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Review

Care of patients with acute pulmonary emboli: a clinical review with cardiovascular focus

, , &
Pages 235-250 | Published online: 10 Jan 2014

References

  • Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest133(Suppl. 6), S454–S545 (2008).
  • Jaff MR, McMurtry MS, Archer SL et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation123(16), 1788–1830 (2011).
  • Goldhaber SZ. Pulmonary embolism. N. Engl. J. Med.339(2), 93–104 (1998).
  • Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet353(9162), 1386–1389 (1999).
  • Heit JA, Silverstein MD, Mohr DN et al. The epidemiology of venous thromboembolism in the community. Thromb. Haemost.86(1), 452–463 (2001).
  • Pollack CV, Schreiber D, Goldhaber SZ et al. Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department initial report of EMPEROR: (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry). J. Am. Coll. Cardiol.57(6), 700–706 (2011).
  • Calder KK, Herbert M, Henderson SO. The mortality of untreated pulmonary embolism in emergency department patients. Ann. Emerg. Med.45(3), 302–310 (2005).
  • Dalen JE. Pulmonary embolism: what have we learned since Virchow? Treatment and prevention. Chest122(5), 1801–1817 (2002).
  • Jimenez Castro D, Sueiro A, Diaz G et al. Prognostic significance of delays in diagnosis of pulmonary embolism. Thromb. Res.121(2), 153–158 (2007).
  • Ryu JH, Olson EJ, Pellikka PA. Clinical recognition of pulmonary embolism: problem of unrecognized and asymptomatic cases. Mayo Clin. Proc.73(9), 873–879 (1998).
  • Torbicki A, Perrier A, Konstantinides S et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur. Heart J.29(18), 2276–2315 (2008).
  • Silverstein MD, Heit JA, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch. Intern. Med.158(6), 585–593 (1998).
  • Ruppert A, Steinle T, Lees M. Economic burden of venous thromboembolism: a systematic review. J. Med. Econ.14(1), 65–74 (2011).
  • Stein PD, Fowler SE, Goodman LR et al. Multidetector computed tomography for acute pulmonary embolism. N. Engl. J. Med.354(22), 2317–2327 (2006).
  • No authors listed. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). The PIOPED-Investigators. JAMA263(20), 2753–2759 (1990).
  • Roy PM, Meyer G, Vielle B et al. Appropriateness of diagnostic management and outcomes of suspected pulmonary embolism. Ann. Intern. Med.144(3), 157–164 (2006).
  • Torbicki A, Perrier A, Konstantinides S et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur. Heart J.29(18), 2276–2315 (2008).
  • Wells PS, Anderson DR, Rodger M et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer. Ann. Intern. Med.135(2), 98–107 (2001).
  • Wolf SJ, McCubbin TR, Feldhaus KM, Faragher JP, Adcock DM. Prospective validation of Wells criteria in the evaluation of patients with suspected pulmonary embolism. Ann. Emerg. Med.44(5), 503–510 (2004).
  • Wicki J, Perneger TV, Junod AF, Bounameaux H, Perrier A. Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score. Arch. Intern. Med.161(1), 92–97 (2001).
  • Iles S, Hodges AM, Darley JR et al. Clinical experience and pretest probability scores in the diagnosis of pulmonary embolism. QJM96(3), 211–215 (2003).
  • Klok FA, Mos IC, Nijkeuter M et al. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism. Arch. Intern. Med.168(19), 2131–2136 (2008).
  • Gibson NS, Sohne M, Kruip MJ et al. Further validation and simplification of the Wells clinical decision rule in pulmonary embolism. Thromb. Haemost.99(1), 229–234 (2008).
  • Le Gal G, Righini M, Roy PM et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann. Intern. Med.144(3), 165–171 (2006).
  • Miniati M, Pistolesi M. Assessing the clinical probability of pulmonary embolism. Q. J. Nucl. Med.45(4), 287–293 (2001).
  • Kline JA, Wells PS. Methodology for a rapid protocol to rule out pulmonary embolism in the emergency department. Ann. Emerg. Med.42(2), 266–275 (2003).
  • Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J. Thromb. Haemost.2(8), 1247–1255 (2004).
  • Kline JA, Courtney DM, Kabrhel C et al. Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. J. Thromb. Haemost.6(5), 772–780 (2008).
