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Perspective

Host cholesterol and inflammation as common key regulators of toxoplasmosis and artherosclerosis development

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Pages 807-819 | Published online: 10 Jan 2014

References

  • Curtiss LK, Tobias PS. The toll of Toll-like receptors, especially Toll-like receptor 2, on murine atherosclerosis. Curr. Drug Targets8(12), 1230–1238 (2007).
  • Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology and the role of novel risk factors: a clinicobiochemical perspective. Angiology58(5), 513–522 (2007).
  • Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr. Rev.65(12 Pt 2), S140–S146 (2007).
  • Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat. Rev. Immunol.8(10), 802–815 (2008).
  • von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ. Res.100(1), 27–40 (2007).
  • Insull W Jr. The pathology of atherosclerosis: plaque development and plaque responses to medical treatment. Am. J. Med.122(1 Suppl.), S3–S14 (2009).
  • Insull W Jr. Introduction. Review of major recent findings supporting treatments to control advanced plaques of atherosclerosis. Am. J. Med.122(1 Suppl.), S1–S2 (2009).
  • Olofsson KE, Björkbacka H. Atherosclerosis: cell biology and lipoproteins. Curr. Opin. Lipidol.20, 82–84 (2009).
  • Kaski JC. Infection, endothelial dysfunction, and atherogenesis. Circulation108(25), E171–E172; author reply E171–E172 (2003).
  • Muhlestein JB, Anderson JL. Chronic infection and coronary artery disease. Cardiol. Clin.21(3), 333–362 (2003).
  • Kaski JC. Infection, endothelial dysfunction, and atherogenesis. Circulation108(25), E171–E172; author reply E171–E172 (2003).
  • Stassen FR, Vainas T, Bruggeman CA. Infection and atherosclerosis. An alternative view on an outdated hypothesis. Pharmacol. Rep.60(1), 85–92 (2008).
  • Sawayama Y, Hamada M, Otaguro S et al. Chronic Helicobacter pylori infection is associated with peripheral arterial disease. J. Infect. Chemother.14(3), 250–254 (2008).
  • Feingold KR, Shigenaga JK, Chui LG, Moser A, Khovidhunkit W, Grunfeld C. Infection and inflammation decrease apolipoprotein M expression. Atherosclerosis199(1), 19–26 (2008).
  • Chen S, Sorrentino R, Shimada K et al.Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J. Immunol.181(10), 7186–7193 (2008).
  • Mussa FF, Chai H, Wang X, Yao Q, Lumsden AB, Chen C. Chlamydia pneumoniae and vascular disease: an update. J. Vasc. Surg.43(6), 1301–1307 (2006).
  • Niedzielska I, Janic T, Cierpka S, Swietochowska E. The effect of chronic periodontitis on the development of atherosclerosis: review of the literature. Med. Sci. Monit.14(7), RA103–RA106 (2008).
  • Paquette DW, Williams RC. Modulation of host inflammatory mediators as a treatment strategy for periodontal diseases. Periodontol.24, 239–252 (2000).
  • Turkay C, Saba R, Sahin N et al. Effect of chronic Pseudomonas aeruginosa infection on the development of atherosclerosis in a rat model. Clin. Microbiol. Infect.10(8), 705–708 (2004).
  • Monteiro AM, Jardini MA, Alves S et al. Cardiovascular disease parameters in periodontitis. J. Periodontol.80(3), 378–388 (2009).
  • Prediman K, Shah MD. Link Between infection and atherosclerosis: who are the culprits: viruses, bacteria, both, or neither? Circulation103, 5–6 (2001).
  • Ciervo A, Mancini F, Sale P, Russo A, Cassone A. Real-time polymerase chain reaction and laser capture microdissection: an efficient combination tool for Chlamydophila pneumoniae DNA quantification and localization of infection in atherosclerotic lesions. Int. J. Immunopathol. Pharmacol.21(2), 421–428 (2008).
  • Madan M, Amar S. Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS ONE3(9), e3204 (2008).
  • Sunnemark D, Frostegard J, Orn A, Harris RA. Cellular and cytokine characterization of vascular inflammation in CBA/J mice chronically infected with Trypanosoma cruzi. Scand. J. Immunol.48(5), 480–484 (1998).
