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Review

Impact of Clostridium difficile on inflammatory bowel disease

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Pages 589-600 | Published online: 10 Jan 2014

References

  • Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N. Engl. J. Med.298, 531–534 (1978).
  • Jarvis WR, Schlosser J, Jarvis AA, Chinn RY. National point prevalence of Clostridium difficile in US health care facility inpatients, 2008. Am. J. Infect. Control37, 263–270 (2009).
  • Kuijper EJ, Coignard B, Tull P. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin. Microbiol. Infect.12(Suppl. 6), 2–18 (2006).
  • McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996–2003. Emerg. Infect. Dis.12, 409–415 (2006).
  • Pepin J, Valiquette L, Alary ME et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ171, 466–472 (2004).
  • Rupnik M, Wilcox MH, Gerding DN. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat. Rev. Microbiol.7, 526–536 (2009).
  • Dubberke ER, Wertheimer AI. Review of current literature on the economic burden of Clostridium difficile infection. Infect. Control Hosp. Epidemiol.30, 57–66 (2009).
  • Pituch H. Clostridium difficile is no longer just a nosocomial infection or an infection of adults. Int. J. Antimicrob. Agents33(Suppl. 1), S42–S45 (2009).
  • Ananthakrishnan AN, Issa M, Binion DG. Clostridium difficile and inflammatory bowel disease. Gastroenterol. Clin. North Am.38, 711–728 (2009).
  • Ananthakrishnan AN, McGinley EL, Binion DG. Excess hospitalisation burden associated with Clostridium difficile in patients with inflammatory bowel disease. Gut57, 205–210 (2008).
  • Issa M, Vijayapal A, Graham MB et al. Impact of Clostridium difficile on inflammatory bowel disease. Clin. Gastroenterol. Hepatol.5, 345–351 (2007).
  • Rodemann JF, Dubberke ER, Reske KA, Seo da H, Stone CD. Incidence of Clostridium difficile infection in inflammatory bowel disease. Clin. Gastroenterol. Hepatol.5, 339–344 (2007).
  • Jodorkovsky D, Young Y, Abreu MT. Clinical outcomes of patients with ulcerative colitis and co-existing Clostridium difficile infection. Dig. Dis. Sci.55(2), 415–420 (2010).
  • Nguyen GC, Kaplan GG, Harris ML, Brant SR. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am. J. Gastroenterol.103, 1443–1450 (2008).
  • Mylonaki M, Langmead L, Pantes A, Johnson F, Rampton DS. Enteric infection in relapse of inflammatory bowel disease: importance of microbiological examination of stool. Eur. J. Gastroenterol. Hepatol.16, 775–778 (2004).
  • Rolny P, Jarnerot G, Mollby R. Occurrence of Clostridium difficile toxin in inflammatory bowel disease. Scand. J. Gastroenterol.18, 61–64 (1983).
  • Weber P, Koch M, Heizmann WR, Scheurlen M, Jenss H, Hartmann F. Microbic superinfection in relapse of inflammatory bowel disease. J. Clin. Gastroenterol.14, 302–308 (1992).
  • Gryboski JD. Clostridium difficile in inflammatory bowel disease relapse. J. Pediatr. Gastroenterol. Nutr.13, 39–41 (1991).
  • Seaver RL. Screening for Clostridium difficile in chronic inflammatory bowel disease in relapse. Is it helpful? Is it cost efficient? J. Clin. Gastroenterol.8, 397–400 (1986).
  • Bossuyt P, Verhaegen J, Van Assche G, Rutgeerts P, Vermeire S. Increasing incidence of Clostridium difficile-associated diarrhea in inflammatory bowel disease. J. Crohns Colitis.3, 4–7 (2009).
  • Pascarella F, Martinelli M, Miele E, Del Pezzo M, Roscetto E, Staiano A. Impact of Clostridium difficile infection on pediatric inflammatory bowel disease. J. Pediatr.154, 854–858 (2009).
  • Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N. Engl. J. Med.346, 334–339 (2002).
  • Bartlett JG, Gerding DN. Clinical recognition and diagnosis of Clostridium difficile infection. Clin. Infect. Dis.46(Suppl. 1), S12–S18 (2008).
  • Kelly CP. A 76-year-old man with recurrent Clostridium difficile-associated diarrhea: review of C. difficile infection. JAMA301, 954–962 (2009).
  • McFarland LV. Renewed interest in a difficult disease: Clostridium difficile infections – epidemiology and current treatment strategies. Curr. Opin. Gastroenterol.25, 24–35 (2009).
