New molecular insights into inflammatory bowel disease-induced diarrhea

References

• Gismera CS, Aladren BS. Inflammatory bowel diseases: a disease(s) of modern times? Is incidence still increasing? World J. Gastroenterol.14(36), 5491–5498 (2008).
   PubMedGoogle Scholar
• Shah SB, Hanauer SB. Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions. Rev. Gastroenterol. Disord.7(Suppl. 3), S3–S10 (2007).
   PubMedGoogle Scholar
• Payne CM, Fass R, Bernstein H et al. Pathogenesis of diarrhea in the adult: diagnostic challenges and life-threatening conditions. Eur. J. Gastroenterol. Hepatol.18(10), 1047–1051 (2006).
   PubMedGoogle Scholar
• Seidler U, Lenzen H, Cinar A, Tessema T, Bleich A, Riederer B. Molecular mechanisms of disturbed electrolyte transport in intestinal inflammation. Ann. NY Acad. Sci.1072, 262–275 (2006).
   PubMedGoogle Scholar
• Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature448(7152), 427–434 (2007).
   PubMed Web of Science ®Google Scholar
• Keighley MR, Stockbrugger RW. Inflammatory bowel disease. Aliment. Pharmacol. Ther.18(Suppl. 3), 66–70 (2003).
   PubMedGoogle Scholar
• Binder HJ. Mechanisms of diarrhea in inflammatory bowel diseases. Ann. NY Acad. Sci.1165, 285–293 (2009).
   PubMed Web of Science ®Google Scholar
• Field M. Intestinal ion transport and the pathophysiology of diarrhea. J. Clin. Invest.111(7), 931–943 (2003).
   PubMed Web of Science ®Google Scholar
• Ivanov AI, Parkos CA, Nusrat A. Cytoskeletal regulation of epithelial barrier function during inflammation. Am. J. Pathol.177(2), 512–524 (2010).
   PubMed Web of Science ®Google Scholar
• Schulzke JD, Ploeger S, Amasheh M et al. Epithelial tight junctions in intestinal inflammation. Ann. NY Acad. Sci.1165, 294–300 (2009).
   PubMed Web of Science ®Google Scholar
• Mankertz J, Schulzke JD. Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr. Opin. Gastroenterol.23(4), 379–383 (2007).
   PubMed Web of Science ®Google Scholar
• Harris J, Shields R. Absorption and secretion of water and electrolytes by the intact human colon in diffuse untreated proctocolitis. Gut11(1), 27–33 (1970).
   PubMed Web of Science ®Google Scholar
• Rask-Madsen J, Hammersgaard EA, Knudsen E. Rectal electrolyte transport and mucosal permeability in ulcerative colitis and Crohn’s disease. J. Lab. Clin. Med.81(3), 342–353 (1973).
   PubMed Web of Science ®Google Scholar
• Rask-Madsen J, Jensen PB. Electrolyte transport capacity and electrical potentials of the normal and the inflamed human rectum in vivo. Scand. J. Gastroenterol.8(2), 169–175 (1973).
   PubMed Web of Science ®Google Scholar
• Archampong EQ, Harris J, Clark CG. The absorption and secretion of water and electrolytes across the healthy and the diseased human colonic mucosa measured in vitro. Gut13(11), 880–886 (1972).
   PubMed Web of Science ®Google Scholar
• Hawker PC, McKay JS, Turnberg LA. Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease. Gastroenterology79(3), 508–511 (1980).
   PubMed Web of Science ®Google Scholar
• Amasheh S, Barmeyer C, Koch CS et al. Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis. Gastroenterology126(7), 1711–1720 (2004).
   PubMedGoogle Scholar
• Yang H, Jiang W, Furth EE et al. Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea. Am. J. Physiol.275(6 Pt 1), G1445–G1453 (1998).
   Google Scholar
• Friswell M, Campbell B, Rhodes J. The role of bacteria in the pathogenesis of inflammatory bowel disease. Gut Liver4(3), 295–306 (2010).
   PubMed Web of Science ®Google Scholar
• Nell S, Suerbaum S, Josenhans C. The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models. Nat. Rev. Microbiol.8(8), 564–577 (2010).
   PubMed Web of Science ®Google Scholar
• Hollander D. The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn’s disease. Scand. J. Gastroenterol.27(9), 721–726 (1992).
   PubMed Web of Science ®Google Scholar
• Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab. Invest.84(3), 282–291 (2004).
