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Review

Electrocardiographic findings associated with cocaine use in humans: a systematic review

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Pages 105-127 | Published online: 10 Jan 2014

References

  • Substance Abuse and Mental Health Services Administration. Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of national findings. (NSDUH Series H-38A, HHS Publication No. SMA 10-4586). Office of Applied Studies, Rockville, MD, USA (2010).
  • Substance Abuse and Mental Health Services Administration. Results from the 2003 National Survey on Drug Use and Health: National Findings. (NSDUH Series H–25, DHHS Publication No. SMA 04-3964). Office of Applied Studies, Rockville, MD, USA (2004).
  • Health Canada. Canadian addiction survey: focus on gender. Minister of Public Works and Government Services Ottawa, Canada (2008).
  • Substance Abuse and Mental Health Services Administration: Drug Abuse Warning Network, 2008: area profiles of drug-related mortality. Office of Applied Studies, Rockville, MD, USA (2010).
  • Tazelaar HD, Karch SB, Stephens BG et al. Cocaine and the heart. Hum. Pathol.18, 195–199 (1987).
  • Virmani R, Robinwitz M, Smialek JE et al. Cardiovascular effects of cocaine: an autopsy study of 40 patients. Am. Heart J.115, 1068–1076 (1988).
  • Michaud K, Augsburger M, Sporkert F et al. Interpretation of lesions of the cardiac conduction system in cocaine-related fatalities. J. Forensic. Leg. Med.147, 416–422 (2007).
  • Whitby LG, Hertting G, Axelrod J. Effect of cocaine on the disposition of noradrenaline labelled with tritium. Nature187, 604–605 (1960).
  • Muscholl E. Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen. Br. J. Pharmacol. Chemother.16, 352–359 (1961).
  • Furchgott RF, Kirpekar SM, Rieker M et al. Actions and interactions of norepinephrine, tyramine, and cocaine on aortic strips of rabbit and left atria of guinea pig and cat. J. Pharmacol. Exp. Ther.142, 39–58 (1963).
  • Vongapatanasin W, Mansour Y, Chavoshan B et al. Cocaine stimulates the human cardiovascular system via a central mechanism of action. Circulation100, 497–502 (1999).
  • Jacobsen TN, Grayburn PA, Snyder RW 2nd et al. Effects of intranasal cocaine on sympathetic nerve discharge in humans. J. Clin. Invest.99, 628–634 (1997).
  • Wilkerson RD. Cardiovascular effects of cocaine in conscious dogs: importance of fully functional autonomic and central nervous systems. J. Pharmacol. Exp. Ther.246, 466–471 (1988).
  • Resnick RB, Kestenbaum RS, Schwartz LK. Acute systemic effects of cocaine in man: a controlled study by intranasal and intravenous routes. Science195, 696–698 (1977).
  • Kanani PM, Guse PA, Smith WM et al. Acute deleterious effects of cocaine on cardiac conduction, hemodynamics, and ventricular fibrillation threshold: effects of interaction with a selective dopamine D1 antagonist SCH 39166. J. Cardiovasc. Pharmacol.32, 42–48 (1998).
  • Schwartz AB, Janzen D, Jones RT. Electrophysiologic effects of cocaine on the canine ventricle. J. Cardiovasc. Pharmacol.13, 253–257 (1989).
  • Tisdale JE, Shimoyama H, Sabbah HN et al. The effect of cocaine on ventricular fibrillation threshold in the normal canine heart. Pharmacotherapy16, 429–437 (1996).
  • Manoach M, Erez M, Wozner D et al. Ventricular defibrillating properties of catecholamine uptake inhibitors. Life Sci.51, PL159–PL164 (1992).
  • Crumb WJ Jr, Clarkson CW. Characterization of cocaine-induced block of cardiac sodium channels. Biophys J.57, 589–599 (1990).
  • Clarkson CW, Xu Y-Q, Chang C et al. Analysis of the ionic basis for cocaine’s biphasic effect on action potential duration in guinea-pig ventricular myocytes. J. Mol. Cell Cardiol.28, 667–678 (1996).