  • Gaynes R, Rimland D, Killum E et al. Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. Clin. Infect. Dis.38, 640–645 (2004).
  • Pepin J, Saheb N, Coulombe MA et al. Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin. Infect. Dis.41, 1254–1260 (2005).
  • Monaghan T, Boswell T, Mahida YR. Recent advances in Clostridium difficile-associated disease. Gut57, 850–860 (2008).
  • Dial S, Delaney JA, Barkun AN, Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA294, 2989–2995 (2005).
  • Dial S, Alrasadi K, Manoukian C, Huang A, Menzies D. Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case–control studies. CMAJ171, 33–38 (2004).
  • Arif M, Weber LR, Knox JF et al. Patterns of proton pump inhibitor use in inflammatory bowel disease and concomitant risk of Clostridium difficile infection. Gastroenterology132, A513 (2007).
  • Kelly CP, LaMont JT. Clostridium difficile infection. Annu. Rev. Med.49, 375–390 (1998).
  • Ananthakrishnan AN, McGinley EL, Binion DG. Inflammatory bowel disease in the elderly is associated with worse outcomes: a national study of hospitalizations. Inflamm. Bowel Dis.15, 182–189 (2009).
  • Sonnenberg A, Richardson PA, Abraham NS. Hospitalizations for inflammatory bowel disease among US military veterans 1975–2006. Dig. Dis. Sci.54, 1740–1745 (2009).
  • Ananthakrishnan AN, McGinley EL, Saeian K, Binion DG. Trends in ambulatory and emergency room visits for inflammatory bowel diseases in the United States: 1994–2005. Am. J. Gastroenterol. (2009).
  • Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N. Engl. J. Med.342, 390–397 (2000).
  • Kyne L, Warny M, Qamar A, Kelly CP. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet357, 189–193 (2001).
  • Lowy I, Molrine DC, Leav BA et al. Treatment with monoclonal antibodies against Clostridium difficile toxins. N. Engl. J. Med.362, 197–205 (2010).
  • Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, Radford-Smith GL. Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease. Gut57, 903–910 (2008).
  • Shen BO, Jiang ZD, Fazio VW et al. Clostridium difficile infection in patients with ileal pouch-anal anastomosis. Clin. Gastroenterol. Hepatol.6, 782–788 (2008).
  • Lundeen SJ, Otterson MF, Binion DG, Carman ET, Peppard WJ. Clostridium difficile enteritis: an early postoperative complication in inflammatory bowel disease patients after colectomy. J. Gastrointest. Surg.11, 138–142 (2007).
  • Powell N, Jung SE, Krishnan B. Clostridium difficile infection and inflammatory bowel disease: a marker for disease extent? Gut57, 1183–1184 (2008).
  • Voth DE, Ballard JD. Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev.18, 247–263 (2005).
  • Rupnik M, Grabnar M, Geric B. Binary toxin producing Clostridium difficile strains. Anaerobe9, 289–294 (2003).
  • Giesemann T, Egerer M, Jank T, Aktories K. Processing of Clostridium difficile toxins. J. Med. Microbiol.57, 690–696 (2008).
  • Jank T, Giesemann T, Aktories K. Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding. J. Biol. Chem.282, 35222–35231 (2007).
  • Taylor NS, Thorne GM, Bartlett JG. Comparison of two toxins produced by Clostridium difficile. Infect. Immun.34, 1036–1043 (1981).
  • Drudy D, Harnedy N, Fanning S, O’Mahony R, Kyne L. Isolation and characterisation of toxin A-negative, toxin B-positive Clostridium difficile in Dublin, Ireland. Clin. Microbiol. Infect.13, 298–304 (2007).
  • Johnson S, Kent SA, O’Leary KJ et al. Fatal pseudomembranous colitis associated with a variant clostridium difficile strain not detected by toxin A immunoassay. Ann. Intern. Med.135, 434–438 (2001).
  • Barbut F, Decre D, Lalande V et al. Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains. J. Med. Microbiol.54, 181–185 (2005).
  • McEllistrem MC, Carman RJ, Gerding DN, Genheimer CW, Zheng L. A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes. Clin. Infect. Dis.40, 265–272 (2005).
  • Loo VG, Poirier L, Miller MA et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N. Engl. J. Med.353, 2442–2449 (2005).
  • McDonald LC, Killgore GE, Thompson A et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N. Engl. J. Med.353, 2433–2441 (2005).
  • Warny M, Pepin J, Fang A et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet366, 1079–1084 (2005).
  • Goorhuis A, Bakker D, Corver J et al. Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clin. Infect. Dis.47, 1162–1170 (2008).
