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Review

Tumor markers for early detection of ovarian cancer

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Pages 787-798 | Published online: 09 Jan 2014

References

  • Bertone-Johnson ER. Epidemiology of ovarian cancer: a status report. Lancet365, 101–102 (2005).
  • Ye B, Gagnon A, Mok SC. Recent technical strategies to identify diagnostic biomarkers for ovarian cancer. Expert Rev. Proteomics4(1), 121–131 (2007).
  • Ebert MP, Korc M, Malfertheiner P et al. Advances, challenges, and limitations in serum-proteome-based cancer diagnosis. J. Proteome Res.5, 19–25 (2006).
  • Jacobs IJ, Skates SJ, MacDonald N et al. Screening for ovarian cancer: a pilot randomised controlled trial. Lancet353(9160), 1207–1210 (1999).
  • Nossov V, Amneus M, Su F et al. The early detection of ovarian cancer: from traditional methods to proteomics. Can we really do better than serum CA-125? Am. J. Obstet. Gynecol.199(3), 215–223 (2008).
  • Abstracts of the first scientific workshop of the Early Detection Research Network. Dis. Markers17(1), 3–38 (2001).
  • Kabawat SE, Bast RC Jr, Bhan AK et al. Tissue distribution of a coelomic–epithelium-related antigen recognized by the monoclonal antibody OC125. Int. J. Gynecol. Pathol.2(3), 275–85 (1983).
  • Bast RC Jr. Status of tumor markers in ovarian screening. J. Clin. Oncol.21(10), 200s–205s (2003).
  • Duffy MJ, Bonfrer JM, Kulpa J et al. CA125 in ovarian cancer: European Group on tumor markers guidelines for clinical use. Int. J. Gynecol. Cancer15, 679–691 (2005).
  • Medeiros L, Rosa D, da Rosa M et al. Accuracy of CA 125 in the diagnosis of ovarian tumors: a quantitative systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol.142(2), 99–105 (2009).
  • Skates SJ, Menon U, MacDonald N et al. Calculation of the risk of ovarian cancer from serial CA-125 values for preclinical detection in postmenopausal women. J. Clin. Oncol.21(10 Suppl.), 206–210 (2003).
  • Menon U, Skates SJ, Lewis S et al. Prospective study using the risk of ovarian cancer algorithm to screen for ovarian cancer. J. Clin. Oncol.23(31), 7919–7926 (2005).
  • Menon U, Gentry-Maharaj A, Hallett R et al. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet Oncol.10(4), 327–340 (2009).
  • Partridge E, Kreimer AR, Greenlee RT et al. Results from four rounds of ovarian cancer screening in a randomized trial. Obstet. Gynecol.113(4), 775–782(2009).
  • Gadducci A, Cosio S, Carpi A et al. Serum tumor markers in the management of ovarian, endometrial and cervical cancer. Biomed. Pharmacother.58(1), 24–38 (2004).
  • Koprowski H, Steplesky Z, Mitchell K et al. Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet.5, 957–72 (1979)
  • Gadducci A, Ferdeghini M, Prontera C et al. The concomitant determination of different tumor markers in patients with epithelial ovarian cancer and benign ovarian masses: relevance for differential diagnosis. Gynecol. Oncol.44(2), 147–154 (1992).
  • Skates SJ, Horick N, Yu Y et al. Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15–13, CA 72–74, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions. J. Clin. Oncol.22(20), 4059–4066 (2004).
  • Xu FJ, Yu YH, Daly L et al. OVX1 radioimmunoassay complements CA-125 for predicting the presence of residual ovarian carcinoma at second-look surgical surveillance procedures. J. Clin. Oncol.11(8), 1506–1510 (1993).
  • Woolas RP, Conaway MR, Xu F et al. Combinations of multiple serum markers are superior to individual assays for discriminating malignant from benign pelvic masses. Gynecol. Oncol.59(1), 111–116 (1995).
  • van Haaften-Day C, Shen Y, Xu F et al. OVX1, Macrophage-colony stimulating factor, and CA-125-II as tumor markers for epithelial ovarian carcinoma. Cancer92(11), 2837–2844 (2001).
