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Review

Management of bacteremia in patients undergoing hematopoietic stem cell transplantation

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Pages 607-621 | Published online: 10 Jan 2014

References

  • Castagnola E, Bagnasco F, Faraci M et al. Incidence of bacteremias and invasive mycoses in children undergoing allogeneic hematopoietic stem cell transplantation: a single center experience. Bone Marrow Transplant.41, 339–347 (2008).
  • Mihu CN, Schaub J, Kesh S et al. Risk factors for late Staphylococcus aureus bacteremia after allogeneic hematopoietic stem cell transplantation: a single-institution, nested case–controlled study. Biol. Blood Marrow Transplant.14(12), 1429–1433 (2008).
  • Poutsiaka DD, Price LL, Ucuzian A, Chan GW, Mille KB, Snydman DR. Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality. Bone Marrow Transplant.40, 63–70 (2007).
  • Yamasaki S, Heike Y, Mori S et al. Infectious complications in chronic graft-versus-host disease: a retrospective study of 145 recipients of allogeneic hematopoietic stem cell transplantation with reduced- and conventional-intensity conditioning regimens. Transpl. Infect. Dis.10(4), 252–259 (2008).
  • van der Velden WJFM, Blijlevens NMA, Feuth T, Donnelly JP. Febrile mucositis in haematopoietic SCT recipients. Bone Marrow Transplant.43(1), 55–60 (2008).
  • Blijlevens NM, Donnelly JP, de Pauw BE. Prospective evaluation of gut mucosal barrier injury following various myeloablative regimens for haematopoietic stem cell transplant. Bone Marrow Transplant.35(7), 707–711 (2005).
  • Kelly M, Roy DC, Labbe AC, Laverdiere M. What is the clinical significance of infusing hematopoietic cell grafts contaminated with bacteria? Bone Marrow Transplant.38, 183–188 (2006).
  • Klein MA, Kadidlo D, McCullough J, McKenna DH, Burns LJ. Microbial contamination of hematopoietic stem cell products: incidence and clinical sequelae. Biol. Blood Marrow Transplant.12, 1142–1149 (2006).
  • Chehata S, Grira C, Legrand P et al. Applying the concept of healthcare-associated infections to hematology programs. Haematologica91, 1414–1417 (2006).
  • Mullen CA, Nair J, Sandesh S, Chan KW. Fever and neutropenia in pediatric hematopoietic stem cell transplant patients. Bone Marrow Transplant.25(1), 59–65 (2000).
  • Reich G, Mapara MY, Reichardt P, Doerken B, Maschmeyer G. Infectious complications after high-dose chemotherapy and autologous stem cell transplantation: comparison between patients with lymphoma or multiple myeloma and patients with solid tumors. Bone Marrow Transplant.27, 525–529 (2001).
  • Kroschinsky F, Wichmann G, Bornhauser M et al. Efficacy and tolerability of prophylactic treatment with intravenous piperacillin/tazobactam in patients undergoing hematopoietic stem cell transplantation. Transpl. Infect. Dis.4(3), 132–136 (2002).
  • Junghanss C, Marr KA, Carter RA et al. Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study. Biol. Blood Marrow Transpl.8, 512–520 (2002).
  • Busca A, Locatelli F, Barbui A et al. Infectious complications following nonmyeloablative allogeneic hematopoietic stem cell transplantation. Transpl. Infect. Dis.5, 132–139 (2003).
  • Mohty M, Jacot W, Faucher C et al. Infectious complications following allogeneic HLA-identical sibling transplantation with antithymocyte globulin-based reduced intensity preparative regimen. Leukemia17, 2168–2177 (2003).
  • Mitchell AE, Derrington P, Turner P, Hunt LP, Oakhill A, Marks DI. Gram-negative bacteraemia (GNB) after 428 unrelated donor bone marrow transplants (UD-BMT): risk factors, prophylaxis, therapy and outcome. Bone Marrow Transplant.33, 303–310 (2004).
  • Chizuka A, Kami M, Kanda Y et al. Value of surveillance blood culture for early diagnosis of occult bacteremia in patients on corticosteroid therapy following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant.35, 577–582 (2005).
  • Kersun LS, Propert KJ, Lautenbach E, Bunin N, DeMichele A. Early bacteremia in pediatric hematopoietic stem cell transplant patients on oral antibiotic prophylaxis. Pediatr. Blood Cancer.45, 162–169 (2005).
