan KR, Leslie H, McCance DR, Sheridan B, Atkinson AB. The PPAR-γ activator rosiglitazone fails to lower plasma ACTH levels in patients with Nelson’s syndrome. Clin. Endocrinol. (Oxf.)64(5), 519–522 (2006).
  • Munir A, Song F, Ince P, Walters SJ, Ross R, Newell-Price J. Ineffectiveness of rosiglitazone therapy in Nelson’s syndrome. J. Clin. Endocrinol. Metab.92(5), 1758–1763 (2007).
  • Catrina SB, Virtanen K, Hällsten K, Lönnqvist F, Nuutila P, Brismar K. Effect of rosiglitazone on early-morning plasma cortisol levels. Neuro Endocrinol. Lett.26(6), 763–776 (2005).
  • Barbaro D, Lapi P, Orsini P, Pasquini C, Ciaccio S. Pioglitazone treatment in Cushing’s disease. J. Endocrinol. Invest.28(4), 388–389 (2005).
  • Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. Dopamine receptors: from structure to function. Physiol. Rev.78(1), 189–225 (1998).
  • Pivonello R, Ferone D, Lombardi G, Colao A, Lamberts SW, Hofland LJ. Novel insights in dopamine receptor physiology. Eur. J. Endocrinol.156(Suppl. 1), S13–S21 (2007); erratum in: Eur. J. Endocrinol.157(4), 543 (2007).
  • Pivonello R, Ferone D, de Herder WW. Dopamine receptor expression and function in corticotroph pituitary tumors. J. Clin. Endocrinol. Metab.89(5), 2452–2462 (2004).
  • de Bruin C, Pereira AM, Feelders RA et al. Co-expression of dopamine and somatostatin receptor subtypes in corticotroph adenomas. J. Clin. Endocrinol. Metab.9(4), 118–1124 (2009).
  • Chen CL, Dionne FT, Roberts JL.Regulation of the pro-opiomelanocortin mRNA levels in rat pituitary by dopaminergic compounds. Proc. Natl Acad. Sci. USA80(8), 2211–2215 (1983).
  • Loeffler JP, Demeneix BA, Kley NA, Höllt V. Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary. Interactions with corticotropin-releasing factor and the β-adrenergic receptors and the adenylate cyclase system. Neuroendocrinology47(2), 95–101 (1988).
  • Pardy K, Carter D, Murphy D. Dopaminergic mediation of physiological changes in proopiomelanocortin messenger ribonucleic acid expression in the neurointermediate lobe of the rat pituitary. Endocrinology126(6), 2960–2964 (1990).
  • Saiardi A, Borrelli E. Absence of dopaminergic control on melanotrophs leads to Cushing’s-like syndrome in mice. Mol. Endocrinol.12(8), 1133–1139 (1998).
  • Laurent V, Kimble A, Peng B, Zhu P, Pintar JE, Steiner DF, Lindberg I. Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion. Proc. Natl Acad. Sci. USA99(5), 3087–3092 (2002).
  • Shomali ME, Hussain MA. Cushing’s syndrome: from patients to proteins. Eur. J. Endocrinol.143(3), 313–315 (2000).
  • de Bruin C, Feelders RA, Waaijers AM et al. Differential regulation of human dopamine D2 and somatostatin receptor subtype expression by glucocorticoids in vitro. J. Mol. Endocrinol.42(1), 47–56 (2009).
  • de Bruin C, Feelders RA, Lamberts SW, Hofland LJ. Somatostatin and dopamine receptors as targets for medical treatment of Cushing’s syndrome. Rev. Endocr. Metab. Disord. (2008) (Epub ahead of print).
  • Miyoshi T, Otsuka F, Takeda M et al. Effect of cabergoline treatment on Cushing’s disease caused by aberrant adrenocorticotropin-secreting macroadenoma. J. Endocrinol. Invest.27(11), 1055–1059 (2004).
  • Pivonello R, Faggiano A, Di Salle F, Filippella M, Lombardi G, Colao A. Complete remission of Nelson’s syndrome after 1-year treatment with cabergoline. J. Endocrinol. Invest.22(11), 860–865 (1999).
  • Casulari LA, Naves LA, Mello PA, Pereira Neto A, Papadia C. Nelson’s syndrome: complete remission with cabergoline but not with bromocriptine or cyproheptadine treatment. Horm. Res.62(6), 300–305 (2004).
  • Pivonello R, De Martino MC, Cappabianca P et al. The medical treatment of Cushing’s disease: effectiveness of chronic treatment with the dopamine agonist cabergoline in patients unsuccessfully treated by surgery. J. Clin. Endocrinol. Metab.94(1), 223–230 (2008).
