Calcium regulation of keratinocyte differentiation

References

• Green KJ, Simpson CL. Desmosomes: new perspectives on a classic. J. Invest. Dermatol. 127(11), 2499–2515 (2007).
   PubMed Web of Science ®Google Scholar
• Yuki T, Haratake A, Koishikawa H, Morita K, Miyachi Y, Inoue S. Tight junction proteins in keratinocytes: localization and contribution to barrier function. Exp. Dermatol. 16(4), 324–330 (2007).
   PubMed Web of Science ®Google Scholar
• Marchisio PC, Bondanza S, Cremona O, Cancedda R, De Luca M. Polarized expression of integrin receptors (α 6 β 4, α 2 β 1, α 3 β 1, and α v β 5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes. J. Cell Biol. 112(4), 761–773 (1991).
   PubMed Web of Science ®Google Scholar
• Peltonen J, Larjava H, Jaakkola S et al. Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas. J. Clin. Invest. 84(6), 1916–1923 (1989).
   PubMed Web of Science ®Google Scholar
• Guo M, Kim LT, Akiyama SK, Gralnick HR, Yamada KM, Grinnell F. Altered processing of integrin receptors during keratinocyte activation. Exp. Cell Res. 195(2), 315–322 (1991).
   PubMed Web of Science ®Google Scholar
• Müller EJ, Williamson L, Kolly C, Suter MM. Outside–in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation? J. Invest. Dermatol. 128(3), 501–516 (2008).
   PubMed Web of Science ®Google Scholar
• Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31(1), 11–24 (1982).
   PubMed Web of Science ®Google Scholar
• Eichner R, Sun TT, Aebi U. The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments. J. Cell Biol. 102(5), 1767–1777 (1986).
   PubMed Web of Science ®Google Scholar
• Warhol MJ, Roth J, Lucocq JM, Pinkus GS, Rice RH. Immuno-ultrastructural localization of involucrin in squamous epithelium and cultured keratinocytes. J. Histochem. Cytochem. 33(2), 141–149 (1985).
   PubMed Web of Science ®Google Scholar
• Thacher SM, Rice RH. Keratinocyte-specific transglutaminase of cultured human epidermal cells: relation to cross-linked envelope formation and terminal differentiation. Cell 40(3), 685–695 (1985).
   PubMed Web of Science ®Google Scholar
• Steven AC, Bisher ME, Roop DR, Steinert PM. Biosynthetic pathways of filaggrin and loricrin - two major proteins expressed by terminally differentiated epidermal keratinocytes. J. Struct. Biol. 104(1–3), 150–162 (1990).
   PubMed Web of Science ®Google Scholar
• Dale BA, Resing KA, Lonsdale-Eccles JD. Filaggrin: a keratin filament associated protein. Ann. NY Acad. Sci. 455, 330–342 (1985).
   PubMed Web of Science ®Google Scholar
• Mehrel T, Hohl D, Rothnagel JA et al. Identification of a major keratinocyte cell envelope protein, loricrin. Cell 61(6), 1103–1112 (1990).
   PubMed Web of Science ®Google Scholar
• Elias PM, Menon GK, Grayson S, Brown BE. Membrane structural alterations in murine stratum corneum: relationship to the localization of polar lipids and phospholipases. J. Invest. Dermatol. 91(1), 3–10 (1988).
   PubMed Web of Science ®Google Scholar
• Hohl D. Cornified cell envelope. Dermatologica 180(4), 201–211 (1990).
   PubMedGoogle Scholar
• Menon GK, Grayson S, Elias PM. Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J. Invest. Dermatol. 84(6), 508–512 (1985).
   PubMed Web of Science ®Google Scholar
• Celli A, Sanchez S, Behne M, Hazlett T, Gratton E, Mauro T. The epidermal Ca(2+) gradient: measurement using the phasor representation of fluorescent lifetime imaging. Biophys. J. 98(5), 911–921 (2010).
   PubMed Web of Science ®Google Scholar
• Leinonen PT, Hägg PM, Peltonen S et al. Reevaluation of the normal epidermal calcium gradient, and analysis of calcium levels and ATP receptors in Hailey–Hailey and Darier epidermis. J. Invest. Dermatol. 129(6), 1379–1387 (2009).