  • Hyers TM. Diagnosis of pulmonary embolism. Thorax50(9), 930–932 (1995).
  • Moores LK, King CS, Holley AB. Current approach to the diagnosis of acute nonmassive pulmonary embolism. Chest140(2), 509–518 (2011).
  • Douma RA, Mos IC, Erkens PM et al. Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study. Ann. Intern. Med.154(11), 709–718 (2011).
  • Righini M, Le Gal G, Aujesky D et al. Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial. Lancet371(9621), 1343–1352 (2008).
  • Stein PD, Chenevert TL, Fowler SE et al. Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED-III). Ann. Intern. Med.152(7), 434–443, W142–W433 (2010).
  • Ferrari E, Imbert A, Chevalier T, Mihoubi A, Morand P, Baudouy M. The ECG in pulmonary embolism. Predictive value of negative T waves in precordial leads – 80 case reports. Chest111(3), 537–543 (1997).
  • Punukollu G, Gowda RM, Vasavada BC, Khan IA. Role of electrocardiography in identifying right ventricular dysfunction in acute pulmonary embolism. Am. J. Cardiol.96(3), 450–452 (2005).
  • Rodger M, Makropoulos D, Turek M et al. Diagnostic value of the electrocardiogram in suspected pulmonary embolism. Am. J. Cardiol.86(7), 807–809, A10 (2000).
  • Sreeram N, Cheriex EC, Smeets JL, Gorgels AP, Wellens HJ. Value of the 12-lead electrocardiogram at hospital admission in the diagnosis of pulmonary embolism. Am. J. Cardiol.73(4), 298–303 (1994).
  • Stein PD, Terrin ML, Hales CA et al. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest100(3), 598–603 (1991).
  • Kostrubiec M, Jankowski K, Pedowska-Wloszek J et al. Signs of myocardial ischemia on electrocardiogram correlate with elevated plasma cardiac troponin and right ventricular systolic dysfunction in acute pulmonary embolism. Cardiol J.17(2), 157–162 (2010).
  • Sukhija R, Aronow WS, Ahn C, Kakar P. Electrocardiographic abnormalities in patients with right ventricular dilation due to acute pulmonary embolism. Cardiology105(1), 57–60 (2006).
  • Elliott CG, Goldhaber SZ, Visani L, DeRosa M. Chest radiographs in acute pulmonary embolism. Results from the International Cooperative Pulmonary Embolism Registry. Chest118(1), 33–38 (2000).
  • Worsley DF, Alavi A, Aronchick JM, Chen JT, Greenspan RH, Ravin CE. Chest radiographic findings in patients with acute pulmonary embolism: observations from the PIOPED Study. Radiology189(1), 133–136 (1993).
  • Stollberger C, Finsterer J, Lutz W et al. Multivariate analysis-based prediction rule for pulmonary embolism. Thromb. Res.97(5), 267–273 (2000).
  • Greenspan RH, Ravin CE, Polansky SM, McLoud TC. Accuracy of the chest radiograph in diagnosis of pulmonary embolism. Invest. Radiol.17(6), 539–543 (1982).
  • Stein PD, Hull RD, Patel KC et al.D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann. Intern. Med.140(8), 589–602 (2004).
  • Di Nisio M, Squizzato A, Rutjes AW, Buller HR, Zwinderman AH, Bossuyt PM. Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review. J. Thromb. Haemost.5(2), 296–304 (2007).
  • Le Gal G, Righini M, Roy PM et al. Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolism. Arch. Intern. Med.166(2), 176–180 (2006).
  • Wells PS, Ginsberg JS, Anderson DR et al. Utility of ultrasound imaging of the lower extremities in the diagnostic approach in patients with suspected pulmonary embolism. J. Intern. Med.250(3), 262–264 (2001).
  • Sostman HD, Stein PD, Gottschalk A, Matta F, Hull R, Goodman L. Acute pulmonary embolism: sensitivity and specificity of ventilation-perfusion scintigraphy in PIOPED-II study. Radiology246(3), 941–946 (2008).
  • Kortekaas KA, Eikenboom J, Stokkel MP, van Gent H, de Roos A, Huisman MV. Is a V/Q scan based algorithm correctly used to diagnose acute pulmonary embolism? A daily practice survey. Thromb. Res.128(3), 221–226 (2011).
