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Review

Management of antipsychotic-related weight gain

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Pages 1175-1200 | Published online: 09 Jan 2014

References

  • Finkelstein EA, Trogdon JG, Cohen JW, Dietz W. Annual medical spending attributable to obesity: payer-and service-specific estimates. Health Aff. (Millwood)28(5), w822–w831 (2009).
  • Weiden PJ, Mackell JA, McDonnell DD. Obesity as a risk factor for antipsychotic noncompliance. Schizophr. Res.66(1), 51–57 (2004).
  • Lieberman JA, Stroup TS, McEvoy JP et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N. Engl. J. Med.353(12), 1209–1223 (2005).
  • Allison DB, Mackell JA, McDonnell DD. The impact of weight gain on quality of life among persons with schizophrenia. Psychiatr. Serv.54(4), 565–567 (2003).
  • Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs19(Suppl. 1), 1–93 (2005).
  • Allison DB, Mentore JL, Heo M et al. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am. J. Psychiatry156(11), 1686–1696 (1999).
  • Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet373(9657), 31–41 (2009).
  • American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. Consensus development conference on antipsychotic drugs and obesity and diabetes. J. Clin. Psychiatry65(2), 267–272 (2004).
  • Kinon BJ, Kaiser CJ, Ahmed S, Rotelli MD, Kollack-Walker S. Association between early and rapid weight gain and change in weight over one year of olanzapine therapy in patients with schizophrenia and related disorders. J. Clin. Psychopharmacol.25(3), 255–258 (2005).
  • Kahn RS, Fleischhacker WW, Boter H et al. Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet371(9618), 1085–1097 (2008).
  • McEvoy JP, Lieberman JA, Perkins DO et al. Efficacy and tolerability of olanzapine, quetiapine, and risperidone in the treatment of early psychosis: a randomized, double-blind 52-week comparison. Am. J. Psychiatry164(7), 1050–1060 (2007).
  • Ratzoni G, Gothelf D, Brand-Gothelf A et al. Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study. J. Am. Acad. Child Adolesc. Psychiatry41(3), 337–343 (2002).
  • Sikich L, Frazier JA, McClellan J et al. Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. Am. J. Psychiatry165(11), 1420–1431 (2008).
  • McClellan J, Sikich L, Findling RL et al. Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods. J. Am. Acad. Child Adolesc. Psychiatry46(8), 969–978 (2007).
  • Safer DJ. A comparison of risperidone-induced weight gain across the age span. J. Clin. Psychopharmacol.24(4), 429–436 (2004).
  • Maayan L, Vakhrusheva J, Sheridan EM, Correll CU. Risperidone across the age span: a meta-analytic comparison of placebo-controlled trials. Presented at: New Clinical Drug Evaluation Unit Meeting. Boca Raton, FL, USA, 14–17 June 2010.
  • Basson BR, Kinon BJ, Taylor CC, Szymanski KA, Gilmore JA, Tollefson GD. Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone. J. Clin. Psychiatry62(4), 231–238 (2001).
  • Gebhardt S, Haberhausen M, Heinzel-Gutenbrunner M et al. Antipsychotic-induced body weight gain: predictors and a systematic categorization of the long-term weight course. J. Psychiatr. Res.43(6), 620–626 (2009).
  • Lane HY, Chang YC, Cheng YC, Liu GC, Lin XR, Chang WH. Effects of patient demographics, risperidone dosage, and clinical outcome on body weight in acutely exacerbated schizophrenia. J. Clin. Psychiatry64(3), 316–320 (2003).
  • Lane HY, Liu YC, Huang CL et al. Risperidone-related weight gain: genetic and nongenetic predictors. J. Clin. Psychopharmacol.26(2), 128–134 (2006).
  • Wetterling T, Mussigbrodt HE. Weight gain: side effect of atypical neuroleptics? J. Clin. Psychopharmacol.19(4), 316–321 (1999).
  • Calarge CA, Acion L, Kuperman S, Tansey M, Schlechte JA. Weight gain and metabolic abnormalities during extended risperidone treatment in children and adolescents. J. Child Adolesc. Psychopharmacol.19(2), 101–109 (2009).
  • Neovius M, Eberhard J, Lindstrom E, Levander S. Weight development in patients treated with risperidone: a 5-year naturalistic study. Acta Psychiatr. Scand.115(4), 277–285 (2007).
  • Weiss M, Panagiotopoulos C, Giles L et al. A naturalistic study of predictors and risks of atypical antipsychotic use in an attention-deficit/hyperactivity disorder clinic. J. Child Adolesc. Psychopharmacol.19(5), 575–582 (2009).