   PubMed Web of Science ®Google Scholar
• Dhitavat J, Cobbold C, Leslie N, Burge S, Hovnanian A. Impaired trafficking of the desmoplakins in cultured Darier’s disease keratinocytes. J. Invest. Dermatol. 121(6), 1349–1355 (2003).
   PubMed Web of Science ®Google Scholar
• Mauro T, Bench G, Sidderas-Haddad E, Feingold K, Elias P, Cullander C. Acute barrier perturbation abolishes the Ca2+ and K+ gradients in murine epidermis: quantitative measurement using PIXE. J. Invest. Dermatol. 111(6), 1198–1201 (1998).
   PubMed Web of Science ®Google Scholar
• Elias PM, Ahn SK, Denda M et al. Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J. Invest. Dermatol. 119(5), 1128–1136 (2002).
   PubMed Web of Science ®Google Scholar
• Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19(1), 245–254 (1980).
   PubMed Web of Science ®Google Scholar
• Hennings H, Holbrook KA. Calcium regulation of cell–cell contact and differentiation of epidermal cells in culture. An ultrastructural study. Exp. Cell Res. 143(1), 127–142 (1983).
   PubMed Web of Science ®Google Scholar
• Niessen CM. Tight junctions/adherens junctions: basic structure and function. J. Invest. Dermatol. 127(11), 2525–2532 (2007).
   PubMed Web of Science ®Google Scholar
• Zamansky GB, Nguyen U, Chou IN. An immunofluorescence study of the calcium-induced coordinated reorganization of microfilaments, keratin intermediate filaments, and microtubules in cultured human epidermal keratinocytes. J. Invest. Dermatol. 97(6), 985–994 (1991).
   PubMed Web of Science ®Google Scholar
• Inohara S, Tatsumi Y, Cho H, Tanaka Y, Sagami S. Actin filament and desmosome formation in cultured human keratinocytes. Arch. Dermatol. Res. 282(3), 210–212 (1990).
   PubMed Web of Science ®Google Scholar
• Yoneda K, Fujimoto T, Imanura S et al. Fodrin is localized in the cytoplasm of keratinocytes cultured in low calcium medium: immunoelectron microscopic study. Acta Histochem. Cytochem. 23, 139–148 (1990).
   Web of Science ®Google Scholar
• Pillai S, Bikle DD, Mancianti ML, Cline P, Hincenbergs M. Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium. J. Cell. Physiol. 143(2), 294–302 (1990).
   PubMed Web of Science ®Google Scholar
• Rubin AL, Parenteau NL, Rice RH. Coordination of keratinocyte programming in human SCC-13 squamous carcinoma and normal epidermal cells. J. Cell. Physiol. 138(1), 208–214 (1989).
   PubMed Web of Science ®Google Scholar
• Su MJ, Bikle DD, Mancianti ML, Pillai S. 1,25-dihydroxyvitamin D3 potentiates the keratinocyte response to calcium. J. Biol. Chem. 269(20), 14723–14729 (1994).
   PubMed Web of Science ®Google Scholar
• Hohl D, Lichti U, Breitkreutz D, Steinert PM, Roop DR. Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid. J. Invest. Dermatol. 96(4), 414–418 (1991).
   PubMed Web of Science ®Google Scholar
• Yuspa SH, Kilkenny AE, Steinert PM, Roop DR. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J. Cell Biol. 109(3), 1207–1217 (1989).
   PubMed Web of Science ®Google Scholar
• Ng DC, Su MJ, Kim R, Bikle DD. Regulation of involucrin gene expression by calcium in normal human keratinocytes. Front. Biosci. 1, a16–a24 (1996).
   Google Scholar
• Huff CA, Yuspa SH, Rosenthal D. Identification of control elements 3′ to the human keratin 1 gene that regulate cell type and differentiation-specific expression. J. Biol. Chem. 268(1), 377–384 (1993).
   PubMed Web of Science ®Google Scholar
• Denning MF, Dlugosz AA, Williams EK, Szallasi Z, Blumberg PM, Yuspa SH. Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ. 6(2), 149–157 (1995).
   PubMedGoogle Scholar
• Deucher A, Efimova T, Eckert RL. Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)α and PKCdelta. J. Biol. Chem. 277(19), 17032–17040 (2002).
