41
Views
5
CrossRef citations to date
0
Altmetric
Special Report

Neovascular age-related macular degeneration and anti-VEGF nonresponders

, , &
Pages 35-41 | Published online: 09 Jan 2014

References

  • West SK. Looking forward to 20/20: a focus on the epidemiology of eye diseases. Epidemiol. Rev.22(1), 64–70 (2000).
  • Lee PP, Feldman ZW, Ostermann J, Brown DS, Sloan FA. Longitudinal prevalence of major eye diseases. Arch. Ophthalmol.121(9), 1303–1310 (2003).
  • Ferris FL 3rd, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch. Ophthalmol.102(11), 1640–1642 (1984).
  • Ferrara N, Gerber HP, Lecouter J. The biology of VEGF and its receptors. Nat. Med.9(6), 669–676 (2003).
  • Kliffen M, Sharma HS, Mooy CM, Kerkvliet S, De Jong PT. Increased expression of angiogenic growth factors in age-related maculopathy. Br. J. Ophthalmol.81(2), 154–162 (1997).
  • Brown DM, Kaiser PK, Michels M et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N. Engl. J. Med.355(14), 1432–1444 (2006).
  • Rosenfeld PJ, Brown DM, Heier JS et al. Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med.355(14), 1419–1431 (2006).
  • Macular Photocoagulation Study Group. Argon laser photocoagulation for senile macular degeneration. Results of a randomized clinical trial. Arch. Ophthalmol.100(6), 912–918 (1982).
  • Bressler NM. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-tap report 2. Arch. Ophthalmol.119(2), 198–207 (2001).
  • Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med.351(27), 2805–2816 (2004).
  • Carmeliet P, Ferreira V, Breier G et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature380(6573), 435–439 (1996).
  • Ferrara N, Carver-Moore K, Chen H et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature380(6573), 439–442 (1996).
  • Ivan M, Kondo K, Yang H et al. Hifa targeted for vhl-mediated destruction by proline hydroxylation: implications for O2 sensing. Science292(5516), 464–468 (2001).
  • Jaakkola P, Mole DR, Tian YM et al. Targeting of HIF-a to the von Hippel–Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science292(5516), 468–472 (2001).
  • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol.20(21), 4368–4380 (2002).
  • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell86(3), 353–364 (1996).
  • Luo JC, Yamaguchi S, Shinkai A, Shitara K, Shibuya M. Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors. Cancer Res.58(12), 2652–2660 (1998).
  • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med.350(23), 2335–2342 (2004).
  • Nozaki M, Raisler BJ, Sakurai E et al. Drusen complement components c3a and c5a promote choroidal neovascularization. Proc. Natl Acad. Sci. USA103(7), 2328–2333 (2006).
  • Kvanta A, Algvere PV, Berglin L, Seregard S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest. Ophthalmol. Vis. Sci.37(9), 1929–1934 (1996).
  • Dipietro LA. Thrombospondin as a regulator of angiogenesis. EXS79, 295–314 (1997).
  • Watanabe K, Hasegawa Y, Yamashita H et al. Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J. Clin. Invest.114(7), 898–907 (2004).
  • Nowak JZ. Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol. Rep.58(3), 353–363 (2006).
  • Mori K, Duh E, Gehlbach P et al. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J. Cell Physiol.188(2), 253–263 (2001).
  • Zhang SX, Wang JJ, Gao G, Shao C, Mott R, Ma JX. Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. FASEB J.20(2), 323–325 (2006).
  • Tong JP, Chan WM, Liu DT et al. Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. Am. J. Ophthalmol.141(3), 456–462 (2006).
  • Ogata N, Matsuoka M, Imaizumi M, Arichi M, Matsumura M. Decrease of pigment epithelium-derived factor in aqueous humor with increasing age. Am. J. Ophthalmol.137(5), 935–936 (2004).
  • Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch. Ophthalmol.122(4), 598–614 (2004).
  • Rakic JM, Lambert V, Devy L et al. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest. Ophthalmol. Vis. Sci.44(7), 3186–3193 (2003).
  • Avery RL, Pieramici DJ, Rabena MD, Castellarin AA, Nasir MA, Giust MJ. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology113(3), 363–372.e5 (2006).
  • Geitzenauer W, Michels S, Prager F et al. Early effects of systemic and intravitreal bevacizumab (Avastin) therapy for neovascular age-related macular degeneration. Klin. Monatsbl. Augenheilkd.223(10), 822–827 (2006).
  • Lazic R, Gabric N. Intravitreally administered bevacizumab (Avastin) in minimally classic and occult choroidal neovascularization secondary to age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol.245(1), 68–73 (2007).