  • Correll CU. Weight gain and metabolic effects of mood stabilizers and antipsychotics in pediatric bipolar disorder: a systematic review and pooled analysis of short-term trials. J. Am. Acad. Child Adolesc. Psychiatry46(6), 687–700 (2007).
  • Strassnig M, Miewald J, Keshavan M, Ganguli R. Weight gain in newly diagnosed first-episode psychosis patients and healthy comparisons: one-year analysis. Schizophr. Res.93(1–3), 90–98 (2007).
  • Correll CU, Manu P, Olshanskiy V, Napolitano B, Kane JM, Malhotra AK. Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA302(16), 1765–1773 (2009).
  • Gentile S. Contributing factors to weight gain during long-term treatment with second-generation antipsychotics. A systematic appraisal and clinical implications. Obes. Rev.10(5), 527–542 (2009).
  • Keck PE, Jr., Calabrese JR, McIntyre RS et al. Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo. J. Clin. Psychiatry68(10), 1480–1491 (2007).
  • Hummer M, Kemmler G, Kurz M, Kurzthaler I, Oberbauer H, Fleischhacker WW. Weight gain induced by clozapine. Eur. Neuropsychopharmacol.5(4), 437–440 (1995).
  • Lee E, Leung CM, Wong E. Atypical antipsychotics and weight gain in Chinese patients: a comparison of olanzapine and risperidone. J. Clin. Psychiatry65(6), 864–866 (2004).
  • Saddichha S, Manjunatha N, Ameen S, Akhtar S. Metabolic syndrome in first episode schizophrenia – a randomized double-blind controlled, short-term prospective study. Schizophr. Res.101(1–3), 266–272 (2008).
  • Allison DB, Loebel AD, Lombardo I, Romano SJ, Siu CO. Understanding the relationship between baseline BMI and subsequent weight change in antipsychotic trials: effect modification or regression to the mean? Psychiatry Res.170(2–3), 172–176 (2009).
  • Lipkovich I, Jacobson JG, Hardy TA, Hoffmann VP. Early evaluation of patient risk for substantial weight gain during olanzapine treatment for schizophrenia, schizophreniform, or schizoaffective disorder. BMC Psychiatry8, 78 (2008).
  • Stauffer VL, Lipkovich I, Hoffmann VP, Heinloth AN, McGregor HS, Kinon BJ. Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents: a post-hoc analysis. BMC Psychiatry9, 12 (2009).
  • Hennen J, Perlis RH, Sachs G, Tohen M, Baldessarini RJ. Weight gain during treatment of bipolar I patients with olanzapine. J. Clin. Psychiatry65(12), 1679–1687 (2004).
  • Simon V, van Winkel R, De Hert M. Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? A literature review. J. Clin. Psychiatry70(7), 1041–1050 (2009).
  • Reaven GM, Lieberman JA, Sethuraman G et al. In search of moderators and mediators of hyperglycemia with atypical antipsychotic treatment. J. Psychiatr. Res.43(11), 997–1002 (2009).
  • Ader M, Garvey WT, Phillips LS et al. Ethnic heterogeneity in glucoregulatory function during treatment with atypical antipsychotics in patients with schizophrenia. J. Psychiatr. Res.42(13), 1076–1085 (2008).
  • Houseknecht KL, Robertson AS, Zavadoski W, Gibbs EM, Johnson DE, Rollema H. Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects. Neuropsychopharmacology32(2), 289–297 (2007).
  • Mukherjee S, Schnur DB, Reddy R. Family history of type 2 diabetes in schizophrenic patients. Lancet1(8636), 495 (1989).
  • Cohn TA, Remington G, Zipursky RB, Azad A, Connolly P, Wolever TM. Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: a preliminary report. Can. J. Psychiatry51(6), 382–386 (2006).
  • Ryan MC, Collins P, Thakore JH. Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. Am. J. Psychiatry160(2), 284–289 (2003).
  • Spelman LM, Walsh PI, Sharifi N, Collins P, Thakore JH. Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia. Diabet. Med.24(5), 481–485 (2007).
  • Verma SK, Subramaniam M, Liew A, Poon LY. Metabolic risk factors in drug-naive patients with first-episode psychosis. J. Clin. Psychiatry70(7), 997–1000 (2009).
  • Fernandez-Egea E, Bernardo M, Donner T et al. Metabolic profile of antipsychotic-naive individuals with non-affective psychosis. Br. J. Psychiatry194(5), 434–438 (2009).
  • Meyer JM, Stahl SM. The metabolic syndrome and schizophrenia. Acta Psychiatr. Scand.119(1), 4–14 (2009).
