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Editorial

Eplerenone works. Does it matter how?

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Pages 131-133 | Published online: 10 Jan 2014

References

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  • Rossignol P, Ménard J, Fay R et al. Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects: insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy. J. Am. Coll. Cardiol.58, 1958–1966 (2011).
  • Pitt B, Williams G, Remme W et al. The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. Eplerenone Post-AMI Heart Failure Efficacy and Survival study. Cardiovasc. Drugs Ther.15, 79–87 (2001).
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  • Pitt B, White H, Nicolau J et al. Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J. Am. Coll. Cardiol.46, 425–431 (2005).
  • Pitt B, Zannad F, Remme W et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N. Engl. J. Med.341, 709–717 (1999).
  • Zannad F, McMurray JJV, Krum H et al. Eplerenone in patients with systolic heart failure and mild symptoms. N. Engl. J. Med.364, 11–21 (2011).
  • Iraqi W, Rossignol P, Angioi M et al. Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival study (EPHESUS). Circulation119, 2471–2479 (2009).
  • Rousseau MF, Gurné O, Duprez D et al. Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: results from the RALES neurohormonal substudy. J. Am. Coll. Cardiol.40(9), 1596–1601 (2002).
  • Enomoto S, Yoshiyama M, Omura T et al. Effects of eplerenone on transcriptional factors and mRNA expression related to cardiac remodeling after myocardial infarction. Heart91(12), 1595–1600 (2005).

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