   PubMed Web of Science ®Google Scholar
• Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am. J. Pathol.169(6), 1901–1909 (2006).
   PubMed Web of Science ®Google Scholar
• Ivanov AI, Nusrat A, Parkos CA. Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers. Bioessays27(4), 356–365 (2005).
   PubMed Web of Science ®Google Scholar
• Laukoetter MG, Bruewer M, Nusrat A. Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr. Opin. Gastroenterol.22(2), 85–89 (2006).
   PubMed Web of Science ®Google Scholar
• Madara JL. Warner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier. Am. J. Pathol.137(6), 1273–1281 (1990).
   PubMed Web of Science ®Google Scholar
• Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science307(5717), 1915–1920 (2005).
   PubMed Web of Science ®Google Scholar
• Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell118(2), 229–241 (2004).
   PubMed Web of Science ®Google Scholar
• Andoh A, Benno Y, Kanauchi O, Fujiyama Y. Recent advances in molecular approaches to gut microbiota in inflammatory bowel disease. Curr. Pharm. Des.15(18), 2066–2073 (2009).
   PubMed Web of Science ®Google Scholar
• Qin J, Li R, Raes J et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature464(7285), 59–65 (2010).
   PubMed Web of Science ®Google Scholar
• Salzman NH, de Jong H, Paterson Y, Harmsen HJ, Welling GW, Bos NA. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology148(Pt 11), 3651–3660 (2002).
   PubMed Web of Science ®Google Scholar
• Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl Acad. Sci. USA104(34), 13780–13785 (2007).
   PubMed Web of Science ®Google Scholar
• Chapman-Kiddell CA, Davies PS, Gillen L, Radford-Smith GL. Role of diet in the development of inflammatory bowel disease. Inflamm. Bowel Dis.16(1), 137–151 (2010).
   PubMed Web of Science ®Google Scholar
• Mutlu E, Keshavarzian A, Engen P, Forsyth CB, Sikaroodi M, Gillevet P. Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol Clin. Exp. Res.33(10), 1836–1846 (2009).
   PubMed Web of Science ®Google Scholar
• Gophna U, Sommerfeld K, Gophna S, Doolittle WF, Veldhuyzen van Zanten SJ. Differences between tissue-associated intestinal microfloras of patients with Crohn’s disease and ulcerative colitis. J. Clin. Microbiol.44(11), 4136–4141 (2006).
   PubMed Web of Science ®Google Scholar
• Bibiloni R, Mangold M, Madsen KL, Fedorak RN, Tannock GW. The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn’s disease and ulcerative colitis patients. J. Med. Microbiol.55(Pt 8), 1141–1149 (2006).
   PubMed Web of Science ®Google Scholar
• Kassinen A, Krogius-Kurikka L, Makivuokko H et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology133(1), 24–33 (2007).
   PubMed Web of Science ®Google Scholar
• Othman M, Aguero R, Lin HC. Alterations in intestinal microbial flora and human disease. Curr. Opin. Gastroenterol.24(1), 11–16 (2008).
   PubMed Web of Science ®Google Scholar
• Hoffmann C, Hill DA, Minkah N et al. Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing. Infect. Immun.77(10), 4668–4678 (2009).
   PubMedGoogle Scholar
• Lupp C, Robertson ML, Wickham ME et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe2(2), 119–129 (2007).
   PubMed Web of Science ®Google Scholar
• Stecher B, Robbiani R, Walker AW et al.Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol.5(10), 2177–2189 (2007).
   PubMed Web of Science ®Google Scholar
• Heimesaat MM, Fischer A, Siegmund B et al. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One2(7), e662 (2007).
   PubMed Web of Science ®Google Scholar
• Garrett WS, Gallini CA, Yatsunenko T et al.Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe8(3), 292–300 (2010).
   PubMed Web of Science ®Google Scholar
• Walk ST, Blum AM, Ewing SA, Weinstock JV, Young VB. Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus. Inflamm. Bowel Dis.16(11), 1841–1849 (2010).
   PubMedGoogle Scholar
• Willing BP, Dicksved J, Halfvarson J et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology139(6), 1844–1854 (2010).
   PubMed Web of Science ®Google Scholar
• Uronis JM, Arthur JC, Keku T et al. Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm. Bowel Dis.17(1), 289–297 (2010).