  • Remy-Jardin M, Pistolesi M, Goodman LR et al. Management of suspected acute pulmonary embolism in the era of CT angiography: a statement from the Fleischner Society. Radiology245(2), 315–329 (2007).
  • Macdonald WB, Patrikeos AP, Thompson RI, Adler BD, van der Schaaf AA. Diagnosis of pulmonary embolism: ventilation perfusion scintigraphy versus helical computed tomography pulmonary angiography. Australas Radiol.49(1), 32–38 (2005).
  • Anderson DR, Kahn SR, Rodger MA et al. Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial. JAMA298(23), 2743–2753 (2007).
  • van Belle A, Buller HR, Huisman MV et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA295(2), 172–179 (2006).
  • Schoepf UJ, Kucher N, Kipfmueller F, Quiroz R, Costello P, Goldhaber SZ. Right ventricular enlargement on chest computed tomography: a predictor of early death in acute pulmonary embolism. Circulation110(20), 3276–3280 (2004).
  • Kuiper JW, Geleijns J, Matheijssen NA, Teeuwisse W, Pattynama PM. Radiation exposure of multi-row detector spiral computed tomography of the pulmonary arteries: comparison with digital subtraction pulmonary angiography. Eur. Radiol.13(7), 1496–1500 (2003).
  • Gupta A, Frazer CK, Ferguson JM et al. Acute pulmonary embolism: diagnosis with MR angiography. Radiology210(2), 353–359 (1999).
  • Meaney JF, Weg JG, Chenevert TL, Stafford-Johnson D, Hamilton BH, Prince MR. Diagnosis of pulmonary embolism with magnetic resonance angiography. N. Engl. J. Med.336(20), 1422–1427 (1997).
  • Oudkerk M, van Beek EJ, Wielopolski P et al. Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Lancet359(9318), 1643–1647 (2002).
  • Vieillard-Baron A, Qanadli SD, Antakly Y et al. Transesophageal echocardiography for the diagnosis of pulmonary embolism with acute cor pulmonale: a comparison with radiological procedures. Intensive Care Med.24(5), 429–433 (1998).
  • McConnell MV, Solomon SD, Rayan ME, Come PC, Goldhaber SZ, Lee RT. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am. J. Cardiol.78(4), 469–473 (1996).
  • Casazza F, Bongarzoni A, Capozi A, Agostoni O. Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarction. Eur. J. Echocardiogr.6(1), 11–14 (2005).
  • Jahnke C, Kaufmann J, Stauber B, Goetze S, Fleck E, Paetsch I. Magnetic resonance imaging for monitoring the efficacy of thrombolytic therapy in subacute pulmonary artery embolism. J. Am. Coll. Cardiol.54(14), 1335 (2009).
  • Torbicki A, Kurzyna M, Ciurzynski M et al. Proximal pulmonary emboli modify right ventricular ejection pattern. Eur. Respir. J.13(3), 616–621 (1999).
  • Kurzyna M, Torbicki A, Pruszczyk P et al. Disturbed right ventricular ejection pattern as a new Doppler echocardiographic sign of acute pulmonary embolism. Am. J. Cardiol.90(5), 507–511 (2002).
  • Jackson RE, Rudoni RR, Hauser AM, Pascual RG, Hussey ME. Prospective evaluation of two-dimensional transthoracic echocardiography in emergency department patients with suspected pulmonary embolism. Acad. Emerg. Med.7(9), 994–998 (2000).
  • Miniati M, Monti S, Pratali L et al. Value of transthoracic echocardiography in the diagnosis of pulmonary embolism: results of a prospective study in unselected patients. Am. J. Med.110(7), 528–535 (2001).
  • Aujesky D, Obrosky DS, Stone RA et al. Derivation and validation of a prognostic model for pulmonary embolism. Am. J. Respir. Crit. Care Med.172(8), 1041–1046 (2005).
  • Jimenez D, Aujesky D, Moores L et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch. Intern. Med.170(15), 1383–1389 (2010).
  • Wicki J, Perrier A, Perneger TV, Bounameaux H, Junod AF. Predicting adverse outcome in patients with acute pulmonary embolism: a risk score. Thromb. Haemost.84(4), 548–552 (2000).