   PubMed Web of Science ®Google Scholar
• Ryynänen J, Jaakkola S, Engvall E, Peltonen J, Uitto J. Expression of β 4 integrins in human skin: comparison of epidermal distribution with β 1-integrin epitopes, and modulation by calcium and vitamin D3 in cultured keratinocytes. J. Invest. Dermatol. 97(3), 562–567 (1991).
   PubMed Web of Science ®Google Scholar
• Pillai S, Bikle DD. Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3. J. Cell. Physiol. 146(1), 94–100 (1991).
   PubMed Web of Science ®Google Scholar
• Hennings H, Kruszewski FH, Yuspa SH, Tucker RW. Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes. Carcinogenesis 10(4), 777–780 (1989).
   PubMed Web of Science ®Google Scholar
• Kruszewski FH, Hennings H, Tucker RW, Yuspa SH. Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations. Cancer Res. 51(16), 4206–4212 (1991).
   PubMed Web of Science ®Google Scholar
• Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J. Clin. Invest. 97(4), 1085–1093 (1996).
   PubMed Web of Science ®Google Scholar
• Pillai S, Bikle DD. Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation. J. Cell. Physiol. 151(3), 623–629 (1992).
   PubMed Web of Science ®Google Scholar
• Reiss M, Lipsey LR, Zhou ZL. Extracellular calcium-dependent regulation of transmembrane calcium fluxes in murine keratinocytes. J. Cell. Physiol. 147(2), 281–291 (1991).
   PubMed Web of Science ®Google Scholar
• Galietta LJ, Barone V, De Luca M, Romeo G. Characterization of chloride and cation channels in cultured human keratinocytes. Pflugers Arch. 418(1–2), 18–25 (1991).
   PubMed Web of Science ®Google Scholar
• Mauro TM, Pappone PA, Isseroff RR. Extracellular calcium affects the membrane currents of cultured human keratinocytes. J. Cell. Physiol. 143(1), 13–20 (1990).
   PubMed Web of Science ®Google Scholar
• Mauro TM, Isseroff RR, Lasarow R, Pappone PA. Ion channels are linked to differentiation in keratinocytes. J. Membr. Biol. 132(3), 201–209 (1993).
   PubMed Web of Science ®Google Scholar
• Grando SA, Horton RM, Mauro TM, Kist DA, Lee TX, Dahl MV. Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation. J. Invest. Dermatol. 107(3), 412–418 (1996).
   PubMed Web of Science ®Google Scholar
• Oda Y, Timpe LC, McKenzie RC, Sauder DN, Largman C, Mauro T. Alternatively spliced forms of the cGMP-gated channel in human keratinocytes. FEBS Lett. 414(1), 140–145 (1997).
   PubMed Web of Science ®Google Scholar
• Müller M, Essin K, Hill K et al. Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation. J. Biol. Chem. 283(49), 33942–33954 (2008).
   PubMed Web of Science ®Google Scholar
• Tu CL, Chang W, Bikle DD. Phospholipase Cγ1 is required for activation of store-operated channels in human keratinocytes. J. Invest. Dermatol. 124(1), 187–197 (2005).
   PubMed Web of Science ®Google Scholar
• Cai S, Fatherazi S, Presland RB et al. Evidence that TRPC1 contributes to calcium-induced differentiation of human keratinocytes. Pflugers Arch. 452(1), 43–52 (2006).
   PubMed Web of Science ®Google Scholar
• Pillai S, Bikle DD, Mancianti ML, Hincenbergs M. Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines. Exp. Cell Res. 192(2), 567–573 (1991).
   PubMed Web of Science ®Google Scholar
• Holladay K, Fujiki H, Bowden GT. Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes. Mol. Carcinog. 5(1), 16–24 (1992).
   PubMed Web of Science ®Google Scholar
• Bollag WB, Xiong Y, Ducote J, Harmon CS. Regulation of FOS-LACZ fusion gene expression in primary mouse epidermal keratinocytes isolated from transgenic mice. Biochem. J. 300(Pt 1), 263–270 (1994).
   PubMed Web of Science ®Google Scholar
• Pillai S, Bikle DD. Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes. J. Clin. Invest. 90(1), 42–51 (1992).
