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Review

Past, present and future uses of methacholine testing

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Pages 321-329 | Published online: 09 Jan 2014

References

  • Tiffeneau R, Pinelli A. Air circulant et air captive dans l’exploration de la function ventilatrice pulmonaire. Paris Med. 37, 624–628 (1947).
  • Tiffeneau R, Beauvallet M. Epreuve de bronchoconstriction et de bronchodilation par aerosols. Bull. Acad. Med. 129, 165–168 (1945).
  • Crapo RO, Casaburi R, Coates AL et al. Guidelines for methacholine and exercise challenge testing–1999. Am. J. Respir. Crit. Care Med. 161(1), 309–329 (2000).
  • Cockcroft DW, Davis BE, Todd DC, Smycniuk AJ. Methacholine challenge: comparison of two methods. Chest 127(3), 839–844 (2005).
  • Prieto L, Ferrer A, Domenech J, Pérez-Francés C. Effect of challenge method on sensitivity, reactivity, and maximal response to methacholine. Ann. Allergy Asthma Immunol. 97(2), 175–181 (2006).
  • Burke RR, Obeid IM, Williams LK, Morris ZQ. Two ATS recommended protocols for administration of methacholine are not equal. J. Asthma 46(7), 740–744 (2009).
  • Todd DC, Davis BE, Hurst TS, Cockcroft DW. Dosimeter methacholine challenge: comparison of maximal versus submaximal inhalations. J. Allergy Clin. Immunol. 114(3), 517–519 (2004).
  • Allen ND, Davis BE, Hurst TS, Cockcroft DW. Difference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection. Chest 128(6), 4018–4023 (2005).
  • Sverrild A, Porsbjerg C, Thomsen SF, Backer V. Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: a random-sample population study. J. Allergy Clin. Immunol. 126(5), 952–958 (2010).
  • Cockcroft DW, Davis BE. The bronchoprotective effect of inhaling methacholine by using total lung capacity inspirations has a marked influence on the interpretation of the test result. J. Allergy Clin. Immunol. 117(6), 1244–1248 (2006).
  • McGrath KW, Fahy JV. Negative methacholine challenge tests in subjects who report physician-diagnosed asthma. Clin. Exp. Allergy 41(1), 46–51 (2011).
  • Carlsten C, Dimich-Ward H, Ferguson A, Becker A, Dybuncio A, Chan-Yeung M. Airway hyperresponsiveness to methacholine in 7-year-old children: sensitivity and specificity for pediatric allergist-diagnosed asthma. Pediatr. Pulmonol. 46(2), 175–178 (2011).
  • Liem JJ, Kozyrskyj AL, Cockroft DW, Becker AB. Diagnosing asthma in children: what is the role for methacholine bronchoprovocation testing? Pediatr. Pulmonol. 43(5), 481–489 (2008).
  • de Meer G, Marks GB, Postma DS. Direct or indirect stimuli for bronchial challenge testing: what is the relevance for asthma epidemiology? Clin. Exp. Allergy 34(1), 9–16 (2004).
  • Sverrild A, Porsbjerg C, Thomsen SF, Backer V. Diagnostic properties of inhaled mannitol in the diagnosis of asthma: a population study. J. Allergy Clin. Immunol. 124(5), 928.e1–932.e1 (2009).
  • Anderson SD. Indirect challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138(Suppl. 2), S25–S30 (2010).
  • Koskela HO, Hyvärinen L, Brannan JD, Chan HK, Anderson SD. Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest 124(4), 1341–1349 (2003).
  • Porsbjerg C, Brannan JD, Anderson SD, Backer V. Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients. Clin. Exp. Allergy 38(1), 43–50 (2008).
  • Shaaban R, Zureik M, Soussan D et al. Allergic rhinitis and onset of bronchial hyperresponsiveness: a population-based study. Am. J. Respir. Crit. Care Med. 176(7), 659–666 (2007).
  • Ciprandi G, Signori A, Cirillo I. Relationship between bronchial hyperreactivity and bronchodilation in patients with allergic rhinitis. Ann. Allergy Asthma Immunol. 106(6), 460–466 (2011).
  • Lanças T, Kasahara DI, Gross JL et al. Cholinergic hyperresponsiveness of peripheral lung parenchyma in chronic obstructive pulmonary disease. Respiration 82(2), 177–184 (2011).
  • Cockcroft DW, Davis BE. Mechanisms of airway hyperresponsiveness. J. Allergy Clin. Immunol. 118(3), 551–559; quiz 560–561 (2006).