  • McEvoy JP, Meyer JM, Goff DC et al. Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III. Schizophr. Res.80(1), 19–32 (2005).
  • De Hert M, van Winkel R, Van Eyck D et al. Prevalence of diabetes, metabolic syndrome and metabolic abnormalities in schizophrenia over the course of the illness: a cross-sectional study. Clin. Pract. Epidemiol. Ment. Health2, 14 (2006).
  • Isomaa B, Almgren P, Tuomi T et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care24(4), 683–689 (2001).
  • Colton CW, Manderscheid RW. Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev. Chronic Dis.3(2), A42 (2006).
  • Brown S, Kim M, Mitchell C, Inskip H. Twenty-five year mortality of a community cohort with schizophrenia. Br. J. Psychiatry196(2), 116–121 (2010).
  • Tiihonen J, Lonnqvist J, Wahlbeck K et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet374(9690), 620–627 (2009).
  • De Hert M, Correll CU, Cohen D. Do antipsychotic medications reduce or increase mortality in schizophrenia? A critical appraisal of the FIN-11 study. Schizophr. Res.117(1), 68–74 (2009).
  • Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch. Gen. Psychiatry64(10), 1123–1131 (2007).
  • Arjona AA, Zhang SX, Adamson B, Wurtman RJ. An animal model of antipsychotic-induced weight gain. Behav. Brain Res.152(1), 121–127 (2004).
  • Gothelf D, Falk B, Singer P et al. Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic inpatients treated with olanzapine. Am. J. Psychiatry159(6), 1055–1057 (2002).
  • Graham KA, Perkins DO, Edwards LJ, Barrier RC Jr, Lieberman JA, Harp JB. Effect of olanzapine on body composition and energy expenditure in adults with first-episode psychosis. Am. J. Psychiatry162(1), 118–123 (2005).
  • Zurlo F, Lillioja S, Esposito-Del Puente A et al. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am. J. Physiol.259(5 Pt 1), E650–E657 (1990).
  • Sharpe JK, Stedman TJ, Byrne NM, Wishart C, Hills AP. Energy expenditure and physical activity in clozapine use: implications for weight management. Aust. N Z J. Psychiatry40(9), 810–814 (2006).
  • Correll CU, Malhotra AK. Pharmacogenetics of antipsychotic-induced weight gain. Psychopharmacology (Berl.)174(4), 477–489 (2004).
  • Sentissi O, Viala A, Bourdel MC et al. Impact of antipsychotic treatments on the motivation to eat: preliminary results in 153 schizophrenic patients. Int. Clin. Psychopharmacol.24(5), 257–264 (2009).
  • Ota M, Mori K, Nakashima A et al. Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats. Clin. Exp. Pharmacol. Physiol.29(11), 980–989 (2002).
  • Sikich L, Hamer RM, Bashford RA, Sheitman BB, Lieberman JA. A pilot study of risperidone, olanzapine, and haloperidol in psychotic youth: a double-blind, randomized, 8-week trial. Neuropsychopharmacology29(1), 133–145 (2004).
  • Woods SW, Martin A, Spector SG, McGlashan TH. Effects of development on olanzapine-associated adverse events. J. Am. Acad. Child Adolesc. Psychiatry41(12), 1439–1446 (2002).
  • Newcomer JW, Haupt DW, Fucetola R et al. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch. Gen. Psychiatry59(4), 337–345 (2002).
  • Henderson DC, Cagliero E, Copeland PM et al. Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysis. Arch. Gen. Psychiatry62(1), 19–28 (2005).
  • Johnson DE, Yamazaki H, Ward KM et al. Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia. Diabetes54(5), 1552–1558 (2005).
  • Reynolds GP, Kirk SL. Metabolic side effects of antipsychotic drug treatment – pharmacological mechanisms. Pharmacol. Ther.125(1), 169–179 (2010).
  • Bai YM, Chen TT, Yang WS et al. Association of adiponectin and metabolic syndrome among patients taking atypical antipsychotics for schizophrenia: a cohort study. Schizophr. Res.111(1–3), 1–8 (2009).
  • Muldoon MF, Mackey RH, Korytkowski MT, Flory JD, Pollock BG, Manuck SB. The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers. J. Clin. Endocrinol. Metab.91(2), 718–721 (2006).
  • Maayan LA, Vakhrusheva J. Risperidone associated weight, leptin, and anthropometric changes in children and adolescents with psychotic disorders in early treatment. Hum. Psychopharmacol.25(2), 133–138 (2010).