   PubMed Web of Science ®Google Scholar
• Jaken S, Yuspa SH. Early signals for keratinocyte differentiation: role of Ca 2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells. Carcinogenesis 9(6), 1033–1038 (1988).
   PubMed Web of Science ®Google Scholar
• Tang W, Ziboh VA, Isseroff R, Martinez D. Turnover of inositol phospholipids in cultured murine keratinocytes: possible involvement of inositol triphosphate in cellular differentiation. J. Invest. Dermatol. 90(1), 37–43 (1988).
   PubMed Web of Science ®Google Scholar
• Moscat J, Fleming TP, Molloy CJ, Lopez-Barahona M, Aaronson SA. The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase C activation. J. Biol. Chem. 264(19), 11228–11235 (1989).
   PubMed Web of Science ®Google Scholar
• Lee E, Yuspa SH. Aluminum fluoride stimulates inositol phosphate metabolism and inhibits expression of differentiation markers in mouse keratinocytes. J. Cell. Physiol. 148(1), 106–115 (1991).
   PubMed Web of Science ®Google Scholar
• Pillai S, Bikle DD, Su MJ, Ratnam A, Abe J. 1,25-dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels. J. Clin. Invest. 96(1), 602–609 (1995).
   PubMed Web of Science ®Google Scholar
• Xie Z, Bikle DD. Phospholipase C-γ1 is required for calcium-induced keratinocyte differentiation. J. Biol. Chem. 274(29), 20421–20424 (1999).
   PubMed Web of Science ®Google Scholar
• Carpenter G, Ji Q. Phospholipase C-γ as a signal-transducing element. Exp. Cell Res. 253(1), 15–24 (1999).
   PubMed Web of Science ®Google Scholar
• Falasca M, Logan SK, Lehto VP, Baccante G, Lemmon MA, Schlessinger J. Activation of phospholipase C γ by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J. 17(2), 414–422 (1998).
   PubMed Web of Science ®Google Scholar
• Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG. Phosphoinositide 3-kinase regulates phospholipase Cγ-mediated calcium signaling. J. Biol. Chem. 273(37), 23750–23757 (1998).
   PubMed Web of Science ®Google Scholar
• Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. Activation of phospholipase C-γ by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273(8), 4465–4469 (1998).
   PubMed Web of Science ®Google Scholar
• Kim HK, Kim JW, Zilberstein A et al. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ 1 phosphorylation on tyrosine residues 783 and 1254. Cell 65(3), 435–441 (1991).
   PubMed Web of Science ®Google Scholar
• Xie Z, Singleton PA, Bourguignon LY, Bikle DD. Calcium-induced human keratinocyte differentiation requires Src- and Fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-γ1. Mol. Biol. Cell 16(7), 3236–3246 (2005).
   PubMed Web of Science ®Google Scholar
• Xie Z, Chen Y, Lias E-Y, Jian Y, Liu F-Y, Pennypacker SD. Phospholipase C-γ1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis. Biochem. Biophy. Res. Comm. 397, 296–300 (2010).
   PubMed Web of Science ®Google Scholar
• Hawley-Nelson P, Stanley JR, Schmidt J, Gullino M, Yuspa SH. The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate accelerates keratinocyte differentiation and stimulates growth of an unidentified cell type in cultured human epidermis. Exp. Cell Res. 137(1), 155–167 (1982).
   PubMed Web of Science ®Google Scholar
• Yuspa SH, Ben T, Hennings H, Lichti U. Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 42(6), 2344–2349 (1982).
   PubMed Web of Science ®Google Scholar
• Kitajima Y, Inoue S, Nagao S, Nagata K, Yaoita H, Nozawa Y. Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C. Cancer Res. 48(4), 964–970 (1988).
   PubMed Web of Science ®Google Scholar
• Rice RH, Rong XH, Chakravarty R. Suppression of keratinocyte differentiation in SSC-9 human squamous carcinoma cells by benzo[a]pyrene, 12-O-tetradecanoylphorbol-13-acetate and hydroxyurea. Carcinogenesis 9(10), 1885–1890 (1988).
   PubMed Web of Science ®Google Scholar
• Yuspa SH, Ben T, Hennings H. The induction of epidermal transglutaminase and terminal differentiation by tumor promoters in cultured epidermal cells. Carcinogenesis 4(11), 1413–1418 (1983).