  • Schwartz AB, Janzen D, Jones RT et al. Electrocardiographic and hemodynamic effects of intravenous cocaine in awake and anesthetized dogs. J. Electrocardiol.22, 159–166 (1989).
  • Tracy CM, Bachenheimer L, Solomon A et al. Evidence that cocaine slows cardiac conduction by an action on both AV nodal and His-Purkinje tissue in the dog. J. Electrocardiol.24, 257–262 (1991).
  • Kabas JS, Blanchard SM, Matsuyama Y et al. Cocaine-mediated impairment of cardiac conduction in the dog: a potential mechanism for sudden death after cocaine. J. Pharmacol. Exp. Ther.252, 185–191 (1990).
  • Przywara DA, Dambach GE. Direct actions of cocaine on cardiac cellular electrical activity. Circ. Res.65, 185–192 (1989).
  • O’Leary ME, Chahine M. Cocaine binds to a common site on open and inactivated human heart (Nav1.5) sodium channels. J. Physiol.541, 701–716 (2002).
  • Kimura S, Bassett AL, Xi H et al. Early afterdepolarizations and triggered activity induced by cocaine: a possible mechanism of cocaine arrhythmogenesis. Circulation85, 2227–2235 (1992).
  • Witchel HJ, Hancox JC. Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current. Clin. Exp. Pharmacol. Physiol.27, 753–766 (2000).
  • O’Leary ME, Hancox JC. Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias. Br. J. Clin. Pharmacol.69, 427–442 (2010).
  • Premkumar LS. Selective potentiation of L-type calcium channel currents by cocaine in cardiac myocytes. Mol. Pharmacol.56, 1138–1142 (1999).
  • Lange RA, Cigarroa RG, Yancy CW Jr et al. Cocaine-induced coronary-artery vasoconstriction. N. Engl. J. Med.321, 1557–1562 (1989).
  • Togna G, Tempesta E, Togna AR et al. Platelet responsiveness and biosynthesis of thromboxane and prostacyclin in response to in vitro cocaine treatment. Haemostasis15, 100–107 (1985).
  • Substance Abuse and Mental Health Services Administration; Drug Abuse Warning Network. 2008: Selected Tables of National Estimates of Drug-Related Emergency Department Visits. Office of Applied Studies, Rockville, MD, USA (2009).
  • Afonso L, Mohammad T, Thatai D. Crack whips the heart: a review of the cardiovascular toxicity of cocaine. Am. J. Cardiol.100, 1040–1043 (2007).
  • Albrecht CA. Proarrhythmia with non-antiarrhythmics: a review. Cardiology10, 122–139 (2004).
  • Bauman JL, Grawe JJ, Winecoff AP et al. Cocaine-related sudden cardiac death: a hypothesis correlating basic science and clinical observations. J. Clin. Pharmacol.34, 902–911 (1994).
  • Billman GE. Cocaine: a review of its toxic actions on cardiac function. Crit. Rev. Toxicol.25, 113–132 (1995).
  • Billman GE. Mechanisms responsible for the cardiotoxic effects of cocaine. FASEB J.4, 2469–2475 (1990).
  • Blumenthal RS, Flaherty JT. Recognizing cardiac crisis in cocaine abusers. J. Crit. Illness5, 225–239 (1990).
  • Bunn WH, Giannini AJ. Cardiovascular complications of cocaine abuse. Am. Fam. Physician46, 769–773 (1992).
  • Chakko S. Arrhythmias associated with cocaine abuse. Card. Electrophysiol. Rev.6, 168–169 (2002).
  • Chakko S. Arrhythmias, syncope and sudden death associated with cocaine abuse. Card. Electrophysiol. Rev.1, 287–288 (1997).
  • Cregler LL. Adverse health consequences of cocaine abuse. J. Natl Med. Assoc.81, 27–38 (1989).