  • Clayton EM, Rea MC, Shanahan F et al. The vexed relationship between Clostridium difficile and inflammatory bowel disease: an assessment of carriage in an outpatient setting among patients in remission. Am. J. Gastroenterol.104, 1162–1169 (2009).
  • Fekety R, Shah AB. Diagnosis and treatment of Clostridium difficile colitis. JAMA269, 71–75 (1993).
  • Crobach MJ, Dekkers OM, Wilcox MH, Kuijper EJ. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin. Microbiol. Infect.15, 1053–1066 (2009).
  • Nemat H, Khan R, Ashraf MS et al. Diagnostic value of repeated enzyme immunoassays in Clostridium difficile infection. Am. J. Gastroenterol.104, 2035–2041 (2009).
  • Issa M, Weber LR, Skaros S et al. Decreasing rates of colectomy despite high rates of hospitalization in C. difficile. infection IBD patients: a tertiary referral center experience. Gastroenterology132, A663 (2007).
  • Aslam S, Hamill RJ, Musher DM. Treatment of Clostridium difficile-associated disease: old therapies and new strategies. Lancet Infect. Dis.5, 549–557 (2005).
  • Garey KW, Sethi S, Yadav Y, DuPont HL. Meta-analysis to assess risk factors for recurrent Clostridium difficile infection. J. Hosp. Infect.70, 298–304 (2008).
  • Gerding DN, Muto CA, Owens RC Jr. Treatment of Clostridium difficile infection. Clin. Infect. Dis.46(Suppl. 1), S32–S42 (2008).
  • Chiplunker A, Ananthakrishnan AN, Beaulieu DB et al. Long-term impact of clostridium difficile on inflammatory bowel disease. Gastroenterology136(Suppl. 1), S1145 (2009).
  • Singh S, Graff LA, Bernstein CN. Do NSAIDs, antibiotics, infections, or stress trigger flares in IBD? Am. J. Gastroenterol.104, 1298–1313 (2009).
  • Leffler DA, Lamont JT. Treatment of Clostridium difficile-associated disease. Gastroenterology136, 1899–1912 (2009).
  • Bartlett JG. New drugs for Clostridium difficile infection. Clin. Infect. Dis.43, 428–431 (2006).
  • Musher DM, Aslam S, Logan N et al. Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin. Infect. Dis.40, 1586–1590 (2005).
  • Pepin J, Alary ME, Valiquette L et al. Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin. Infect. Dis.40, 1591–1597 (2005).
  • Hu MY, Maroo S, Kyne L et al. A prospective study of risk factors and historical trends in metronidazole failure for Clostridium difficile infection. Clin. Gastroenterol. Hepatol.6, 1354–1360 (2008).
  • Bartlett JG. The case for vancomycin as the preferred drug for treatment of Clostridium difficile infection. Clin. Infect. Dis.46, 1489–1492 (2008).
  • Pepin J. Vancomycin for the treatment of Clostridium difficile Infection: for whom is this expensive bullet really magic? Clin. Infect. Dis.46, 1493–1498 (2008).
  • Fekety R, Silva J, Kauffman C, Buggy B, Deery HG. Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimens. Am. J. Med.86, 15–19 (1989).
  • Nelson R. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database Syst. Rev.CD004610 (2007).
  • Bauer MP, van Dissel JT, Kuijper EJ. Clostridium difficile: controversies and approaches to management. Curr. Opin. Infect. Dis.22, 517–524 (2009).
  • Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin. Infect. Dis.45, 302–307 (2007).
  • Louie T. Results of a Phase III trial comparing tolveamer, vancomycin and metronidazole in Clostridium difficile-associated diarrhea (CDAD). Program and abstracts of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA, ASM Press (2007) (Abstract k-4259).
  • Ben-Horin S, Margalit M, Bossuyt P et al. Combination immunomodulator and antibiotic treatment in patients with inflammatory bowel disease and clostridium difficile infection. Clin. Gastroenterol. Hepatol.7, 981–987 (2009).
  • Pillai A, Nelson R. Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst. Rev.CD004611 (2008).
  • Jiang ZD, Dupont HL, La Rocco M, Garey KW. WITHDRAWN: In vitro activity of rifaximin and rifampin against clinical isolates of Clostridium difficile in Houston, Texas, Anaerobe DOI: 10.1016/j.anaerobe.2008.12.008 (2009) (Epub ahead of print).
  • Bobak DA. Rifaximin to Treat recurrent Clostridium difficile colitis. Curr. Infect. Dis. Rep.10, 90–91 (2008).
