419
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Iron overload in myelodysplastic syndromes

&
Pages 215-218 | Published online: 10 Jan 2014

References

  • Cazzola M, Malcovati L. Myelodysplastic syndromes – coping with ineffective hematopoiesis. N. Engl. J. Med.352(6), 536–538 (2005).
  • A randomized double-blind placebo-controlled study with subcutaneous recombinant human erythropoietin in patients with low-risk myelodysplastic syndromes. Italian Cooperative Study Group for rHuEpo in Myelodysplastic Syndromes. Br. J. Haematol.103(4), 1070–1074 (1998).
  • Porter JB. Practical management of iron overload. Br. J. Haematol.115(2), 239–252 (2001).
  • Mahesh S, Ginzburg Y, Verma A. Iron overload in myelodysplastic syndromes. Leuk. Lymphoma49(3), 427–438 (2008).
  • Mittelman M, Lugassy G, Merkel D et al. Iron chelation therapy in patients with myelodysplastic syndromes: consensus conference guidelines. Isr. Med. Assoc. J.10(5), 374–376 (2008).
  • Valent P, Krieger O, Stauder R et al. Iron overload in myelodysplastic syndromes (MDS) - diagnosis, management, and response criteria: a proposal of the Austrian MDS platform. Eur. J. Clin. Invest.38(3), 143–149 (2008).
  • Greenberg PL. Myelodysplastic syndromes: iron overload consequences and current chelating therapies. J. Natl Compr. Canc. Netw.4(1), 91–96 (2006).
  • Rose C, Cambier N, Mahieu M, Ernst O, Fenaux P. [Iron overload and myelodysplastic syndromes]. Transfus. Clin. Biol.8(5), 422–432 (2001).
  • Bennett JM. Consensus statement on iron overload in myelodysplastic syndromes. Am. J. Hematol.83(11), 858–861 (2008).
  • Alessandrino EP, Amadori S, Barosi G et al. Evidence- and consensus-based practice guidelines for the therapy of primary myelodysplastic syndromes. A statement from the Italian Society of Hematology. Haematologica87(12), 1286–1306 (2002).
  • Jabbour E, Kantarjian HM, Koller C, Taher A. Red blood cell transfusions and iron overload in the treatment of patients with myelodysplastic syndromes. Cancer112(5), 1089–1095 (2008).
  • Gattermann N. Overview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload. Int. J. Hematol.88(1), 24–29 (2008).
  • Bowen D, Culligan D, Jowitt S et al. Guidelines for the diagnosis and therapy of adult myelodysplastic syndromes. Br. J. Haematol.120(2), 187–200 (2003).
  • Wells RA, Leber B, Buckstein R et al. Iron overload in myelodysplastic syndromes: a Canadian consensus guideline. Leuk. Res.32(9), 1338–1353 (2008).
  • Weintraub LR, Conrad ME, Crosby WH. Regulation of the intestinal absorption of iron by the rate of erythropoiesis. Br. J. Haematol.11, 432–438 (1965).
  • Nemeth E, Tuttle MS, Powelson J et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science306(5704), 2090–2093 (2004).
  • Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu. Rev. Nutr.26, 323–342 (2006).
  • Papanikolaou G, Tzilianos M, Christakis JI et al. Hepcidin in iron overload disorders. Blood105(10), 4103–4105 (2005).
  • Winder A, Lefkowitz R, Ghoti H et al. Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. Br. J. Haematol.142(4), 669–671 (2008).
  • Ramirez JM, Schaad O, Durual S et al. Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br. J. Haematol.144(2), 251–262 (2009).
  • Tanno T, Bhanu NV, Oneal PA et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med.13(9), 1096–1101 (2007).
  • Tamary H, Shalev H, Perez-Avraham G et al. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood112(13), 5241–5244 (2008).
  • Finkenstedt A, Bianchi P, Theurl I et al. Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. Br. J. Haematol.144(5), 789–793 (2009).
  • Breuer W, Hershko C, Cabantchik ZI. The importance of non-transferrin bound iron in disorders of iron metabolism. Transfus. Sci.23(3), 185–192 (2000).
  • Breuer W, Ronson A, Slotki IN et al. The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation. Blood95(9), 2975–2982 (2000).
  • Esposito BP, Breuer W, Sirankapracha P et al. Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood102(7), 2670–2677 (2003).