  • Meyer E, Beyersmann J, Bertz H et al. Risk factor analysis of blood stream infection and pneumonia in neutropenic patients after peripheral blood stem-cell transplantation. Bone Marrow Transplant.39, 173–178 (2007).
  • Cappellano P, Viscoli C, Bruzzi P, Van Lint MT, Pereira CA, Bacigalupo A. Epidemiology and risk factors for bloodstream infections after allogeneic hematopoietic stem cell transplantion. New Microbiol.30(2), 89–99 (2007).
  • Mikulska M, Del Bono V, Raiola AM et al. Bood stream infections in allogeneic hematopoietic stem cell transplant recipients: re-emegrence of Gram-negative rods and increasing antibiotic resistance. Biol. Blood Marrow Transplant.15, 47–53 (2009).
  • Castagnola R, Faraci M, Moroni C et al. Bacteremias in children receiving hemopoietic SCT. Bone Marrow Transplant.41, S104–S110 (2008).
  • Oliveira AL, de Souza M, Carvalho-Dias VM et al. Epidemiology of bacteremia and factors associated with multi-drug-resistant Gram-negative bacteremia in hematopoietic stem cell transplant recipients. Bone Marrow Transplant.39(12), 775–781 (2007).
  • Slavin MA, Grigg AP, Schwarer AP et al. A randomized comparison of empiric or pre-emptive antibiotic therapy after hematopoietic stem cell transplantation. Bone Marrow Transplant.40(2), 157–163 (2007).
  • Frère P, Baron F, Bonnet C et al. Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen. Bone Marrow Transplant.37, 411–418 (2006).
  • Laws HJ, Kobbe G, Dilloo D et al. Surveillance of nosocomial infections in paediatric recipients of bone marrow or peripheral blood stem cell transplantation during neutropenia, compared with adult recipients. J. Hosp. Infect.62(1), 80–88 (2006).
  • Almyroudis NG, Fuller A, Jakubowski A et al. Pre- and postengraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients. Transpl. Infect. Dis.7(1), 11–17 (2005).
  • Ortega M, Rovira M, Almela M et al. Bacterial and fungal bloodstream isolates from 796 hematopoietic stem cell transplant recipients between 1991 and 2000. Ann. Hematol.84, 40–47 (2005).
  • Solano C, Gutierrez A, Martinez F et al. Prophylaxis of early bacterial infections after autologous peripheral blood stem cell transplantation (PBSCT): a matched-pair study comparing oral fluoroquinolones and intravenous piperacillin–tazobactam. Bone Marrow Transplant.36(1), 59–65 (2005).
  • Dettenkofer M, Wenzler-Röttele S, Babikir R et al. Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant: a multicenter project. Clin. Infect. Dis.40(7), 926–931 (2005).
  • Frère P, Hermanne JP, Debouge MH, de Mol P, Fillet G, Beguin Y. Bacteremia after hematopoietic stem cell transplantation: incidence and predictive value of surveillance cultures. Bone Marrow Transplant.33, 745–749 (2004).
  • Reich G, Cornely OA, Sandherr M et al. Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial. Br. J. Haematol.130, 265–270 (2005).
  • Dettenkofer M, Ebner W, Bertz H et al. Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation. Bone Marrow Transplant.31, 795–801 (2003).
  • Saavedra S, Jarque I, Sanz GF et al. Infectious complications in patients undergoing unrelated donor bone marrow transplantation: experience from a single institution. Clin. Microbiol. Infect.8, 725–733 (2002).
  • Saavedra S, Sanz GF, Jarque I et al. Early infections in adult patients undergoing unrelated donor cord blood transplantation. Bone Marrow Transplant.30, 937–943 (2002).
  • Chandrasekar PH, Abraham OC, Klein J et al. Low infectious morbidity after intensive chemotherapy and autologous peripheral blood progenitor cell transplantation in the outpatient setting for women with breast cancer. Clin. Infect. Dis.32, 546–551 (2001).
  • Ninin E, Milpied N, Moreau P et al. Longitudinal study of bacterial, viral, and fungal infections in adult recipients of bone marrow transplants. Clin. Infect. Dis.33(1), 41–47 (2001).
  • Barton TD, Collis T, Stadtmauer E, Schuster MG. Infectious complications the year after autologous bone marrow transplantation or peripheral stem cell transplantation for treatment of breast cancer. Clin. Infect. Dis.32, 391–395 (2001).
