282
Views
35
CrossRef citations to date
0
Altmetric
Review

Therapeutic hypothermia for acute ischemic stroke

&
Pages 593-603 | Published online: 10 Jan 2014

References

  • Rosamond W, Flegal K, Furie K et al. Heart disease and stroke statistics – 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation117(4), E25–E146 (2008).
  • Ginsberg MD. Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology55(3), 363–389 (2008).
  • Lipton P. Ischemic cell death in brain neurons. Physiol. Rev.79(4), 1431–1568 (1999).
  • Zhao H, Steinberg GK, Sapolsky RM. General versus specific actions of mild–moderate hypothermia in attenuating cerebral ischemic damage. J. Cereb. Blood Flow Metab.27(12), 1879–1894 (2007).
  • Rosomoff HL, Holaday DA. Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am. J. Physiol.179(1), 85–88 (1954).
  • Bernard S. Therapeutic hypothermia after cardiac arrest: now a standard of care. Crit. Care Med.34(3), 923–924 (2006).
  • Froehler MT, Geocadin RG. Hypothermia for neuroprotection after cardiac arrest: mechanisms, clinical trials and patient care. J. Neurol. Sci.261(1–2), 118–126 (2007).
  • Krause GS, White BC, Aust SD, Nayini NR, Kumar K. Brain cell death following ischemia and reperfusion: a proposed biochemical sequence. Crit. Care Med.16(7), 714–726 (1988).
  • White BC, Sullivan JM, DeGracia DJ et al. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neurol. Sci.179(S1–S2), 1–33 (2000).
  • Neumar RW, Hagle SM, DeGracia DJ, Krause GS, White BC. Brain mu-calpain autolysis during global cerebral ischemia. J. Neurochem.66(1), 421–424 (1996).
  • Schroeter M, Jander S, Witte OW, Stoll G. Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J. Neuroimmunol.55(2), 195–203 (1994).
  • Zheng Z, Yenari MA. Post-ischemic inflammation: molecular mechanisms and therapeutic implications. Neurol. Res.26(8), 884–892 (2004).
  • Otis AB, Jude J. Effect of body temperature on pulmonary gas exchange. Am. J. Physiol.188(2), 355–359 (1957).
  • McCullough JN, Zhang N, Reich DL et al. Cerebral metabolic suppression during hypothermic circulatory arrest in humans. Ann. Thorac. Surg.67(6), 1895–1899; discussion 1919–1821 (1999).
  • Laptook AR, Corbett RJ, Sterett R, Garcia D, Tollefsbol G. Quantitative relationship between brain temperature and energy utilization rate measured in vivo using 31P and 1H magnetic resonance spectroscopy. Pediatr. Res.38(6), 919–925 (1995).
  • Laptook AR, Corbett RJ, Burns D, Sterett R. Neonatal ischemic neuroprotection by modest hypothermia is associated with attenuated brain acidosis. Stroke26(7), 1240–1246 (1995).
  • Kaibara T, Sutherland GR, Colbourne F, Tyson RL. Hypothermia: depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation. J. Neurosurg.90(2), 339–347 (1999).
  • Sick TJ, Xu G, Perez-Pinzon MA. Mild hypothermia improves recovery of cortical extracellular potassium ion activity and excitability after middle cerebral artery occlusion in the rat. Stroke30(11), 2416–2421; discussion 2422 (1999).
  • Bart RD, Takaoka S, Pearlstein RD, Dexter F, Warner DS. Interactions between hypothermia and the latency to ischemic depolarization: implications for neuroprotection. Anesthesiology88(5), 1266–1273 (1998).
  • Busto R, Globus MY, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke20(7), 904–910 (1989).
  • Harada K, Maekawa T, Tsuruta R et al. Hypothermia inhibits translocation of CaM kinase II and PKC-α, β, γ isoforms and fodrin proteolysis in rat brain synaptosome during ischemia-reperfusion. J. Neurosci. Res.67(5), 664–669 (2002).
  • Niwa M, Hara A, Iwai T et al. Relationship between magnitude of hypothermia during ischemia and preventive effect against post-ischemic DNA fragmentation in the gerbil hippocampus. Brain Res.794(2), 338–342 (1998).
  • Fukuda H, Tomimatsu T, Watanabe N et al. Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia-ischemia. Brain Res.910(1–2), 187–191 (2001).
  • Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am. J. Physiol. Cell. Physiol.282(2), C227–C241 (2002).
  • Globus MY, Alonso O, Dietrich WD, Busto R, Ginsberg MD. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J. Neurochem.65(4), 1704–1711 (1995).
  • Lei B, Adachi N, Arai T. The effect of hypothermia on H2O2 production during ischemia and reperfusion: a microdialysis study in the gerbil hippocampus. Neurosci. Lett.222(2), 91–94 (1997).
  • Han HS, Karabiyikoglu M, Kelly S, Sobel RA, Yenari MA. Mild hypothermia inhibits nuclear factor-κβ translocation in experimental stroke. J. Cereb. Blood Flow Metab.23(5), 589–598 (2003).