  • Haupt DW, Luber A, Maeda J, Melson AK, Schweiger JA, Newcomer JW. Plasma leptin and adiposity during antipsychotic treatment of schizophrenia. Neuropsychopharmacology30(1), 184–191 (2005).
  • Zhang ZJ, Yao ZJ, Liu W, Fang Q, Reynolds GP. Effects of antipsychotics on fat deposition and changes in leptin and insulin levels. Magnetic resonance imaging study of previously untreated people with schizophrenia. Br. J. Psychiatry184, 58–62 (2004).
  • Deng C, Weston-Green K, Huang XF. The role of histaminergic H1 and H3 receptors in food intake: a mechanism for atypical antipsychotic-induced weight gain? Prog. Neuropsychopharmacol. Biol. Psychiatry34(1), 1–4 (2010).
  • Kroeze WK, Hufeisen SJ, Popadak BA et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology28(3), 519–526 (2003).
  • Kim SF, Huang AS, Snowman AM, Teuscher C, Snyder SH. From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc. Natl Acad. Sci. USA104(9), 3456–3459 (2007).
  • Reynolds GP, Templeman LA, Zhang ZJ. The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment. Prog. Neuropsychopharmacol. Biol. Psychiatry29(6), 1021–1028 (2005).
  • Mulder H, Franke B, van der-Beek van der AA et al. The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study. Pharmacogenomics J.7(5), 318–324 (2007).
  • De Luca V, Muller DJ, Hwang R et al. HTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysis. Hum. Psychopharmacol.22(7), 463–467 (2007).
  • Templeman LA, Reynolds GP, Arranz B, San L. Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis. Pharmacogenet. Genomics15(4), 195–200 (2005).
  • Souza RP, De Luca V, Muscettola G et al. Association of antipsychotic induced weight gain and body mass index with GNB3 gene: a meta-analysis. Prog. Neuropsychopharmacol. Biol. Psychiatry32(8), 1848–1853 (2008).
  • Siffert W, Forster P, Jockel KH et al. Worldwide ethnic distribution of the G protein b3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J. Am. Soc. Nephrol.10(9), 1921–1930 (1999).
  • Lencz T, Malhotra AK. Pharmacogenetics of antipsychotic-induced side effects. Dialogues Clin. Neurosci.11(4), 405–415 (2009).
  • Tiwari AK, Zai CC, Likhodi O et al. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in schizophrenia. Neuropsychopharmacology35(6), 1315–1324 (2010).
  • Liu YR, Loh EW, Lan TH et al. ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics. Pharmacogenomics J.10(1), 30–39 (2010).
  • Buckley PF, Correll CU. Strategies for dosing and switching antipsychotics for optimal clinical management. J. Clin. Psychiatry69(Suppl. 1), 4–17 (2008).
  • Pae CU, Serretti A, Chiesa A et al. Immediate versus gradual suspension of previous treatments during switch to aripiprazole: results of a randomized, open label study. Eur. Neuropsychopharmacol.19(8), 562–570 (2009).
  • Ganguli R, Brar JS, Mahmoud R, Berry SA, Pandina GJ. Assessment of strategies for switching patients from olanzapine to risperidone: a randomized, open-label, rater-blinded study. BMC Med.6, 17 (2008).
  • Essock SM, Covell NH, Davis SM, Stroup TS, Rosenheck RA, Lieberman JA. Effectiveness of switching antipsychotic medications. Am. J. Psychiatry163(12), 2090–2095 (2006).
  • Rosenheck RA, Davis S, Covell N et al. Does switching to a new antipsychotic improve outcomes? Data from the CATIE Trial. Schizophr. Res.107(1), 22–29 (2009).
  • De Hert M, Hanssens L, van Winkel R et al. A case series: evaluation of the metabolic safety of aripiprazole. Schizophr. Bull.33(3), 823–830 (2007).
  • Meyer JM, Davis VG, Goff DC et al. Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1. Schizophr. Res.101(1–3), 273–286 (2008).
  • Meyer JM, Pandina G, Bossie CA, Turkoz I, Greenspan A. Effects of switching from olanzapine to risperidone on the prevalence of the metabolic syndrome in overweight or obese patients with schizophrenia or schizoaffective disorder: analysis of a multicenter, rater-blinded, open-label study. Clin. Ther.27(12), 1930–1941 (2005).
  • Newcomer JW, Campos JA, Marcus RN et al. A multicenter, randomized, double-blind study of the effects of aripiprazole in overweight subjects with schizophrenia or schizoaffective disorder switched from olanzapine. J. Clin. Psychiatry69(7), 1046–1056 (2008).