  • Sunnemark D, Harris RA, Frostegard J, Orn A. Induction of early atherosclerosis in CBA/J mice by combination of Trypanosoma cruzi infection and high cholesterol diet. Atherosclerosis153, 273–282 (2000).
  • Portugal LR, Fernandes LR, Cesar GC et al. Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice. Infect. Immun.72(6), 3571–3576 (2004).
  • Portugal LR, Fernandes LR, Pietra Pedroso VS, Santiago HC, Gazzinelli RT, Alvarez-Leite JI. Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection. Microbes Infect.10(3), 276–284 (2008).
  • Fernandes LR. Influence of Leishmania major infection on lipid profile and atherogenesis in Apo E deficient mice. In: Biochemistry and Immunology. Federal University of Minas Gerais, Belo Horizonte, Brazil 90 (2006).
  • Golgher D, Gazzinelli RT. Innate and acquired immunity in the pathogenesis of Chagas disease. Autoimmunity37(5), 399–409 (2004).
  • Gazzinelli RT, Talvani A, Camargo MM et al. Induction of cell-mediated immunity during early stages of infection with intracellular protozoa. Braz. J. Med. Biol. Res.31, 89–104 (1998).
  • Schulte S, Sukhova GK, Libby P. Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Am. J. Pathol.172(6), 1500–1508 (2008).
  • Shibata Y, Ohata H, Yamashita M et al. Immunologic response enhances atherosclerosis-type 1 helper T cell (Th1)-to-type 2 helper T cell (Th2) shift and calcified atherosclerosis in Bacillus Calmette–Guérin (BCG)-treated apolipoprotein E-knockout (Apo E-/-) mice. Transl. Res.149(2), 62–69 (2007).
  • Zenovich AG, Panoskaltsis-Mortari A, Caron GJ et al. Sex-based differences in vascular repair with bone marrow cell therapy: relevance of regulatory and Th2-type cytokines. Transplant Proc.40(2), 641–643 (2008).
  • Doenhoff MJ, Stanley RG, Griffiths K, Jackson CL. An anti-atherogenic effect of Schistosoma mansoni infections in mice associated with a parasite-induced lowering of blood total cholesterol. Parasitology125(Pt 5), 415–421 (2002).
  • Assaad-Khalil SH, Lachine N, Sidrak M, Amara F, Jacotot B, Fahmy MH. Immuno-metabolic factors in schistosomal hepatic fibrosis modulating atherogenesis. Ann. Biol. Clin. (Paris)50(10–11), 697–701 (1992).
  • La Flamme AC, Ruddenklau K, Backstrom BT. Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infect. Immun.71(9), 4996–5004 (2003).
  • Sewell D, Qing Z, Reinke E et al. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int. Immunol.15(1), 59–69 (2003).
  • La Flamme AC, Harvie M, Kenwright D et al. Chronic exposure to schistosome eggs reduces serum cholesterol but has no effect on atherosclerotic lesion development. Parasite Immunol.29(5), 259–266 (2007).
  • Mahmoudi M, Curzen N, Gallagher PJ. Atherogenesis: the role of inflammation and infection. Histopathology50(5), 535–546 (2007).
  • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med.352(16), 1685–1695 (2005).
  • Rader DJ, Daugherty A. Translating molecular discoveries into new therapies for atherosclerosis. Nature451(7181), 904–913 (2008).
  • Kume N, Kita T. Roles of lectin-like oxidized LDL receptor-1 and its soluble forms in atherogenesis. Curr. Opin. Lipidol.12, 419–423 (2001).
  • Minami M, Kume N, Shimaoka T et al. Expression of SR-PSOX, a novel cell-surface scavenger receptor for phosphatidylserine and oxidized LDL in human athero-sclerotic lesions. Arterioscler. Thromb. Vasc. Biol.21, 1796–1800 (2001).
  • Ishii KJ, Uematsu S, Akira S. ‘Toll’ gates for future immunotherapy. Curr. Pharm. Des.12(32), 4135–4142 (2006).