  • Cortelezzi A, Cattaneo C, Cristiani S et al. Non-transferrin-bound iron in myelodysplastic syndromes: a marker of ineffective erythropoiesis? Hematol. J.1(3), 153–158 (2000).
  • Breuer W, Ermers MJ, Pootrakul P et al. Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy. Blood97(3), 792–798 (2001).
  • Wang WC, Ahmed N, Hanna M. Non-transferrin-bound iron in long-term transfusion in children with congenital anemias. J. Pediatr.108(4), 552–557 (1986).
  • Pootrakul P, Breuer W, Sametband M et al. Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded β-thalassemia/HbE patients treated with an oral chelator. Blood104(5), 1504–1510 (2004).
  • Jaeger M, Aul C, Sohngen D, Germing U, Schneider W. [Secondary hemochromatosis in polytransfused patients with myelodysplastic syndromes]. Beitr. Infusionsther.30, 464–468 (1992).
  • Cazzola M, Barosi G, Gobbi PG et al. Natural history of idiopathic refractory sideroblastic anemia. Blood71(2), 305–312 (1988).
  • Delea TE, Hagiwara M, Phatak PD. Retrospective study of the association between transfusion frequency and potential complications of iron overload in patients with myelodysplastic syndrome and other acquired hematopoietic disorders. Curr. Med. Res. Opin.25(1), 139–147 (2009).
  • Goldberg SL, Mody-Patel N, Chen ER. Clinical and economic consequences of myelodysplastic syndromes in the United States: an analysis of the medicare database. Blood112(11), A237 (2008) (Abstract 636).
  • Malcovati L, Porta MG, Pascutto C et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. J. Clin. Oncol.23(30), 7594–7603 (2005).
  • Garcia-Manero G, Shan J, Faderl S et al. A prognostic score for patients with lower risk myelodysplastic syndrome. Leukemia22(3), 538–543 (2008).
  • Takatoku M, Uchiyama T, Okamoto S et al. Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality. Eur. J. Haematol.78(6), 487–494 (2007).
  • Sanz G, Nomdedeu B, Such E et al. Independent impact of iron overload and transfusion dependency on survival and leukemic evolution in patients with myelodysplastic syndrome. Blood112(11), 238a–239a (2008) (Abstarct 640).
  • Chan LSA, Buckstein R, Reis MD et al. Iron overload and haematopoiesis in MDS: does blood transfusion promote progression to AML? Blood112(11), A928 (2008) (Abstract 2685).
  • Kersten MJ, Lange R, Smeets ME et al. Long-term treatment of transfusional iron overload with the oral iron chelator deferiprone (L1): a Dutch multicenter trial. Ann. Hematol.73(5), 247–252 (1996).
  • Gattermann N, Schmid M, Della Porta M et al. Efficacy and safety of deferasirox (Exjade) during 1 year of treatment in transfusion-dependent patients with myelodsysplastic syndromes: results from EPIC Trial. Blood112(11), A235–A236 (2008) (Abstract 633).
  • Jensen PD, Jensen FT, Christensen T et al. Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: indication of close relation between myocardial iron content and chelatable iron pool. Blood101(11), 4632–4639 (2003).
  • Porter J, Galanello R, Saglio G et al. Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study. Eur. J. Haematol.80(2), 168–176 (2008).
  • Cappellini MD, Cohen A, Piga A et al. A Phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia. Blood107(9), 3455–3462 (2006).
  • List AF, Baer MR, Steensma DP, Raza A. Iron chelation with deferasirox (Exjade) improves iron burden in patients with myelodysplastic syndrome (MDS). Blood112(11), A236 (2008) (Abstract 634).
  • Rachmilewitz E, Merkel D, Ghoti H et al. Improvement of oxidative stress parameters in MDS patients with iron overload treated with deferasirox. Blood112(11), A924–A925 (2008) (Abstract 2675).
  • Leitch HA, Leger CS, Goodman TA et al. Improved survival in patients with myelodysplastic syndrome receiving iron chelation therapy. Clin. Leuk.2, 205–211 (2008).
  • Rose C, Brechignac S, Vassilief D et al. Positive impact of iron chelation therapy (CT) on survival in regularly transfused MDS patients. A prospective analysis by the GFM. Blood110(11), A80–A81 (2007) (Abstract 249).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.