130
Views
23
CrossRef citations to date
0
Altmetric
Special Report

Tackling the human adipose tissue proteome to gain insight into obesity and related pathologies

, , &
Pages 353-361 | Published online: 09 Jan 2014

References

  • Haslam DW, James WP. Obesity. Lancet366(9492), 1197–1209 (2005).
  • Daniels SR, Jacobson MS, McCrindle BW, Eckel RH, Sanner BM. American Heart Association childhood obesity research summit report. Circulation119(15), e489–e517 (2009).
  • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet371(9612), 569–578 (2008).
  • Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell104(4), 531–543 (2001).
  • Matsuzawa Y. Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat. Clin. Pract. Cardiovasc. Med.3(1), 35–42 (2006).
  • Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature444(7121), 847–853 (2006).
  • Gesta S, Tseng YH, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell131(2), 242–256 (2007).
  • Dominguez DC, Lopes R, Torres ML. Proteomics: clinical applications. Clin. Lab. Sci.20(4), 245–248 (2007).
  • Hanash S. 2-D or not 2-D - is there a future for 2-D gels in proteomics? Insights from the York proteomics meeting. Proteomics1(5), 635–637 (2001).
  • Unlu M, Morgan ME, Minden JS. Difference gel electrophoresis: a single gel method for detecting changes in protein extracts. Electrophoresis18(11), 2071–2077 (1997).
  • Boysen RI, Hearn MT. HPLC of peptides and proteins. In: Current Protocols in Protein Science (Chapter 8). John Wiley & Sons, Inc., NJ, USA (2001).
  • Ross PL, Huang YN, Marchese JN et al. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol. Cell. Proteomics3(12), 1154–1169 (2004).
  • Liao H, Wu J, Kuhn E et al. Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis. Arthritis Rheum.50(12), 3792–3803 (2004).
  • Corton M, Villuendas G, Botella JI, San Millan JL, Escobar-Morreale HF, Peral B. Improved resolution of the human adipose tissue proteome at alkaline and wide range pH by the addition of hydroxyethyl disulfide. Proteomics4(2), 438–441 (2004).
  • Olsson I, Larsson K, Palmgren R, Bjellqvist B. Organic disulfides as a means to generate streak-free two-dimensional maps with narrow range basic immobilized pH gradient strips as first dimension. Proteomics2(11), 1630–1632 (2002).
  • Fox CS, Massaro JM, Hoffmann U et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the framingham heart study. Circulation116(1), 39–48 (2007).
  • Ramis JM, Franssen-van Hal NL, Kramer E et al. Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects. Cell. Mol. Life Sci.59(11), 1960–1971 (2002).
  • Gabrielsson BG, Johansson JM, Lonn M et al. High expression of complement components in omental adipose tissue in obese men. Obes. Res.11(6), 699–708 (2003).
  • Linder K, Arner P, Flores-Morales A, Tollet-Egnell P, Norstedt G. Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women. J. Lipid Res.45(1), 148–154 (2004).
  • Vohl MC, Sladek R, Robitaille J et al. A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men. Obes. Res.12(8), 1217–1222 (2004).
  • Gesta S, Bluher M, Yamamoto Y et al. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc. Natl. Acad. Sci. USA103(17), 6676–6681 (2006).
  • van Beek EA, Bakker AH, Kruyt PM, Hofker MH, Saris WH, Keijer J. Intra- and interindividual variation in gene expression in human adipose tissue. Pflugers Arch.453(6), 851–861 (2007).
  • MacLaren R, Cui W, Simard S, Cianflone K. Influence of obesity and insulin sensitivity on insulin signaling genes in human omental and subcutaneous adipose tissue. J. Lipid Res.49(2), 308–323 (2008).
  • Perez-Perez R, Ortega-Delgado FJ, Garcia-Santos E et al. Differential proteomics of omental and subcutaneous adipose tissue reflects their unalike biochemical and metabolic properties. J. Proteome Res.8(4), 1682–1693 (2009).
  • Schug TT, Berry DC, Shaw NS, Travis SN, Noy N. Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell129(4), 723–733 (2007).
  • Cancello R, Tordjman J, Poitou C et al. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes55(6), 1554–1561 (2006).
  • Harman-Boehm I, Bluher M, Redel H et al. Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J. Clin. Endocrinol. Metab.92(6), 2240–2247 (2007).
  • Cinti S, Mitchell G, Barbatelli G et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res.46(11), 2347–2355 (2005).
  • Wilkosz S, Ireland G, Khwaja N et al. A comparative study of the structure of human and murine greater omentum. Anat. Embryol.209(3), 251–261 (2005).