  • Oude Nijhuis MM, van Keulen JK, Pasterkamp G, Quax PH, de Kleijn DP. Activation of the innate immune system in atherosclerotic disease. Curr. Pharm. Des.13(10), 983–994 (2007).
  • Erridge C. The roles of pathogen-associated molecular patterns in atherosclerosis. Trends Cardiovasc. Med.18(2), 52–56 (2008).
  • Mullick AE, Soldau K, Kiosses WB, Bell TA 3rd, Tobias PS, Curtiss LK. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J. Exp. Med.205(2), 373–383 (2008).
  • Mullick AE, Tobias PS, Curtiss LK. Modulation of atherosclerosis in mice by Toll-like receptor 2. J. Clin. Invest.115(11), 3149–3156 (2005).
  • Mullick AE, Tobias PS, Curtiss LK. Toll-like receptors and atherosclerosis: key contributors in disease and health? Immunol. Res.34(3), 193–209 (2006).
  • Tobias P, Curtiss LK. Thematic review series: The immune system and atherogenesis. Paying the price for pathogen protection: Toll receptors in atherogenesis. J. Lipid Res.46(3), 404–411 (2005).
  • Tobias PS, Curtiss LK. Toll-like receptors in atherosclerosis. Biochem. Soc. Trans.35(Pt 6), 1453–1455 (2007).
  • Tobias PS, Curtiss LK. TLR2 in murine atherosclerosis. Semin. Immunopathol.30(1), 23–27 (2008).
  • Edfeldt K, Swedenborg J, Hansson GK, Yan ZQ. Expression of Toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation105(10), 1158–1161 (2002).
  • Pryshchep O, Ma-Krupa W, Younge BR, Goronzy JJ, Weyand CM. Vessel-specific Toll-like receptor profiles in human medium and large arteries. Circulation118(12), 1276–1284 (2008).
  • Xu XH, Shah PK, Faure E et al. Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation104, 3103–3108 (2001).
  • Vink A, Schoneveld AH, van der Meer JJ et al.In vivo evidence for a role of Toll-like receptor 4 in the development of intimal lesions. Circulation106(15), 1985–1990 (2002).
  • Ranjbaran H, Sokol SI, Gallo A et al. An inflammatory pathway of IFN-γ production in coronary atherosclerosis. J. Immunol.178(1), 592–604 (2007).
  • Aukrust P, Otterdal K, Yndestad A et al. The complex role of T-cell-based immunity in atherosclerosis. Curr. Atheroscler. Rep.10(3), 236–243 (2008).
  • Zhang H, Park Y, Wu J et al. Role of TNF-α in vascular dysfunction. Clin. Sci. (Lond.)116(3), 219–230 (2009).
  • Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol.8, 345–350 (2007).
  • Patel DN, King CA, Bailey SR. Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-κB and C/EBPβ activation. J. Biol. Chem.282, 27229–27238 (2007).
  • Eid RE, Rao DA, Zhou J et al. Interleukin-17 and interferon-γ are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation119(10), 1424–1432 (2009).
  • Gazzinelli RT, Ropert C, Campos MA. Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites. Immunol. Rev.201, 9–25 (2004).
  • Yarovinsky F, Zhang D, Andersen JF et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science308(5728), 1626–1629 (2005).
  • Gazzinelli RT, Denkers EY. Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism. Nat. Rev. Immunol.6(12), 895–906 (2006).
  • Yarovinsky F. Toll-like receptors and their role in host resistance to Toxoplasma gondii. Immunol. Lett.119(1–2), 17–21 (2008).
  • Yarovinsky F, Hieny S, Sher A. Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology. J. Immunol.181(12), 8478–8484 (2008).
  • Debierre-Grockiego F, Campos MA, Azzouz N et al. Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. J. Immunol.179(2), 1129–1137 (2007).
  • Debierre-Grockiego F, Azzouz N, Schmidt J et al. Roles of glycosylphosphatidylinositols of Toxoplasma gondii. Induction of tumor necrosis factor-α production in macrophages. J. Biol. Chem.278(35), 32987–32993 (2003).