  • Godbout A, Manavela M, Danilowicz K, Beauregard H, Bruno OD, Lacroix A. Long-term therapy with cabergoline in Cushings disease. Presented at: ENDO 08; The Endocrine Society’s 50th Annual Meeting. San Francisco, CA, USA, 5–18 June 2008.
  • Illouz F, Dubois-Ginouves S, Laboureau S, Rohmer V, Rodien P. Use of cabergoline in persisting Cushing’s disease. Ann. Endocrinol.67(4), 353–356 (2006).
  • T’Sjoen G, Defeyter I, Van De Saffele J, Rubens R, Vandeweghe M. Macroprolactinemia associated with Cushing’s disease, successfully treated with cabergoline. J. Endocrinol. Invest.25(2), 172–175 (2002).
  • Castillo VA, Gomez NV, Lalia JC, Cabrera Blatter MF, Garcia JD. Cushing’s disease in dogs: cabergoline treatment. Res. Vet. Sci.85, 26–34 (2008).
  • Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G. Valvular heart disease and the use of dopamine agonists for Parkinson’s disease. N. Engl. J. Med.356(1), 39–46 (2007).
  • Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E. Dopamine agonists and risk of cardiac-valve regurgitation. N. Engl. J. Med.356(1), 29–38 (2007).
  • Roth BL. Drugs and valvular heart disease. N. Engl. J. Med.356(1), 6–9 (2007).
  • Rasmussen VG, Poulsen SH, Dupont E, østergaard K, Safikhany G, Egeblad H. Heart valve disease associated with treatment with ergot-derived dopamine agonists: a clinical and echocardiographic study of patients with Parkinson’s disease. J. Intern. Med.263(1), 90–98 (2008).
  • Kars M, Delgado V, Holman ER et al. Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma. J. Clin. Endocrinol. Metab.93(9), 3348–3356 (2008).
  • Kars M, Pereira AM, Bax JJ, Romijn JA. Cabergoline and cardiac valve disease in prolactinoma patients: additional studies during long-term treatment are required. Eur. J. Endocrinol.159(4), 363–367 (2008).
  • Colao A, Galderisi M, Di Sarno A et al. Increased prevalence of tricuspid regurgitation in patients with prolactinomas chronically treated with cabergoline. J. Clin. Endocrinol. Metab.93(10), 3777–3784 (2008).
  • Herring N, Szmigielski C, Becher H, Karavitaki N, Wass JA. Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. Clin. Endocrinol. (Oxf.)70(1), 104–108 (2009).
  • Patel YC. Somatostatin and its receptor family. Front. Neuroendocrinol.20(3), 157–198 (1999).
  • Murray RD, Melmed S. A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly. J. Clin. Endocrinol. Metab.93(8), 2957–2968 (2008).
  • Modlin IM, Oberg K, Chung DC et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol.9(1), 61–72 (2008).
  • Van der Hoek J, Lamberts SW, Hofland LJ. The role of somatostatin analogs in Cushing’s disease. Pituitary7(4), 257–264 (2004).
  • Arnaldi G, Polenta B, Cardinaletti M, Boscaro M. Potential indications for somatostatin analogs in Cushing’s syndrome. J. Endocrinol. Invest.28(11 Suppl. Int.), 106–110 (2005).
  • Lamberts SW, Uitterlinden P, Klijn JM. The effect of the long-acting somatostatin analogue SMS 201–995 on ACTH secretion in Nelson’s syndrome and Cushing’s disease. Acta Endocrinol. (Copenh.)6, 760–766 (1989).
  • Stalla GK, Brockmeier SJ, Renner U et al. Octreotide exerts different effects in vivo and in vitroin Cushing’s disease. Eur. J. Endocrinol.2, 125–131 (1994).
  • Ambrosi B, Bochicchio D, Fadin C, Colombo P, Faglia G. Failure of somatostatin and octreotide to acutely affect the hypothalamic–pituitary–adrenal function in patients with corticotropin hypersecretion. J. Endocrinol. Invest.3, 257–261 (1990).
  • Van der Hoek J, Lamberts SWJ, Hofland LJ. Preclinical and clinical experiences with the role of somatostatin receptors in the treatment of pituitary adenomas. Eur. J. Endocrinol.156, S45–S51 (2007).
  • Hofland LJ, van der Hoek J, Feelders R et al. The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5. Eur. J. Endocrinol.152(4), 645–654 (2005).
  • Batista DL , Zhang X, Gejman R et al. The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas. J. Clin. Endocrinol. Metab.91(11), 4482–4488 (2006).
  • Invitti C, de Martin M, Brunani A, Piolini M, Cavagnini F. Treatment of Cushing’s syndrome with the long-acting somatostatin analogue SM 201-995 (sandostatin). Clin. Endocrinol. (Oxf.)32(3), 275–281 (1990).
