280
Views
14
CrossRef citations to date
0
Altmetric
Theme: Kidney Cancer - Review

Neoadjuvant and adjuvant treatment of renal cell carcinoma

, , , &
Pages 765-776 | Published online: 10 Jan 2014

References

  • Kane CJ, Mallin K, Ritchey J, Cooperberg MR, Carroll PR. Renal cell cancer stage migration: analysis of the national cancer data bases. Cancer113(1), 78–83 (2009).
  • Sun M, Thuret R, Abdollah F et al. Age-adjusted incidence, mortality, and survival rates of stage-specific renal cell carcinoma in North America: a trend analysis. Eur. Urol.59(1), 135–141 (2011).
  • Golimbu M, Tessler A, Joshi P, Al-Askari S, Sperber A, Morales P. Renal cell carcinoma: survival and prognostic factors. Urology27(4), 291–301 (1986).
  • Kim SP, Alt AL, Weight CJ et al. Independent validation of the 2010 American Joint Committee on Cancer TNM classification for renal cell carcinoma: results from a large, single institution cohort. J. Urol.185(6), 2035–2039 (2011).
  • DeVita VT, Lawrence TS, Rosenberg SA, DePinho RA, Weinberg RA. DeVita, Hellman and Rosenberg’s Cancer: Principles and Practice of Oncology. DeVita VT, Lawrence TS, Rosenberg SA, Weinberg RA, Depinho RA (Eds). Lippincott Williams and Wilkins, PA, USA (2011).
  • Klatte T, Pantuck AJ. Molecular biology of renal cortical tumors. Urol. Clin. North Am.35(4), 573–580 (2008).
  • Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nat. Rev. Urol.7(5), 277–285 (2010).
  • Hudes GR. Targeting mTOR in renal cell carcinoma. Cancer115(Suppl. 10), 2313–2320 (2009).
  • Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med.356(2), 115–124 (2007).
  • Motzer RJ, Hutson TE, Tomczak P et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J. Clin. Oncol.27(22), 3584–3590 (2009).
  • Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind Phase III trial. Lancet370(9605), 2103–2111 (2007).
  • Rini BI, Halabi S, Rosenberg JE et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J. Clin. Oncol.26(33), 5422–5428 (2008).
  • Escudier B, Eisen T, Stadler WM et al. Sorenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med.356(2), 125–134 (2007).
  • Escudier B, Eisen T, Stadler WM et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the Phase III treatment approaches in renal cancer global evaluation trial. J. Clin. Oncol.27(20), 3312–3318 (2009).
  • Sternberg CN, Davis ID, Jardiak J et al. Pazopanib in locally advanced or metastic renal cell carcinoma: results of a randomized Phase III trial. J. Clin. Oncol.28(6), 1061–1068 (2010).
  • Hudes G, Carducci M, Tomczak P et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N. Engl. J. Med.356(22), 2271–2281 (2007).
  • Motzer RJ, Escudier B, Oudard S et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer116(18), 4256–4265 (2010).
  • Motzer RJ, Escudier B, Oudard S et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomized, placebo-controlled Phase III trial. Lancet372(9637), 449–456 (2008).
  • Leibovich BC, Lohse CM, Crispen PL et al. Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma. J. Urol.183(4), 1309–1316 (2010).
  • Gudbjartson T, Hardarson S, Petursdottir V, Thoroddsen A, Magnusson J, Einarsson GV. Histological subtyping and nuclear grading of renal cell carcinoma and their implications for survival: a retrospective nation-wide study of 629 patients. Eur. Urol.48(4), 593–600 (2005).
  • Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am. J. Surg. Pathol.27(5), 612–624 (2003).
  • dePeralta-Venturina M, Amin M, Tamboli P et al. Sarcomotoid differentiation in renal cell carcinoma. Am. J. Surg. Pathol.25(3), 275–284 (2001).
  • Flanigan RC, Polcari AJ, Hugen CM. Prognostic variables and nomograms for renal cell carcinoma. Int. J. Urol.18(1), 20–31 (2011).
  • Kattan MW, Reuter V, Motzer RJ, Katz J, Russo P. A postoperative prognostic nomogram for renal cell carcinoma. J. Urol.166(1), 63–67 (2001).
  • Sorbellini M, Kattan MW, Snyder ME et al. A postoperative prognostic nomogram predicting recurrence for patients with conventional clear cell renal cell carcinoma. J. Urol.173(1), 48–51 (2005).
  • Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J. Urol.168(6), 2395–2400 (2001).
  • Zisman A, Pantuck AJ, Dorey F et al. Improved prognostication of renal cell carcinoma using an integrated staging system. J. Clin. Oncol.19(6), 1649–1657 (2001).
  • Zisman A, Pantuck AJ, Wieder J et al. Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J. Clin. Oncol.20(23), 4559–4566 (2002).