  • Garey KW, Jiang ZD, Bellard A, Dupont HL. Rifaximin in treatment of recurrent Clostridium difficile-associated diarrhea: an uncontrolled pilot study. J. Clin. Gastroenterol.43(1), 91–93 (2009).
  • Issa M, Weber LR, Brandenburg H et al. Rifaximin and treatment of recurrent Clostridium difficile infection in patients with inflammatory bowel disease. Am. J. Gastroenterol.101, S469 (2006).
  • Chan S, Kelly M, Helme S, Gossage J, Modarai B, Forshaw M. Outcomes following colectomy for Clostridium difficile colitis. Int. J. Surg.7, 78–81 (2009).
  • Longo WE, Mazuski JE, Virgo KS, Lee P, Bahadursingh AN, Johnson FE. Outcome after colectomy for Clostridium difficile colitis. Dis. Colon. Rectum47, 1620–1626 (2004).
  • Hall JF, Berger D. Outcome of colectomy for Clostridium difficile colitis: a plea for early surgical management. Am. J. Surg.196, 384–388 (2008).
  • Johnson S. Recurrent Clostridium difficile infection: a review of risk factors, treatments, and outcomes. J. Infect.58, 403–410 (2009).
  • McFarland LV, Elmer GW, Surawicz CM. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am. J. Gastroenterol.97, 1769–1775 (2002).
  • Johnson S, Schriever C, Galang M, Kelly CP, Gerding DN. Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin. Clin. Infect. Dis.44, 846–848 (2007).
  • Johnson S, Schriever C, Patel U, Patel T, Hecht DW, Gerding DN. Rifaximin redux: treatment of recurrent Clostridium difficile infections with rifaximin immediately post-vancomycin treatment. Anaerobe15, 290–291 (2009).
  • McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am. J. Gastroenterol.101, 812–822 (2006).
  • Salcedo J, Keates S, Pothoulakis C et al. Intravenous immunoglobulin therapy for severe Clostridium difficile colitis. Gut41, 366–370 (1997).
  • McPherson S, Rees CJ, Ellis R, Soo S, Panter SJ. Intravenous immunoglobulin for the treatment of severe, refractory, and recurrent Clostridium difficile diarrhea. Dis. Colon Rectum49, 640–645 (2006).
  • Abougergi MS, Broor A, Cui W, Jaar BG. Intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis: an observational study and review of the literature. J. Hosp. Med.5, E1–E9 (2010).
  • Mann SD, Pitt J, Springall RG, Thillainayagam AV. Clostridium difficile infection – an unusual cause of refractory pouchitis: report of a case. Dis. Colon Rectum46, 267–270 (2003).
  • Shen B, Goldblum JR, Hull TL, Remzi FH, Bennett AE, Fazio VW. Clostridium difficile-associated pouchitis. Dig. Dis. Sci.51, 2361–2364 (2006).
  • Tsironi E, Irving PM, Feakins RM, Rampton DS. ‘Diversion’ colitis caused by Clostridium difficile infection: report of a case. Dis. Colon Rectum49, 1074–1077 (2006).
  • Miller DL, Sedlack JD, Holt RW. Perforation complicating rifampin-associated pseudomembranous enteritis. Arch. Surg.124, 1082 (1989).
  • Vesoulis Z, Williams G, Matthews B. Pseudomembranous enteritis after proctocolectomy: report of a case. Dis. Colon Rectum43, 551–554 (2000).
  • Yee HF Jr, Brown RS Jr, Ostroff JW. Fatal Clostridium difficile enteritis after total abdominal colectomy. J. Clin. Gastroenterol.22, 45–47 (1996).
  • Causey MW, Spencer MP, Steele SR. Clostridium difficile enteritis after colectomy. Am. Surg.75, 1203–1206 (2009).
  • Lavallee C, Laufer B, Pepin J, Mitchell A, Dube S, Labbe AC. Fatal Clostridium difficile enteritis caused by the BI/NAP1/027 strain: a case series of ileal C. difficile infections. Clin. Microbiol. Infect.15, 1093–1099 (2009).
  • Gerding DN, Muto CA, Owens RC Jr. Measures to control and prevent Clostridium difficile infection. Clin. Infect. Dis.46(Suppl. 1), S43–S49 (2008).
  • Oughton MT, Loo VG, Dendukuri N, Fenn S, Libman MD. Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of Clostridium difficile. Infect. Control Hosp. Epidemiol.30, 939–944 (2009).
  • Vonberg RP, Kuijper EJ, Wilcox MH et al. Infection control measures to limit the spread of Clostridium difficile. Clin. Microbiol. Infect.14(Suppl. 5), 2–20 (2008).

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