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Expert Review of Neurotherapeutics Volume 10, 2010 - Issue 12
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Theme: Epilepsy - Editorial

Antiepileptic drugs and suicide risk: could stopping medications pose a greater hazard?

Marco Mula Division of Neurology, University Hospital Maggiore della Carità, Amedeo Avogadro University, Novara, Italy. [email protected]
&
Josemir W Sander Department of Clinical & Experimental Epilepsy, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, London, UK and SEIN – Epilepsy Institutes in the Netherlands Foundation, SW Heemstede, The Netherlands
Pages 1775-1776 | Published online: 09 Jan 2014

References

  • Mula M, Bell GS, Sander JW. Suicidality in epilepsy and possible effects of antiepileptic drugs. Curr. Neurol. Neurosci. Rep.10(4), 327–332 (2010).
  • Mula M, Sander JW. Antiepileptic drugs and suicidality. Much ado about very little? Neurology75(4), 300–301 (2010).
  • US Food and Drug Administration. Antiepileptic drugs and suicidality. May 23 (2008).
  • Hesdorffer DC, Kanner AM. The FDA alert on suicidality and antiepileptic drugs: fire or false alarm? Epilepsia50(5), 978–986 (2009).
  • Bell GS, Mula M, Sander JW. Suicidality in people taking antiepileptic drugs: what is the evidence? CNS Drugs23(4), 281–292 (2009).
  • Christensen J, Vestergaard M, Mortensen PB, Sidenius P, Agerbo E. Epilepsy and risk of suicide: a population-based case–control study. Lancet Neurol.6(8), 693–698 (2007).
  • Bell GS, Gaitatzis A, Bell CL, Johnson AL, Sander JW. Suicide in people with epilepsy: how great is the risk? Epilepsia50(8), 1933–1942 (2009).
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  • Surges R, Thijs RD, Tan HL, Sander JW. Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat. Rev. Neurol.5(9), 492–504 (2009).
  • Faught E, Duh MS, Weiner JR, Guérin A, Cunnington MC. Nonadherence to antiepileptic drugs and increased mortality: findings from the RANSOM study. Neurology71(20), 1572–1578 (2008).
  • Reith DM, Edmonds L. Assessing the role of drugs in suicidal ideation and suicidality. CNS Drugs21(6), 463–472 (2007).
  • Mula M, Trimble MR, Sander JW. Are psychiatric adverse events of antiepileptic drugs a unique entity? A study on topiramate and levetiracetam. Epilepsia48(12), 2322–2326 (2007).
  • Ettinger AB. Psychotropic effects of antiepileptic drugs. Neurology67(11), 1916–1925 (2006).
  • Hesdorffer DC, Ishihara-Paul L, Mynepalli L et al. Epilepsy and psychiatric disorders: evidence for a bidirectional relationship. Epilepsia50(Suppl. 11), 220–221 (2009).
  • Gibbons R, Hur K, Brown CH, Mann JJ. Relationship between antiepileptic drugs and suicide attempts in patients with bipolar disorder. Arch. Gen. Psychiatry66, 1354–1360 (2009).

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