  • Cregler LL. Cocaine: the newest risk factor for cardiovascular disease. Clin. Cardiol.14, 449–456 (1991).
  • Cregler LL, Mark H. Medical complications of cocaine abuse. N. Engl. J. Med.315, 1495–1500 (1986).
  • Das G. Cardiovascular effects of cocaine abuse. Int. J. Clin. Pharmacol. Ther. Toxicol.31, 521–528 (1993).
  • Derlet RW. Acute cocaine intoxication: cardiac manifestations. Prim. Cardiol.18, 92–96 (1992).
  • Fischman MW, Schuster CR. Cocaine self-administration in humans. Fed. Proc.41, 241–246 (1982).
  • Frishman WH, Del Vecchio A, Sanal S et al. Cardiovascular manifestations of substance abuse part 1: cocaine. Heart Dis.5, 187–201 (2003).
  • Gallo JA Jr. Catecholamine anesthetic interaction in ENT surgery. Contemp. Anesth. Pract.9, 7–30 (1987).
  • Gay GR. Clinical management of acute and chronic cocaine poisoning. Ann. Emerg. Med.11, 562–572 (1982).
  • Gay GR. You’ve come a long way, baby! Coke time for the new American lady of the eighties. J. Psychoactive Drugs13, 297–318 (1981).
  • Gay GR, Sheppard CW, Inaba DS. Cocaine: history, epidemiology, human pharmacology, and treatment. a perspective on a new debut for an old girl. Clin. Toxicol.8, 149–178 (1975).
  • Gradman AH. Cardiac effects of cocaine: a review. Yale J. Biol. Med.61, 137–147 (1988).
  • Grinspoon L, Bakalar JB. Adverse effects of cocaine: selected issues. Ann. NY Acad. Sci.362, 125–131 (1981).
  • Hackel DB, Reimer KA. Role of recreational and therapeutic drugs in occurrence of sudden death. Cardiovasc. Rev. Rep.15, 16–34 (1994).
  • Isner JM, Chokshi SK. Cardiovascular complications of cocaine. Curr. Probl. Cardiol.16, 95–123 (1991).
  • Karch SB, Billingham ME. The pathology and etiology of cocaine-induced heart disease. Arch. Pathol. Lab. Med.112, 225–230 (1988).
  • Kloner RA, Hale S, Alker K et al. The effects of acute and chronic cocaine use on the heart. Circulation85, 407–419 (1992).
  • Lange RA, Hillis LD. Cardiovascular complications of cocaine use. N. Engl. J. Med.345, 351–358 (2001).
  • Lathers CM, Tyau LSY, Spino MM et al. Cocaine-induced seizures, arrhythmias and sudden death. J. Clin. Pharmacol.28, 584–593 (1988).
  • Mittleman HS, Mittleman E, Elser B. Cocaine. Am. J. Nurs.84, 1092–1095 (1984).
  • Om A, Ellahham S, DiSciascio G. Management of cocaine-induced cardiovascular complications. Am. Heart J.125, 469–475 (1993).
  • Phillips K, Luk A, Soor G et al. Cocaine use is associated with a number of life-threatening cardiovascular complications that require careful treatment. Drugs Ther. Perspect.26, 15–17 (2010).
  • Williams RG, Kavanagh KM, Teo KK. Pathophysiology and treatment of cocaine toxicity: implications for the heart and cardiovascular system. Can. J. Cardiol.12, 1295–1301 (1996).
  • Wood DM, Dargan PI, Hoffman RS. Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin. Toxicol.47, 14–23 (2009).
  • Valladares BK, Lemberg L. The Miami vices in the CCU. Part I. cardiac manifestations of cocaine use. Heart Lung16, 456–458 (1987).
  • Frassica JJ, Orav EJ, Walsh EP et al. Arrhythmias in children prenatally exposed to cocaine. Arch. Pediatr. Adolesc. Med.148, 1163–1169 (1994).
  • Antzelevitch C, Brugada P, Borggrefe M et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation111, 659–670 (2005).
