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Expert Review of Cardiovascular Therapy Volume 10, 2012 - Issue 9
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Key Paper Evaluation

Evidence for a beneficial effect of glucose–insulin–potassium in patients with acute coronary syndromes. Did the IMMEDIATE trial solve an unanswered question?

Linda Mellbin Department of Medicine Solna, Cardiology Unit, Karolinska Institutet, Solna, Sweden. [email protected]
&
Lars Rydén Department of Medicine Solna, Cardiology Unit, Karolinska Institutet, Solna, Sweden
Pages 1097-1099 | Published online: 10 Jan 2014

References

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  • Sodi-Pallares D, Testelli MR, Fishleder BL et al. Effects of an intravenous infusion of a potassium–glucose–insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am. J. Cardiol. 9, 166–181 (1962).
  • Demircan S, Yazici M, Diraman E et al. The effect of glucose–insulin–potassium treatment on myocardial oxidative stress in patients with acute coronary syndromes undergoing percutaneous coronary intervention. Coron. Artery Dis. 19(2), 99–104 (2008).
  • Bucciarelli-Ducci C, Bianchi M, De Luca L et al. Effects of glucose–insulin–potassium infusion on myocardial perfusion and left ventricular remodeling in patients treated with primary angioplasty for ST-elevation acute myocardial infarction. Am. J. Cardiol. 98(10), 1349–1353 (2006).
  • Zhao YT, Weng CL, Chen ML et al. Comparison of glucose–insulin–potassium and insulin–glucose as adjunctive therapy in acute myocardial infarction: a contemporary meta-analysis of randomised controlled trials. Heart 96(20), 1622–1626 (2010).
  • Selker HP, Ingwall J, Rackley CE. Glucose–insulin–potassium therapy in patients with STEMI. JAMA 299(20), 2385; author reply 2387–2385; author reply 2388 (2008).
  • Opie LH. Glucose–insulin–potassium therapy in patients with STEMI. JAMA 299(20), 2385–2386; author reply 2387 (2008).
  • Selker HP, Beshansky JR, Griffith JL et al. Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: a double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndromes in emergency medical services. Am. Heart J. 163(3), 315–322 (2012).
  • Selker HP, Beshansky JR, Sheehan PR et al. Out-of-hospital administration of intravenous glucose–insulin–potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial. JAMA 307(18), 1925–1933 (2012).

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