  • Xu Y, Fang XJ, Casey G et al. Lysophospholipids activate ovarian and breast cancer cells. Biochem. J.309(3), 933–940 (1995).
  • Xu Y, Shen Z, Wiper DW et al. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA280(8), 719–723 (1998).
  • Sutphen R, Xu Y, Wilbanks GD et al. Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol. Biomarkers Prev.13(7), 1185–1191 (2004).
  • Sedláková I, Vávrová J, Tosner J et al. Lysophosphatidic acid: an ovarian cancer marker. Eur. J. Gynaecol. Oncol.29(5), 511–514 (2008).
  • Tchagang AB, Tewfik AH, DeRycke MS et al. Early detection of ovarian cancer using group biomarkers. Mol. Cancer Ther.7(1), 27–37 (2008).
  • Gorelik E, Landsittel DP, Marrangoni AM et al. Multiplexed immunobead-based cytokine profiling for early detection of ovarian cancer. Cancer Epidemiol. Biomarkers Prev.14(4), 981–987 (2005).
  • Lokshin AE, Winans M, Landsittel D et al. Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer. Gynecol. Oncol.102(2), 244–251 (2006).
  • Oehler MK, Caffier H. Prognostic relevance of serum vascular endothelial growth factor in ovarian cancer. Anticancer Res.20, 5109–5112 (2000).
  • Cooper BC, Ritchie JM, Broghammer CL et al. Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer. Clin. Cancer Res.8, 3193–3197 (2002).
  • Peng XP, Li JD, Li MD et al. Clinical significance of vascular endothelial growth factor in sera of patients with gynaecologicant malignant tumors. Ai Zheng.21, 181–185 (2002).
  • Rosen DG, Wang L, Atkinson JN et al. Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol. Oncol.99(2), 267–277 (2005).
  • Kirchhoff C, Habben I, Ivell R, Krull N. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. Biol. Reprod.1991, 45(2), 350–357 (1991).
  • Moore RG, MacLaughlan S, Bast RC. Current state of biomarker development for clinical application in epithelial ovarian cancer. Gynecol. Oncol.116(2), 240–245 (2010).
  • Hough CD, Sherman-Baust CA, Pizer ES et al. Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res.60(22), 6281–6287 (2000).
  • Ono K, Tanaka T, Tsunoda T et al. Identification by cDNA microarray of genes involved in ovarian carcinogenesis. Cancer Res.60(18), 5007–5011 (2000).
  • Hellstrom I, Raycraft J, Hayden-Ledbetter M et al. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res.63(13), 3695–3700 (2003).
  • Rapkiewicz AV, Espina V, Petricoin EF 3rd et al. Biomarkers of ovarian tumours. Eur. J. Cancer.40(17), 2604–2612 (2004).
  • Lu KH, Patterson AP, Wang L et al. Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin. Cancer Res.10(10), 3291–3300 (2004).
  • Visintin I, Feng Z, Longton G et al. Diagnostic markers for early detection of ovarian cancer. Clin. Cancer Res.14(4), 1065–1072 (2008).
  • Scholler N, Crawford M, Sato A et al. Bead-based ELISA for validation of ovarian cancer early detection markers. Clin. Cancer Res.12(7 Pt 1), 2117–2124 (2006).
  • Moore RG, McMeekin DS, Brown AK et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol. Oncol.112(1), 40–46 (2009).
  • Moore RG, Brown AK, Miller MC et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol. Oncol.108(2), 402–408 (2008).
  • Mok SC, Chao J, Skates S et al. Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology. J. Natl Cancer Inst.93(19), 1458–1464 (2001).
  • Costa FP, Batista JEL, Zelmanowicz A et al. Prostatin, a potential tumor marker in ovarian cancer – a pilot study. Clinics64(7), 641–644 (2009).
  • Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho YM, Hayashi N. Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Prostate54, 187–193 (2003).
  • Chen M, Chen LM, Lin CY, Chai KX. The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells. Biochim. Biophys. Acta.1783, 896–903 (2008).