   PubMed Web of Science ®Google Scholar
• Dlugosz AA, Yuspa SH. Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium. J. Invest. Dermatol. 102(4), 409–414 (1994).
   PubMed Web of Science ®Google Scholar
• Matsui MS, Illarda I, Wang N, DeLeo VA. Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes. Exp. Dermatol. 2(6), 247–256 (1993).
   PubMedGoogle Scholar
• Dlugosz AA, Yuspa SH. Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C. J. Cell Biol. 120(1), 217–225 (1993).
   PubMed Web of Science ®Google Scholar
• Ng DC, Shafaee S, Lee D, Bikle DD. Requirement of an AP-1 site in the calcium response region of the involucrin promoter. J. Biol. Chem. 275(31), 24080–24088 (2000).
   PubMed Web of Science ®Google Scholar
• Filvaroff E, Stern DF, Dotto GP. Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation. Mol. Cell. Biol. 10(3), 1164–1173 (1990).
   PubMed Web of Science ®Google Scholar
• Chakravarthy BR, Isaacs RJ, Morley P, Durkin JP, Whitfield JF. Stimulation of protein kinase C during Ca(2+)-induced keratinocyte differentiation. Selective blockade of MARCKS phosphorylation by calmodulin. J. Biol. Chem. 270(3), 1362–1368 (1995).
   PubMed Web of Science ®Google Scholar
• Punnonen K, Denning M, Lee E, Li L, Rhee SG, Yuspa SH. Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes. J. Invest. Dermatol. 101(5), 719–726 (1993).
   PubMed Web of Science ®Google Scholar
• Hepler JR, Earp HS, Harden TK. Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization. J. Biol. Chem. 263(16), 7610–7619 (1988).
   PubMed Web of Science ®Google Scholar
• Kojima I, Shibata H, Ogata E. Phorbol ester inhibits angiotensin-induced activation of phospholipase C in adrenal glomerulosa cells. Its implication in the sustained action of angiotensin. Biochem. J. 237(1), 253–258 (1986).
   PubMed Web of Science ®Google Scholar
• Dlugosz AA, Mischak H, Mushinski JF, Yuspa SH. Transcripts encoding protein kinase C-α, Δ, ε, ζ, and η are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells Mol. Carcinog. 5(4), 286–292 (1992).
   PubMed Web of Science ®Google Scholar
• Denning MF, Dlugosz AA, Howett MK, Yuspa SH. Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta. J. Biol. Chem. 268(35), 26079–26081 (1993).
   PubMed Web of Science ®Google Scholar
• Reynolds NJ, Baldassare JJ, Henderson PA et al. Translocation and downregulation of protein kinase C isoenzymes-α and -epsilon by phorbol ester and bryostatin-1 in human keratinocytes and fibroblasts. J. Invest. Dermatol. 103(3), 364–369 (1994).
   PubMed Web of Science ®Google Scholar
• Fisher GJ, Tavakkol A, Leach K et al. Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-β II in psoriasis. J. Invest. Dermatol. 101(4), 553–559 (1993).
   PubMed Web of Science ®Google Scholar
• Goodnight J, Mischak H, Mushinski JF. Selective involvement of protein kinase C isozymes in differentiation and neoplastic transformation. Adv. Cancer Res. 64, 159–209 (1994).
   PubMed Web of Science ®Google Scholar
• Yang LC, Ng DC, Bikle DD. Role of protein kinase C α in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. J. Cell. Physiol. 195(2), 249–259 (2003).
   PubMed Web of Science ®Google Scholar
• Downward J, Waterfield MD, Parker PJ. Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. J. Biol. Chem. 260(27), 14538–14546 (1985).
   PubMed Web of Science ®Google Scholar
• Schlessinger J. Allosteric regulation of the epidermal growth factor receptor kinase. J. Cell Biol. 103(6 Pt 1), 2067–2072 (1986).
   PubMed Web of Science ®Google Scholar
• Kolch W, Heidecker G, Kochs G et al. Protein kinase C α activates RAF-1 by direct phosphorylation. Nature 364(6434), 249–252 (1993).