  • Weiss LM, Dubey JP. Toxoplasmosis: a history of clinical observations. Int. J. Parasitol.39(8), 895–901 (2009).
  • Kim K, Weiss LM. Toxoplasma: the next 100 years. Microbes Infect.10(9), 978–984 (2008).
  • Aliberti J. Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma gondii. Nat. Rev. Immunol.5(2), 162–170 (2005).
  • Sehgal A, Bettiol S, Pypaert M et al. Peculiarities of host cholesterol transport to the unique intracellular vacuole containing Toxoplasma. Traffic6(12), 1125–1141 (2005).
  • Coppens I, Vielemeyer O. Insights into unique physiological features of neutral lipids in Apicomplexa: from storage to potential mediation in parasite metabolic activities. Int. J. Parasitol.35(6), 597–615 (2005).
  • Besteiro S, Bertrand-Michel J, Lebrun M, Vial H, Dubremetz JF. Lipidomic analysis of Toxoplasma gondii tachyzoites rhoptries: further insights into the role of cholesterol. Biochem. J.415(1), 87–96 (2008).
  • Coppens I. Contribution of host lipids to Toxoplasma pathogenesis. Cell Microbiol.8(1), 1–9 (2006).
  • Wenk MR. Lipidomics of host–pathogen interactions. FEBS Lett.580(23), 5541–5551 (2006).
  • D’Avila H, Maya-Monteiroa CM, Bozza PT. Lipid bodies in innate immune response to bacterial and parasite infections. Int. Immunopharmacol.8, 1308–1315 (2008).
  • Sonda S, Hehl AB. Lipid biology of Apicomplexa: perspectives for new drug targets, particularly for Toxoplasma gondii. Trends Parasitol.22(1), 41–47 (2006).
  • Charron AJ, Sibley LD. Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii. J. Cell. Sci.115(Pt 15), 3049–3059 (2002).
  • Goldstein JL, Brown MS. The LDL receptor. Arterioscler. Thromb. Vasc. Biol.29(4), 431–438 (2009).
  • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest.109, 1125–1131 (2002).
  • Coppens I, Joiner KA. Host but not parasite cholesterol controls Toxoplasma cell entry by modulating organelle discharge. Mol. Biol. Cell.14(9), 3804–3820 (2003).
  • Coppens I, Sinai AP, Joiner KA. Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. J. Cell. Biol.149(1), 167–180 (2000).
  • Nishikawa Y, Quittnat F, Stedman TT et al. Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma. Cell Microbiol.7(6), 849–867 (2005).
  • Bansal D, Bhatti HS, Sehgal R. Role of cholesterol in parasitic infections. Lipids Health Dis.4(1), 10 (2005).
  • Lige B, Jayabalasingham B, Zhang H, Pypaert M, Coppens I. Role of an ancestral D-bifunctional protein containing two sterol-carrier protein-2 domains in lipid uptake and trafficking in Toxoplasma. Mol. Biol. Cell.20(2), 658–672 (2009).
  • Sonda S, Ting LM, Novak S et al. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J. Biol. Chem.276(37), 34434–34440 (2001).
  • Sleat DE, Wiseman JA, El-Banna M et al. Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport. Proc. Natl Acad. Sci. USA101, 5886–5891 (2004).
  • Lobzin I, Bĭtsov SA, Filippov AE, Linchak RM, Mangutov DA. Effect of respiratory infections on the clinical course of coronary artery disease. Klin. Med. (Mosk.)83(11), 22–26 (2005).
  • Choudhury RP, Carrelli AL, Stern JD et al. Effects of simvastatin on plasma lipoproteins and response to arterial injury in wild-type and apolipoprotein-E-deficient mice. J. Vasc. Res.41(1), 75–83 (2004).
  • Fu T, Borensztajn J. Simvastatin causes the formation of cholesterol-rich remnants in mice lacking apoE. Biochem. Biophys. Res. Commun.341(4), 1172–1176 (2006).
  • Ali K, Middleton M, Pure E, Rader DJ. Apolipoprotein E suppresses the type I inflammatory response in vivo. Circ. Res.97(9), 922–927 (2005).

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