  • Wong KK, Cheng RS, Mok SC. Identification of differentially expressed genes from ovarian cancer cells by MICROMAX cDNA microarray system. Biotechniques30(3), 670–675 (2001).
  • Kim JH, Skates SJ, Uede T et al. Osteopontin as a potential diagnostic biomarker for ovarian cancer. JAMA287(13), 1671–1679 (2002).
  • Scholler N, Fu N, Yang Y et al. Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. Proc. Natl Acad. Sci. USA96(20), 11531–11536 (1999).
  • McIntosh MW, Drescher C, Karlan B et al. Combining CA125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma. Gynecol. Oncol.95(1), 9–15 (2004).
  • Shah CA, Lowe KA, Paley P et al. Influence of ovarian cancer risk status on the diagnostic performance of the serum biomarkers mesothelin, HE4, and CA125. Cancer Epidemiol. Biomarkers Prev.18(5), 1365–1372 (2009).
  • Badgwell D, Lu Z, Cole L et al. Urinary mesothelin provides greater sensitivity for early stage ovarian cancer than serum mesothelin, urinary hCG free β subunit and urinary hCG β core fragment. Gynecol. Oncol.106(3), 490–497 (2007).
  • Yousef GM, Diamandis EP. Tissue kallikreins: new players in normal and abnormal cell growth? Thromb. Haemost.90(1), 7–16 (2003).
  • Yousef GM, Polymeris ME, Yacoub GM et al. Parallel overexpression of seven kallikrein genes in ovarian cancer. Cancer Res.63(9), 2223–2227 (2003).
  • Shvartsman HS, Lu KH, Lee J et al. Overexpression of kallikrein 10 in epithelial ovarian carcinomas. Gynecol. Oncol.90(1), 44–50 (2003).
  • Adib TR, Henderson S, Perrett C et al. Predicting biomarkers for ovarian cancer using gene-expression microarrays. Br. J. Cancer.90, 686–692 (2004).
  • Simon I, Zhuo S, Corral L et al. B7-H4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer. Cancer Res.66, 1570–1575 (2006).
  • Iorio MV, Visone R, Di Leva G et al. MicroRNA signatures in human ovarian cancer. Cancer Res.67(18), 8699–8707 (2007).
  • Bast RC Jr, Urban N, Shridhar V et al. Early detection of ovarian cancer: promise and reality. In: Ovarian Cancer. Stack MS, Fishman DA (Eds). Kluwer, Boston, MA, USA 61–97 (2002).
  • Zhang Z, Yu Y, Xu F et al. Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer. Gynecol. Oncol.107(3), 526–531 (2007).
  • Nakae M, Iwamoto I, Fujino T et al. Preoperative plasma osteopontin level as a biomarker complementary to carbohydrate antigen 125 in predicting ovarian cancer. J. Obstet. Gynaecol. Res.32(3), 309–314 (2006).
  • Zhang Z, Bast RC Jr, Yu Y et al. Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res.64(16), 5882–5890 (2004).
  • Nosov V, Su F, Amneus M et al. Validation of serum biomarkers for detection of early-stage ovarian cancer. Am. J. Obstet. Gynecol.200(6), 639–641 (2009).
  • Mor G, Visintin I, Lai Y et al. Serum protein markers for early detection of ovarian cancer. Proc. Natl Acad. Sci.102, 7677–7682 (2005).
  • Ardekani AM, Akhondi MM, Sadeghi MR. Application of genomic and proteomic technologies to early detection of cancer. Arch. Iran. Med.11(4), 427–434 (2008).
  • Petricoin EF, Ardekani AM, Hitt BA et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet359(9306), 572–577(2002).
  • Kong F, Nicole White C, Xiao X et al. Using proteomic approaches to identify new biomarkers for detection and monitoring of ovarian cancer. Gynecol. Oncol.100(2), 247–253 (2006).
  • Kozak KR, Su F, Whitelegge JP et al. Characterization of serum biomarkers for detection of early stage ovarian cancer. Proteomics5(17), 4589–4596 (2005).
  • Lin YW, Lin CY, Lai HC et al. Plasma proteomic pattern as biomarkers for ovarian cancer. Int. J. Gynecol. Cancer16(1), 139–146 (2006).