  • Leibovich BC, Blute ML, Cheville JC et al. Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma. Cancer97(7), 1663–1671 (2003).
  • Karakiewicz PI, Briganti A, Chun FKH et al. Multi-institutional validation of a new renal cancer-specific survival nomogram. J. Clin. Oncol.25(11), 1316–1322 (2007).
  • Rosenberg SA, Lotze MT, Muui LM et al. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high dose interleukin-2 alone. N. Engl. J. Med.316(15), 889–897 (1987).
  • Fisher RI, Coltman CA, Doroshow JH et al. Metastatic renal cancer treated with interleukin-2 and lymphokine-activated killer cells. Ann. Intern. Med.108(5), 518–523 (1988).
  • Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC. Results of treatment of 255 paitents with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol.13(3), 688–696 (1995).
  • Yang JC, Sherry RM, Steinberg SM et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J. Clin. Oncol.21(16), 3127–3132 (2003).
  • McDermott DF, Regan MM, Clark JI et al. Randomized Phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J. Clin. Oncol.23(1), 133–141 (2005).
  • Klapper J, Downey SG, Smith FO et al. High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma. Cancer113(2), 293–301 (2008).
  • Pizzocaro G, Piva L, Colavita M et al. Interferon adjuvant to radical nephrectomy in Robson stages II and III renal cell carcinoma: a multicentric randomized study. J. Clin. Oncol.19(2), 425–431 (2001).
  • Messing E, Manola J, Wilding G et al. Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: an Eastern Cooperative Oncology Group/Intergroup trial. J. Clin. Oncol.21(7), 1214–1222 (2003).
  • Clark JI, Atkins MB, Urba WJ et al. Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a Cytokine Working Group randomized trial. J. Clin. Oncol.21(16), 3133–3140 (2003).
  • Passalacqua R, Buzio C, Buti S et al. Adjuvant low-dose interleukin-2 plus interon-alpha in operable renal cell cancer. A Phase III, randomized, multicenter independent trial of the Italian Oncology Group for Clinical Research(GOIRC). J. Clin. Oncol.25(18S), (2007).
  • Atzpodien J, Schmitt E, Gertenbach U et al. Adjuvant treatment with interleukin-2 and interferon alpha2 based chemoimmunotherapy in renal cell carcinoma post tumour nephrectomy: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN). Br. J. Cancer92, 843–846 (2005).
  • Aitchison M, Bray C, Van Poppel H et al. Final results from an EORTC(GU Group)/NCRI randomized Phase III trial of adjuvant interleukin-2, interferon alpha, and 5-fluorouracil in patients with a high risk of relapse after nephrectomy for renal cell carcinoma (RCC). J. Clin. Oncol.29 (2011) (Abstract 4505).
  • Pizzocaro G, Piva L, Fronzo GD et al. Adjuvant medroxyprogesterone acetate to radical nephrectomy in renal cancer: 5-year results of a prospective randomized study. J. Urol.138, 1379–1381 (1987).
  • Naito S, Kumazawa J, Omoto T et al. Postoperative UFT adjuvant and the risk factors for recurrence in renal cell carcinoma: a long-term follow-up study. Int. J. Urol.4(1), 8–12 (1997).
  • Margulis V, Matin SF, Tannir N et al. Randomized trial of adjuvant thalidomide versus observation in patients with completely resected high-risk renal cell carcinoma. Urology73, 337–341 (2009).
  • Galligioni E, Quaia M, Nerlo A et al. Adjuvant immunotherapy treatment of renal carcinoma patients with autologous tumor cells and bacillus Calmette–Guerin. Cancer77(12), 2560–2566 (1996).
  • Jocham D, Richter A, Hoffmann L et al. Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: Phase III, randomised controlled trial. Lancet363(9409), 594–599 (2004).
  • Scherr AJ, Lima JPS, Sasse EC, Lima CS, Sasse AD. Adjuvant therapy for locally advanced renal cell cancer: a systematic review with meta-analysis. BMC Cancer11, 115 (2011).
  • Fishman M, Antonia S. Specific antitumour vaccine for renal cancer. Lancet363(9409), 583–584 (2004).
  • Wood C, Srivastava P, Bukowski R et al. An adjuvant autologous therapeutic vaccine (HSPPC-96;vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised Phase III trial. Lancet372(9633), 145–154 (2008).
  • Reichert JM. Antibody-based therapeutics to watch in 2011. MAbs3(1), 76–99 (2011).
  • Wood C, Srivastava P, Lacombe L et al. Survival update from a multicenter, randomized, Phase III trial of vitespin versus observation as adjuvant therapy for renal cell carcinoma in patients at high risk of recurrence. J. Clin. Oncol.27(Suppl.), 15s (2009) (Abstract 3009).