  • Marena C, Zecca M, Carenini ML et al. Incidence of, and risk factors for, nosocomial infections among hematopoietic stem cell transplantation recipients, with impact of procedure-related mortality. Infect. Control Hosp. Epidemiol.22, 510–517 (2001).
  • Castagnola E, Fontana V, Caviglia I et al. A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation. Clin. Infect. Dis.45(10), 1296–1304 (2007).
  • Sonis ST, Oster G, Fuchs H et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J. Clin. Oncol.19(8), 2201–2205 (2001).
  • Castagnola E, Caviglia I, Pistorio A et al. Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment: a 13-year experience at a single Italian institution. Eur. J. Cancer41(10), 1439–1445 (2005).
  • Klastersky J, Ameye L, Maertens J et al. Bacteraemia in febrile neutropenic cancer patients. Int. J. Antimicrob. Agents30S, S51–S59 (2007).
  • Lehrnbecher T, Varwig D, Kaiser J, Reinhardt D, Klingebiel T, Creutzig U. Infectious complications in pediatric acute myeloid leukemia: analysis of the prospective multi-institutional clinical trial AML-BFM 93. Leukemia18(1), 72–77 (2004).
  • Urrea M, Rives S, Cruz O, Navarro A, García JJ, Estella J. Nosocomial infections among pediatric hematology/oncology patients: results of a prospective incidence study. Am. J. Infect. Control32(4), 205–208 (2004).
  • Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin. Infect. Dis.36(9), 1103–1110 (2003).
  • Elishoov H, Or R, Strauss N, Engelhard D. Nosocomial colonization, septicemia, and Hickman/Broviac catheter-related infections in bone marrow transplant recipients. A 5-year prospective study. Medicine (Baltimore)77, 83–101 (1998).
  • Romano V, Castagnola E, Dallorso S et al. Bloodstream infections can develop late (after day 100) and/or in the absence of neutropenia in children receiving allogeneic bone marrow transplantation. Bone Marrow Transplant.23(3), 271–275 (1999).
  • Kumar D, Humar A, Plevneshi A et al. Invasive pneumococcal disease in adult hematopoietic stem cell transplant recipients: a decade of prospective population-based surveillance. Bone Marrow Transplant.41(8), 743–747 (2008).
  • Engelhard D, Cordonnier C, Shaw PJ et al. Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey. Br. J. Haematol.117, 444–450 (2002).
  • Castagnola E, Fioredda F. Prevention of life-threatening infections due to encapsulated bacteria in children with hyposplenia or asplenia: a brief review of current recommendations for practical purposes. Eur. J. Haematol.71(5), 319–326 (2003).
  • Shaw BE, Boswell T, Byrne JL, Yates C, Russell NH. Clinical impact of MRSA in a stem cell transplant unit: analysis before, during and after an MRSA outbreak. Bone Marrow Transplant.39(10), 623–629 (2007).
  • Weinstock DM, Conlon M, Iovino C et al. Colonization, bloodstream infection, and mortality caused by vancomycin-resistant enterococcus early after allogeneic hematopoietic stem cell transplant. Biol. Blood Marrow Transplant.13, 615–621 (2007).
  • Tsiatis AC, Manes B, Calder C, Billheimer D, Wilkerson KS, Frangoul H. Incidence and clinical complications of vancomycin-resistant enterococcus in pediatric stem cell transplant patients. Bone Marrow Transplant.33, 937–941 (2004).
  • Zirakzadeh A, Gastineau DA, Mandrekar JN, Burke JP, Johnston PB, Patel R. Vancomycin-resistant enterococcal colonization appears associated with increased mortality among allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant.41, 385–392 (2008).
  • Avery R, Kalaycio M, Pohlman B et al. Early vancomycin-resistant enterococcus (VRE) bacteremia after allogeneic bone marrow transplantation is associated with a rapidly deteriorating clinical course. Bone Marrow Transplant.35, 497–499 (2005).
  • Kumashi P, Girgawy E, Tarrand JJ, Rolston KV, Raad II, Safdar A. Streptococcus pneumoniae bacteremia in patients with cancer: disease characteristics and outcomes in the era of escalating drug resistance (1998–2002). Medicine (Baltimore)84, 303–312 (2005).
  • Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann. Intern. Med.64(2), 328–340 (1966).