  • Kasper W, Konstantinides S, Geibel A et al. Management strategies and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry. J. Am. Coll. Cardiol.30(5), 1165–1171 (1997).
  • Konstantinides S. Clinical practice. Acute pulmonary embolism. N. Engl. J. Med.359(26), 2804–2813 (2008).
  • Kucher N, Rossi E, De Rosa M, Goldhaber SZ. Massive pulmonary embolism. Circulation113(4), 577–582 (2006).
  • Price LC, Wort SJ, Finney SJ, Marino PS, Brett SJ. Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review. Crit. Care14(5), R169 (2010).
  • Thabut G, Logeart D. Thrombolysis for pulmonary embolism in patients with right ventricular dysfunction: con. Arch. Intern. Med.165(19), 2200–2203; discussion 2204–2205 (2005).
  • Toosi MS, Merlino JD, Leeper KV. Prognostic value of the shock index along with transthoracic echocardiography in risk stratification of patients with acute pulmonary embolism. Am. J. Cardiol.101(5), 700–705 (2008).
  • Sugiura E, Dohi K, Onishi K et al. Reversible right ventricular regional non-uniformity quantified by speckle-tracking strain imaging in patients with acute pulmonary thromboembolism. J. Am. Soc. Echocardiogr.22(12), 1353–1359 (2009).
  • Kreit JW. The impact of right ventricular dysfunction on the prognosis and therapy of normotensive patients with pulmonary embolism. Chest125(4), 1539–1545 (2004).
  • Kucher N, Rossi E, De Rosa M, Goldhaber SZ. Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mmHg or higher. Arch. Intern. Med.165(15), 1777–1781 (2005).
  • Sanchez O, Trinquart L, Colombet I et al. Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic review. Eur. Heart J.29(12), 1569–1577 (2008).
  • Grifoni S, Olivotto I, Cecchini P et al. Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction. Circulation101(24), 2817–2822 (2000).
  • Kasper W, Konstantinides S, Geibel A, Tiede N, Krause T, Just H. Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism. Heart77(4), 346–349 (1997).
  • Ribeiro A, Juhlin-Dannfelt A, Brodin LA, Holmgren A, Jorfeldt L. Pulmonary embolism: relation between the degree of right ventricle overload and the extent of perfusion defects. Am. Heart J.135(5 Pt 1), 868–874 (1998).
  • Goldhaber SZ, Haire WD, Feldstein ML et al. Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Lancet341(8844), 507–511 (1993).
  • Fremont B, Pacouret G, Jacobi D, Puglisi R, Charbonnier B, de Labriolle A. Prognostic value of echocardiographic right/left ventricular end-diastolic diameter ratio in patients with acute pulmonary embolism: results from a monocenter registry of 1416 patients. Chest133(2), 358–362 (2008).
  • Becattini C, Vedovati MC, Agnelli G. Prognostic value of troponins in acute pulmonary embolism: a meta-analysis. Circulation116(4), 427–433 (2007).
  • Kostrubiec M, Labyk A, Pedowska-Wloszek J et al. Assessment of renal dysfunction improves troponin-based short-term prognosis in patients with acute symptomatic pulmonary embolism. J. Thromb. Haemost.8(4), 651–658 (2010).
  • Jimenez D, Uresandi F, Otero R et al. Troponin-based risk stratification of patients with acute nonmassive pulmonary embolism: systematic review and metaanalysis. Chest136(4), 974–982 (2009).
  • Klok FA, Mos IC, Huisman MV. Brain-type natriuretic peptide levels in the prediction of adverse outcome in patients with pulmonary embolism: a systematic review and meta-analysis. Am. J. Respir. Crit. Care Med.178(4), 425–430 (2008).
  • Dellas C, Puls M, Lankeit M et al. Elevated heart-type fatty acid-binding protein levels on admission predict an adverse outcome in normotensive patients with acute pulmonary embolism. J. Am. Coll. Cardiol.55(19), 2150–2157 (2010).
  • Scridon T, Scridon C, Skali H, Alvarez A, Goldhaber SZ, Solomon SD. Prognostic significance of troponin elevation and right ventricular enlargement in acute pulmonary embolism. Am. J. Cardiol.96(2), 303–305 (2005).
  • Sanchez O, Trinquart L, Caille V et al. Prognostic factors for pulmonary embolism: the prep study, a prospective multicenter cohort study. Am. J. Respir. Crit. Care Med.181(2), 168–173 (2010).