   Google Scholar
• Rose DJ, Venema K, Keshavarzian A, Hamaker BR. Starch-entrapped microspheres show a beneficial fermentation profile and decrease in potentially harmful bacteria during in vitro fermentation in faecal microbiota obtained from patients with inflammatory bowel disease. Br. J. Nutr.103(10), 1514–1524 (2010).
   PubMed Web of Science ®Google Scholar
• Komiyama Y, Andoh A, Fujiwara D et al. New prebiotics from rice bran ameliorate inflammation in murine colitis models through the modulation of intestinal homeostasis and the mucosal immune system. Scand. J. Gastroenterol.46(1), 40–52 (2010).
   PubMedGoogle Scholar
• Petersen AM, Nielsen EM, Litrup E, Brynskov J, Mirsepasi H, Krogfelt KA. A phylogenetic group of Escherichia coli associated with active left-sided inflammatory bowel disease. BMC Microbiol.9, 171 (2009).
   PubMed Web of Science ®Google Scholar
• Packey CD, Sartor RB. Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases. Curr. Opin. Infect. Dis.22(3), 292–301 (2009).
   PubMed Web of Science ®Google Scholar
• Chow J, Mazmanian SK. A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe7(4), 265–276 (2010).
   PubMed Web of Science ®Google Scholar
• Sokol H, Seksik P, Furet JP et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm. Bowel Dis.15(8), 1183–1189 (2009).
   PubMed Web of Science ®Google Scholar
• Sokol H, Pigneur B, Watterlot L et al.Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl Acad. Sci. USA105(43), 16731–16736 (2008).
   PubMed Web of Science ®Google Scholar
• Darfeuille-Michaud A, Neut C, Barnich N et al. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn’s disease. Gastroenterology115(6), 1405–1413 (1998).
   PubMed Web of Science ®Google Scholar
• Boudeau J, Glasser AL, Masseret E, Joly B, Darfeuille-Michaud A. Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn’s disease. Infect. Immun.67(9), 4499–4509 (1999).
   PubMed Web of Science ®Google Scholar
• Lodes MJ, Cong Y, Elson CO et al. Bacterial flagellin is a dominant antigen in Crohn disease. J. Clin. Invest.113(9), 1296–1306 (2004).
   PubMed Web of Science ®Google Scholar
• Miller H, Zhang J, Kuolee R, Patel GB, Chen W. Intestinal M cells: the fallible sentinels? World J. Gastroenterol.13(10), 1477–1486 (2007).
   PubMed Web of Science ®Google Scholar
• Garside P, Millington O, Smith KM. The anatomy of mucosal immune responses. Ann. NY Acad. Sci.1029, 9–15 (2004).
   PubMed Web of Science ®Google Scholar
• Lamb-Rosteski JM, Kalischuk LD, Inglis GD, Buret AG. Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation. Infect. Immun.76(8), 3390–3398 (2008).
   PubMed Web of Science ®Google Scholar
• Rhee SH, Im E, Riegler M, Kokkotou E, O’Brien M, Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc. Natl Acad. Sci. USA102(38), 13610–13615 (2005).
   PubMed Web of Science ®Google Scholar
• Martin HM, Campbell BJ, Hart CA et al. Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer. Gastroenterology127(1), 80–93 (2004).
   PubMed Web of Science ®Google Scholar
• Geier MS, Butler RN, Howarth GS. Inflammatory bowel disease: current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics. Int. J. Food Microbiol.115(1), 1–11 (2007).
   PubMed Web of Science ®Google Scholar
• van Vliet MJ, Harmsen HJ, de Bont ES, Tissing WJ. The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog.6(5), e1000879 (2010).
   PubMed Web of Science ®Google Scholar
• Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science292(5519), 1115–1118 (2001).
   PubMed Web of Science ®Google Scholar
• Blumberg RS, Li L, Nusrat A, Parkos CA, Rubin DC, Carrington JL. Recent insights into the integration of the intestinal epithelium within the mucosal environment in health and disease. Mucosal Immunol.1(5), 330–334 (2008).
   PubMedGoogle Scholar
• Turner JR. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol.9(11), 799–809 (2009).
   PubMed Web of Science ®Google Scholar
• Murphy MS, Eastham EJ, Nelson R, Pearson AD, Laker MF. Intestinal permeability in Crohn’s disease. Arch. Dis. Child64(3), 321–325 (1989).
   PubMed Web of Science ®Google Scholar
• Wyatt J, Vogelsang H, Hubl W, Waldhoer T, Lochs H. Intestinal permeability and the prediction of relapse in Crohn’s disease. Lancet341(8858), 1437–1439 (1993).