  • Newcomer JW, Meyer JM, Baker RA et al. Changes in non-high-density lipoprotein cholesterol levels and triglyceride/high-density lipoprotein cholesterol ratios among patients randomized to aripiprazole versus olanzapine. Schizophr. Res.106(2–3), 300–307 (2008).
  • Lin CC, Bai YM, Wang YC et al. Improved body weight and metabolic outcomes in overweight or obese psychiatric patients switched to amisulpride from other atypical antipsychotics. J. Clin. Psychopharmacol.29(6), 529–536 (2009).
  • Ried LD, Brumback B, Bengtson MA, Garman PM, Hsu C, McConkey JR. Glucose dysregulation among veterans living with schizophrenia-related disorders after switching second-generation antipsychotics. J. Am. Pharm. Assoc.49(2), 223–231 (2009).
  • Weiden PJ, Newcomer JW, Loebel AD, Yang R, Lebovitz HE. Long-term changes in weight and plasma lipids during maintenance treatment with ziprasidone. Neuropsychopharmacology33(5), 985–994 (2008).
  • Casey DE, Carson WH, Saha AR et al. Switching patients to aripiprazole from other antipsychotic agents: a multicenter randomized study. Psychopharmacology (Berl.)166(4), 391–399 (2003).
  • Montes JM, Rodriguez JL, Balbo E et al. Improvement in antipsychotic-related metabolic disturbances in patients with schizophrenia switched to ziprasidone. Prog. Neuropsychopharmacol. Biol. Psychiatry31(2), 383–388 (2007).
  • Alvarez-Jimenez M, Hetrick SE, Gonzalez-Blanch C, Gleeson JF, McGorry PD. Non-pharmacological management of antipsychotic-induced weight gain: systematic review and meta-analysis of randomised controlled trials. Br. J. Psychiatry193(2), 101–107 (2008).
  • Gabriele JM, Dubbert PM, Reeves RR. Efficacy of behavioural interventions in managing atypical antipsychotic weight gain. Obes. Rev.10(4), 442–455 (2009).
  • Alvarez-Jimenez M, Gonzalez-Blanch C, Vazquez-Barquero JL et al. Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients: a randomized controlled trial. J. Clin. Psychiatry67(8), 1253–1260 (2006).
  • Kalarchian MA, Levine MD, Arslanian SA et al. Family-based treatment of severe pediatric obesity: randomized, controlled trial. Pediatrics124(4), 1060–1068 (2009).
  • Epstein LH, Valoski A, Wing RR, McCurley J. Ten-year follow-up of behavioral, family-based treatment for obese children. JAMA264(19), 2519–2523 (1990).
  • Johnston CA, Steele RG. Treatment of pediatric overweight: an examination of feasibility and effectiveness in an applied clinical setting. J. Pediatr. Psychol.32(1), 106–110 (2007).
  • Correll CU, Carlson HE. Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. J. Am. Acad. Child Adolesc. Psychiatry45(7), 771–791 (2006).
  • Faulkner G, Cohn T, Remington G. Interventions to reduce weight gain in schizophrenia. Schizophr. Bull.33(3), 654–656 (2007).
  • Baptista T, ElFakih Y, Uzcategui E et al. Pharmacological management of atypical antipsychotic-induced weight gain. CNS Drugs22(6), 477–495 (2008).
  • Maayan L, Vakhrusheva J, Correll CU. Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis. Neuropsychopharmacology35(7), 1520–1530 (2010).
  • Baptista T, Martinez J, Lacruz A et al. Metformin for prevention of weight gain and insulin resistance with olanzapine: a double-blind placebo-controlled trial. Can. J. Psychiatry51(3), 192–196 (2006).
  • Baptista T, Rangel N, Fernandez V et al. Metformin as an adjunctive treatment to control body weight and metabolic dysfunction during olanzapine administration: a multicentric, double-blind, placebo-controlled trial. Schizophr. Res.93(1–3), 99–108 (2007).
  • Carrizo E, Fernandez V, Connell L et al. Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double-blind, parallel group, placebo-controlled study. Schizophr. Res.113(1), 19–26 (2009).
  • Wu RR, Zhao JP, Guo XF et al. Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study. Am. J. Psychiatry165(3), 352–358 (2008).
  • Wu RR, Zhao JP, Jin H et al. Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial. JAMA299(2), 185–193 (2008).
  • Arman S, Sadramely MR, Nadi M, Koleini N. A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents. Saudi Med. J.29(8), 1130–1134 (2008).
  • Klein DJ, Cottingham EM, Sorter M, Barton BA, Morrison JA. A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. Am. J. Psychiatry163(12), 2072–2079 (2006).