  • Dekker MS, Mosterd A, van’t Hof AW, Hoes AW. Novel biochemical markers in suspected acute coronary syndrome: systematic review and critical appraisal. Heart96(13), 1001–1010 (2010).
  • Hogg K, Haslam S, Hinchliffe E, Sellar L, Lecky F, Cruickshank K. Does high-sensitivity troponin measurement aid in the diagnosis of pulmonary embolism? J. Thromb. Haemost.9(2), 410–412 (2011).
  • Lankeit M, Friesen D, Aschoff J et al. Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism. Eur. Heart J.31(15), 1836–1844 (2010).
  • Bradley MJ, Alexander L. The role of venous colour flow Doppler to aid the non-diagnostic lung scintigram for pulmonary embolism. Clin. Radiol.50(4), 232–234 (1995).
  • Girard P, Sanchez O, Leroyer C et al. Deep venous thrombosis in patients with acute pulmonary embolism: prevalence, risk factors, and clinical significance. Chest128(3), 1593–1600 (2005).
  • Jimenez D, Aujesky D, Diaz G et al. Prognostic significance of deep vein thrombosis in patients presenting with acute symptomatic pulmonary embolism. Am. J. Respir. Crit. Care Med.181(9), 983–991 (2010).
  • Jimenez D, Aujesky D, Moores L et al. Combinations of prognostic tools for identification of high-risk normotensive patients with acute symptomatic pulmonary embolism. Thorax66(1), 75–81 (2011).
  • Barritt DW, Jordan SC. Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial. Lancet1(7138), 1309–1312 (1960).
  • Raschke RA, Reilly BM, Guidry JR, Fontana JR, Srinivas S. The weight-based heparin dosing nomogram compared with a ‘standard care’ nomogram. A randomized controlled trial. Ann. Intern. Med.119(9), 874–881 (1993).
  • Smith SB, Geske JB, Maguire JM, Zane NA, Carter RE, Morgenthaler TI. Early anticoagulation is associated with reduced mortality for acute pulmonary embolism. Chest137(6), 1382–1390 (2010).
  • van Dongen CJ, van den Belt AG, Prins MH, Lensing AW. Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism. Cochrane Database Syst. Rev.4, CD001100 (2004).
  • Dolovich LR, Ginsberg JS, Douketis JD, Holbrook AM, Cheah G. A meta-analysis comparing low-molecular-weight heparins with unfractionated heparin in the treatment of venous thromboembolism: examining some unanswered questions regarding location of treatment, product type, and dosing frequency. Arch. Intern. Med.160(2), 181–188 (2000).
  • Merli G, Spiro TE, Olsson CG et al. Subcutaneous enoxaparin once or twice daily compared with intravenous unfractionated heparin for treatment of venous thromboembolic disease. Ann. Intern. Med.134(3), 191–202 (2001).
  • Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. The Columbus investigators. N. Engl. J. Med.337(10), 657–662 (1997).
  • Simonneau G, Sors H, Charbonnier B et al. A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. The THESEE Study Group. Tinzaparine ou heparine standard: evaluations dans l’embolie pulmonaire. N. Engl. J. Med.337(10), 663–669 (1997).
  • Warkentin TE, Greinacher A, Koster A, Lincoff AM. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest133(Suppl. 6), S340–S380 (2008).
  • Quinlan DJ, McQuillan A, Eikelboom JW. Low-molecular-weight heparin compared with intravenous unfractionated heparin for treatment of pulmonary embolism: a meta-analysis of randomized, controlled trials. Ann. Intern. Med.140(3), 175–183 (2004).
  • Buller HR, Davidson BL, Decousus H et al. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N. Engl. J. Med.349(18), 1695–1702 (2003).
  • Hyers TM, Stengle JM, Sherry S. Treatment of pulmonary embolism with urokinase. Results of clinical trial (Phase 1). Circulation42(6), 979–980 (1970).
  • USPET. Urokinase-streptokinase embolism trial. Phase 2 results. A cooperative study. JAMA229(12), 1606–1613 (1974).
  • Sharma GV, Folland ED, McIntyre KM, Sasahara AA. Long-term benefit of thrombolytic therapy in patients with pulmonary embolism. Vasc. Med.5(2), 91–95 (2000).