  • Moshfeghi AA, Rosenfeld PJ, Puliafito CA et al. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: twenty-four-week results of an uncontrolled open-label clinical study. Ophthalmology113(11), 2002.e1–2002.e12 (2006).
  • Yoganathan P, Deramo VA, Lai JC, Tibrewala RK, Fastenberg DM. Visual improvement following intravitreal bevacizumab (Avastin) in exudative age-related macular degeneration. Retina26(9), 994–998 (2006).
  • Lux A, Llacer H, Heussen FM, Joussen AM. Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions. Br. J. Ophthalmol.91(10), 1318–1322 (2007).
  • Lee S, Chen TT, Barber CL et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell130(4), 691–703 (2007).
  • Yu JL, Rak JW, Coomber BL, Hicklin DJ, Kerbel RS. Effect of p53 status on tumor response to antiangiogenic therapy. Science295(5559), 1526–1528 (2002).
  • Glade Bender J, Cooney EM, Kandel JJ, Yamashiro DJ. Vascular remodeling and clinical resistance to antiangiogenic cancer therapy. Drug Resist. Update7(4–5), 289–300 (2004).
  • Cho CH, Kim KE, Byun J et al. Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow. Circ. Res.97(1), 86–94 (2005).
  • Uemura A, Ogawa M, Hirashima M et al. Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J. Clin. Invest.110(11), 1619–1628 (2002).
  • Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature438(7070), 946–953 (2005).
  • Ikeda Y, Yonemitsu Y, Onimaru M et al. The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium. Exp. Eye Res.83(5), 1031–1040 (2006).
  • Witmer AN, Van Blijswijk BC, Dai J et al. VEGFR-3 in adult angiogenesis. J. Pathol.195(4), 490–497 (2001).
  • Schaal S, Kaplan HJ, Tezel TH. Is there tachyphylaxis to intravitreal anti-vascular endothelial growth factor pharmacotherapy in age-related macular degeneration? Ophthalmology115(12), 2199–2205 (2008).
  • Hlushchuk R, Baum O, Gruber G, Wood J, Djonov V. The synergistic action of a VEGF-receptor tyrosine-kinase inhibitor and a sensitizing PDGF-receptor blocker depends upon the stage of vascular maturation. Microcirculation14(8), 813–825 (2007).
  • Forooghian F, Cukras C, Meyerle CB, Chew EY, Wong WT. Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration. Retina29(6), 723–731 (2009).
  • Espinosa-Heidmann DG, Suner IJ, Hernandez EP, Monroy D, Csaky KG, Cousins SW. Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization. Invest. Ophthalmol. Vis. Sci.44(8), 3586–3592 (2003).
  • Grossniklaus HE, Ling JX, Wallace TM et al. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol. Vis.8, 119–126 (2002).
  • Sakurai E, Anand A, Ambati BK, van Rooijen N, Ambati J. Macrophage depletion inhibits experimental choroidal neovascularization. Invest. Ophthalmol. Vis. Sci.44(8), 3578–3585 (2003).
  • Tatar O, Yoeruek E, Szurman P et al. Effect of bevacizumab on inflammation and proliferation in human choroidal neovascularization. Arch. Ophthalmol.126(6), 782–790 (2008).
  • Lafaut BA, Aisenbrey S, van Den Broecke C, Bartz-Schmidt KU, Heimann K. Polypoidal choroidal vasculopathy pattern in age-related macular degeneration: a clinicopathologic correlation. Retina20(6), 650–654 (2000).
  • Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA. Polypoidal choroidal vasculopathy. Surv. Ophthalmol.49(1), 25–37 (2004).
  • Cho M, Barbazetto IA, Freund KB. Refractory neovascular age-related macular degeneration secondary to polypoidal choroidal vasculopathy. Am. J. Ophthalmol.148(1), 70.e1–78.e1 (2009).
  • Gerhardt H, Betsholtz C. Endothelial–pericyte interactions in angiogenesis. Cell Tissue Res.314(1), 15–23 (2003).
  • Hirschi KK, Rohovsky SA, D’Amore PA. PDGF, TGF-β, and heterotypic cell–cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J. Cell Biol.141(3), 805–814 (1998).
  • Sims DE. Diversity within pericytes. Clin. Exp. Pharmacol. Physiol.27(10), 842–846 (2000).
  • Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene18(38), 5356–5362 (1999).
  • Brown DM, Regillo CD. Anti-VEGF agents in the treatment of neovascular age-related macular degeneration: applying clinical trial results to the treatment of everyday patients. Am. J. Ophthalmol.144(4), 627–637 (2007).
  • Fung AE, Lalwani GA, Rosenfeld PJ et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am. J. Ophthalmol.143(4), 566–583 (2007).
  • Shah GK, Sang DN, Hughes MS. Verteporfin combination regimens in the treatment of neovascular age-related macular degeneration. Retina29(2), 133–148 (2009).
  • Augustin AJ, Puls S, Offermann I. Triple therapy for choroidal neovascularization due to age-related macular degeneration: verteporfin PDT, bevacizumab, and dexamethasone. Retina27(2), 133–140 (2007).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.