  • Citrome L. Compelling or irrelevant? Using number needed to treat can help decide. Acta Psychiatr. Scand.117(6), 412–419 (2008).
  • Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Ann. Intern. Med.137(1), 25–33 (2002).
  • Canitano R. Clinical experience with Topiramate to counteract neuroleptic induced weight gain in 10 individuals with autistic spectrum disorders. Brain Dev.27(3), 228–232 (2005).
  • Roerig JL, Steffen KJ, Mitchell JE, Crosby RD, Gosnell BA. An exploration of the effect of modafinil on olanzapine associated weight gain in normal human subjects. Biol. Psychiatry65(7), 607–613 (2009).
  • Gross C, Blasey CM, Roe RL, Allen K, Block TS, Belanoff JK. Mifepristone treatment of olanzapine-induced weight gain in healthy men. Adv. Ther.26(10), 959–969 (2009).
  • Gross C, Blasey CM, Roe RL, Belanoff JK. Mifepristone reduces weight gain and improves metabolic abnormalities associated with risperidone treatment in normal men. Obesity (Silver Spring) DOI: 10.1038/oby.2010.51 (2010) (Epub ahead of print).
  • Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA295(7), 761–775 (2006).
  • Smith SR, Aronne LJ, Burns CM, Kesty NC, Halseth AE, Weyer C. Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity. Diabetes Care31(9), 1816–1823 (2008).
  • Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet372(9653), 1906–1913 (2008).
  • Roth JD, Roland BL, Cole RL et al. Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc. Natl Acad. Sci. USA105(20), 7257–7262 (2008).
  • Chakrabarti R. Pharmacotherapy of obesity: emerging drugs and targets. Expert Opin. Ther. Targets13(2), 195–207 (2009).
  • Baptista T, Uzcategui E, Rangel N et al. Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study. Psychiatry Res.159(1–2), 250–253 (2008).
  • American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. Consensus development conference on antipsychotic drugs and obesity and diabetes. J. Clin. Psychiatry65(2), 267–272 (2004).
  • Barnes TR, Paton C, Cavanagh MR, Hancock E, Taylor DM. A UK audit of screening for the metabolic side effects of antipsychotics in community patients. Schizophr. Bull.33(6), 1397–1403 (2007).
  • Haupt DW, Rosenblatt LC, Kim E, Baker RA, Whitehead R, Newcomer JW. Prevalence and predictors of lipid and glucose monitoring in commercially insured patients treated with second-generation antipsychotic agents. Am. J. Psychiatry166(3), 345–353 (2009).
  • Morrato EH, Cuffel B, Newcomer JW, Lombardo I, Kamat S, Barron J. Metabolic risk status and second-generation antipsychotic drug selection: a retrospective study of commercially insured patients. J. Clin. Psychopharmacol.29(1), 26–32 (2009).
  • Morrato EH, Druss B, Hartung DM et al. Metabolic testing rates in 3 state Medicaid programs after FDA warnings and ADA/APA recommendations for second-generation antipsychotic drugs. Arch. Gen. Psychiatry67(1), 17–24 (2010).
  • Morrato EH, Newcomer JW, Allen RR, Valuck RJ. Prevalence of baseline serum glucose and lipid testing in users of second-generation antipsychotic drugs: a retrospective, population-based study of Medicaid claims data. J. Clin. Psychiatry69(2), 316–322 (2008).
  • Morrato EH, Newcomer JW, Kamat S, Baser O, Harnett J, Cuffel B. Metabolic screening after the American Diabetes Association’s consensus statement on antipsychotic drugs and diabetes. Diabetes Care32(6), 1037–1042 (2009).
  • Morrato EH, Nicol GE, Maahs D et al. Metabolic screening in children receiving antipsychotic drug treatment. Arch. Pediatr. Adolesc. Med.164(4), 344–351 (2010).
  • Le Foll B, Gorelick DA, Goldberg SR. The future of endocannabinoid-oriented clinical research after CB1 antagonists. Psychopharmacology (Berl.)205(1), 171–174 (2009).
  • Brar JS, Ganguli R, Pandina G, Turkoz I, Berry S, Mahmoud R. Effects of behavioral therapy on weight loss in overweight and obese patients with schizophrenia or schizoaffective disorder. J. Clin. Psychiatry66(2), 205–212 (2005).
  • Khazaal Y, Fresard E, Rabia S et al. Cognitive behavioural therapy for weight gain associated with antipsychotic drugs. Schizophr. Res.91(1–3), 169–177 (2007).
  • Kwon JS, Choi JS, Bahk WM et al. Weight management program for treatment-emergent weight gain in olanzapine-treated patients with schizophrenia or schizoaffective disorder: a 12-week randomized controlled clinical trial. J. Clin. Psychiatry67(4), 547–553 (2006).