  • Kumar K, Evans AT. Effect of hypothermia on microglial reaction in ischemic brain. Neuroreport8(4), 947–950 (1997).
  • Inamasu J, Suga S, Sato S et al. Intra-ischemic hypothermia attenuates intercellular adhesion molecule-1 (ICAM-1) and migration of neutrophil. Neurol. Res.23(1), 105–111 (2001).
  • Wang GJ, Deng HY, Maier CM, Sun GH, Yenari MA. Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke. Neuroscience114(4), 1081–1090 (2002).
  • Karibe H, Zarow GJ, Graham SH, Weinstein PR. Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood–brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab.14(4), 620–627 (1994).
  • Rosomoff HL. Some effects of hypothermia on the normal and abnormal physiology of the nervous system. Proc. R. Soc. Med.49(6), 358–364 (1956).
  • van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain130(Pt 12), 3063–3074 (2007).
  • Ohta H, Terao Y, Shintani Y, Kiyota Y. Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia. Neurosci. Res.57(3), 424–433 (2007).
  • Zhao WH, Ji XM, Ling F et al. Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol. Res.31(1), 43–51 (2009).
  • Berger C, Xia F, Kohrmann M, Schwab S. Hypothermia in acute stroke – slow versus fast rewarming an experimental study in rats. Exp. Neurol.204(1), 131–137 (2007).
  • Kollmar R, Blank T, Han JL, Georgiadis D, Schwab S. Different degrees of hypothermia after experimental stroke: short- and long-term outcome. Stroke38(5), 1585–1589 (2007).
  • Doerfler A, Schwab S, Hoffmann TT, Engelhorn T, Forsting M. Combination of decompressive craniectomy and mild hypothermia ameliorates infarction volume after permanent focal ischemia in rats. Stroke32(11), 2675–2681 (2001).
  • Jieyong B, Zhong W, Shiming Z et al. Decompressive craniectomy and mild hypothermia reduces infarction size and counterregulates Bax and Bcl-2 expression after permanent focal ischemia in rats. Neurosurg. Rev.29(2), 168–172 (2006).
  • Kuhnen GE-JN, Tisherman SA. Cooling methods. In: Therapeutic Hypothermia. Tisherman SA, Sterz F (Eds). Springer, NY, USA, 211–234 (2005).
  • Hoesch RE, Geocadin RG. Therapeutic hypothermia for global and focal ischemic brain injury – a cool way to improve neurologic outcomes. Neurologist13(6), 331–342 (2007).
  • Bernard S. Hypothermia after cardiac arrest: how to cool and for how long? Crit. Care Med.32(3), 897–899 (2004).
  • Marion D, Bullock MR. Current and future role of therapeutic hypothermia. J. Neurotrauma26(3), 455–467 (2009).
  • Mayer SA, Kowalski RG, Presciutti M et al. Clinical trial of a novel surface cooling system for fever control in neurocritical care patients. Crit. Care Med.32(12), 2508–2515 (2004).
  • De Georgia MA, Krieger DW, Abou-Chebl A et al. Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology63(2), 312–317 (2004).
  • Steinberg GK, Ogilvy CS, Shuer LM et al. Comparison of endovascular and surface cooling during unruptured cerebral aneurysm repair. Neurosurgery55(2), 307–314; discussion 314–305 (2004).
  • Mack WJ, Huang J, Winfree C et al. Ultrarapid, convection-enhanced intravascular hypothermia: a feasibility study in nonhuman primate stroke. Stroke34(8), 1994–1999 (2003).
  • Kim F, Olsufka M, Carlbom D et al. Pilot study of rapid infusion of 2 l of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest. Circulation112(5), 715–719 (2005).
  • Kollmar R, Schellinger PD, Steigleder T, Kohrmann M, Schwab S. Ice-cold saline for the induction of mild hypothermia in patients with acute ischemic stroke: a pilot study. Stroke40(5), 1907–1909 (2009).
  • Polderman KH, Rijnsburger ER, Peerdeman SM, Girbes AR. Induction of hypothermia in patients with various types of neurologic injury with use of large volumes of ice-cold intravenous fluid. Crit. Care Med.33(12), 2744–2751 (2005).
  • Kranke P, Eberhart LH, Roewer N, Tramer MR. Pharmacological treatment of postoperative shivering: a quantitative systematic review of randomized controlled trials. Anesth. Analg.94(2), 453–460 (2002).
  • Mokhtarani M, Mahgoub AN, Morioka N et al. Buspirone and meperidine synergistically reduce the shivering threshold. Anesth. Analg.93(5), 1233–1239 (2001).
  • Delaunay L, Bonnet F, Liu N, Beydon L, Catoire P, Sessler DI. Clonidine comparably decreases the thermoregulatory thresholds for vasoconstriction and shivering in humans. Anesthesiology79(3), 470–474 (1993).
  • Hemmen TM, Lyden PD. Hypothermia after acute ischemic stroke. J. Neurotrauma26(3), 387–391 (2009).