  • Osborn JJ. Experimental hypothermia: respiratory and blood pH changes in relation to cardiac function. Am. J. Physiol.175, 389–398 (1953).
  • Magnano AR, Talathoti NB, Hallur R et al. Effect of acute cocaine administration on the QTc interval of habitual users. Am. J. Cardiol.97, 1244–1246 (2006).
  • Kajdasz DK, Moore JW, Donepudi H et al. Cardiac and mood-related changes during short-term abstinence from crack cocaine: the identification of possible withdrawal phenomena. Am. J. Drug Alcohol Abuse25, 629–637 (1999).
  • Hollander JE, Lozano M, Fairweather P et al. ‘Abnormal’ electrocardiograms in patients with cocaine-associated chest pain are due to ‘normal’ variants. J. Emerg. Med.12, 199–205 (1994).
  • Levin KH, Copersino ML, Epstein D et al. Longitudinal ECG changes in cocaine users during extended abstinence. Drug Alcohol Depend.95, 160–163 (2008).
  • Daniel WC, Pirwitz MJ, Horton RP et al. Electrophysiologic effects of intranasal cocaine. Am. J. Cardiol.76, 398–400 (1995).
  • Fischman MW, Schuster CR, Resnekov L et al. Cardiovascular and subjective effects of intravenous cocaine administration in humans. Arch. Gen. Psychiatry33, 983–989 (1976).
  • Tanenbaum JH, Miller F. Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers. Gen. Hosp. Psychiatry14, 201–203 (1992).
  • Chakko S, Sepulveda S, Kessler KM et al. Frequency and type of electrocardiographic abnormalities in cocaine abusers (electrocardiogram in cocaine abuse). Am. J. Cardiol.74, 710–713 (1994).
  • Chakko S, Fernandez A, Mellman TA et al. Cardiac manifestations of cocaine abuse: a cross-sectional study of asymptomatic men chronically abusing ‘crack’ cocaine. J. Am. Coll. Cardiol.20, 1168–1174 (1992).
  • Tuboku-Metzger AJ, O’Shea JS, Campbell RM et al. Cardiovascular effects of cocaine in neonates exposed prenatally. Am. J. Perinatol.13, 1–4 (1996).
  • Kalimullah EA, Bryant SM. Case files of the Medical Toxicology Fellowship at the Toxikon Consortium in Chicago: cocaine-associated wide-complex dysrhythmias and cardiac arrest – treatment nuances and controversies. J. Med. Toxciol.4, 277–283 (2008).
  • Weiner RB, Weiner SD, Yurchak PM. Removing the mask. Am. J. Med.121, 113–116 (2008).
  • Ortega-Carnicer J, Bertos-Polo J, Gutierrez-Tirado C. Aborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion. J. Electrocardiol.34, 345–349 (2001).
  • Kerns W 2nd, Garvey L, Owens J. Cocaine-induced wide complex dysrhythmia. J. Emerg. Med.15, 321–329 (1997).
  • Grigorov V, Goldberg L, Foccard JP. Cardiovascular complications of acute cocaine poisoning: a clinical case report. Cardiovasc. J. S. Afr.15, 139–142 (2004).
  • Om A, Ellenbogen KA, Vetrovec GW. Cocaine-induced bradyarrhythmias. Am. Heart J.124, 232–234 (1992).
  • Tanen DA, Graeme KA, Curry SC. Crack cocaine ingestion with prolonged toxicity requiring electrical pacing. J. Toxicol. Clin. Toxicol.38, 653–657 (2000).
  • Isner JM, Estes NA 3rd, Thompson PD. Acute cardiac events temporally related to cocaine abuse. N. Engl. J. Med.315, 1438–1443 (1986).
  • Sternberg RG, Winniford MD, Hillis LD et al. Simultaneous acute thrombosis of two major coronary arteries following intravenous cocaine use. Arch. Pathol. Lab. Med.113, 521–524 (1989).