   PubMed Web of Science ®Google Scholar
• Goode N, Hughes K, Woodgett JR, Parker PJ. Differential regulation of glycogen synthase kinase-3 β by protein kinase C isotypes. J. Biol. Chem. 267(24), 16878–16882 (1992).
   PubMed Web of Science ®Google Scholar
• Yaar M, Gilani A, DiBenedetto PJ, Harkness DD, Gilchrest BA. Gene modulation accompanying differentiation of normal versus malignant keratinocytes. Exp. Cell Res. 206(2), 235–243 (1993).
   PubMed Web of Science ®Google Scholar
• Stanwell C, Denning MF, Rutberg SE, Cheng C, Yuspa SH, Dlugosz AA. Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes. J. Invest. Dermatol. 106(3), 482–489 (1996).
   PubMedGoogle Scholar
• Welter JF, Eckert RL. Differential expression of the Fos and Jun family members c-Fos, FosB, Fra-1, Fra-2, c-Jun, JunB and JunD during human epidermal keratinocyte differentiation. Oncogene 11(12), 2681–2687 (1995).
   PubMed Web of Science ®Google Scholar
• Welter JF, Crish JF, Agarwal C, Eckert RL. Fos-related antigen (Fra-1), JunB, and JunD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J. Biol. Chem. 270(21), 12614–12622 (1995).
   PubMed Web of Science ®Google Scholar
• Forman BM, Casanova J, Raaka BM, Ghysdael J, Samuels HH. Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers. Mol. Endocrinol. 6(3), 429–442 (1992).
   PubMedGoogle Scholar
• Troyanovsky S. Cadherin dimers in cell–cell adhesion. Eur. J. Cell Biol. 84(2–3), 225–233 (2005).
   PubMed Web of Science ®Google Scholar
• van Roy F, Berx G. The cell–cell adhesion molecule E-cadherin. Cell. Mol. Life Sci. 65(23), 3756–3788 (2008).
   PubMed Web of Science ®Google Scholar
• Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo Dotto G. Tyrosine phosphorylation and Src family kinases control keratinocyte cell–cell adhesion. J. Cell Biol. 141(6), 1449–1465 (1998).
   PubMed Web of Science ®Google Scholar
• Calautti E, Grossi M, Mammucari C et al. Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell–cell adhesion. J. Cell Biol. 156(1), 137–148 (2002).
   PubMed Web of Science ®Google Scholar
• Calautti E, Li J, Saoncella S, Brissette JL, Goetinck PF. Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J. Biol. Chem. 280(38), 32856–32865 (2005).
   PubMed Web of Science ®Google Scholar
• Pece S, Chiariello M, Murga C, Gutkind JS. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell–cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J. Biol. Chem. 274(27), 19347–19351 (1999).
   PubMed Web of Science ®Google Scholar
• Pang JH, Kraemer A, Stehbens SJ, Frame MC, Yap AS. Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function. J. Biol. Chem. 280(4), 3043–3050 (2005).
   PubMed Web of Science ®Google Scholar
• Xie Z, Bikle DD. The recruitment of phosphatidylinositol 3-kinase to the E-cadherin–catenin complex at the plasma membrane is required for calcium-induced phospholipase C-γ1 activation and human keratinocyte differentiation. J. Biol. Chem. 282(12), 8695–8703 (2007).
   PubMed Web of Science ®Google Scholar
• Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD. Phosphatidylinositol-4-phosphate 5-kinase 1α mediates extracellular calcium-induced keratinocyte differentiation. Mol. Biol. Cell 20(6), 1695–1704 (2009).
   PubMed Web of Science ®Google Scholar
• Perez-Moreno M, Jamora C, Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 112(4), 535–548 (2003).
   PubMed Web of Science ®Google Scholar
• Braga VM, Machesky LM, Hall A, Hotchin NA. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell–cell contacts. J. Cell Biol. 137(6), 1421–1431 (1997).
   PubMed Web of Science ®Google Scholar
• Furukawa F, Fujii K, Horiguchi Y et al. Roles of E- and P-cadherin in the human skin. Microsc. Res. Tech. 38(4), 343–352 (1997).
   PubMed Web of Science ®Google Scholar
• Young P, Boussadia O, Halfter H et al. E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. EMBO J. 22(21), 5723–5733 (2003).