  • Sickles EA, Greene WH, Wiernik PH. Clinical presentation of infection in granulocytopenic patients. Arch. Intern. Med.135, 715–719 (1975).
  • Malik I, Hussain M, Yousuf H. Clinical characteristics and therapeutic outcome of patients with febrile neutropenia who present septic shock: need for better strategies. J. Infect.42, 120–125 (2001).
  • Levy MM, Fink MP, Marshall JC et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit. Care Med.31, 1250–1256 (2003).
  • Claessens YE, Dhainaut JF. Diagnosis and treatment of severe sepsis. Crit. Care11(Suppl. 5), S2 (2007).
  • Regazzoni CJ, Irrazabal C, Luna CM, Poderoso JJ. Cancer patients with septic shock: mortality predictors and neutropenia. Support. Care Cancer12, 833–839 (2004).
  • van Gestel JP, Bollen CW, Bierings MB, Boelens JJ, Wulffraat NM, van Vught AJ. Survival in a recent cohort of mechanically ventilated pediatric allogeneic hematopoietic stem cell transplantation recipients. Biol. Blood Marrow Transplant.14(12), 1385–1393 (2008).
  • Tamburro RF, Barfield RC, Shaffer ML et al. Changes in outcomes (1996–2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation. Pediatr. Crit. Care Med.9(3), 270–277 (2008).
  • Pene F, Aubron C, Azoulay E et al. Outcome of critically ill allogeneic hematopoietic stem-cell transplantation recipients: a reappraisal of indications for organ failure supports. J. Clin. Oncol.24(4), 643–649 (2006).
  • Caillot D, Casasnovas O, Bernard A et al. Improved management of invasive pulmonary aspergillosis in neutropenic patient using early thoracic computed tomographic scan and surgery. J. Clin. Oncol.15, 139–147 (1997).
  • Caillot D, Cauaillier JF, Bernard A et al. Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia. J. Clin. Oncol.19, 253–259 (2001).
  • Cartoni C, Dragoni F, Micozzi A et al. Neutropenic enterocolitis in patients with acute leukemia: prognostic significance of bowel wall thickening detected by ultrasonography J. Clin. Oncol.19, 756–761 (2001).
  • Gorschlüter M, Marklein G, Höfling K et al. Abdominal infections in patients with acute leukaemia: a prospective study applying ultrasonography and microbiology. Br. J. Haematol.117, 351–358 (2002).
  • Davila ML. Neutropenic enterocolitis: current issues in diagnosis and management. Curr. Infect. Dis. Rep.9, 116–120 (2007).
  • Gorschlüter M, Mey U, Strehl J et al. Neutropenic enterocolitis in adults: systematic analysis of evidence quality. Eur. J. Haematol.75(1), 1–13 (2005).
  • DesJardin JA, Falagas ME, Ruthazer R et al. Clinical utility of blood cultures drawn from in-dwelling central venous catheters in hospitalized patients with cancer. Ann. Intern. Med.131(9), 641–647 (1999).
  • Bally F, Erard V, Vallet Y et al. 5-year survey of blood cultures (BC) results in febrile neutropenic cancer patients: excellent yield of sampling via non-tunneled central venous catheter (CVC) without peripheral venipuncture (PV). Presented at: 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA, 14–17 September 2003.
  • Mermel LA, Farr BM, Sherertz RJ et al. Guidelines for the management of intravascular catheter-related infections. Clin. Infect. Dis.32(9), 1249–1272 (2001).
  • Franklin JA, Gaur AH, Shenep JL, Hu XJ, Flynn PM. In situ diagnosis of central venous catheter-related bloodstream infection without peripheral blood culture. Pediatr. Infect. Dis. J.23(7), 614–618 (2004).
  • Calandra T, Cohen J; International Sepsis Forum Definition of Infection in the ICU Consensus Conference. The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit. Crit. Care Med.33, 1538–1548 (2005).
  • Viscoli C, Castagnola E, Giacchino M et al. Bloodstream infections in children with cancer: a multicentre surveillance study of the Italian Association of Paediatric Haematology and Oncology. Supportive Therapy Group-Infectious Diseases Section. Eur. J. Cancer35(5), 770–774 (1999).
  • Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin. Infect. Dis.39, 206–217 (2004).
  • Sakr Y, Sponholz C, Tuche F, Brunkhorst F, Reinhart K. The role of procalcitonin in febrile neutropenic patients: review of the literature. Infection36, 396–407 (2008).