  • Stafford PJ, Kopelman PG, Davidson K et al. The pituitary-adrenal response to CRF-41 is unaltered by intravenous somatostatin in normal subjects. Clin. Endocrinol. (Oxf.)30(6), 661–666 (1989).
  • Fehm HL, Voigt KH, Lang R, Beinert KE, Raptis S, Pfeiffer EF. Somatostatin: a potent inhibitor of ACTH-hypersecretion in adrenal insufficiency. Klin. Wochenschr.4, 173–175 (1976).
  • Schonbrunn A. Glucocorticoids down-regulate somatostatin receptors on pituitary cells in culture. Endocrinology4, 1147–1154 (1982).
  • Kraus J, Woltje M, Hollt V. Regulation of mouse somatostatin receptor type 2 gene expression by glucocorticoids. FEBS Lett.2, 200–204 (1999).
  • Kraus J, Woltje M, Schonwetter N, Hollt V. Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene. FEBS Lett.3, 165–170 (1998).
  • Van der Hoek J, Waaijers M, van Koetsveld PM et al. Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells. Am. J. Physiol. Endocrinol. Metab.289(2), E278–E287 (2005).
  • Strowski MZ, Dashkevicz MP, Parmar RM et al. Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells. Neuroendocrinology6, 339–346 (2002).
  • Cervia D, Nunn C, Fehlmann D, Langenegger D, Schuepbach E, Hoyer D. Pharmacological characterisation of native somatostatin receptors in AtT-20 mouse tumour corticotrophs. Br. J. Pharmacol.1, 109–121 (2003).
  • Danila DC, Haidar JN, Zhang X, Katznelson L, Culler MD, Klibanski A. Somatostatin receptor-specific analogs: effects on cell proliferation and growth hormone secretion in human somatotroph tumors. J. Clin. Endocrinol. Metab.86, 2976–2981 (2001).
  • Silva AP, Schoeffter P, Weckbecker G, Bruns C, Schmid HA. Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats. Eur. J. Endocrinol.153(3), R7–R10 (2005).
  • Boscaro M, Ludlam WH, Atkinson B et al. Treatment of pituitary-dependent Cushing’s disease with multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, Phase II trial. J. Clin. Endocrinol. Metab.94(1), 115–122 (2009).
  • Unger N, Serdiuk I, Sheu SY et al. Immunohistochemical localization of somatostatin receptor subtypes in benign and malignant adrenal tumours. Clin. Endocrinol. (Oxf.)68, 850–857 (2008).
  • Paez-Pereda M, Kovalovsky D, Hopfner U et al. Retinoic acid prevents experimental Cushing syndrome. J. Clin. Invest.108(8), 1123–1131 (2001).
  • Lauber M, Theodoropoulou M, Sievers C. New aspects in the diagnosis and treatment of Cushing disease. Front. Horm. Res.35, 169–178 (2006).
  • Castillo V, Giacomini D, Paez-Pereda M et al. Retinoic acid as a novel medical therapy for Cushing’s disease in dogs. Endocrinology147(9), 4438–4444 (2006).
  • Bernstein ZP, Chanan-Khan A, Miller KC, Northfelt DW, Lopez-Berestein G, Gill PS. A multicenter Phase II study of the intravenous administration of liposomal tretinoin in patients with acquired immunodeficiency syndrome-associated Kaposi’s sarcoma. Cancer95(12), 2555–2561 (2002).
  • Aboulafia DM, Norris D, Henry D et al. 9-cis-retinoic acid capsules in the treatment of AIDS-related Kaposi sarcoma: results of a Phase 2 multicenter clinical trial. Arch. Dermatol.139(2), 178–186 (2003).
  • Miles SA, Dezube BJ, Lee JY et al.; AIDS Malignancy Consortium. Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi’s sarcoma. AIDS16(3), 421–429 (2002).
  • Rocheville M, Lange DC, Kumar U, Patel SC, Patel RC, Patel YC. Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science288(5463), 154–157 (2000).
  • Baragli A, Alturaihi H, Watt HL, Abdallah A, Kumar U. Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 co-immunoprecipitation and fluorescence resonance energy transfer analysis. Cell Signal.19(11), 2304–2316 (2007).
  • Pivonello R, Ferone D, Lamberts SW, Colao A. Cabergoline plus lanreotide for ectopic Cushing’s syndrome. N. Engl. J. Med.352(23), 2457–2458 (2005).
  • Vignati F, Loli P. Additive effect of ketoconazole and octreotide in the treatment of severe adrenocorticotropin-dependent hypercortisolism. J. Clin. Endocrinol. Metab.81(8), 2885–2890 (1996).

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