  • van Hinsbergh VW, Kooistra T, Scheffer MA, Hajo van Bockel J, van Muijen GN. Characterization and fibrinolytic properties of human omental tissue mesothelial cells. Comparison with endothelial cells. Blood75(7), 1490–1497 (1990).
  • Ozcan U, Cao Q, Yilmaz E et al. Endoplasmic reticulum stress links obesity, insulin action, and Type 2 diabetes. Science306(5695), 457–461 (2004).
  • Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected caucasian women from Spain. J. Clin. Endocrinol. Metab.85(7), 2434–2438 (2000).
  • Azziz R, Carmina E, Dewailly D et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J. Clin. Endocrinol. Metab.91(11), 4237–4245 (2006).
  • Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J. Clin. Endocrinol. Metab.89(6), 2745–2749 (2004).
  • Alvarez-Blasco F, Botella-Carretero JI, San Millan JL, Escobar-Morreale HF. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch. Intern. Med.166(19), 2081–2086 (2006).
  • Fernandez-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr. Rev.24(3), 278–301 (2003).
  • Escobar-Morreale HF, Luque-Ramirez M, San Millan JL. The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome. Endocr. Rev.26, 251–282 (2005).
  • Escobar-Morreale HF, Botella-Carretero JI, Alvarez-Blasco F, Sancho J, San Millan JL. The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery. J. Clin. Endocrinol. Metab.90(12), 6364–6369 (2005).
  • Corton M, Botella-Carretero JI, Benguria A et al. Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab.92(1), 328–337 (2007).
  • Corton M, Botella-Carretero JI, Lopez JA et al. Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry. Hum. Reprod.23(3), 651–661 (2008).
  • Fenkci V, Fenkci S, Yilmazer M, Serteser M. Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease. Fertil. Steril.80(1), 123–127 (2003).
  • Sabuncu T, Vural H, Harma M, Harma M. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin. Biochem.34(5), 407–413 (2001).
  • Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N. Low grade chronic inflammation in women with polycystic ovarian syndrome. J. Clin. Endocrinol. Metab.86(6), 2453–2455 (2001).
  • Celis JE, Moreira JM, Cabezon T et al. Identification of extracellular and intracellular signaling components of the mammary adipose tissue and its interstitial fluid in high risk breast cancer patients: toward dissecting the molecular circuitry of epithelial-adipocyte stromal cell interactions. Mol. Cell. Proteomics4(4), 492–522 (2005).
  • DeLany JP, Floyd ZE, Zvonic S et al. Proteomic analysis of primary cultures of human adipose-derived stem cells: modulation by adipogenesis. Mol. Cell. Proteomics4(6), 731–740 (2005).
  • Chung J, Nguyen AK, Henstridge DC et al. HSP72 protects against obesity-induced insulin resistance. Proc. Natl. Acad. Sci. USA105(5), 1739–1744 (2008).
  • Kurucz I, Morva A, Vaag A et al. Decreased expression of heat shock protein 72 in skeletal muscle of patients with Type 2 diabetes correlates with insulin resistance. Diabetes51(4), 1102–1109 (2002).
  • Chouchane L, Danguir J, Beji C et al. Genetic variation in the stress protein hsp70–2 gene is highly associated with obesity. Int. J. Obes. Relat. Metab. Disord.25(4), 462–466 (2001).
  • Zouari Bouassida K, Chouchane L, Jellouli K et al. Polymorphism of stress protein HSP70–2 gene in Tunisians: susceptibility implications in Type 2 diabetes and obesity. Diabetes Metab.30(2), 175–180 (2004).
  • Lee HK, Lee BH, Park SA, Kim CW. The proteomic analysis of an adipocyte differentiated from human mesenchymal stem cells using two-dimensional gel electrophoresis. Proteomics6(4), 1223–1229 (2006).
  • Zvonic S, Lefevre M, Kilroy G et al. Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis. Mol. Cell. Proteomics6(1), 18–28 (2007).
  • Alvarez-Llamas G, Szalowska E, de Vries MP et al. Characterization of the human visceral adipose tissue secretome. Mol. Cell. Proteomics6(4), 589–600 (2007).
  • Klimcakova E, Moro C, Mazzucotelli A et al. Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists. Biochem. Biophys. Res. Commun.358(3), 897–902 (2007).
  • Maury E, Ehala-Aleksejev K, Guiot Y, Detry R, Vandenhooft A, Brichard SM. Adipokines oversecreted by omental adipose tissue in human obesity. Am. J. Physiol. Endocrinol. Metab.293(3), E656–E665 (2007).
  • Barceló-Batllori S, Gomis R. Proteomics in obesity research. Proteomics Clin. Appl.3, 263–278 (2009).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.