  • Prat C, Sancho JM, Dominguez J et al. Evaluation of procalcitonin, neopterin, C-reactive protein, IL-6 and IL-8 as a diagnostic marker of infection in patients with febrile neutropenia. Leuk. Lymphoma49, 1752–1761 (2008).
  • Blijlevens NM, Donnelly JP, Meis JF, De Keizer MH, De Pauw BE. Procalcitonin does not discriminate infection from inflammation after allogeneic bone marrow transplantation. Clin. Diagn. Lab. Immunol.7, 889–892 (2000).
  • Gafter-Gvili A, Fraser A, Paul M, Leibovici L. Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients. Ann. Intern. Med.142(12 Pt 1), 979–995 (2005).
  • Bucaneve G, Micozzi A, Menichetti F et al. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N. Engl. J. Med.353(10), 977–987 (2005).
  • Afsharian P, Mollgard L, Hassan Z, Xie H, Kimby E, Hassan M. The effect of ciprofloxacin on cyclophosphamide pharmacokinetics in patients with non-Hodgkin lymphoma. Eur. J. Haematol.75(3), 206–211 (2005).
  • Carlens S, Ringden O, Aschan J et al. Risk factors in bone marrow transplant recipients with leukaemia. Increased relapse risk in patients treated with ciprofloxacin for gut decontamination. Clin. Transplant.12(2), 84–92 (1998).
  • Xie HJ, Broberg U, Griskevicius L et al. Alteration of pharmacokinetics of cyclophosphamide and suppression of the cytochrome p450 genes by ciprofloxacin. Bone Marrow Transplant.31(3), 197–203 (2003).
  • Bucaneve G, Castagnola E, Viscoli C, Leibovici L, Menichetti F. Quinolone prophylaxis for bacterial infections in afebrile high risk neutropenic patients. Eur. J. Cancer Suppl.5, 5–12 (2007).
  • Perez-Simon JA, Garcia-Escobar I, Martinez J et al. Antibiotic prophylaxis with meropenem after allogeneic stem cell transplantation. Bone Marrow Transplant.33(2), 183–187 (2004).
  • Hayes-Lattin B, Leis JF, Maziarz RT. Isolation in the allogeneic transplant environment: how protective is it? Bone Marrow Transplant.36(5), 373–381 (2005).
  • van Tiel F, Harbers MM, Terporten PH et al. Normal hospital and low-bacterial diet in patients with cytopenia after intensive chemotherapy for hematological malignancy: a study of safety. Ann. Oncol.18(6), 1080–1084 (2007).
  • van Tiel FH, Harbers MM, Kessels AG, Schouten HC. Home care versus hospital care of patients with hematological malignancies and chemotherapy-induced cytopenia. Ann. Oncol.16(2), 195–205 (2005).
  • Safdar A, Maki DG. Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective, randomized trials. Clin. Infect. Dis.43, 474–484 (2006).
  • Maki DG, Kluger DM, Crnich CJ. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. Mayo Clin. Proc.81(9), 1159–1171 (2006).
  • Castagnola E, Molinari AC, Fratino G, Viscoli C. Conditions associated with infections of in-dwelling central venous catheters in cancer patients: a summary. Br. J. Haematol.121(2), 233–239 (2003).
  • Viscoli C. Management of infection in cancer patients: studies of the EORTC International Antimicrobial Therapy Group (IATG). Eur. J. Cancer38, S82–S87 (2002).
  • Drgona L, Paul M, Bucaneve G, Calandra T, Menichetti F. The need for aminoglycosides in combination with β-lactams for high-risk, febrile neutropaenic patients with leukaemia. Eur. J. Can. Suppl.5, 13–22 (2007).
  • Bliziotis IA, Michalopoulos A, Kasiakou SK et al. Ciprofloxacin vs an aminoglycoside in combination with a β-lactam for the treatment of febrile neutropenia: a meta-analysis of randomized controlled trials. Mayo Clin. Proc.80, 114–1156 (2005).
  • Cometta A, Marchetti O, Calandra T. Empirical use of anti-Gram-positive antibiotics in febrile neutropaenic cancer patients with acute leukaemia. Eur. J. Can. Suppl.5, 23–31 (2007).