   PubMed Web of Science ®Google Scholar
• Zeissig S, Burgel N, Gunzel D et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease. Gut56(1), 61–72 (2007).
   PubMed Web of Science ®Google Scholar
• Rosenstiel P, Fantini M, Brautigam K et al. TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology124(4), 1001–1009 (2003).
   PubMed Web of Science ®Google Scholar
• Buhner S, Buning C, Genschel J et al. Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? Gut55(3), 342–347 (2006).
   PubMed Web of Science ®Google Scholar
• D’Inca R, Annese V, di Leo V et al. Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn’s disease. Aliment. Pharmacol. Ther.23(10), 1455–1461 (2006).
   PubMed Web of Science ®Google Scholar
• Musch MW, Clarke LL, Mamah D et al. T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J. Clin. Invest.110(11), 1739–1747 (2002).
   PubMed Web of Science ®Google Scholar
• Clayburgh DR, Barrett TA, Tang Y et al. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J. Clin. Invest.115(10), 2702–2715 (2005).
   PubMed Web of Science ®Google Scholar
• Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J. Clin. Invest.116(10), 2682–2694 (2006).
   PubMed Web of Science ®Google Scholar
• Mauri DN, Ebner R, Montgomery RI et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity8(1), 21–30 (1998).
   PubMed Web of Science ®Google Scholar
• Tang Y, Clayburgh DR, Mittal N et al. Epithelial NF-κB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Am. J. Pathol.176(1), 158–167 (2010).
   PubMedGoogle Scholar
• Amin MR, Orenuga T, Tyagi S, Dudeja PK, Ramaswamy K, Malakooti J. Tumor necrosis factor-α represses the expression of NHE2 through NF-κB activation in intestinal epithelial cell model, C2BBe1. Inflamm. Bowel Dis.17(3), 720–731 (2010).
   PubMedGoogle Scholar
• Carthew RW. Gene regulation by microRNAs. Curr. Opin. Genet. Dev.16(2), 203–208 (2006).
   PubMed Web of Science ®Google Scholar
• Ambros V. The functions of animal microRNAs. Nature431(7006), 350–355 (2004).
   PubMed Web of Science ®Google Scholar
• Krutzfeldt J, Stoffel M. MicroRNAs: a new class of regulatory genes affecting metabolism. Cell Metab.4(1), 9–12 (2006).
   PubMed Web of Science ®Google Scholar
• Krutzfeldt J, Poy MN, Stoffel M. Strategies to determine the biological function of microRNAs. Nat. Genet.38(Suppl.), S14–S19 (2006).
   PubMed Web of Science ®Google Scholar
• Gauthier BR, Wollheim CB. MicroRNAs: ‘ribo-regulators’ of glucose homeostasis. Nat. Med.12(1), 36–38 (2006).
   PubMedGoogle Scholar
• Fasseu M, Treton X, Guichard C et al. Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS One5(10), e13160 (2010).
   PubMed Web of Science ®Google Scholar
• Wu F, Zhang S, Dassopoulos T et al. Identification of microRNAs associated with ileal and colonic Crohn’s disease. Inflamm. Bowel Dis.16(10), 1729–1738 (2010).
   PubMed Web of Science ®Google Scholar
• Wu F, Zikusoka M, Trindade A et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 α. Gastroenterology135(5), 1624–1635.e1624 (2008).
   PubMed Web of Science ®Google Scholar
• Tang Y, Banan A, Forsyth CB et al. Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin. Exp. Res.32(2), 355–364 (2008).
   PubMed Web of Science ®Google Scholar
• Blow MJ, Grocock RJ, van Dongen S et al. RNA editing of human microRNAs. Genome Biol.7(4), R27 (2006).
   PubMed Web of Science ®Google Scholar
• Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res.34(Database issue), D140–D144 (2006).
   PubMed Web of Science ®Google Scholar
• Kapeller J, Houghton LA, Monnikes H et al. First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum. Mol. Genet.17(19), 2967–2977 (2008).
   PubMed Web of Science ®Google Scholar
• Cho JH, Brant SR. Recent insights into the genetics of inflammatory bowel disease. Gastroenterology140(6), 1704–1712 (2010).
   Google Scholar
• Hering NA, Schulzke JD. Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig. Dis.27(4), 450–454 (2009).
   PubMed Web of Science ®Google Scholar