  • Shuch B, Li Z, Belldegrun AS. Carbonic anhydrase IX and renal cell carcinoma: prognosis, response to systemic therapy, and future vaccine strategies. Br. J. Urol. Int.101(Suppl. 4), 25–30 (2008).
  • Flanigan RC, Salmon SE, Blumenstein BA et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl. J. Med.345(23), 1655–1659 (2001).
  • Mickisch GHJ, Garin A, Poppel HV, Prijck LD, Sylvester R. Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet358(9286), 966–970 (2001).
  • Flanigan RC, Mickisch G, Sylvester R, Tangen C, Poppel HV, Crawford ED. Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J. Urol.171, 1071–1076 (2004).
  • Fallick ML, Mcdermott DF, LaRock D, Long JP, Atkins MB. Nephrectomy before interleukin-2 therapy for patients with metastatic renal cell carcinoma. J. Urol.158(5), 1691–1695 (1997).
  • Choueiri TK, Xie W, Kollmannsberger C et al. The impact of cytoreductive nephrectomy on survival of patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor targeted therapy. J. Urol.185(1), 60–65 (2011).
  • Szczylik C, Porta C, Bracarda S et al. Sunitinib in patients with or without prior nephrectomy (Nx) in an expanded access trial of metastatic renal cell carcinoma. J. Clin. Oncol.26(Suppl.), (2008) (Abstract 5124).
  • Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J. Clin. Oncol.20(1), 289–296 (2002).
  • Heng DYC, Xie W, Regan MM et al. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large multicenter study. J. Clin. Oncol.27(34), 5794–5799 (2009).
  • van der Veldt AA, Meijerink MR, van den Eertwegh AJ. Sunitinib for treatment of advanced renal cell cancer: primary tumour response. Clin. Cancer Res.14(8), 2431–2436 (2008).
  • Thomas AA, Rini BI, Lane BR et al. Response of the primary tumor to neoadjuvant sunitinib in patients with advanced renal cell carcinoma. J. Urol.181(2), 518–523 (2009).
  • Abel EJ, Culp SH, Tannir NM, Matin SF, Tamboli P. Primary tumour response to targeted agents in patients with metastatic renal cell carcinoma. Eur. Urol.59(1), 10–15 (2011).
  • Abel EJ, Culp SH, Tannir NM, Tamboli P, Matin SF, Wood CG. Early primary tumor size reduction is an independent predictor of improved overall survial in metastatic renal cell carcinoma patients treated with sunitinib. Eur. Urol.60(6), 1273–1279 (2011).
  • Karakiewicz P, Suardi N, Jeldres C. Neoadjuvant sutent induction therapy may effectively down-stage renal cell carcinoma atrial thrombi. Eur. Urol.53(4), 845–848 (2008).
  • Cost NG, Delacroix SE, Sleeper JP, Smith PJ. The impact of targeted molecular therapies on the level of renal cell carcinoma vena caval thrombus. Eur. Urol.59, 912–918 (2011).
  • Bose D, Meric-Bernstam F, Hofstetter W, Reardon DA, Flaherty KT, Ellis LM. Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care. Lancet Oncol.11(4), 373–382 (2010).
  • Margulis V, Matin SF, Tannir N, Tamboli P. Surgical morbidity associated with administration of targeted molecular therapies before cytoreductive nephrectomy or resection of locally recurrent renal cell carcinoma. J. Urol.180(1), 94–98 (2008).
  • Thomas AA, Rini BI, Stephenson AJ, Garcia JA. Surgical resection of renal cell carcinoma after targeted therapy. J. Urol.182(3), 881–886 (2009).
  • Chapin BF, Delacroix SE, Culp SH, Gonzalez G, Wood CG. Postoperative complications from cytoredutive nephrectomy after neoadjuvant targeted therapy for metastatic renal cell carcinoma. J. Clin. Oncol.29(Suppl. 7), (2011) (Abstract 300).
  • Jonasch E, Wood CG, Matin SF et al. Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma. J. Clin. Oncol.27(25), 4076–4081 (2009).
  • Cowey CL, Amin C, Pruthi RS, Wallen EM. Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma. J. Clin. Oncol.28(9), 1502–1507 (2010).
  • Hellenthal NJ, Underwood W, Penetrante R et al. Prospective clinical trial of preoperative sunitinib in patients with renal cell carcinoma. J. Urol.184(3), 859–864 (2010).
  • Powles T, Blank C, Chowdhury S et al. The outcome of patients treated with sunitinib prior to planned nephrectomy in metastatic clear cell renal cancer. Eur. Urol.60(3), 448–454 (2011).
  • Bukowski R, Kabbinavar FF, Figlin RA et al. Randomized Phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell carcinoma. J. Clin. Oncol.25(29), 4536–4541 (2007).
  • Oosterwijk E, Rathmell WK, Junker K et al. Basic research in kidney cancer. Eur. Urol.60(4), 622–633 (2011).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.