  • Ye B, Skates S, Mok SC et al. Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Clin. Cancer Res.12(2), 432–441 (2006).
  • Zhang H, Kong B, Qu X et al. Biomarker discovery for ovarian cancer using SELDI-TOFMS. Gynecol. Oncol.102(1), 61–66 (2006).
  • Faca VM, Ventura AP, Fitzgibbon MP et al. Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extracellular domains. PLoS ONE3(6), e2425 (2008).
  • Pitteri SJ, JeBailey L, Fac¸a VM et al. Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE4(11), e7916 (2009).
  • Gortzak-Uzan L, Ignatchenko A, Evangelou AI et al. A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers. J. Proteome Res.7(1), 339–351 (2008).
  • Ross PL, Huang YN, Marchese JN et al. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol. Cell Proteomics3, 1154–1169 (2004).
  • Gagné JP, Éthier C, Gagné P et al. Comparative proteome analysis of human epithelial ovarian cancer. Proteome Sci.5, 16 (2007).
  • Kothandaraman N, Zhao CQ, Mahesh C. Ovarian cancer proteomics: many technologies one goal. Proteomics Clin. Appl.2(2), 195–218 (2008).
  • Denkert C, Budczies J, Kind T et al. Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res.66, 10795–10804 (2006).
  • Nelson A, Francis JE, Zorbas H. Population screening and early detection of ovarian cancer in asymptomatic women. Aust. NZ J. Obstet. Gynaecol.49, 448–450 (2009).
  • Anderson GL, McIntosh M, Wu Ll et al. Assessing lead time of selected ovarian cancer biomarkers: a nested case–control study. J. Natl Cancer Inst.102, 26–38 (2010).
  • Williams TI, Toups KL, Saggese DA., Kalli KR, Cliby WA, Muddiman DC. Epithelial ovarian cancer: disease etiology, treatment, detection, and investigational gene, metabolite, and protein biomarkers. J. Proteome Res.6, 2936–2962 (2007).
  • Sjovall K, Nilsson B, Einhorn N et al. The significance of serum CA 125 elevation in malignant and nonmalignant diseases. Gynecol. Oncol.85(1), 175–178 (2002).
  • Buys SS, Partridge E, Greene MH et al. Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. Am. J. Obstet. Gynecol.193(5), 1630–1639 (2005)
  • Meinhold-Heerlein I, Brautigam K, Bauerschlag DO et al. Serum biomarkers for early detection of ovarian cancer. Geburtshilfe Frauenheilkd68(8), 830–837 (2008).
  • Kim K, Visintin I, Alvero AB et al. Development and validation of a protein-based signature for the detection of ovarian cancer. Clin. Lab. Med.29(1), 47–55 (2009).
  • Rai AJ, Zhang Z, Rosenzweig J et al. Proteomic approaches to tumor marker discovery – identification of biomarkers for ovarian cancer. Arch. Pathol. Lab. Med.126(12), 1518–1526 (2002).
  • Ye B, Cramer DW, Skates SJ et al. Haptoglobin-α subunit as potential serum biomarker in ovarian cancer: Identification and characterization using proteomic profiling and mass spectrometry. Clin. Cancer Res.9(8), 2904–2911 (2003).
  • Vlahou A, Schorge JO, Gregory BW et al. Diagnosis of ovarian cancer using decision tree classification of mass spectral data. J. Biomed. Biotechnol.5, 308–314 (2003).
  • Liu CW, Shea N, Rucker S et al. Proteomic patterns for classification of ovarian cancer and CTCL serum samples utilizing peak pairs indicative of post-translational modifications. Proteomics7(22), 4045–4052 (2007).
  • Assareh A, Moradi MH. Extracting efficient fuzzy if-then rules from mass spectra of blood samples to early diagnosis of ovarian cancer. Proceedings of the 2007 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology 502–506 (2007).
  • Lopez MF, Mikulskis A, Kuzdzal S et al. A novel, high-throughput workflow for discovery and identification of serum carrier protein-bound peptide biomarker candidates in ovarian cancer samples. Clin. Chem.53(6), 1067–1074 (2007).

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