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Perspective

The association between acetaminophen and asthma: should its pediatric use be banned?

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Pages 113-122 | Published online: 09 Jan 2014

References

  • Custovic A, Marinho S, Simpson A. Gene–environment interactions in the development of asthma and atopy. Expert Rev. Respir. Med. 6(3), 301–308 (2012).
  • Varner AE, Busse WW, Lemanske RF Jr. Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma. Ann. Allergy Asthma Immunol. 81(4), 347–351 (1998).
  • McBride JT. The association of acetaminophen and asthma prevalence and severity. Pediatrics 128(6), 1181–1185 (2011).
  • Lowe AJ, Carlin JB, Bennett CM et al. Paracetamol use in early life and asthma: prospective birth cohort study. BMJ 341, c4616 (2010).
  • Pereira GL, Dagostini JM, Pizzol Tda S. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials. J. Pediatr. (Rio. J.) 88(4), 289–296 (2012).
  • Shaheen SO, Sterne JA, Songhurst CE, Burney PG. Frequent paracetamol use and asthma in adults. Thorax 55(4), 266–270 (2000).
  • Newson RB, Shaheen SO, Chinn S, Burney PG. Paracetamol sales and atopic disease in children and adults: an ecological analysis. Eur. Respir. J. 16(5), 817–823 (2000).
  • Beasley R, Clayton T, Crane J et al.; ISAAC Phase Three Study Group. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme. Lancet 372(9643), 1039–1048 (2008).
  • Beasley RW, Clayton TO, Crane J et al.; ISAAC Phase Three Study Group. Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. Am. J. Respir. Crit. Care Med. 183(2), 171–178 (2011).
  • Amberbir A, Medhin G, Alem A, Britton J, Davey G, Venn A. The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study. Am. J. Respir. Crit. Care Med. 183(2), 165–170 (2011).
  • Etminan M, Sadatsafavi M, Jafari S, Doyle-Waters M, Aminzadeh K, Fitzgerald JM. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. Chest 136(5), 1316–1323 (2009).
  • García-Marcos L, Sanchez-Solis M, Perez-Fernandez V. Early exposure to acetaminophen and allergic disorders. Curr. Opin. Allergy Clin. Immunol. 11(3), 162–173 (2011).
  • Gonzalez-Barcala FJ, Pertega S, Castro TP et al. Exposure to paracetamol and asthma symptoms. Eur. J. Public Health doi:10.1093/eurpub/cks061 (2012) (Epub ahead of print).
  • Andersen AB, Farkas DK, Mehnert F, Ehrenstein V, Erichsen R. Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study. Clin. Epidemiol. 4, 33–40 (2012).
  • Lesko SM, Louik C, Vezina RM, Mitchell AA. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 109(2), E20 (2002).
  • Holgate ST. The acetaminophen enigma in asthma. Am. J. Respir. Crit. Care Med. 183(2), 147–148 (2011).
  • Soferman R, Tsivion A, Farber M, Sivan Y. The effect of a single dose of acetaminophen on airways response in children with asthma. Clin. Pediatr. (Phila). 52(1), 42–48 (2013).
  • Henderson AJ, Shaheen SO. Acetaminophen and asthma. Paediatr. Respir. Rev. 14(1), 9–16 (2013).
  • Moral L, Marco N, Fuentes MJ et al. Asthma and paracetamol: Could we really know what happens between them? Allergol. Immunopathol. (Madr.) doi:10.1016/j.aller.2012.07.012 (2012) (Epub ahead of print).
  • Farquhar H, Stewart A, Mitchell E et al. The role of paracetamol in the pathogenesis of asthma. Clin. Exp. Allergy 40(1), 32–41 (2010).
  • Dimova S, Hoet PH, Dinsdale D, Nemery B. Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro. Int. J. Biochem. Cell Biol. 37(8), 1727–1737 (2005).
  • Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic. Biol. Med. 9(3), 235–243 (1990).
  • Smith LJ, Houston M, Anderson J. Increased levels of glutathione in bronchoalveolar lavage fluid from patients with asthma. Am. Rev. Respir. Dis. 147(6 Pt 1), 1461–1464 (1993).
  • Jarjour NN, Calhoun WJ. Enhanced production of oxygen radicals in asthma. J. Lab. Clin. Med. 123(1), 131–136 (1994).
  • Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc. Natl Acad. Sci. USA 95(6), 3071–3076 (1998).
  • Graham NM, Burrell CJ, Douglas RM, Debelle P, Davies L. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers. J. Infect. Dis. 162(6), 1277–1282 (1990).
  • Hill AB. The environment and disease: association or causation? Proc. R. Soc. Med. 58, 295–300 (1965).
  • Lowe A, Abramson M, Dharmage S, Allen K. Paracetamol as a risk factor for allergic disorders. Lancet 373(9658), 120; author reply 120–121 (2009).
  • Schnabel E, Heinrich J; LISA Study Group. Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood. J. Allergy Clin. Immunol. 126(5), 1071–1073 (2010).
  • Kreiner-Møller E, Sevelsted A, Vissing NH, Schoos AM, Bisgaard H. Infant acetaminophen use associates with early asthmatic symptoms independently of respiratory tract infections: the Copenhagen Prospective Study on Asthma in Childhood 2000 (COPSAC(2000)) cohort. J. Allergy Clin. Immunol. 130(6), 1434–1436 (2012).
  • Chang KC, Leung CC, Tam CM, Kong FY. Acetaminophen and asthma: spurious association? Am. J. Respir. Crit. Care Med. 183(11), 1570; author reply 1570–1571 (2011).
  • Martínez-Gimeno A. Onions, myths, beliefs, fashion and reality in asthma. Allergol. Immunopathol. (Madr.) 37(6), 309–313 (2009).
  • Dharmage SC, Allen KJ. Does regular paracetamol ingestion increase the risk of developing asthma? Clin. Exp. Allergy 41(4), 459–460 (2011).
  • No authors listed. Paracetamol during pregnancy: no particular danger for the child. Prescrire Int. 21(129), 188–189 (2012).
  • No authors listed. Paracetamol exposure in utero or during infancy: no increase in asthma. Prescrire Int. 21(129), 188–189 (2012).
  • Heintze K, Petersen KU. The case of drug causation of childhood asthma: antibiotics and paracetamol. Eur. J. Clin. Pharmacol. doi:10.1007/s00228-012-1463-7 (2013) (Epub ahead of print).

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