Vitamin D and corticosteroids in asthma: synergy, interaction and potential therapeutic effects

References

• Masoli M, Fabian D, Holt S, Beasley R; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59(5), 469–478 (2004).
   PubMed Web of Science ®Google Scholar
• CDC. Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001–2009. MMWR Morb. Mortal. Wkly Rep. 60(17), 547–552 (2011).
   PubMedGoogle Scholar
• Barnett SB, Nurmagambetov TA. Costs of asthma in the United States: 2002–2007. J. Allergy Clin. Immunol. 127(1), 145–152 (2011).
   PubMed Web of Science ®Google Scholar
• CDC. Asthma Prevalence, Health Care Use, and Mortality, 2002. US Department of Health and Human Services, CDC, National Center for Health Statistics, Hyattsville, MD, USA (2004).
   Google Scholar
• Tse SM, Tantisira K, Weiss ST. The pharmacogenetics and pharmacogenomics of asthma therapy. Pharmacogenomics J. 11(6), 383–392 (2011).
   PubMed Web of Science ®Google Scholar
• Litonjua AA, Weiss ST. Is vitamin D deficiency to blame for the asthma epidemic? J. Allergy Clin. Immunol. 120(5), 1031–1035 (2007).
   PubMed Web of Science ®Google Scholar
• Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J. Immunol. 179(4), 2060–2063 (2007).
   PubMed Web of Science ®Google Scholar
• Banerjee A, Damera G, Bhandare R et al. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br. J. Pharmacol. 155(1), 84–92 (2008).
   PubMed Web of Science ®Google Scholar
• Damera G, Fogle HW, Lim P et al. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1. Br. J. Pharmacol. 158(6), 1429–1441 (2009).
   PubMed Web of Science ®Google Scholar
• Brehm JM, Schuemann B, Fuhlbrigge AL et al.; Childhood Asthma Management Program Research Group. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J. Allergy Clin. Immunol. 126(1), 52–58.e5 (2010).
   PubMed Web of Science ®Google Scholar
• Li F, Peng M, Jiang L et al. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration. 81(6), 469–475 (2011).
   PubMed Web of Science ®Google Scholar
• Brehm JM, Celedón JC, Soto-Quiros ME et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am. J. Respir. Crit. Care Med. 179(9), 765–771 (2009).
   PubMed Web of Science ®Google Scholar
• Expert Panel Report 3 (EPR-3). Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J. Allergy. Clin. Immunol. 120(Suppl. 5), S94–138 (2007).
   PubMed Web of Science ®Google Scholar
• Adcock IM, Ford PA, Bhavsar P, Ahmad T, Chung KF. Steroid resistance in asthma: mechanisms and treatment options. Curr. Allergy Asthma Rep. 8(2), 171–178 (2008).
   PubMed Web of Science ®Google Scholar
• Jang AS, Lee JH, Park SW et al. Factors influencing the responsiveness to inhaled glucocorticoids of patients with moderate-to-severe asthma. Chest 128(3), 1140–1145 (2005).
   PubMed Web of Science ®Google Scholar
• Szefler SJ, Martin RJ, King TS et al.; Asthma Clinical Research Network of the National Heart Lung, and Blood Institute. Significant variability in response to inhaled corticosteroids for persistent asthma. J. Allergy Clin. Immunol. 109(3), 410–418 (2002).
   PubMed Web of Science ®Google Scholar
• Ernst P, Suissa S. Systemic effects of inhaled corticosteroids. Curr. Opin. Pulm. Med. 18(1), 85–89 (2012).
   PubMed Web of Science ®Google Scholar
• Xystrakis E, Kusumakar S, Boswell S et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J. Clin. Invest. 116(1), 146–155 (2006).
   PubMed Web of Science ®Google Scholar
• Wu AC, Tantisira K, Li L, Fuhlbrigge AL, Weiss ST, Litonjua A; Childhood Asthma Management Program Research Group. Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am. J. Respir. Crit. Care Med. 186(6), 508–513 (2012).
   PubMed Web of Science ®Google Scholar
• Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J. Allergy Clin. Immunol. 125(5), 995–1000 (2010).
   PubMed Web of Science ®Google Scholar
• Goleva E, Searing DA, Jackson LP, Richers BN, Leung DY. Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma. J. Allergy Clin. Immunol. 129(5), 1243–1251 (2012).
   PubMed Web of Science ®Google Scholar
• Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma. Am. J. Respir. Crit. Care Med. 181(7), 699–704 (2010).
   PubMed Web of Science ®Google Scholar
• Ferreira GB, Kleijwegt FS, Waelkens E et al. Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells. J. Proteome Res. 11(2), 941–971 (2012).
   PubMed Web of Science ®Google Scholar
• Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat. Rev. Cancer 7(9), 684–700 (2007).
   PubMed Web of Science ®Google Scholar
• Fleet JC, DeSmet M, Johnson R, Li Y. Vitamin D and cancer: a review of molecular mechanisms. Biochem. J. 441(1), 61–76 (2012).
   PubMed Web of Science ®Google Scholar
• Johnson CS, Muindi JR, Hershberger PA, Trump DL. The antitumor efficacy of calcitriol: preclinical studies. Anticancer Res. 26(4A), 2543–2549 (2006).
   PubMed Web of Science ®Google Scholar
• Trump DL, Potter DM, Muindi J, Brufsky A, Johnson CS. Phase II trial of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer. Cancer 106(10), 2136–2142 (2006).
   PubMed Web of Science ®Google Scholar
• Hidalgo AA, Deeb KK, Pike JW, Johnson CS, Trump DL. Dexamethasone enhances 1α,25-dihydroxyvitamin D3 effects by increasing vitamin D receptor transcription. J. Biol. Chem. 286(42), 36228–36237 (2011).
   PubMed Web of Science ®Google Scholar
• Zella LA, Meyer MB, Nerenz RD, Lee SM, Martowicz ML, Pike JW. Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription. Mol. Endocrinol. 24(1), 128–147 (2010).
   PubMedGoogle Scholar