  • Rijcken B, Schouten JP, Weiss ST, Speizer FE, van der Lende R. The relationship of nonspecific bronchial responsiveness to respiratory symptoms in a random population sample. Am. Rev. Respir. Dis. 136(1), 62–68 (1987).
  • Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise RA. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am. J. Respir. Crit. Care Med. 153(6 Pt 1), 1802–1811 (1996).
  • de Marco R, Accordini S, Marcon A et al.; European Community Respiratory Health Survey (ECRHS). Risk factors for chronic obstructive pulmonary disease in a European cohort of young adults. Am. J. Respir. Crit. Care Med. 183(7), 891–897 (2011).
  • Tarlo SM, Boulet LP, Cartier A et al. Canadian Thoracic Society Guidelines for Occupational Asthma. Can. Respir. J. 5(5), 397–410 (1998).
  • Dufour MH, Lemière C, Prince P, Boulet LP. Comparative airway response to high- versus low-molecular weight agents in occupational asthma. Eur. Respir. J. 33(4), 734–739 (2009).
  • Lemiere C, Miedinger D, Jacob V, Chaboillez S, Tremblay C, Brannan JD. Comparison of methacholine and mannitol bronchial provocation tests in workers with occupational asthma. J. Allergy Clin. Immunol. 129(2), 555–556 (2012).
  • Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS; A305 Study Group. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir. Res. 10, 4 (2009).
  • Lemière C, Bai T, Balter M et al.; Canadian Adult Consensus Group of the Canadian Thoracic Society. Adult Asthma Consensus Guidelines update 2003. Can. Respir. J. 11 (Suppl. A), A9–A18 (2004).
  • Bel EH, Timmers MC, Zwinderman AH, Dijkman JH, Sterk PJ. The effect of inhaled corticosteroids on the maximal degree of airway narrowing to methacholine in asthmatic subjects. Am. Rev. Respir. Dis. 143(1), 109–113 (1991).
  • Booms P, Cheung D, Timmers MC, Zwinderman AH, Sterk PJ. Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma. J. Allergy Clin. Immunol. 99(3), 330–337 (1997).
  • Sont JK, Willems LN, Bel EH, van Krieken JH, Vandenbroucke JP, Sterk PJ. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am. J. Respir. Crit. Care Med. 159(4 Pt 1), 1043–1051 (1999).
  • Leuppi JD, Salome CM, Jenkins CR et al. Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. Eur. Respir. J. 18(3), 444–450 (2001).
  • Hanxiang N, Jiong Y, Yanwei C et al. Persistent airway inflammation and bronchial hyperresponsiveness in patients with totally controlled asthma. Int. J. Clin. Pract. 62(4), 599–605 (2008).
  • Brannan JD. Bronchial hyperresponsiveness in the assessment of asthma control: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138(Suppl. 2), S11–S17 (2010).
  • Lipworth BJ, Short PM, Williamson PA, Clearie KL, Fardon TC, Jackson CM. A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial. Chest 141(3), 607–615 (2012).
  • Brannan JD, Koskela H, Anderson SD. Monitoring asthma therapy using indirect bronchial provocation tests. Clin. Respir. J. 1(1), 3–15 (2007).
  • Prosperini G, Rajakulasingam K, Cacciola RR et al. Changes in sputum counts and airway hyperresponsiveness after budesonide: monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammation. J. Allergy Clin. Immunol. 110(6), 855–861 (2002).
  • Walker PP, Hadcroft J, Costello RW, Calverley PM. Lung function changes following methacholine inhalation in COPD. Respir. Med. 103(4), 535–541 (2009).
  • Leuppi JD, Tandjung R, Anderson SD et al. Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept. Pulm. Pharmacol. Ther. 18(2), 83–88 (2005).
  • Lapperre TS, Snoeck-Stroband JB, Gosman MM et al.; Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease Study Group. Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 170(5), 499–504 (2004).
  • Dima E, Rovina N, Gerassimou C, Roussos C, Gratziou C. Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice. Int. J. Chron. Obstruct. Pulmon. Dis. 5, 287–296 (2010).