  • McKibbin CL, Patterson TL, Norman G et al. A lifestyle intervention for older schizophrenia patients with diabetes mellitus: a randomized controlled trial. Schizophr. Res.86(1–3), 36–44 (2006).
  • Weber M, Wyne K. A cognitive/behavioral group intervention for weight loss in patients treated with atypical antipsychotics. Schizophr. Res.83(1), 95–101 (2006).
  • Poulin MJ, Chaput JP, Simard V et al. Management of antipsychotic-induced weight gain: prospective naturalistic study of the effectiveness of a supervised exercise programme. Aust. N Z J. Psychiatry41(12), 980–989 (2007).
  • Milano W, Grillo F, Del Mastro A et al. Appropriate intervention strategies for weight gain induced by olanzapine: a randomized controlled study. Adv. Ther.24(1), 123–134 (2007).
  • Wu MK, Wang CK, Bai YM, Huang CY, Lee SD. Outcomes of obese, clozapine-treated inpatients with schizophrenia placed on a six-month diet and physical activity program. Psychiatr. Serv.58(4), 544–550 (2007).
  • Mauri M, Simoncini M, Castrogiovanni S et al. A psychoeducational program for weight loss in patients who have experienced weight gain during antipsychotic treatment with olanzapine. Pharmacopsychiatry41(1), 17–23 (2008).
  • Scocco P, Longo R, Caon F. Weight change in treatment with olanzapine and a psychoeducational approach. Eat. Behav.7(2), 115–124 (2006).
  • Alvarez-Jimenez M, Martinez-Garcia O, Perez-Iglesias R, Ramirez ML, Vazquez-Barquero JL, Crespo-Facorro B. Prevention of antipsychotic-induced weight gain with early behavioural intervention in first-episode psychosis: 2-year results of a randomized controlled trial. Schizophr. Res.116(1), 16–19 (2010).
  • Evans S, Newton R, Higgins S. Nutritional intervention to prevent weight gain in patients commenced on olanzapine: a randomized controlled trial. Aust. N Z J. Psychiatry39(6), 479–486 (2005).
  • Littrell KH, Hilligoss NM, Kirshner CD, Petty RG, Johnson CG. The effects of an educational intervention on antipsychotic-induced weight gain. J. Nurs. Scholarsh.35(3), 237–241 (2003).
  • Deberdt W, Winokur A, Cavazzoni PA et al. Amantadine for weight gain associated with olanzapine treatment. Eur. Neuropsychopharmacol.15(1), 13–21 (2005).
  • Graham KA, Gu H, Lieberman JA, Harp JB, Perkins DO. Double-blind, placebo-controlled investigation of amantadine for weight loss in subjects who gained weight with olanzapine. Am. J. Psychiatry162(9), 1744–1746 (2005).
  • Modell W, Hussar AE. Failure of dextroamphetamine sulfate to influence eating and sleeping patterns in obese schizophrenic patients: clinical and pharmacological significance. JAMA193, 275–278 (1965).
  • Goodall E, Oxtoby C, Richards R, Watkinson G, Brown D, Silverstone T. A clinical trial of the efficacy and acceptability of d-fenfluramine in the treatment of neuroleptic-induced obesity. Br. J. Psychiatry153, 208–213 (1988).
  • Bustillo JR, Lauriello J, Parker K et al. Treatment of weight gain with fluoxetine in olanzapine-treated schizophrenic outpatients. Neuropsychopharmacology28(3), 527–529 (2003).
  • Assuncao SS, Ruschel SI, Rosa Lde C et al. Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine. Rev. Bras. Psiquiatr.28(4), 270–276 (2006).
  • Atmaca M, Kuloglu M, Tezcan E, Ustundag B. Nizatidine treatment and its relationship with leptin levels in patients with olanzapine-induced weight gain. Hum. Psychopharmacol.18(6), 457–461 (2003).
  • Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Kilic N. Nizatidine for the treatment of patients with quetiapine-induced weight gain. Hum. Psychopharmacol.19(1), 37–40 (2004).
  • Joffe G, Takala P, Tchoukhine E et al. Orlistat in clozapine- or olanzapine-treated patients with overweight or obesity: a 16-week randomized, double-blind, placebo-controlled trial. J. Clin. Psychiatry69(5), 706–711 (2008).
  • Borovicka MC, Fuller MA, Konicki PE, White JC, Steele VM, Jaskiw GE. Phenylpropanolamine appears not to promote weight loss in patients with schizophrenia who have gained weight during clozapine treatment. J. Clin. Psychiatry63(4), 345–348 (2002).
