50
Views
1
CrossRef citations to date
0
Altmetric
Editorial

Targeting activated Rho proteins: a new approach for treatment of HPV and other virus-related cancers?

, &
Pages 975-978 | Published online: 10 Jan 2014

References

  • Tapon N, Hall A. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol.9(1), 86–92 (1997).
  • Toksoz D, Merdek KD. The Rho small GTPase: functions in health and disease. Histol. Histopathol.17(3), 915–927 (2002).
  • Karlsson R, Pedersen ED, Wang Z, Brakebusch C. Rho GTPase function in tumorigenesis. Biochim. Biophys. Acta1796(2), 91–98 (2009).
  • Aznar S, Fernandez-Valeron P, Espina C, Lacal JC. Rho GTPases: potential candidates for anticancer therapy. Cancer Lett.206(2), 181–191 (2004).
  • Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell. Biol.9(9), 690–701 (2008).
  • Fritz G, Kaina B. Rho GTPases: promising cellular targets for novel anticancer drugs. Curr. Cancer Drug Targets6(1), 1–14 (2006).
  • Chang CS, Huang SM, Lin HH, Wu CC, Wang CJ. Different expression of apoptotic proteins between HBV-infected and non-HBV-infected hepatocellular carcinoma. Hepato-Gastroenterology54(79), 2061–2068 (2007).
  • Lu X, Wu X, Plemenitas A et al. CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr. Biol.6(12), 1677–1684 (1996).
  • Murata T, Goshima F, Daikoku T, Takakuwa H, Nishiyama Y. Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation. Genes Cells5(12), 1017–1027 (2000).
  • Puls A, Eliopoulos AG, Nobes CD, Bridges T, Young LS, Hall A. Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(α) and IL-1, and by the Epstein–Barr virus transforming protein LMP1. J. Cell Sci.112(Pt 17), 2983–2992 (1999).
  • Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P. The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. Oncogene16(5), 643–654 (1998).
  • Reynaud C, Fabre S, Jalinot P. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. J. Biol. Chem.275(43), 33962–33968 (2000).
  • Hampson L, Li C, Oliver AW, Kitchener HC, Hampson IN. The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. Int. J. Oncol.25(5), 1249–1256 (2004).
  • Oliver AW, He X, Borthwick K, Donne AJ, Hampson L, Hampson IN. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. Br. J. Cancer104(2), 324–331 (2011).
  • Alvarez-Salas LM, Benitez-Hess ML, DiPaolo JA. Advances in the development of ribozymes and antisense oligodeoxynucleotides as antiviral agents for human papillomaviruses. Antivir. Ther.8(4), 265–278 (2003).
  • Sinha S, Yang W. Cellular signaling for activation of Rho GTPase Cdc42. Cell Signal.20(11), 1927–1934 (2008).
  • Popoff MR, Geny B. Multifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins. Biochim. Biophys. Acta1788(4), 797–812 (2009).
  • Grise F, Bidaud A, Moreau V. Rho GTPases in hepatocellular carcinoma. Biochim. Biophys. Acta1795(2), 137–151 (2009).
  • Graaf MR, Richel DJ, van Noorden CJ, Guchelaar HJ. Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer. Cancer Treat. Rev.30(7), 609–641 (2004).
  • Gilbert C, Bergeron M, Methot S, Giguere JF, Tremblay MJ. Statins could be used to control replication of some viruses, including HIV-1. Viral Immunol.18(3), 474–489 (2005).
  • Ikeda M, Kato N. Life style-related diseases of the digestive system: cell culture system for the screening of anti-hepatitis C virus (HCV) reagents: suppression of HCV replication by statins and synergistic action with interferon. J. Pharmacol. Sci.105(2), 145–150 (2007).
  • Sun HY, Singh N. Antimicrobial and immunomodulatory attributes of statins: relevance in solid-organ transplant recipients. Clin. Infect. Dis.48(6), 745–755 (2009).
  • Kato S, Smalley S, Sadarangani A et al. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. J. Cell Mol. Med.14(5), 1180–1193 (2010).
  • Nonaka M, Uota S, Saitoh Y et al. Role for protein geranylgeranylation in adult T-cell leukemia cell survival. Exp. Cell Res.315(2), 141–150 (2009).
  • Sleijfer S, van der Gaast A, Planting AS, Stoter G, Verweij J. The potential of statins as part of anti-cancer treatment. Eur. J. Cancer41(4), 516–522 (2005).
  • Vigil D, Cherfils J, Rossman KL, Der CJ. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat. Rev. Cancer10(12), 842–857 (2010).
  • Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y. Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Curr. Top. Med. Chem.6(11), 1109–1116 (2006).
  • Bouquier N, Vignal E, Charrasse S et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem. Biol.16(6), 657–666 (2009).
  • Pontow S, Harmon B, Campbell N, Ratner L. Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay. Virology368(1), 1–6 (2007).
  • Pelish HE, Peterson JR, Salvarezza SB et al. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat. Chem. Biol.2(1), 39–46 (2006).
  • Ambrogio C, Voena C, Manazza AD et al. The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer Res.68(21), 8899–8907 (2008).
  • Whale A, Hashim FN, Fram S, Jones GE, Wells CM. Signalling to cancer cell invasion through PAK family kinases. Front. Biosci.16, 849–864 (2011).
  • Van den Broeke C, Radu M, Chernoff J, Favoreel HW. An emerging role for p21-activated kinases (Paks) in viral infections. Trends Cell Biol.20(3), 160–169 (2010).
  • Deacon SW, Beeser A, Fukui JA et al. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem. Biol.15(4), 322–331 (2008).
  • Kalin S, Amstutz B, Gastaldelli M et al. Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. J. Virol.84(10), 5336–5350 (2010).
  • Van den Broeke C, Radu M, Nauwynck HJ, Chernoff J, Favoreel HW. Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase. Virus Res.155(1), 376–380 (2011).
  • Murray BW, Guo C, Piraino J et al. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc. Natl Acad. Sci. USA107(20), 9446–9451 (2010).
  • Mahata S, Bharti AC, Shukla S, Tyagi A, Husain SA, Das BC. Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol. Cancer10(1), 39 (2011).
  • Tsang CM, Lau EPW, Di KJ et al. Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells. Int. J. Mol. Med.24(1), 131–138 (2009).
  • Wu R, Abramson AL, Symons MH, Steinberg BM. Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression. Int. J. Cancer127(9), 2230–2237 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.