  • Vardakas KZ, Samonis G, Chrysanthopoulou SA, Bliziotis IA, Falagas ME. Role of glycopeptides as part of initial empirical treatment of febrile neutropenic patients: a meta-analysis of randomised controlled trials. Lancet Infect. Dis.5, 431–439 (2005).
  • Gold HS, Moellering RC. Antimicrobial drug resistance. N. Engl. J. Med.335, 1445–1453 (1996).
  • Dellinger RP, Levy MM, Carlet JM et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock. Crit. Care Med.36, 296–327 (2008).
  • Irfan S, Idrees F, Mehraj V, Habib F, Adil S, Hasan R. Emergence of carbapenem resistant Gram negative and vancomycin resistant Gram positive organisms in bacteremic isolates of febrile neutropenic patients: a descriptive study. BMC Infect. Dis.8, 80 (2008).
  • Kattan JN, Villegas MV, Quinn JP. New developments in carbapenems. Clin. Microbiol. Infect.14(12), 1102–1111 (2008).
  • Sader HS, Fritsche TR, Jones RN. Frequency of occurrence and daptomycin susceptibility rates of Gram-positive organisms causing bloodstream infections in cancer patients. J. Chemother.20, 570–576 (2008).
  • Adembri C, Fallani S, Cassetta MI et al. Linezolid pharmacokinetic/pharmacodynamic profile in critically ill septic patients: intermittent versus continuous infusion. Int. J. Antimicrob. Agents31, 122–129 (2008).
  • Raad I, Darouiche R, Vazquez J et al. Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by Gram-positive pathogens. Clin. Infect. Dis.40, 374–380 (2005).
  • Bubalo JS, Munar MY, Cherala G, Hayes-Lattin B, Maziarz R. Daptomycin pharmacokinetics in adult oncology patients with neutropenic fever. Antimicrob. Agents Chemother.53, 428–434 (2009).
  • Zhanel GG, Lam A, Schweizer F et al. Ceftobiprole: a review of a broad-spectrum and anti-MRSA cephalosporin. Am. J. Clin. Dermatol.9(4), 245–254 (2008).
  • Jaksic B, Martinelli G, Perez-Oteyza J, Hartman CS, Leonard LB, Tack KJ. Efficacy and safety of linezolid compared with vancomycin in a randomized, double-blind study of febrile neutropenic patients with cancer. Clin. Infect. Dis.42, 597–607 (2006).
  • Raad I, Hanna H, Jiang Y et al. Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. Antimicrob. Agents Chemother.51, 1656–1660 (2007).
  • Castagnola E, Moroni C, Gandullia P et al. Catheter lock and systemic infusion of linezolid for treatment of persistent Broviac catheter-related staphylococcal bacteremia. Antimicrob. Agents Chemother.50(3), 1120–1121 (2006).
  • Fatkenheuer G, Buchheidt D, Cornely OA et al. Central venous catheter (CVC)-related infections in neutropenic patients – guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann. Hematol.82(Suppl. 2), S149–S157 (2003).
  • Rijnders BJ, Van Wijngaerden E, Vandecasteele SJ, Stas M, Peetermans WE. Treatment of long-term intravascular catheter-related bacteraemia with antibiotic lock: randomized, placebo-controlled trial. J. Antimicrob. Chemother.55(1), 90–94 (2005).
  • Fortun J, Grill F, Martin-Davila P et al. Treatment of long-term intravascular catheter-related bacteraemia with antibiotic-lock therapy. J. Antimicrob. Chemother.58(4), 816–821 (2006).
  • Robinson JL, Tawfik G, Roth A. Barriers to antibiotic lock therapy in children with intravascular catheter-related bloodstream infections. Pediatr. Infect. Dis. J.24(10), 944 (2005).
  • Droste JC, Jeraj HA, MacDonald A, Farrington K. Stability and in vitro efficacy of antibiotic-heparin lock solutions potentially useful for treatment of central venous catheter-related sepsis. J. Antimicrob. Chemother.51(4), 849–855 (2003).
  • Crnich CJ, Maki DG. Infections of vascular devices. In: Infectious Diseases. Cohen J (Ed.). Mosby, London, UK, 629–639 (2004).
  • Anthony TU, Rubin LG. Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (ports). Antimicrob. Agents Chemother.43(8), 2074–2076 (1999).
  • Boubaric D, Curtis J, Peareson L, Shaw PJ. Role of hydrochloric acid in the treatment of central venous catheter infections in children with cancer. Cancer101(8), 1866–1872 (2004).

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