  • Young D, Glauber, JJ. Electrocardiographic changes resulting from acute cocaine intoxication. Am. Heart J.34, 272–279 (1947).
  • Aryana A, Mooss AN. ST elevation alternans in presence of profound myocardial ischemia and injury induced by cocaine toxicity. Clin. Cardiol.32, E43–E44 (2009).
  • Daga B, Minano A, de la Puerta I et al. Electrocardiographic findings typical of Brugada syndrome unmasked by cocaine consumption. Rev. Esp. Cardiol.58, 1355–1357 (2005).
  • Robertson KE, Martin TN, Rae AP. Brugada-pattern ECG and cardiac arrest in cocaine toxicity: reading between the white lines. Heart96, 643–644 (2010).
  • Jonsson S, O’Meara M, Young JB. Acute cocaine poisoning. importance of treating seizures and acidosis. Am. J. Med.75, 1061–1064 (1983).
  • Rollingher IM, Belzberg AS, MacDonald IL. Cocaine-induced myocardial infarction. CMAJ135, 45–46 (1986).
  • Hunter R. Ventricular tachycardia following naloxone administration in an illicit drug misuse. J. Clin. Forensic Med.12, 218–219 (2005).
  • Krantz MJ, Rowan SB, Mehler PS. Cocaine-related torsade de pointes in a methadone maintenance patient. J. Addict Dis.24, 53–60 (2005).
  • Littmann L. Brugada-type electrocardiographic pattern induced by cocaine. Mayo Clin. Proc.75, 845–849 (2000).
  • Bebarta VS, Summers S. Brugada electrocardiographic pattern induced by cocaine toxicity. Ann. Emerg. Med.49, 827–829 (2007).
  • Wang RY. pH-dependent cocaine-induced cardiotoxicity. Am. J. Emerg. Med.17, 364–369 (1999).
  • Benchimol A, Bartall H, Desser KB. Accelerated ventricular rhythm and cocaine abuse. Ann. Intern. Med.88, 519–520 (1978).
  • Kuczkowski KM. Chest pain and dysrhythmias in a healthy parturient: Wolff–Parkinson–White syndrome vs cocaine-induced myocardial ischemia? Anaesth. Intensive Care32, 143–144 (2004).
  • Pentel PR, Thompson T, Hatsukami DK et al. 12-lead and continuous ECG recordings of subjects during inpatient administration of smoked cocaine. Drug Alcohol Depend.35, 107–116 (1994).
  • Hollander JE, Hoffman RS, Gennis P et al. Prospective multicenter evaluation of cocaine-associated chest pain. Cocaine Associated Chest Pain (COCHPA) Study Group. Acad. Emerg. Med.1, 330–339 (1994).
  • Gitter MJ, Goldsmith SR, Dunbar DN et al. Cocaine and chest pain: clinical features and outcome of patients hospitalized to rule out myocardial infarction. Ann. Intern. Med.115, 277–282 (1991).
  • Zimmerman JL, Dellinger RP, Majid PA. Cocaine-associated chest pain. Ann. Emerg. Med.20, 611–615 (1991).
  • Derlet RW, Albertson TE. Emergency department presentation of cocaine intoxication. Ann. Emerg. Med.18, 182–186 (1989).
  • Tokarski GF, Paganussi P, Urbanski R et al. An evaluation of cocaine-induced chest pain. Ann. Emerg. Med.19, 1088–1092 (1990).
  • Kossowsky WA, Lyon AF, Chou SY. Acute non-Q wave cocaine-related myocardial infarction. Chest96, 617–621 (1989).
  • Kossowsky WA, Lyon AF. Cocaine and acute myocardial infarction. A probable connection. Chest86, 729–731 (1984).
  • Mohamad T, Niraj A, Farah J et al. Spectrum of electrocardiographic and angiographic coronary artery disease findings in patients with cocaine-associated myocardial infarction. Coron. Artery Dis.20, 332–336 (2009).