  • Baptista T, Rangel N, El Fakih Y et al. Rosiglitazone in the assistance of metabolic control during olanzapine administration in schizophrenia: a pilot double-blind, placebo-controlled, 12-week trial. Pharmacopsychiatry42(1), 14–19 (2009).
  • Henderson DC, Fan X, Sharma B et al. A double-blind, placebo-controlled trial of rosiglitazone for clozapine-induced glucose metabolism impairment in patients with schizophrenia. Acta Psychiatr. Scand.119(6), 457–465 (2009).
  • Henderson DC, Copeland PM, Daley TB et al. A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain. Am. J. Psychiatry162(5), 954–962 (2005).
  • Henderson DC, Fan X, Copeland PM et al. A double-blind, placebo-controlled trial of sibutramine for clozapine-associated weight gain. Acta Psychiatr. Scand.115(2), 101–105 (2007).
  • Afshar H, Roohafza H, Mousavi G et al. Topiramate add-on treatment in schizophrenia: a randomised, double-blind, placebo-controlled clinical trial. J. Psychopharmacol.23(2), 157–162 (2009).
  • Roy Chengappa K, Kupfer DJ, Parepally H et al. A placebo-controlled, random-assignment, parallel-group pilot study of adjunctive topiramate for patients with schizoaffective disorder, bipolar type. Bipolar Disord.9(6), 609–617 (2007).
  • Ko YH, Joe SH, Jung IK, Kim SH. Topiramate as an adjuvant treatment with atypical antipsychotics in schizophrenic patients experiencing weight gain. Clin. Neuropharmacol.28(4), 169–175 (2005).
  • Narula PK, Rehan HS, Unni KE, Gupta N. Topiramate for prevention of olanzapine associated weight gain and metabolic dysfunction in schizophrenia: a double-blind, placebo-controlled trial. Schizophr. Res.118(1–3), 218–223 (2010).
  • Nickel MK, Nickel C, Muehlbacher M et al. Influence of topiramate on olanzapine-related adiposity in women: a random, double-blind, placebo-controlled study. J. Clin. Psychopharmacol.25(3), 211–217 (2005).
  • Poyurovsky M, Tal V, Maayan R, Gil-Ad I, Fuchs C, Weizman A. The effect of famotidine addition on olanzapine-induced weight gain in first-episode schizophrenia patients: a double-blind placebo-controlled pilot study. Eur. Neuropsychopharmacol.14(4), 332–336 (2004).
  • Poyurovsky M, Pashinian A, Gil-Ad I et al. Olanzapine-induced weight gain in patients with first-episode schizophrenia: a double-blind, placebo-controlled study of fluoxetine addition. Am. J. Psychiatry159(6), 1058–1060 (2002).
  • Hinze-Selch D, Deuschle M, Weber B, Heuser I, Pollmacher T. Effect of coadministration of clozapine and fluvoxamine versus clozapine monotherapy on blood cell counts, plasma levels of cytokines and body weight. Psychopharmacology (Berl.)149(2), 163–169 (2000).
  • Lu ML, Lane HY, Lin SK, Chen KP, Chang WH. Adjunctive fluvoxamine inhibits clozapine-related weight gain and metabolic disturbances. J. Clin. Psychiatry65(6), 766–771 (2004).
  • Cavazzoni P, Tanaka Y, Roychowdhury SM, Breier A, Allison DB. Nizatidine for prevention of weight gain with olanzapine: a double-blind placebo-controlled trial. Eur. Neuropsychopharmacol.13(2), 81–85 (2003).
  • Poyurovsky M, Isaacs I, Fuchs C et al. Attenuation of olanzapine-induced weight gain with reboxetine in patients with schizophrenia: a double-blind, placebo-controlled study. Am. J. Psychiatry160(2), 297–302 (2003).
  • Poyurovsky M, Fuchs C, Pashinian A et al. Attenuating effect of reboxetine on appetite and weight gain in olanzapine-treated schizophrenia patients: a double-blind placebo-controlled study. Psychopharmacology (Berl.)192(3), 441–448 (2007).
  • Kim JH, Yim SJ, Nam JH. A 12-week, randomized, open-label, parallel-group trial of topiramate in limiting weight gain during olanzapine treatment in patients with schizophrenia. Schizophr. Res.82(1), 115–117 (2006).
  • Correll CU. Antipsychotic use in children and adolescents: minimizing adverse effects to maximize outcomes. J. Am. Acad. Child Adolesc. Psychiatry47(1), 9–20 (2008).

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