  • Agnelli G, Becattini C, Kirschstein T. Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis. Arch. Intern. Med.162(22), 2537–2541 (2002).
  • Wan S, Quinlan DJ, Agnelli G, Eikelboom JW. Thrombolysis compared with heparin for the initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trials. Circulation110(6), 744–749 (2004).
  • Dong BR, Hao Q, Yue J, Wu T, Liu GJ. Thrombolytic therapy for pulmonary embolism. Cochrane Database Syst. Rev.3, CD004437 (2009).
  • Goldhaber SZ. Thrombolytic therapy for patients with pulmonary embolism who are hemodynamically stable but have right ventricular dysfunction: pro. Arch. Intern. Med.165(19), 2197–2199; discussion 2204–2195 (2005).
  • Konstantinides S, Geibel A, Heusel G, Heinrich F, Kasper W. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N. Engl. J. Med.347(15), 1143–1150 (2002).
  • Fengler BT, Brady WJ. Fibrinolytic therapy in pulmonary embolism: an evidence-based treatment algorithm. Am. J. Emerg. Med.27(1), 84–95 (2009).
  • Digonnet A, Moya-Plana A, Aubert S et al. Acute pulmonary embolism: a current surgical approach. Interact. Cardiovasc. Thorac. Surg.6(1), 27–29 (2007).
  • Basciani R, Eberle B, Schmidli J, Erdos G, Kadner A. Pulmonary embolectomy: recommendation for early surgical intervention. J. Card. Surg.26(5), 560–561 (2010).
  • Carvalho EM, Macedo FI, Panos AL, Ricci M, Salerno TA. Pulmonary embolectomy: recommendation for early surgical intervention. J. Card. Surg.25(3), 261–266 (2010).
  • Fukuda I, Taniguchi S. Embolectomy for acute pulmonary thromboembolism: from Trendelenburg’s procedure to the contemporary surgical approach. Surg. Today41(1), 1–6 (2011).
  • Fukuda I, Taniguchi S, Fukui K, Minakawa M, Daitoku K, Suzuki Y. Improved outcome of surgical pulmonary embolectomy by aggressive intervention for critically ill patients. Ann. Thorac Surg.91(3), 728–732 (2011).
  • Goldhaber SZ. Advanced treatment strategies for acute pulmonary embolism, including thrombolysis and embolectomy. J. Thromb. Haemost.7(Suppl. 1), 322–327 (2009).
  • Lazar HL, Farber HW. Early pulmonary embolectomy for acute pulmonary embolus: an operation whose time has come. J. Card. Surg.25(3), 259–260 (2010).
  • McFadden PM, Ochsner JL. Aggressive approach to pulmonary embolectomy for massive acute pulmonary embolism: a historical and contemporary perspective. Mayo Clin. Proc.85(9), 782–784 (2010).
  • Sareyyupoglu B, Greason KL, Suri RM, Keegan MT, Dearani JA, Sundt TM 3rd. A more aggressive approach to emergency embolectomy for acute pulmonary embolism. Mayo Clin. Proc.85(9), 785–790 (2010).
  • Vohra HA, Whistance RN, Mattam K et al. Early and late clinical outcomes of pulmonary embolectomy for acute massive pulmonary embolism. Ann. Thorac Surg.90(6), 1747–1752 (2010).
  • Kuo WT, Gould MK, Louie JD, Rosenberg JK, Sze DY, Hofmann LV. Catheter-directed therapy for the treatment of massive pulmonary embolism: systematic review and meta-analysis of modern techniques. J. Vasc. Interv. Radiol.20(11), 1431–1440 (2009).
  • Grau E, Fontcuberta J, Pages MA et al. Massive pulmonary embolism: short-term effects of thrombolytic treatment. Angiology37(11), 832–839 (1986).
  • Ingber S, Geerts WH. Vena caval filters: current knowledge, uncertainties and practical approaches. Curr. Opin. Hematol.16(5), 402–406 (2009).
  • Stein PD, Alnas M, Skaf E et al. Outcome and complications of retrievable inferior vena cava filters. Am. J. Cardiol.94(8), 1090–1093 (2004).
  • Decousus H, Leizorovicz A, Parent F et al. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. Prevention du Risque d’Embolie Pulmonaire par Interruption Cave Study Group. N. Engl. J. Med.338(7), 409–415 (1998).