  • Nademanee K, Gorelick DA, Josephson MA et al. Myocardial ischemia during cocaine withdrawal. Ann. Intern. Med.111, 876–880 (1989).
  • Mehta SK, Finkelhor RS, Anderson RL et al. Transient myocardial ischemia in infants prenatally exposed to cocaine. J. Pediatr.122, 945–949 (1993).
  • Lustik SJ, Chhibber AK, Van Vliet M et al. Ephedrine-induced coronary artery vasospasm in a patient with prior cocaine use. Anesth. Analg.84, 931–933 (1997).
  • Caroselli C, Perfetti P, Bruno G. High serum tryptase value in massive acute myocardial infarction with ventricular arrhythmia exortion in a cocaine abuser. Int. J. Immunopathol. Pharmacol.22, 525–529 (2009).
  • Gharde P, Chauhan S, Patra S. ST elevation is not always a sign of coronary artery disease. Indian Heart J.57, 785 (2005).
  • Sharma RK. Retrospective diagnosis of cocaine addiction: role of preoperative electrocardiogram. Anaesth. Intensive Care36, 752 (2008).
  • Nwosu MC, Nwosu MN, Nwabueze AC et al. Brain cardiac events in Nigerian patients with cocaine abuse. West Afr. J. Med.20, 65–72 (2001).
  • Ascher EK, Stauffer JC, Gaasch WH. Coronary artery spasm, cardiac arrest, transient electrocardiographic Q waves and stunned myocardium in cocaine-associated acute myocardial infarction. Am. J. Cardiol.61, 939–941 (1988).
  • Perera R, Kraebber A, Schwartz MJ. Prolonged QT interval and cocaine use. J. Electrocardiol.30, 337–339 (1997).
  • Somers MP, Brady WJ, Perron AD et al. The prominant T wave: electrocardiographic differential diagnosis. Am. J. Emerg. Med.20, 243–251 (2002).
  • Brady WJ, Chan TC. Electrocardiographic manifestations: benign early repolarization. J. Emerg. Med.17, 473–478 (1999).
  • Christou T, Turnbull T, Cline D. Cardiopulmonary abnormalities after smoking cocaine. South Med. J.83, 335–338 (1990).
  • Coleman DL, Ross TF, Naughton, JL. Myocardial ischemia and infarction related to recreational cocaine use. West J. Med.136, 444–446 (1982).
  • Patel A, Getsos JP, Moussa G et al. The Osborn wave of hypothermia in normothermic patients. Clin. Cardiol.17, 273–276 (1994).
  • Janssens U, Schneider B, Hanrath P. Electrocardiographic changes in unintentional hypothermia – the J wave. Intensive Care Med.24, 1118–1119 (1998).
  • Boag F, Havard CWH. Cardiac arrhythmia and myocardial ischaemia related to cocaine and alcohol consumption. Postgrad. Med. J.61, 997–999 (1985).
  • Chiu YC, Brecht K, DasGupta DS et al. Myocardial infarction with topical cocaine anesthesia for nasal surgery. Arch. Otolaryngol. Head Neck Surg.112, 988–990 (1986).
  • Pollan S, Tadjziechy M. Esmolol in the management of epinephrine- and cocaine-induced cardiovascular toxicity. Anesth. Analg.69, 663–664 (1989).
  • Rummel TS. Cocaine cardiac toxicity. J. Tenn. Med. Assoc.82, 541 (1989).
  • El-Din AS, Mostafa SM. Severe hypertension during anaesthesia for dacryocystorhinostomy. Anaesthesia40, 787–789 (1985).
  • Nicholson KE, Rogers JE. Cocaine and adrenaline paste: a fatal combination? BMJ311, 250–251 (1995).
  • Kuczkowski KM. Cardiovascular complications of recreational cocaine use in pregnancy: myth or reality? Acta Obstet. Gynecol. Scand.84, 100–101 (2005).
  • Lamberts AE, Basinger CE, Meade RH et al. Successful treatment of cardiac arrest occurring twice in the same patient: report of a case. Dis. Chest46, 617–620 (1964).