  • Cheng C, Matsukawa T, Sessler DI et al. Increasing mean skin temperature linearly reduces the core-temperature thresholds for vasoconstriction and shivering in humans. Anesthesiology82(5), 1160–1168 (1995).
  • Kimberger O, Ali SZ, Markstaller M et al. Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study. Crit. Care11(1), R29 (2007).
  • Felberg RA, Krieger DW, Chuang R et al. Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol. Circulation104(15), 1799–1804 (2001).
  • Holzer M, Behringer W. Therapeutic hypothermia after cardiac arrest. Curr. Opin. Anaesthesiol.18(2), 163–168 (2005).
  • Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med.346(8), 549–556 (2002).
  • Bernard SA, Gray TW, Buist MD et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N. Engl. J. Med.346(8), 557–563 (2002).
  • Hachimi-Idrissi S, Corne L, Ebinger G, Michotte Y, Huyghens L. Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation51(3), 275–281 (2001).
  • Nolan JP, Morley PT, Van den Hoek TL et al. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation108(1), 118–121 (2003).
  • Vannucci RC. Current and potentially new management strategies for perinatal hypoxic-ischemic encephalopathy. Pediatrics85(6), 961–968 (1990).
  • Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst. Rev.4, CD003311 (2007).
  • Bratton SL, Chestnut RM, Ghajar J et al. Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermia. J. Neurotrauma24(Suppl. 1), S21–S25 (2007).
  • Guluma KZ, Oh H, Yu SW, Meyer BC, Rapp K, Lyden PD. Effect of endovascular hypothermia on acute ischemic edema: morphometric analysis of the ICTuS trial. Neurocrit. Care8(1), 42–47 (2008).
  • Froehler MT. Management of raised intracranial pressure. In: Principles of Drug Therapy in Neurology. Johnston MV, Gross RA (Eds). Oxford University Press, Oxford, UK (2008).
  • Den Hertog HM, van der Worp HB, Tseng MC, Dippel DW. Temperature-lowering therapy for acute stroke. Stroke (2009) (Epub ahead of print).
  • Martin-Schild S, Hallevi H, Shaltoni H et al. Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: a pilot study of caffeinol and mild hypothermia. J. Stroke Cerebrovasc. Dis.18(2), 86–96 (2009).
  • Lyden PD, Allgren RL, Ng K et al. Intravascular Cooling in the Treatment of Stroke (ICTuS): early clinical experience. J. Stroke Cerebrovasc. Dis.14(3), 107–114 (2005).
  • Els T, Oehm E, Voigt S, Klisch J, Hetzel A, Kassubek J. Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke. Cerebrovasc. Dis.21(1–2), 79–85 (2006).
  • Guluma KZ, Hemmen TM, Olsen SE, Rapp KS, Lyden PD. A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology. Acad. Emerg. Med.13(8), 820–827 (2006).
  • Krieger DW, De Georgia MA, Abou-Chebl A et al. Cooling for Acute Ischemic Brain Damage (COOL AID): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke32(8), 1847–1854 (2001).
  • Georgiadis D, Schwarz S, Kollmar R, Schwab S. Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach. Stroke32(11), 2550–2553 (2001).
  • Schwab S, Georgiadis D, Berrouschot J, Schellinger PD, Graffagnino C, Mayer SA. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke32(9), 2033–2035 (2001).
  • Schwab S, Schwarz S, Spranger M, Keller E, Bertram M, Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke29(12), 2461–2466 (1998).
  • Wolberg AS, Meng ZH, Monroe DM 3rd, Hoffman M. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J. Trauma.56(6), 1221–1228 (2004).
  • Kammersgaard LP, Rasmussen BH, Jorgensen HS, Reith J, Weber U, Olsen TS. Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: a case–control study: the Copenhagen Stroke Study. Stroke31(9), 2251–2256 (2000).
  • Campbell K, Meloni BP, Knuckey NW. Combined magnesium and mild hypothermia (35°C) treatment reduces infarct volumes after permanent middle cerebral artery occlusion in the rat at 2 and 4, but not 6 h. Brain Res.1230, 258–264 (2008).
  • Florian B, Vintilescu R, Balseanu AT et al. Long-term hypothermia reduces infarct volume in aged rats after focal ischemia. Neurosci. Lett.438(2), 180–185 (2008).
  • Lee SH, Kim YH, Kim YJ, Yoon BW. Atorvastatin enhances hypothermia-induced neuroprotection after stroke. J. Neurol. Sci.275(1–2), 64–68 (2008).
  • Zweifler RM, Voorhees ME, Mahmood MA, Alday DD. Induction and maintenance of mild hypothermia by surface cooling in non-intubated subjects. J. Stroke Cerebrovasc. Dis.12(5), 237–243 (2003).
  • Wang H, Olivero W, Lanzino G et al. Rapid and selective cerebral hypothermia achieved using a cooling helmet. J. Neurosurg.100(2), 272–277 (2004).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.