  • Fabbri LM, Romagnoli M, Corbetta L et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 167(3), 418–424 (2003).
  • Nair P, Hargreave FE. Measuring bronchitis in airway diseases: clinical implementation and application: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138(Suppl. 2), S38–S43 (2010).
  • Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N. Engl. J. Med. 352(21), 2163–2173 (2005).
  • Spitale N, Popat N, McIvor A. Update on exhaled nitric oxide in pulmonary disease. Expert Rev. Respir. Med. 6(1), 105–115 (2012).
  • Shaw DE, Berry MA, Thomas M et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am. J. Respir. Crit. Care Med. 176(3), 231–237 (2007).
  • Taylor DA, Jensen MW, Aikman SL, Harris JG, Barnes PJ, O’Connor BJ. Comparison of salmeterol and albuterol-induced bronchoprotection against adenosine monophosphate and histamine in mild asthma. Am. J. Respir. Crit. Care Med. 156(6), 1731–1737 (1997).
  • Yates DH, Worsdell M, Barnes PJ. Effect of an inhaled glucocorticosteroid on mast cell and smooth muscle beta 2 adrenergic tolerance in mild asthma. Thorax 53(2), 110–113 (1998).
  • O’Connor BJ, Aikman SL, Barnes PJ. Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma. N. Engl. J. Med. 327(17), 1204–1208 (1992).
  • Cockcroft DW, McParland CP, Britto SA, Swystun VA, Rutherford BC. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 342(8875), 833–837 (1993).
  • Lai CK, Twentyman OP, Holgate ST. The effect of an increase in inhaled allergen dose after rimiterol hydrobromide on the occurrence and magnitude of the late asthmatic response and the associated change in nonspecific bronchial responsiveness. Am. Rev. Respir. Dis. 140(4), 917–923 (1989).
  • Cockcroft DW, Davis BE, Swystun VA, Marciniuk DD. Tolerance to the bronchoprotective effect of beta2-agonists: comparison of the enantiomers of salbutamol with racemic salbutamol and placebo. J. Allergy Clin. Immunol. 103(6), 1049–1053 (1999).
  • Cockcroft DW, Swystun VA. Effect of single doses of S-salbutamol, R-salbutamol, racemic salbutamol, and placebo on the airway response to methacholine. Thorax 52(10), 845–848 (1997).
  • O’Byrne PM, van der Linde J, Cockcroft DW et al. Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma. J. Allergy Clin. Immunol. 124(6), 1217–1221 (2009).
  • Hozawa S, Haruta Y, Terada M, Yamakido M. Effects of the addition of Beta2-agonist tulobuterol patches to inhaled corticosteroid in patients with asthma. Allergol. Int. 58(4), 509–518 (2009).
  • Cockcroft DW, Murdock KY. Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine. J. Allergy Clin. Immunol. 79(5), 734–740 (1987).
  • Bentley AM, Walker S, Hanotte F, De Vos C, Durham SR. A comparison of the effects of oral cetirizine and inhaled beclomethasone on early and late asthmatic responses to allergen and the associated increase in airways hyperresponsiveness. Clin. Exp. Allergy 26(8), 909–917 (1996).
  • Leigh R, Vethanayagam D, Yoshida M et al. Effects of montelukast and budesonide on airway responses and airway inflammation in asthma. Am. J. Respir. Crit. Care Med. 166(9), 1212–1217 (2002).
  • Duong M, Cockcroft D, Boulet LP et al. The effect of IVX-0142, a heparin-derived hypersulfated disaccharide, on the allergic airway responses in asthma. Allergy 63(9), 1195–1201 (2008).
  • Gauvreau GM, Boulet LP, Cockcroft DW et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. Am. J. Respir. Crit. Care Med. 183(8), 1007–1014 (2011).
  • Davis BE, Illamperuma C, Gauvreau GM et al. Single-dose desloratadine and montelukast and allergen-induced late airway responses. Eur. Respir. J. 33(6), 1302–1308 (2009).
  • Gauvreau GM, Pageau R, Séguin R et al. Dose-response effects of TPI ASM8 in asthmatics after allergen. Allergy 66(9), 1242–1248 (2011).
  • Gauvreau GM, Boulet LP, Cockcroft DW et al. Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses. Am. J. Respir. Crit. Care Med. 177(9), 952–958 (2008).

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