  • Junttila MJ, Gonzalez M, Lizotte E et al. Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Circulation117, 1890–1893 (2008).
  • Hollister LE. Electrocardiographic screening in psychiatric patients. J. Clin. Psychiatry56, 26–29 (1995).
  • Gamouras GA, Monir G, Plunkitt K et al. Cocaine abuse: repolarization abnormalities and ventricular arrhythmias. Am. J. Med. Sci.320, 9–12 (2000).
  • Haigney MC, Alam S, Tebo S et al. Intravenous cocaine and QT variability. J. Cardiovasc. Electrophysiol.17, 610–616 (2006).
  • Riaz K, McCullough PA. Fatal case of delayed repolarization due to cocaine abuse and global ischemia. Rev. Cardiovasc. Med.4, 47–53 (2003).
  • Patel MB, Opreanu M, Shah AJ et al. Cocaine and alcohol: a potential lethal duo. Am. J. Med.122, e5–e6 (2009).
  • Ortega-Carnicer J, Gomez-Grande L, Ambros A. Electrocardiographic changes indicating surgery on cocaine body-packers. Resuscitation65, 373–374 (2005).
  • Singh N, Singh HK, Singh PP et al. Cocaine-induced Torsades de pointes in idiopathic long Q–T syndrome. Am. J. Ther.8, 299–302 (2001).
  • Schrem SS, Belsky P, Schwartzman D et al. Cocaine-induced Torsades de pointes in a patient with the idiopathic long QT syndrome. Am. Heart J.120, 980–984 (1990).
  • Kuczkowski KM. Crack cocaine-induced long QT interval syndrome in a parturient with recreational cocaine use. Ann. Fr. Anesth. Reanim.24, 697–698 (2005).
  • Farooq MU, Bhatt A, Patel M. Neurotoxic and cardiotoxic effects of cocaine and ethanol. J. Med. Toxicol.5, 134–138 (2009).
  • Taylor D, Parish D, Thompson L et al. Cocaine induced prolongation of the QT interval. Emerg. Med. J.21, 252–253 (2004).
  • Yaganti V, Naik C, Jain D. Looks like snow. Am. J. Med.120, 236–238 (2007).
  • Hancock EW. Chest pain and abnormal T waves while at rest. Hosp. Pract. (Minneap.)34, 15–16 (1999).
  • Bauman JL, DiDomenico RJ. Cocaine-induced channelopathies: emerging evidence on the multiple mechanisms of sudden death. J. Cardiovasc. Pharmacol.Ther 7, 195–202 (2002).
  • Khan IA, Win MT, Bali AJ et al. Torsades de pointes: a case with multiple variables. Am. J. Emerg. Med.17, 80–85 (1999).
  • Deamer RL, Wilson DR, Clark DS et al. Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM). J. Addict Dis.20, 7–14 (2001).
  • Sticherling C, Schaer BA, Ammann P et al. Methadone-induced torsade de pointes tachycardias. Swiss Med. Wkly135, 282–285 (2005).
  • Wang T, Hadidi F, Triana F et al. Morning report at charity hospital: myocardial infarction associated with the use of cocaine. Am. J. Med. Sci.295, 569–571 (1988).
  • Meyers EF. Cocaine toxicity during dacryocystorhinostomy. Arch. Ophthalmol.98, 842–843 (1980).
  • Fischman MW, Schuster CR, Hatano Y. A comparison of the subjective and cardiovascular effects of cocaine and lidocaine in humans. Pharmacol. Biochem. Behav.18, 123–127 (1983).
  • Javaid JI, Fischman MW, Schuster CR et al. Cocaine plasma concentration: relation to physiological and subjective effects in humans. Science202, 227–228 (1978).
  • Fischman MW, Schuster CR, Javaid J et al. Acute tolerance development to the cardiovascular and subjective effects of cocaine. J. Pharmacol. Exp. Ther.235, 677–682 (1985).