  • PREPIC Study Group. Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prevention du Risque d’Embolie Pulmonaire par Interruption Cave) randomized study. Circulation112(3), 416–422 (2005).
  • Spencer FA, Bates SM, Goldberg RJ et al. A population-based study of inferior vena cava filters in patients with acute venous thromboembolism. Arch. Intern. Med.170(16), 1456–1462 (2010).
  • Crowther MA. Inferior vena cava filters in the management of venous thromboembolism. Am. J. Med.120(10 Suppl. 2), S13–S17 (2007).
  • Baglin TP, Brush J, Streiff M. Guidelines on use of vena cava filters. Br. J. Haematol.134(6), 590–595 (2006).
  • Pacouret G, Alison D, Pottier JM, Bertrand P, Charbonnier B. Free-floating thrombus and embolic risk in patients with angiographically confirmed proximal deep venous thrombosis. A prospective study. Arch. Intern. Med.157(3), 305–308 (1997).
  • Gould MK, Dembitzer AD, Sanders GD, Garber AM. Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis. A cost–effectiveness analysis. Ann. Intern. Med.130(10), 789–799 (1999).
  • Othieno R, Abu Affan M, Okpo E. Home versus in-patient treatment for deep vein thrombosis. Cochrane Database Syst. Rev.3, CD003076 (2007).
  • Quinlan DJ, McQuillan A, Eikelboom JW. Low-molecular-weight heparin compared with intravenous unfractionated heparin for treatment of pulmonary embolism: a meta-analysis of randomized, controlled trials. Ann. Intern. Med.140(3), 175–183 (2004).
  • Agterof MJ, van Bladel ER, Schutgens RE et al. Risk stratification of patients with pulmonary embolism based on pulse rate and D-dimer concentration. Thromb. Haemost.102(4), 683–687 (2009).
  • Donzé J, Le Gal G, Fine MJ et al. Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism. Thromb. Haemost.100(5), 943–948 (2008).
  • Jiménez D, Aujesky D, Moores L et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch. Intern. Med.170(15), 1383–1389 (2010).
  • Agterof MJ, Schutgens RE, Moumli N et al. A prognostic model for short term adverse events in normotensive patients with pulmonary embolism. Am. J. Hematol.86(8), 646–649 (2011).
  • Janjua M, Badshah A, Matta F, Danescu LG, Yaekoub AY, Stein PD. Treatment of acute pulmonary embolism as outpatients or following early discharge. A systematic review. Thromb. Haemost.100(5), 756–761 (2008).
  • Kovacs MJ, Hawel JD, Rekman JF, Lazo-Langner A. Ambulatory management of pulmonary embolism: a pragmatic evaluation. Thromb. Haemost.8(11), 2406–2411 (2010).
  • Squizzato A, Galli M, Dentali F, Ageno W. Outpatient treatment and early discharge of symptomatic pulmonary embolism: a systematic review. Eur. Respir. J.33(5), 1148–1155 (2009).
  • Erkens PM, Gandara E, Wells P et al. Safety of outpatient treatment in acute pulmonary embolism. J. Thromb. Haemost.8(11), 2412–2417 (2010).
  • Aujesky D, Roy PM, Verschuren F et al. Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial. Lancet378(9785), 41–48 (2011).
  • Otero R, Uresandi F, Jiménez D et al. Home treatment in pulmonary embolism. Thromb. Res.126(1), e1–e5 (2010).
  • van Bladel ER, Agterof MJ, Frijling BD et al. Out of hospital anticoagulant therapy in patients with acute pulmonary embolism is frequently practised but not perfect. Thromb. Res.126(6), 481–485 (2010).
  • Carrier M, Righini M, Wells PS et al. Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studies. J. Thromb. Haemost.8(8), 1716–1722 (2010).
  • Donato AA, Khoche S, Santora J, Wagner B. Clinical outcomes in patients with isolated subsegmental pulmonary emboli diagnosed by multidetector CT pulmonary angiography. Thromb. Res.126(4), e266–e270 (2010).
  • Le Gal G, Righini M, Parent F, van Strijen M, Couturaud F. Diagnosis and management of subsegmental pulmonary embolism. J. Thromb. Haemost.4(4), 724–731 (2006).

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