   PubMed Web of Science ®Google Scholar
• Tinkle CL, Lechler T, Pasolli HA, Fuchs E. Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc. Natl Acad. Sci. USA 101(2), 552–557 (2004).
   PubMed Web of Science ®Google Scholar
• Tunggal JA, Helfrich I, Schmitz A et al. E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24(6), 1146–1156 (2005).
   PubMed Web of Science ®Google Scholar
• Tu CL, Chang W, Bikle DD. The calcium-sensing receptor-dependent regulation of cell–cell adhesion and keratinocyte differentiation requires Rho and filamin A. J. Invest. Dermatol. 131(5), 1119–1128 (2011).
   PubMed Web of Science ®Google Scholar
• Pokutta S, Weis WI. Structure and mechanism of cadherins and catenins in cell–cell contacts. Annu. Rev. Cell Dev. Biol. 23, 237–261 (2007).
   PubMed Web of Science ®Google Scholar
• Tu CL, Chang W, Xie Z, Bikle DD. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell–cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J. Biol. Chem. 283(6), 3519–3528 (2008).
   PubMed Web of Science ®Google Scholar
• Anastasiadis PZ. p120-ctn: a nexus for contextual signaling via Rho GTPases. Biochim. Biophys. Acta 1773(1), 34–46 (2007).
   PubMed Web of Science ®Google Scholar
• Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell 124(3), 631–644 (2006).
   PubMed Web of Science ®Google Scholar
• Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu. Rev. Cell Dev. Biol. 19, 207–235 (2003).
   PubMed Web of Science ®Google Scholar
• Fry MJ. Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? Breast Cancer Res. 3(5), 304–312 (2001).
   PubMed Web of Science ®Google Scholar
• Nemeth EF, Scarpa A. Rapid mobilization of cellular Ca 2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor. J. Biol. Chem. 262(11), 5188–5196 (1987).
   PubMed Web of Science ®Google Scholar
• Brown EM, Gamba G, Riccardi D et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 366(6455), 575–580 (1993).
   PubMed Web of Science ®Google Scholar
• Garrett JE, Capuano IV, Hammerland LG et al. Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J. Biol. Chem. 270(21), 12919–12925 (1995).
   PubMed Web of Science ®Google Scholar
• Oda Y, Tu CL, Pillai S, Bikle DD. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J. Biol. Chem. 273(36), 23344–23352 (1998).
   PubMed Web of Science ®Google Scholar
• Oda Y, Tu CL, Chang W et al. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J. Biol. Chem. 275(2), 1183–1190 (2000).
   PubMed Web of Science ®Google Scholar
• Tu CL, Chang W, Bikle DD. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J. Biol. Chem. 276(44), 41079–41085 (2001).
   PubMed Web of Science ®Google Scholar
• Ratnam AV, Cho JK, Bikle DD. 1,25-dihydroxyvitamin D3 enhances the calcium response of keratinocytes. J. Invest. Dermatol. 106, 910 (1996).
   Google Scholar
• Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci. Signal. 1(35), ra1 (2008).
   PubMedGoogle Scholar
• Tu C-L, Crumrine D, Man M-Q et al. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J. Invest. Dermatol. (2012) (In Press).
   Google Scholar
• Turksen K, Troy TC. Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo. Mech. Dev. 120(6), 733–744 (2003).
   PubMed Web of Science ®Google Scholar
• Tu CL, Chang W, Bikle DD. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. J. Invest. Dermatol. 127(5), 1074–1083 (2007).
   PubMed Web of Science ®Google Scholar
• Hu Z, Bonifas JM, Beech J et al. Mutations in ATP2C1, encoding a calcium pump, cause Hailey–Hailey disease. Nat. Genet. 24(1), 61–65 (2000).
   PubMed Web of Science ®Google Scholar
• Sakuntabhai A, Ruiz-Perez V, Carter S et al. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat. Genet. 21(3), 271–277 (1999).
   PubMed Web of Science ®Google Scholar
• Bikle DD. Vitamin D: role in skin and hair. In: Vitamin D (Volume 1, 2nd Edition). Feldman D, Pike W, Glorieux F (Eds). Elsevier Academic Press, CA, USA, 609–630 (2005).
   Google Scholar