  • Kumor K, Sherer M, Thompson L et al. Lack of cardiovascular tolerance during intravenous cocaine infusions in human volunteers. Life Sci.42, 2063–2071 (1988).
  • Orr D, Jones I. Anaesthesia for laryngoscopy. a comparison of the cardiovascular effects of cocaine and lignocaine. Anaesthesia23, 194–202 (1968).
  • Chazotte C, Forman L, Gandhi J. Heart rate patterns in fetuses exposed to cocaine. Obstet. Gynecol.78, 323–325 (1991).
  • Chokshi SK, Moore R, Pandian NG et al. Reversible cardiomyopathy associated with cocaine intoxication. Ann. Intern. Med.111, 1039–1040 (1989).
  • Samuels J, Schwalbe SS, Marx GF. Speedballs: a new cause of intraoperative tachycardia and hypertension. Anesth. Analg.72, 397–398 (1991).
  • Merigian KS. Cocaine-induced ventricular arrhythmias and rapid atrial fibrillation temporally related to naloxone administration. Am. J. Emerg. Med.11, 96–97 (1993).
  • Kotton CN, Elias N, Delmonico FL et al. Case records of the Massachusetts General Hospital. Case 15-2009: a 25-year-old man with coma after cardiac arrest. N. Engl. J. Med.360, 2118–2125 (2009).
  • Geggel RL, McInerny J, Estes NA 3rd. Transient neonatal ventricular tachycardia associated with maternal cocaine use. Am. J. Cardiol.63, 383–384 (1989).
  • Stannard CF. Ventricular fibrillation during examination of nose. Anaesthesia46, 794–795 (1991).
  • Lormans P, Gaumann D, Schwieger I et al. Myocardial infarction with topical cocaine anesthesia for nasal surgery. ORL J. Otorhinolaryngol. Relat. Spec.54, 160–162 (1992).
  • Nanji AA, Filipenko JD. Asystole and ventricular fibrillation associated with cocaine intoxication. Chest85, 132–133 (1984).
  • McCann B, Hunter R, McCann J. Cocaine/heroin induced rhabdomyolysis and ventricular fibrillation. Emerg. Med. J.19, 264–265 (2002).
  • Burkett G, Bandstra ES, Cohen J et al. Cocaine-related maternal death. Am. J. Obstet. Gynecol.163, 40–41 (1990).
  • Inouye DS, Navin JJ, Hardman JM. Fatal postoperative arrhythmia in a man with a remote history of methamphetamine and cocaine use: a case report. Hawaii Med. J.63, 82–86 (2004).
  • Rouse DA, Fysh R. Body packing presenting as sudden collapse. Med. Sci. Law32, 270–271 (1992).
  • Glancy DL, Makkena B, Wilklow FE et al. ECG of the month: typical and unusual premature complexes. Sinus rhythm and atrial premature complexes. J. LA State Med. Soc.161, 244–246 (2009).
  • Gay GR, Loper KA. The use of labetalol in the management of cocaine crisis. Ann. Emerg. Med.17, 282–283 (1988).
  • Castro VJ, Nacht R. Cocaine-induced bradyarrhythmia: an unsuspected cause of syncope. Chest117, 275–277 (2000).
  • Chasnoff IJ, Bussey ME, Savich R et al. Perinatal cerebral infarction and maternal cocaine. J. Pediatr.108, 456–459 (1986).
  • Kurohara ML, Kwong FK, Klaustermeyer WB. Adverse reactions to cocaine. Ann. Allergy68, 139–142 (1992).
  • Hollander JE, Lozano M Jr, Goldstein E et al. Variations in the electrocardiograms of young adults: are revised criteria for thrombolysis needed? Acad. Emerg. Med.1, 94–102 (1994).
  • Wilson LD, Jeromin J, Garvey L et al. Cocaine, ethanol, and cocaethylene cardiotoxicity in an animal model of cocaine and ethanol abuse. Acad. Emerg. Med.8, 211–22 (2001).

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